LOCUS       NM_024518               3111 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens UL16 binding protein 3 (ULBP3), mRNA.
ACCESSION   NM_024518
VERSION     NM_024518.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3111)
  AUTHORS   Wei,L., He,P., Tan,Z., Zhao,L., Lin,C. and Wei,Z.
  TITLE     Unveiling the role of the KLF4/Lnc18q22.2/ULBP3 axis in the
            tumorigenesis and immune escape of hepatocellular carcinoma under
            hypoxic condition
  JOURNAL   J Cell Mol Med 28 (10), e18411 (2024)
   PUBMED   38780505
  REMARK    GeneRIF: Unveiling the role of the KLF4/Lnc18q22.2/ULBP3 axis in
            the tumorigenesis and immune escape of hepatocellular carcinoma
            under hypoxic condition.
REFERENCE   2  (bases 1 to 3111)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3111)
  AUTHORS   Zuo,J., Willcox,C.R., Mohammed,F., Davey,M., Hunter,S., Khan,K.,
            Antoun,A., Katakia,P., Croudace,J., Inman,C., Parry,H., Briggs,D.,
            Malladi,R., Willcox,B.E. and Moss,P.
  TITLE     A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target
            cell killing by enhancing the stability of NKG2D ligand binding
  JOURNAL   Sci Signal 10 (481) (2017)
   PUBMED   28559451
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3111)
  AUTHORS   Moftah,N.H., El-Barbary,R.A., Rashed,L. and Said,M.
  TITLE     ULBP3: a marker for alopecia areata incognita
  JOURNAL   Arch Dermatol Res 308 (6), 415-421 (2016)
   PUBMED   27142445
  REMARK    GeneRIF: this study shows an increase in ULBP3 level in alopecia
            areata incognita patients, which positively correlates with the age
            and duration of the disease
REFERENCE   5  (bases 1 to 3111)
  AUTHORS   Campbell,T.M., McSharry,B.P., Steain,M., Slobedman,B. and
            Abendroth,A.
  TITLE     Varicella-Zoster Virus and Herpes Simplex Virus 1 Differentially
            Modulate NKG2D Ligand Expression during Productive Infection
  JOURNAL   J Virol 89 (15), 7932-7943 (2015)
   PUBMED   25995251
  REMARK    GeneRIF: Varicella-Zoster Virus differentially modulates expression
            of the NKG2D ligands by upregulating MICA expression and reducing
            ULBP2 and ULBP3 expression in the infected cells.
REFERENCE   6  (bases 1 to 3111)
  AUTHORS   Sutherland,C.L., Chalupny,N.J., Schooley,K., VandenBos,T., Kubin,M.
            and Cosman,D.
  TITLE     UL16-binding proteins, novel MHC class I-related proteins, bind to
            NKG2D and activate multiple signaling pathways in primary NK cells
  JOURNAL   J Immunol 168 (2), 671-679 (2002)
   PUBMED   11777960
  REMARK    GeneRIF: ULBP3 binds to the NGK2D receptor and activates multiple
            signaling pathways in primary natural killer cells.
REFERENCE   7  (bases 1 to 3111)
  AUTHORS   Radosavljevic,M., Cuillerier,B., Wilson,M.J., Clement,O.,
            Wicker,S., Gilfillan,S., Beck,S., Trowsdale,J. and Bahram,S.
  TITLE     A cluster of ten novel MHC class I related genes on human
            chromosome 6q24.2-q25.3
  JOURNAL   Genomics 79 (1), 114-123 (2002)
   PUBMED   11827464
REFERENCE   8  (bases 1 to 3111)
  AUTHORS   Radaev,S., Rostro,B., Brooks,A.G., Colonna,M. and Sun,P.D.
  TITLE     Conformational plasticity revealed by the cocrystal structure of
            NKG2D and its class I MHC-like ligand ULBP3
  JOURNAL   Immunity 15 (6), 1039-1049 (2001)
   PUBMED   11754823
REFERENCE   9  (bases 1 to 3111)
  AUTHORS   Steinle,A., Li,P., Morris,D.L., Groh,V., Lanier,L.L., Strong,R.K.
            and Spies,T.
  TITLE     Interactions of human NKG2D with its ligands MICA, MICB, and
            homologs of the mouse RAE-1 protein family
  JOURNAL   Immunogenetics 53 (4), 279-287 (2001)
   PUBMED   11491531
REFERENCE   10 (bases 1 to 3111)
  AUTHORS   Cosman,D., Mullberg,J., Sutherland,C.L., Chin,W., Armitage,R.,
            Fanslow,W., Kubin,M. and Chalupny,N.J.
  TITLE     ULBPs, novel MHC class I-related molecules, bind to CMV
            glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D
            receptor
  JOURNAL   Immunity 14 (2), 123-133 (2001)
   PUBMED   11239445
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK315275.1, CA488356.1 and
            AL355497.14.
            
            On Nov 22, 2018 this sequence version replaced NM_024518.2.
