LOCUS       NM_025217               1335 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens UL16 binding protein 2 (ULBP2), mRNA.
ACCESSION   NM_025217
VERSION     NM_025217.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1335)
  AUTHORS   Jost,S., Ahn,J., Chen,S., Yoder,T., Gikundiro,K.E., Lee,E.,
            Gressens,S.B., Kroll,K., Craemer,M., Kaynor,G.C., Lifton,M. and
            Tan,C.S.
  TITLE     Upregulation of the NKG2D Ligand ULBP2 by JC Polyomavirus Infection
            Promotes Immune Recognition by Natural Killer Cells
  JOURNAL   J Infect Dis 229 (6), 1836-1844 (2024)
   PUBMED   37774496
  REMARK    GeneRIF: Upregulation of the NKG2D Ligand ULBP2 by JC Polyomavirus
            Infection Promotes Immune Recognition by Natural Killer Cells.
REFERENCE   2  (bases 1 to 1335)
  AUTHORS   Yang,X., Su,X., Wang,Z., Yu,Y., Wu,Z. and Zhang,D.
  TITLE     ULBP2 is a biomarker related to prognosis and immunity in colon
            cancer
  JOURNAL   Mol Cell Biochem 478 (10), 2207-2219 (2023)
   PUBMED   36633827
  REMARK    GeneRIF: ULBP2 is a biomarker related to prognosis and immunity in
            colon cancer.
REFERENCE   3  (bases 1 to 1335)
  AUTHORS   Mellergaard,M., Hogh,R.I., Lund,A., Aldana,B.I., Guerillot,R.,
            Moller,S.H., Hayes,A.S., Panagiotopoulou,N., Frimand,Z.,
            Jepsen,S.D., Hansen,C.H.F., Andresen,L., Larsen,A.R., Peleg,A.Y.,
            Stinear,T.P., Howden,B.P., Waagepetersen,H.S., Frees,D. and Skov,S.
  TITLE     Staphylococcus aureus induces cell-surface expression of immune
            stimulatory NKG2D ligands on human monocytes
  JOURNAL   J Biol Chem 295 (33), 11803-11821 (2020)
   PUBMED   32605922
  REMARK    GeneRIF: Staphylococcus aureus induces cell-surface expression of
            immune stimulatory NKG2D ligands on human monocytes.
REFERENCE   4  (bases 1 to 1335)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1335)
  AUTHORS   Cerwenka,A. and Lanier,L.L.
  TITLE     NKG2D ligands: unconventional MHC class I-like molecules exploited
            by viruses and cancer
  JOURNAL   Tissue Antigens 61 (5), 335-343 (2003)
   PUBMED   12753652
  REMARK    Review article
REFERENCE   6  (bases 1 to 1335)
  AUTHORS   Sutherland,C.L., Chalupny,N.J., Schooley,K., VandenBos,T., Kubin,M.
            and Cosman,D.
  TITLE     UL16-binding proteins, novel MHC class I-related proteins, bind to
            NKG2D and activate multiple signaling pathways in primary NK cells
  JOURNAL   J Immunol 168 (2), 671-679 (2002)
   PUBMED   11777960
  REMARK    GeneRIF: ULBP2 binds to the NKG2D receptor and activates multiple
            signaling pathways in primary natural killer cells.
REFERENCE   7  (bases 1 to 1335)
  AUTHORS   Radosavljevic,M., Cuillerier,B., Wilson,M.J., Clement,O.,
            Wicker,S., Gilfillan,S., Beck,S., Trowsdale,J. and Bahram,S.
  TITLE     A cluster of ten novel MHC class I related genes on human
            chromosome 6q24.2-q25.3
  JOURNAL   Genomics 79 (1), 114-123 (2002)
   PUBMED   11827464
REFERENCE   8  (bases 1 to 1335)
  AUTHORS   Onda,H., Ohkubo,S., Shintani,Y., Ogi,K., Kikuchi,K., Tanaka,H.,
            Yamamoto,K., Tsuji,I., Ishibashi,Y., Yamada,T., Kitada,C.,
            Suzuki,N., Sawada,H., Nishimura,O. and Fujino,M.
