LOCUS       NM_025218               3211 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens UL16 binding protein 1 (ULBP1), transcript variant 1,
            mRNA.
ACCESSION   NM_025218
VERSION     NM_025218.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3211)
  AUTHORS   Tang,B., Guo,M., Zhai,Y., Zhang,K., Ni,K., Zhang,Y. and Huang,L.
  TITLE     Human esophageal cancer stem-like cells escape the cytotoxicity of
            natural killer cells via down-regulation of ULBP-1
  JOURNAL   J Transl Med 22 (1), 737 (2024)
   PUBMED   39103915
  REMARK    GeneRIF: Human esophageal cancer stem-like cells escape the
            cytotoxicity of natural killer cells via down-regulation of ULBP-1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3211)
  AUTHORS   Lai,Z., Li,M., Yang,X. and Xian,Z.
  TITLE     Knockdown of the UL-16 binding protein 1 promotes osteoblast
            differentiation of human mesenchymal stem cells by activating the
            SMAD2/3 pathway
  JOURNAL   BMC Musculoskelet Disord 25 (1), 213 (2024)
   PUBMED   38481217
  REMARK    GeneRIF: Knockdown of the UL-16 binding protein 1 promotes
            osteoblast differentiation of human mesenchymal stem cells by
            activating the SMAD2/3 pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3211)
  AUTHORS   Sleman,S., Hao,H., Najmuldeen,H., Jalal,P., Saeed,N., Othman,D. and
            Qian,Z.
  TITLE     Human Cytomegalovirus UL24 and UL43 Cooperate to Modulate the
            Expression of Immunoregulatory UL16 Binding Protein 1
  JOURNAL   Viral Immunol 35 (8), 529-544 (2022)
   PUBMED   36179070
  REMARK    GeneRIF: Human Cytomegalovirus UL24 and UL43 Cooperate to Modulate
            the Expression of Immunoregulatory UL16 Binding Protein 1.
REFERENCE   4  (bases 1 to 3211)
  AUTHORS   Liu,J., Song,G., Meng,T. and Zhao,G.
  TITLE     UL16-Binding Protein 1 Induced HTR-8/SVneo Autophagy via NF-kappaB
            Suppression Mediated by TNF-alpha Secreted through uNK Cells
  JOURNAL   Biomed Res Int 2020, 9280372 (2020)
   PUBMED   32626772
  REMARK    GeneRIF: UL16-Binding Protein 1 Induced HTR-8/SVneo Autophagy via
            NF-kappaB Suppression Mediated by TNF-alpha Secreted through uNK
            Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3211)
  AUTHORS   Hu,B., Tian,X., Li,Y., Liu,Y., Yang,T., Han,Z., An,J., Kong,L. and
            Li,Y.
  TITLE     Epithelial-mesenchymal transition may be involved in the immune
            evasion of circulating gastric tumor cells via downregulation of
            ULBP1
  JOURNAL   Cancer Med 9 (8), 2686-2697 (2020)
   PUBMED   32077634
  REMARK    GeneRIF: Epithelial-mesenchymal transition may be involved in the
            immune evasion of circulating gastric tumor cells via
            downregulation of ULBP1.
REFERENCE   6  (bases 1 to 3211)
  AUTHORS   Cerwenka,A. and Lanier,L.L.
  TITLE     NKG2D ligands: unconventional MHC class I-like molecules exploited
            by viruses and cancer
  JOURNAL   Tissue Antigens 61 (5), 335-343 (2003)
   PUBMED   12753652
  REMARK    Review article
REFERENCE   7  (bases 1 to 3211)
  AUTHORS   Sutherland,C.L., Chalupny,N.J., Schooley,K., VandenBos,T., Kubin,M.
            and Cosman,D.
  TITLE     UL16-binding proteins, novel MHC class I-related proteins, bind to
            NKG2D and activate multiple signaling pathways in primary NK cells
  JOURNAL   J Immunol 168 (2), 671-679 (2002)
   PUBMED   11777960
  REMARK    GeneRIF: ULBP1 binds to the NKG2D receptor and activates multiple
            signaling pathways in primary natural killer cells.
REFERENCE   8  (bases 1 to 3211)
  AUTHORS   Radosavljevic,M., Cuillerier,B., Wilson,M.J., Clement,O.,
            Wicker,S., Gilfillan,S., Beck,S., Trowsdale,J. and Bahram,S.
  TITLE     A cluster of ten novel MHC class I related genes on human
            chromosome 6q24.2-q25.3
  JOURNAL   Genomics 79 (1), 114-123 (2002)
   PUBMED   11827464
REFERENCE   9  (bases 1 to 3211)
  AUTHORS   Steinle,A., Li,P., Morris,D.L., Groh,V., Lanier,L.L., Strong,R.K.
            and Spies,T.
  TITLE     Interactions of human NKG2D with its ligands MICA, MICB, and
            homologs of the mouse RAE-1 protein family
  JOURNAL   Immunogenetics 53 (4), 279-287 (2001)
   PUBMED   11491531
REFERENCE   10 (bases 1 to 3211)
  AUTHORS   Cosman,D., Mullberg,J., Sutherland,C.L., Chin,W., Armitage,R.,
            Fanslow,W., Kubin,M. and Chalupny,N.J.