            
            Summary: The protein encoded by this gene is one of several related
            ligands of the KLRK1/NKG2D receptor, which is found in primary NK
            cells. Binding of these ligands to the receptor activates several
            signal transduction pathways, including the JAK2, STAT5, and ERK
            pathways. The encoded protein is expressed solubly and on the
            surface of many tumor cells, making it potentially an important
            target for therapeutics. [provided by RefSeq, Nov 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.200087.1,
                                           SRR5189667.311190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367339.7/ ENSP00000356308.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-790               AK315275.1         267-1056
            791-1038            CA488356.1         470-717
            1039-3111           AL355497.14        107167-109239       c
FEATURES             Location/Qualifiers
     source          1..3111
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..3111
                     /gene="ULBP3"
                     /gene_synonym="N2DL-3; NKG2DL3; RAET1N"
                     /note="UL16 binding protein 3"
                     /db_xref="GeneID:79465"
                     /db_xref="HGNC:HGNC:14895"
                     /db_xref="MIM:605699"
     exon            1..143
                     /gene="ULBP3"
                     /gene_synonym="N2DL-3; NKG2DL3; RAET1N"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..790
                     /gene="ULBP3"
                     /gene_synonym="N2DL-3; NKG2DL3; RAET1N"
                     /note="NKG2D ligand 3; ALCAN-gamma; retinoic acid early
                     transcript 1N"
                     /codon_start=1
                     /product="UL16-binding protein 3 precursor"
                     /protein_id="NP_078794.1"
                     /db_xref="CCDS:CCDS5225.1"
                     /db_xref="GeneID:79465"
                     /db_xref="HGNC:HGNC:14895"
                     /db_xref="MIM:605699"
                     /translation="MAAAASPAILPRLAILPYLLFDWSGTGRADAHSLWYNFTIIHLP
                     RHGQQWCEVQSQVDQKNFLSYDCGSDKVLSMGHLEEQLYATDAWGKQLEMLREVGQRL
                     RLELADTELEDFTPSGPLTLQVRMSCECEADGYIRGSWQFSFDGRKFLLFDSNNRKWT
                     VVHAGARRMKEKWEKDSGLTTFFKMVSMRDCKSWLRDFLMHRKKRLEPTAPPTMAPGL
                     AQPKAIATTLSPWSFLIILCFILPGI"
     exon            144..407
                     /gene="ULBP3"
                     /gene_synonym="N2DL-3; NKG2DL3; RAET1N"
                     /inference="alignment:Splign:2.1.0"
     exon            408..683
                     /gene="ULBP3"
                     /gene_synonym="N2DL-3; NKG2DL3; RAET1N"
                     /inference="alignment:Splign:2.1.0"
     exon            684..812
                     /gene="ULBP3"
                     /gene_synonym="N2DL-3; NKG2DL3; RAET1N"
                     /inference="alignment:Splign:2.1.0"
     exon            813..3111
                     /gene="ULBP3"
                     /gene_synonym="N2DL-3; NKG2DL3; RAET1N"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2882..2887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ULBP3"
                     /gene_synonym="N2DL-3; NKG2DL3; RAET1N"
                     /note="hexamer: AATAAA"
     polyA_site      2900
                     /gene="ULBP3"
                     /gene_synonym="N2DL-3; NKG2DL3; RAET1N"
                     /note="major polyA site"
     regulatory      2914..2919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ULBP3"
                     /gene_synonym="N2DL-3; NKG2DL3; RAET1N"
                     /note="hexamer: AATAAA"
     polyA_site      2942
                     /gene="ULBP3"
                     /gene_synonym="N2DL-3; NKG2DL3; RAET1N"
     regulatory      3088..3093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ULBP3"
                     /gene_synonym="N2DL-3; NKG2DL3; RAET1N"
                     /note="hexamer: ATTAAA"
     polyA_site      3111