  TITLE     A novel secreted tumor antigen with a
            glycosylphosphatidylinositol-anchored structure ubiquitously
            expressed in human cancers
  JOURNAL   Biochem Biophys Res Commun 285 (2), 235-243 (2001)
   PUBMED   11444831
REFERENCE   9  (bases 1 to 1335)
  AUTHORS   Steinle,A., Li,P., Morris,D.L., Groh,V., Lanier,L.L., Strong,R.K.
            and Spies,T.
  TITLE     Interactions of human NKG2D with its ligands MICA, MICB, and
            homologs of the mouse RAE-1 protein family
  JOURNAL   Immunogenetics 53 (4), 279-287 (2001)
   PUBMED   11491531
REFERENCE   10 (bases 1 to 1335)
  AUTHORS   Cosman,D., Mullberg,J., Sutherland,C.L., Chin,W., Armitage,R.,
            Fanslow,W., Kubin,M. and Chalupny,N.J.
  TITLE     ULBPs, novel MHC class I-related molecules, bind to CMV
            glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D
            receptor
  JOURNAL   Immunity 14 (2), 123-133 (2001)
   PUBMED   11239445
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG718474.1, AL583835.6 and
            AY358665.1.
            
            On Nov 23, 2018 this sequence version replaced NM_025217.3.
            
            Summary: This gene encodes a major histocompatibility complex (MHC)
            class I-related molecule that binds to the NKG2D receptor on
            natural killer (NK) cells to trigger release of multiple cytokines
            and chemokines that in turn contribute to the recruitment and
            activation of NK cells. The encoded protein undergoes further
            processing to generate the mature protein that is either anchored
            to membrane via a glycosylphosphatidylinositol moiety, or secreted.
            Many malignant cells secrete the encoded protein to evade
            immunosurveillance by NK cells. This gene is located in a cluster
            of multiple MHC class I-related genes on chromosome 6. [provided by
            RefSeq, Jul 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB052906.1, SRR5189661.30853.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367351.4/ ENSP00000356320.3
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BG718474.1         82-117
            37-51               AL583835.6         35005-35019
            52-1335             AY358665.1         1-1284
FEATURES             Location/Qualifiers
     source          1..1335
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..1335
                     /gene="ULBP2"
                     /gene_synonym="ALCAN-alpha; N2DL2; NKG2DL2; RAET1H;
                     RAET1L"
                     /note="UL16 binding protein 2"
                     /db_xref="GeneID:80328"
                     /db_xref="HGNC:HGNC:14894"
                     /db_xref="MIM:605698"
     exon            1..144
                     /gene="ULBP2"
                     /gene_synonym="ALCAN-alpha; N2DL2; NKG2DL2; RAET1H;
                     RAET1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..800
                     /gene="ULBP2"
                     /gene_synonym="ALCAN-alpha; N2DL2; NKG2DL2; RAET1H;
                     RAET1L"
                     /note="NKG2D ligand 2; retinoic acid early transcript 1H;
                     retinoic acid early transcript 1L"
                     /codon_start=1
                     /product="UL16-binding protein 2 preproprotein"
                     /protein_id="NP_079493.1"
                     /db_xref="CCDS:CCDS5222.1"
                     /db_xref="GeneID:80328"