  TITLE     ULBPs, novel MHC class I-related molecules, bind to CMV
            glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D
            receptor
  JOURNAL   Immunity 14 (2), 123-133 (2001)
   PUBMED   11239445
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355497.14, AK292519.1,
            BC035416.1 and BM670923.1.
            
            On Nov 22, 2018 this sequence version replaced NM_025218.3.
            
            Summary: The protein encoded by this gene is a ligand of natural
            killer group 2, member D (NKG2D), an immune system-activating
            receptor on NK cells and T-cells. Binding of the encoded ligand to
            NKG2D leads to activation of several signal transduction pathways,
            including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in
            cytomegalovirus-infected cells, this ligand binds the UL16
            glycoprotein and is prevented from activating the immune system.
            Three transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.75865.1,
                                           SRR1803613.91261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229708.4/ ENSP00000229708.2
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AL355497.14        10057-10087
            32-64               AK292519.1         1-33
            65-3206             BC035416.1         1-3142
            3207-3209           BM670923.1         18-20               c
            3210-3211           AL355497.14        19828-19829
FEATURES             Location/Qualifiers
     source          1..3211
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..3211
                     /gene="ULBP1"
                     /gene_synonym="N2DL-1; NKG2DL1; RAET1I"
                     /note="UL16 binding protein 1"
                     /db_xref="GeneID:80329"
                     /db_xref="HGNC:HGNC:14893"
                     /db_xref="MIM:605697"
     exon            1..192
                     /gene="ULBP1"
                     /gene_synonym="N2DL-1; NKG2DL1; RAET1I"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..842
                     /gene="ULBP1"
                     /gene_synonym="N2DL-1; NKG2DL1; RAET1I"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; NKG2D ligand 1; alcan-beta; retinoic acid early
                     transcript 1I"
                     /codon_start=1
                     /product="UL16-binding protein 1 isoform 1 precursor"
                     /protein_id="NP_079494.1"
                     /db_xref="CCDS:CCDS5223.1"
                     /db_xref="GeneID:80329"
                     /db_xref="HGNC:HGNC:14893"
                     /db_xref="MIM:605697"
                     /translation="MAAAASPAFLLCLPLLHLLSGWSRAGWVDTHCLCYDFIITPKSR
                     PEPQWCEVQGLVDERPFLHYDCVNHKAKAFASLGKKVNVTKTWEEQTETLRDVVDFLK
                     GQLLDIQVENLIPIEPLTLQARMSCEHEAHGHGRGSWQFLFNGQKFLLFDSNNRKWTA
                     LHPGAKKMTEKWEKNRDVTMFFQKISLGDCKMWLEEFLMYWEQMLDPTKPPSLAPGTT
                     QPKAMATTLSPWSLLIIFLCFILAGR"
     exon            193..456
                     /gene="ULBP1"
                     /gene_synonym="N2DL-1; NKG2DL1; RAET1I"
                     /inference="alignment:Splign:2.1.0"
     exon            457..732
                     /gene="ULBP1"
                     /gene_synonym="N2DL-1; NKG2DL1; RAET1I"
                     /inference="alignment:Splign:2.1.0"
     exon            733..864
                     /gene="ULBP1"
                     /gene_synonym="N2DL-1; NKG2DL1; RAET1I"
                     /inference="alignment:Splign:2.1.0"
     exon            865..3211
                     /gene="ULBP1"
                     /gene_synonym="N2DL-1; NKG2DL1; RAET1I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3186..3191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ULBP1"
                     /gene_synonym="N2DL-1; NKG2DL1; RAET1I"
                     /note="hexamer: ATTAAA"
     polyA_site      3211
                     /gene="ULBP1"
                     /gene_synonym="N2DL-1; NKG2DL1; RAET1I"