                     /gene="ULBP3"
                     /gene_synonym="N2DL-3; NKG2DL3; RAET1N"
                     /note="major polyA site"
ORIGIN      
        1 atacgctggt ctccacatcg actgcgcctt gtgtcccggg cgctcctggt ctacaatggc
       61 agcggccgcc agccccgcga tccttccgcg cctcgcgatt cttccgtacc tgctattcga
      121 ctggtccggg acggggcggg ccgacgctca ctctctctgg tataacttca ccatcattca
      181 tttgcccaga catgggcaac agtggtgtga ggtccagagc caggtggatc agaagaattt
      241 tctctcctat gactgtggca gtgacaaggt cttatctatg ggtcacctag aagagcagct
      301 gtatgccaca gatgcctggg gaaaacaact ggaaatgctg agagaggtgg ggcagaggct
      361 cagactggaa ctggctgaca ctgagctgga ggatttcaca cccagtggac ccctcacgct
      421 gcaggtcagg atgtcttgtg agtgtgaagc cgatggatac atccgtggat cttggcagtt
      481 cagcttcgat ggacggaagt tcctcctctt tgactcaaac aacagaaagt ggacagtggt
      541 tcacgctgga gccaggcgga tgaaagagaa gtgggagaag gatagcggac tgaccacctt
      601 cttcaagatg gtctcaatga gagactgcaa gagctggctt agggacttcc tgatgcacag
      661 gaagaagagg ctggaaccca cagcaccacc caccatggcc ccaggcttag ctcaacccaa
      721 agccatagcc accaccctca gtccctggag cttcctcatc atcctctgct tcatcctccc
      781 tggcatctga gaagagtcat ttagagtgac aggtggaagg tgatatcaag aagcctctgt
      841 tagcctggtc tggttcctgc tctcccttca gggaggccgc ctgtctactc accactgtgc
      901 ctttctggaa agcaggagtt caagccttag caagcccaga ggcccccagc agatgatgag
      961 gacattgtcg gctcaacatc tcaggccact cattaccttc gctcatgatc ccagcagcca
     1021 tttttctttt tttttttttg tttttttttt tttttgagac ggagtctcgc tctgtcgccc
     1081 aggccggact gcggactgca gtggcgcaat ctcggctcac tgcaagctcc gcttcccggg
     1141 ttcacgccat tctcctgcct cagcctcccg agtagctggg actacaggca cccgccaccg
     1201 cgcccggcta attttttgta tttttagtag agacagggtt tcaccttgtt agccaggatg
     1261 gtctcgatct cctgacctca tgatccacct gcctcggcct cccagagtgc tgggattaca
     1321 ggcgtgagcc accgcgcccg gccagccatt tttcttaaca ccttctgcca ctttctctcg
     1381 gtgctaatgg atggaattcc tgcacaagtt ttaactgaac aagaaatccc agcaaaaggc
     1441 attttctttc tacttctttg attgtggaaa agcagacatt tctctgaagc atgaccttat
     1501 tcttcgaaac ggtattgcta gtaaaatagc atgcaggact tcagacctca gggatccttt
     1561 ccatgcactg accaagaatt gtattaatcc tttttatcat tatagttttt ttacattttc
     1621 tcattctgtc aaccatattg gagtgaagtg gcatagtcat cactcactgt aatctccaac
     1681 tcctgggctc aagtgatcct ctagactcag cctctagagt agctgggact acaggcgcat
     1741 gccaccatgc ctggcaaatt gttttatatt taggtagaga ttgggtcttc ctatgttgcg
     1801 caggtaataa aactgtgaaa atcctggaat ataagctaag aaataccaat gtggacatag
     1861 ggcctggcaa agatttcatg aagaagacac taaaaacaat tgtaacaaaa acaaaaattg
     1921 acaaatggga cctcattaaa ctaaagagct tctgcacaga aaaagaaact agcaacacgg
     1981 taaacagaca gcgtgtagaa tggggaaact atttgcaaac tctgcatctg acaaaggtcc
     2041 aatatccaga atctacaaag tacttaaaca attagacaag caagaaaaaa aaacccaatt
     2101 aaaaaatgtg caaagacatg aacagacact tttcaaaaga agacatacaa gtggccaaca
     2161 aacgtgaaaa aatgctcaat atcactaatc atcagataag tgcaaatcaa aactgcaatg
     2221 agttaccatc tcttaccagt cacaaagttg gagatggtgg tgaggctgca gaggaaaaga
     2281 aacagacact gttggtggga aagcaaactt gttcagccgc tatggaaagc agtttggaga
     2341 tttctccaag aacttaaaat agaactacca ttcaagcctg caatcccact actcgggata
     2401 tatccacagg aaaagaattc attttatcca aaagacacct gcaccaatat gttcattaca
     2461 gtgctattct tactagcaag gacacagaat caacctaagt gcccagcaac actgaattga
     2521 atgaaaaaaa tgtggtacat aaacaccatg gaaatctatg cagccaccaa acacagcaaa
     2581 atcatgtcct tttcagcaac atggatggaa ctagaggcta ttatcctaag caacctaatg
     2641 caagaacaga aaactacata ctgcatgttc ccattggaaa gtggcagcta cacattgaat
     2701 tcacatgaac cagaggcact ggagattact agacaggtga gacaggaggg gcacctgggc
     2761 tgaaaaacca cctgttgggt accatgctta ctgtttgagt gatgagatca ttgggacacc
     2821 aagcctcagc cttccaaaat ctacccatgt aacaaacctg tatgtgtacc ctttaatcta
     2881 taataaaggt taaaattaaa gattcgtaag taaaataaaa tgacatagag ccctccaaaa
     2941 aatggggtta actgagtgga acgagagaac tttgcactat gaacgctaac ccagatcaaa
     3001 aactaaactc tagtcattta aaataatcgt aagttgtata tgatgataat tgtataaaag
     3061 ttatacgtga aagtgccaaa ccctaaaatt aaacactgca taatgaaatt a
//
