LOCUS       NM_001199298            2574 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ubiquitin interaction motif containing 1 (UIMC1),
            transcript variant 3, mRNA.
ACCESSION   NM_001199298
VERSION     NM_001199298.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2574)
  AUTHORS   Tang,H., Lu,Y.F., Zeng,R., Liu,C., Shu,Y., Wu,Y., Su,J., Di,L.,
            Qian,J., Zhang,J., Tian,Y., Lu,X., Pei,X.H., Zhu,Q. and Zhu,W.G.
  TITLE     DOT1L-mediated RAP80 methylation promotes BRCA1 recruitment to
            elicit DNA repair
  JOURNAL   Proc Natl Acad Sci U S A 121 (35), e2320804121 (2024)
   PUBMED   39172790
  REMARK    GeneRIF: DOT1L-mediated RAP80 methylation promotes BRCA1
            recruitment to elicit DNA repair.
REFERENCE   2  (bases 1 to 2574)
  AUTHORS   Yasuhara,T., Kato,R., Yamauchi,M., Uchihara,Y., Zou,L., Miyagawa,K.
            and Shibata,A.
  TITLE     RAP80 suppresses the vulnerability of R-loops during DNA
            double-strand break repair
  JOURNAL   Cell Rep 38 (5), 110335 (2022)
   PUBMED   35108530
  REMARK    GeneRIF: RAP80 suppresses the vulnerability of R-loops during DNA
            double-strand break repair.
REFERENCE   3  (bases 1 to 2574)
  AUTHORS   Kim,M., Park,J., Bouhaddou,M., Kim,K., Rojc,A., Modak,M.,
            Soucheray,M., McGregor,M.J., O'Leary,P., Wolf,D., Stevenson,E.,
            Foo,T.K., Mitchell,D., Herrington,K.A., Munoz,D.P., Tutuncuoglu,B.,
            Chen,K.H., Zheng,F., Kreisberg,J.F., Diolaiti,M.E., Gordan,J.D.,
            Coppe,J.P., Swaney,D.L., Xia,B., van 't Veer,L., Ashworth,A.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein interaction landscape of breast cancer
  JOURNAL   Science 374 (6563), eabf3066 (2021)
   PUBMED   34591612
REFERENCE   4  (bases 1 to 2574)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2574)
  AUTHORS   Shebzukhov,Y.V., Koroleva,E.P., Khlgatian,S.V., Belousov,P.V.,
            Sazykin,A.Y., Kadachigova,T.S., Pomerantseva,E.A., Lagarkova,M.A.,
            Nedospasov,S.A. and Kuprash,D.V.
  TITLE     RAP80/UIMC1 as cancer-associated antigen: alternative splice
            variants and their immunogenicity
  JOURNAL   Cancer Lett 255 (2), 255-262 (2007)
   PUBMED   17562356
  REMARK    GeneRIF: RAP80/UIMC1, the protein highly expressed in testis, was
            identified as a new cancer-associated antigen.
REFERENCE   6  (bases 1 to 2574)
  AUTHORS   Sobhian,B., Shao,G., Lilli,D.R., Culhane,A.C., Moreau,L.A., Xia,B.,
            Livingston,D.M. and Greenberg,R.A.
  TITLE     RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage
            sites
  JOURNAL   Science 316 (5828), 1198-1202 (2007)
   PUBMED   17525341
  REMARK    GeneRIF: data support a model wherein ubiquitin chains at DNA
            damage sites are used as a targeting mechanism by specific BRCA1
            complexes; RAP80 may represent a new class of DNA repair proteins
            that uses tandem UIM domains as part of its recruitment to DSBs
REFERENCE   7  (bases 1 to 2574)
  AUTHORS   Wang,B., Matsuoka,S., Ballif,B.A., Zhang,D., Smogorzewska,A.,
            Gygi,S.P. and Elledge,S.J.
  TITLE     Abraxas and RAP80 form a BRCA1 protein complex required for the DNA
            damage response
  JOURNAL   Science 316 (5828), 1194-1198 (2007)
   PUBMED   17525340
  REMARK    GeneRIF: Abraxas and RAP80 were required for DNA damage resistance,
            G(2)-M checkpoint control, and DNA repair.
REFERENCE   8  (bases 1 to 2574)
  AUTHORS   Yan,J., Kim,Y.S., Yang,X.P., Albers,M., Koegl,M. and Jetten,A.M.
  TITLE     Ubiquitin-interaction motifs of RAP80 are critical in its
            regulation of estrogen receptor alpha
  JOURNAL   Nucleic Acids Res 35 (5), 1673-1686 (2007)
   PUBMED   17311814
REFERENCE   9  (bases 1 to 2574)
  AUTHORS   Kim,Y.S., Nakanishi,G., Oudes,A.J., Kim,K.H., Wang,H.,
            Kilpatrick,D.L. and Jetten,A.M.