                     /db_xref="HGNC:HGNC:14894"
                     /db_xref="MIM:605698"
                     /translation="MAAAAATKILLCLPLLLLLSGWSRAGRADPHSLCYDITVIPKFR
                     PGPRWCAVQGQVDEKTFLHYDCGNKTVTPVSPLGKKLNVTTAWKAQNPVLREVVDILT
                     EQLRDIQLENYTPKEPLTLQARMSCEQKAEGHSSGSWQFSFDGQIFLLFDSEKRMWTT
                     VHPGARKMKEKWENDKVVAMSFHYFSMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSSG
                     TTQLRATATTLILCCLLIILPCFILPGI"
     exon            145..408
                     /gene="ULBP2"
                     /gene_synonym="ALCAN-alpha; N2DL2; NKG2DL2; RAET1H;
                     RAET1L"
                     /inference="alignment:Splign:2.1.0"
     exon            409..690
                     /gene="ULBP2"
                     /gene_synonym="ALCAN-alpha; N2DL2; NKG2DL2; RAET1H;
                     RAET1L"
                     /inference="alignment:Splign:2.1.0"
     exon            691..822
                     /gene="ULBP2"
                     /gene_synonym="ALCAN-alpha; N2DL2; NKG2DL2; RAET1H;
                     RAET1L"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1335
                     /gene="ULBP2"
                     /gene_synonym="ALCAN-alpha; N2DL2; NKG2DL2; RAET1H;
                     RAET1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1311..1316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ULBP2"
                     /gene_synonym="ALCAN-alpha; N2DL2; NKG2DL2; RAET1H;
                     RAET1L"
                     /note="hexamer: AATAAA"
     polyA_site      1335
                     /gene="ULBP2"
                     /gene_synonym="ALCAN-alpha; N2DL2; NKG2DL2; RAET1H;
                     RAET1L"
                     /note="major polyA site"
ORIGIN      
        1 attcatcttc caggctctcc ttccatcaag tctctcatcc ctagcgctct gggtccttaa
       61 tggcagcagc cgccgctacc aagatccttc tgtgcctccc gcttctgctc ctgctgtccg
      121 gctggtcccg ggctgggcga gccgaccctc actctctttg ctatgacatc accgtcatcc
      181 ctaagttcag acctggacca cggtggtgtg cggttcaagg ccaggtggat gaaaagactt
      241 ttcttcacta tgactgtggc aacaagacag tcacacctgt cagtcccctg gggaagaaac
      301 taaatgtcac aacggcctgg aaagcacaga acccagtact gagagaggtg gtggacatac
      361 ttacagagca actgcgtgac attcagctgg agaattacac acccaaggaa cccctcaccc
      421 tgcaggcaag gatgtcttgt gagcagaaag ctgaaggaca cagcagtgga tcttggcagt
      481 tcagtttcga tgggcagatc ttcctcctct ttgactcaga gaagagaatg tggacaacgg
      541 ttcatcctgg agccagaaag atgaaagaaa agtgggagaa tgacaaggtt gtggccatgt
      601 ccttccatta cttctcaatg ggagactgta taggatggct tgaggacttc ttgatgggca
      661 tggacagcac cctggagcca agtgcaggag caccactcgc catgtcctca ggcacaaccc
      721 aactcagggc cacagccacc accctcatcc tttgctgcct cctcatcatc ctcccctgct
      781 tcatcctccc tggcatctga ggagagtcct ttagagtgac aggttaaagc tgataccaaa
      841 aggctcctgt gagcacggtc ttgatcaaac tcgcccttct gtctggccag ctgcccacga
      901 cctacggtgt atgtccagtg gcctccagca gatcatgatg acatcatgga cccaatagct
      961 cattcactgc cttgattcct tttgccaaca attttaccag cagttatacc taacatatta
     1021 tgcaattttc tcttggtgct acctgatgga attcctgcac ttaaagttct ggctgactaa
     1081 acaagatata tcattttctt tcttctcttt ttgtttggaa aatcaagtac ttctttgaat
     1141 gatgatctct ttcttgcaaa tgatattgtc agtaaaataa tcacgttaga cttcagacct
     1201 ctggggattc tttccgtgtc ctgaaagaga atttttaaat tatttaataa gaaaaaattt
     1261 atattaatga ttgtttcctt tagtaattta ttgttctgta ctgatattta aataaagagt
     1321 tctatttccc aaaaa
//