                     /note="major polyA site"
ORIGIN      
        1 gtatccctgc gcgcggcggg ccgggctggg cagctttata aacagccgtg gtgtgagcct
       61 cgaagggaac catcagcgcc tcctgtccac ggagctccag gtctacaatg gcagcggccg
      121 ccagccccgc gttccttctg tgcctcccgc ttctgcacct gctgtctggc tggtcccggg
      181 caggatgggt cgacacacac tgtctttgct atgacttcat catcactcct aagtccagac
      241 ctgaaccaca gtggtgtgaa gttcaaggcc tggtggatga aaggcctttt cttcactatg
      301 actgtgttaa ccacaaggcc aaagcctttg cttctctggg gaagaaagtc aatgtcacaa
      361 aaacctggga agaacaaact gaaacactaa gagacgtggt ggatttcctt aaagggcaac
      421 tgcttgacat tcaagtggag aatttaatac ccattgagcc cctcaccctg caggccagga
      481 tgtcttgtga gcatgaagcc catggacacg gcagaggatc ttggcagttc ctcttcaatg
      541 gacagaagtt cctcctcttt gactcaaaca acagaaagtg gacagcactt catcctggag
      601 ccaagaagat gacagagaag tgggagaaga acagggatgt gaccatgttc ttccagaaga
      661 tttcactggg ggattgtaag atgtggcttg aagaattttt gatgtactgg gaacaaatgc
      721 tggatccaac aaaaccaccc tctctggccc caggcacaac ccaacccaag gccatggcca
      781 ccaccctcag tccctggagc cttctcatca tcttcctctg cttcattcta gctggcagat
      841 gaggagagtt gtttagagtg acaggtggaa agtgatatca agaagcctct gttagcctgg
      901 tctgggtcct gctctccctt cagggaggcc gcctgtctac tcaccactgt gcctttctgg
      961 aaagcaggag ttcaagcctt agcaagccca gaggccccca gcagacgatg aggacattgt
     1021 cggctcaaca tctcaggcca ctcattacct tcgctcatga tcccagcagc catttttctt
     1081 aacaccttct gccactttct gtcggtgcta atggatggaa ctcctgcaca agttttaact
     1141 gaacaagaaa tcccagcaaa aggcattttt ttttctactt ctttgattgt agaaaagcag
     1201 acacttctct gaaacatgac cttattcttc caaacagtat cgctagtaaa atagcatgct
     1261 ggacttcaga cctcagggat ccttttgatg cactgaccag gaattgtgat aatccttttc
     1321 atttttatgg ctttttacag tttctcattc tgtcaaccat attgaagtga agtggcatag
     1381 tcttcactca ctgtaatctc cagctcctgg gctcaagtga tcctctagac tcagcctcta
     1441 gaatagctgg gactacaggc acatgccacc aggactggca aactgtttta tttttaggta
     1501 gaggtagggt cttcctatgt tgcccaggat ggtcttcaaa tcttggtctc gagcaatgct
     1561 accaccttgg cctcccaatg ctctgggatt acagacatga accacagtgc ctgttgtaga
     1621 aatttttaat tatttaatat gaaaatatta cattcatgat tattttattt agtaaataaa
     1681 ataatagaga gcccagaaat caacctgcac acctaccgcc atctaatctt caatagaaat
     1741 gggcaatgtg ggaaagactc cctattcgaa aattagtgct ggaatatctg gccaaccata
     1801 tgcagaagaa tgaaactgaa cccctacttc tccccatata tgtaaaataa ttcaatatgg
     1861 atgaaagatt taaatataag tactaaaact gtaaaaatcc tggaatataa cctaagaaat
     1921 accaatgtgg acatagggcc tggcaaagat ttcatgaaga agacactaaa aacaattgca
     1981 acaaaaacag aaattgacaa atggggcctc attaaactaa agagcttctg cacagaaaaa
     2041 gaaactagca acacagtaaa cagacagcct gtagaatggg gaaaactatt tgcaaactct
     2101 gcatctgatg aaggtccaat atccagaatc tacaaggaac ttaaacaatt caacaagcaa
     2161 gaagaaaaaa cccaattaaa attgggcaaa ggcatgaaca gacacttttc aaaagaagac
     2221 ctacaattgg ccaacaaaca tgaaaaaatg ctcagtatca ctaatcatca gataagtgca
     2281 aatcaaaact gcaatgagtt accatctctt accagtcaca aagtcagaga tggtggtgag
     2341 gctgcagagc aaaagaaaca gacactgttg gtgggaaagc aaacttgttc agccactatg
     2401 gaaagcagtt tggagatttc tccaagaact taaaatagaa ctaccattca atcccgcaat
     2461 cccactactc gggatatacc cacaggaaaa gaattcattt tatcaaaaag acacctgcac
     2521 caatatgttc attacagtgc tattctcacc agcaaggaca gagaatcaat ctaagtgccc
     2581 aacaacagta aattcaatga aaaaaaatgt ggtacataga tacgatggaa aactatgcag
     2641 ccatgaaaca caagaaaatc atgtcctttt cagcaacatg gatgcaacta gaggctatta
     2701 tcctaagcaa cctaatgcaa gaacagaaaa ccacatactg catcttccca ttggaaagtg
     2761 gcagctaaac attaaattcg catgaaccac agatgctgga gatcaccaga ccggggagag
     2821 aagaggggca cctgggctga aaaacacacc tgttgggtat catgcttact gtctgggcga
     2881 tgggatcatt gggacaccaa gcctcagctt ctcaaattct acccatgtaa caaacctgta
     2941 tatgtacctt gtattatata ggttgaaatt aaagatgaat aaataaaata aaatgacaca
     3001 aggccaaaaa caaatgggtt taactgacca gagcgagaga actctgcact atgaacccaa
     3061 acccagctca aaaagataaa atctagtcat ttaagataat cataagttgt atgatgataa
     3121 ttgtataaaa atttgtatga tgataattgt ataataatta tacatgaaag tgccaaaacc
     3181 ctacaattaa acactgtata atggaattac a
//