  TITLE     Tsp57: a novel gene induced during a specific stage of
            spermatogenesis
  JOURNAL   Biol Reprod 70 (1), 106-113 (2004)
   PUBMED   12954732
REFERENCE   10 (bases 1 to 2574)
  AUTHORS   Yan,Z., Kim,Y.S. and Jetten,A.M.
  TITLE     RAP80, a novel nuclear protein that interacts with the
            retinoid-related testis-associated receptor
  JOURNAL   J Biol Chem 277 (35), 32379-32388 (2002)
   PUBMED   12080054
  REMARK    GeneRIF: a novel nuclear protein that interacts with the
            retinoid-related testis-associated receptor
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP270983.1, AF349313.1,
            AC027318.5 and BX537376.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001199298.1.
            
            Summary: This gene encodes a nuclear protein that interacts with
            Brca1 (breast cancer 1) in a complex to recognize and repair DNA
            lesions. This protein binds ubiquitinated lysine 63 of histone H2A
            and H2AX. This protein may also function as a repressor of
            transcription. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 encode the same protein (isoform
            1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006078.1, AF349313.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000511320.6/ ENSP00000421926.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               BP270983.1         16-142
            128-863             AF349313.1         99-834
            864-1338            AC027318.5         111330-111804       c
            1339-1400           AC027318.5         100868-100929       c
            1401-1477           AC027318.5         98734-98810         c
            1478-1581           AC027318.5         94249-94352         c
            1582-1691           AC027318.5         86154-86263         c
            1692-2353           AF349313.1         1663-2324
            2354-2574           BX537376.1         2383-2603
FEATURES             Location/Qualifiers
     source          1..2574
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.2"
     gene            1..2574
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /note="ubiquitin interaction motif containing 1"
                     /db_xref="GeneID:51720"
                     /db_xref="HGNC:HGNC:30298"
                     /db_xref="MIM:609433"
     exon            1..130
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            131..285
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2298
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /note="isoform 1 is encoded by transcript variant 3;
                     BRCA1-A complex subunit RAP80; receptor-associated protein
                     80; retinoid X receptor-interacting protein 110"
                     /codon_start=1
                     /product="BRCA1-A complex subunit RAP80 isoform 1"
                     /protein_id="NP_001186227.1"
                     /db_xref="CCDS:CCDS4408.1"
                     /db_xref="GeneID:51720"
                     /db_xref="HGNC:HGNC:30298"
                     /db_xref="MIM:609433"
                     /translation="MPRRKKKVKEVSESRNLEKKDVETTSSVSVKRKRRLEDAFIVIS
                     DSDGEEPKEENGLQKTKTKQSNRAKCLAKRKIAQMTEEEQFALALKMSEQEAREVNSQ
                     EEEEEELLRKAIAESLNSCRPSDASATRSRPLATGPSSQSHQEKTTDSGLTEGIWQLV
                     PPSLFKGSHISQGNEAEEREEPWDHTEKTEEEPVSGSSGSWDQSSQPVFENVNVKSFD
                     RCTGHSAEHTQCGKPQESTGRGSAFLKAVQGSGDTSRHCLPTLADAKGLQDTGGTVNY
                     FWGIPFCPDGVDPNQYTKVILCQLEVYQKSLKMAQRQLLNKKGFGEPVLPRPPSLIQN
                     ECGQGEQASEKNECISEDMGDEDKEERQESRASDWHSKTKDFQESSIKSLKEKLLLEE
                     EPTTSHGQSSQGIVEETSEEGNSVPASQSVAALTSKRSLVLMPESSAEEITVCPETQL
                     SSSETFDLEREVSPGSRDILDGVRIIMADKEVGNKEDAEKEVAISTFSSSNQVSCPLC
                     DQCFPPTKIERHAMYCNGLMEEDTVLTRRQKEAKTKSDSGTAAQTSLDIDKNEKCYLC
                     KSLVPFREYQCHVDSCLQLAKADQGDGPEGSGRACSTVEGKWQQRLKNPKEKGHSEGR
                     LLSFLEQSEHKTSDADIKSSETGAFRVPSPGMEEAGCSREMQSSFTRRDLNESPVKSF
                     VSISEATDCLVDFKKQVTVQPGSRTRTKAGRGRRRKF"
     exon            286..370
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            371..495
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            496..601
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            602..1338
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1400
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1477
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1581
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1735
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1814
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1986
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2050
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2087
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2574
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2525..2530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /note="hexamer: AATATA"
     polyA_site      2530
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /note="major polyA site"
     polyA_site      2552
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
     regulatory      2557..2562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
                     /note="hexamer: AATAGA"
     polyA_site      2574
                     /gene="UIMC1"
                     /gene_synonym="RAP80; X2HRIP110"
ORIGIN      
        1 gcccgccccg agagcgtgtc tctggcatcg gacgcgcgcg cccctccccc tccccccgcg
       61 ctcccaacgt gtggcggctc gcgacccccg gcaacccgga gaaggtctac agagcggcct
      121 gcgccagcga acaaaaggat gccacggaga aagaaaaaag ttaaagaagt ctccgaatct
      181 cggaacctgg agaagaagga tgtggaaact accagttctg tcagtgtgaa gaggaagcgt
      241 agacttgagg atgcattcat tgtgatatcc gatagtgatg gagaggaacc aaaggaggaa
      301 aatgggttgc agaaaacgaa gacaaaacag tcgaatagag caaagtgttt ggccaaaaga
      361 aaaatcgcac agatgacaga agaagaacag tttgctctgg ctctcaaaat gagtgagcag
      421 gaagctaggg aggtgaacag ccaggaggag gaagaagagg agctcttgag gaaagccatt
      481 gctgaaagcc tgaatagttg ccggccttct gatgcttccg ctaccagatc tcgacctctg
      541 gccactggac cgtcttccca gtcccatcaa gagaaaacca cagactctgg gctcactgaa
      601 ggcatatggc agctggtacc tccatcactg tttaaaggct cacatatcag tcagggaaac
      661 gaggctgagg aaagagagga gccttgggac cacactgaaa aaactgaaga ggagccggtc
      721 tctggcagct caggaagctg ggaccagtca agccagccag tgtttgagaa tgtgaacgtt
      781 aaatcttttg acagatgtac tggccactcg gctgagcaca cacagtgtgg gaagccacag
      841 gaaagtactg ggaggggttc tgcttttctc aaagctgtcc agggtagcgg ggacacatct
      901 aggcactgtc tacctaccct agcagatgcc aaaggtctcc aggacactgg gggcactgtg
      961 aactatttct ggggtattcc attctgccct gatggagtag accctaacca gtataccaag
     1021 gtcattctct gccagttgga ggtttatcaa aagagcctga aaatggctca gaggcagctc
     1081 cttaataaaa aaggttttgg ggaaccagtg ttacctagac ctccttctct gatccagaat
     1141 gaatgtggcc aaggagagca ggctagtgag aaaaatgaat gcatctcaga agatatggga
     1201 gatgaagaca aagaggagag gcaggagtct agggcatctg actggcactc aaaaaccaag
     1261 gatttccagg aaagctcaat taaaagcttg aaagagaaac ttttgttgga ggaagaacca
     1321 acaaccagtc atggtcagtc ttcccaaggg attgttgaag aaacttctga agagggaaac
     1381 tctgtacctg cttcacaaag tgttgctgct ttgaccagta agagaagctt agtccttatg
     1441 ccagagagtt ctgcagaaga aatcactgtt tgtcctgaga cccagctaag ttcctctgaa
     1501 acttttgacc ttgaaagaga agtctctcca ggtagcagag atatcttgga tggagtcaga
     1561 ataataatgg cagataagga ggttggtaac aaggaagatg ctgagaagga agtagctatt
     1621 tctaccttct catccagtaa ccaggtatcc tgcccgctat gtgaccaatg ctttccaccc
     1681 acaaagattg aacgacatgc catgtactgc aatggtctga tggaggaaga tacagtattg
     1741 actcggagac aaaaagaggc caagaccaag agtgacagtg ggacagctgc ccagacttct
     1801 ctagacattg acaagaatga gaagtgttac ctctgtaaat ccctggtccc atttagagag
     1861 tatcagtgtc atgtggactc ctgtctccag cttgcaaagg ctgaccaagg agatggacct
     1921 gaagggagtg gaagagcatg ttcaactgtg gaggggaagt ggcagcagag gctgaagaac
     1981 ccaaaggaaa aaggccacag tgaaggccga ctccttagtt tcttggaaca gtctgagcac
     2041 aagacttcag atgcagacat caagtcttca gaaacaggag ccttcagggt gccttcacca
     2101 gggatggaag aggcaggctg cagcagagag atgcagagtt ctttcacacg tcgtgactta
     2161 aatgaatctc ccgtcaagtc ttttgtttcc atttcagaag ccacagattg cttagtggac
     2221 tttaaaaagc aagttactgt ccagccaggt agtcggacac ggaccaaagc tggcagagga
     2281 agaaggagaa aattctgaat ttctagggtc caaaagttga caaaaccatt agtaggaggg
     2341 gtgggccatg ttcattaagc catagtggtc cctagttcat tgttgagcaa gttttagccc
     2401 tgcagttttc accaccagca cctacccagc attctggttt ttatgttttt tatgatctat
     2461 gcagacaact gtgtattctg ttttataaca gtttgtttga atttacttac agttaaaaaa
     2521 tttaaatata tttatgtttg tacgaaatct tatttcaata gatggaaatt ttaa
//
