LOCUS       NM_152896               3576 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens ubiquitin like with PHD and ring finger domains 2
            (UHRF2), transcript variant 1, mRNA.
ACCESSION   NM_152896
VERSION     NM_152896.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3576)
  AUTHORS   Hu,C.M., Peng,J., Lv,L., Wang,X.H., Huo,J.R. and Liu,D.L.
  TITLE     MiR-196a promotes the proliferation and migration of esophageal
            cancer via the UHRF2/TET2 axis
  JOURNAL   Mol Cell Biochem 477 (2), 537-547 (2022)
   PUBMED   34826027
  REMARK    GeneRIF: MiR-196a promotes the proliferation and migration of
            esophageal cancer via the UHRF2/TET2 axis.
REFERENCE   2  (bases 1 to 3576)
  AUTHORS   Liu,X., Xu,B., Yang,J., He,L., Zhang,Z., Cheng,X., Yu,H., Liu,X.,
            Jin,T., Peng,Y., Huang,Y., Xia,L., Wang,Y., Wu,J., Wu,X., Liu,S.,
            Shan,L., Yang,X., Sun,L., Liang,J., Zhang,Y. and Shang,Y.
  TITLE     UHRF2 commissions the completion of DNA demethylation through
            allosteric activation by 5hmC and K33-linked ubiquitination of
            XRCC1
  JOURNAL   Mol Cell 81 (14), 2960-2974 (2021)
   PUBMED   34111398
  REMARK    GeneRIF: UHRF2 commissions the completion of DNA demethylation
            through allosteric activation by 5hmC and K33-linked ubiquitination
            of XRCC1.
REFERENCE   3  (bases 1 to 3576)
  AUTHORS   Sun,J., Wu,K., Chen,S., Jiang,S., Chen,Y. and Duan,C.
  TITLE     UHRF2 promotes Hepatocellular Carcinoma Progression by Upregulating
            ErbB3/Ras/Raf Signaling Pathway
  JOURNAL   Int J Med Sci 18 (14), 3097-3105 (2021)
   PUBMED   34400880
  REMARK    GeneRIF: UHRF2 promotes Hepatocellular Carcinoma Progression by
            Upregulating ErbB3/Ras/Raf Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3576)
  AUTHORS   Cheng,F., Qian,G., Fang,X., Sun,J., Chen,S., Chen,R., Liu,S.,
            Li,Z., Wu,K., Jiang,S., Chen,Y., Tang,N., Chen,J. and Duan,C.
  TITLE     HBx promotes hepatocarcinogenesis by enhancing phosphorylation and
            blocking ubiquitinylation of UHRF2
  JOURNAL   Hepatol Int 15 (3), 707-719 (2021)
   PUBMED   33876395
  REMARK    GeneRIF: HBx promotes hepatocarcinogenesis by enhancing
            phosphorylation and blocking ubiquitinylation of UHRF2.
REFERENCE   5  (bases 1 to 3576)
  AUTHORS   Fang,X.Y., Sun,J.J., Chen,S.Y., Wu,K.J., Yu,Y., Zhang,C. and
            Duan,C.Z.
  TITLE     IGF2BP1/UHRF2 Axis Mediated by miR-98-5p to Promote the
            Proliferation of and Inhibit the Apoptosis of Esophageal Squamous
            Cell Carcinoma
  JOURNAL   Ann Clin Lab Sci 51 (3), 329-338 (2021)
   PUBMED   34162562
  REMARK    GeneRIF: IGF2BP1/UHRF2 Axis Mediated by miR-98-5p to Promote the
            Proliferation of and Inhibit the Apoptosis of Esophageal Squamous
            Cell Carcinoma.
REFERENCE   6  (bases 1 to 3576)
  AUTHORS   Unoki,M., Nishidate,T. and Nakamura,Y.
  TITLE     ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG
            through its SRA domain
  JOURNAL   Oncogene 23 (46), 7601-7610 (2004)
   PUBMED   15361834
REFERENCE   7  (bases 1 to 3576)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   8  (bases 1 to 3576)
  AUTHORS   Li,Y., Mori,T., Hata,H., Homma,Y. and Kochi,H.
  TITLE     NIRF induces G1 arrest and associates with Cdk2
  JOURNAL   Biochem Biophys Res Commun 319 (2), 464-468 (2004)
   PUBMED   15178429
  REMARK    GeneRIF: may participate in the G1/S transition regulation
            GeneRIF: Overexpression of NIRF induces cell cycle arrest at G1
            phase. NIRF binds to the cyclin E-Cdk2 complex in vivo, and is
            phosphorylated by Cdk2 in vitro.
REFERENCE   9  (bases 1 to 3576)
  AUTHORS   Mori,T., Li,Y., Hata,H. and Kochi,H.
  TITLE     NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP,
            a PEST-containing nuclear protein
  JOURNAL   FEBS Lett 557 (1-3), 209-214 (2004)
   PUBMED   14741369
  REMARK    GeneRIF: NIRF has ubiquitination activity, the hallmark of a
            ubiquitin ligase. PCNP was readily ubiquitinated in 293 and COS-7
            cells, and NIRF ubiquitinated PCNP in vitro as well as in vivo.
            GeneRIF: NIRF is a ubiquitin ligase that is capable of
            ubiquitinating PCNP (PEST-containing nuclear protein).
REFERENCE   10 (bases 1 to 3576)
  AUTHORS   Mori,T., Li,Y., Hata,H., Ono,K. and Kochi,H.
  TITLE     NIRF, a novel RING finger protein, is involved in cell-cycle
            regulation
  JOURNAL   Biochem Biophys Res Commun 296 (3), 530-536 (2002)
   PUBMED   12176013
  REMARK    GeneRIF: NIRF is involved in cell-cycle regulation
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG709183.1, AF274049.1 and
            AB071698.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152896.2.
            
            Summary: This gene encodes a nuclear protein which is involved in
            cell-cycle regulation. The encoded protein is a ubiquitin-ligase
            capable of ubiquinating PCNP (PEST-containing nuclear protein), and
            together they may play a role in tumorigenesis. The encoded protein
            contains an NIRF_N domain, a PHD finger, a set- and ring-associated
            (SRA) domain, and a RING finger domain and several of these domains
            have been shown to be essential for the regulation of cell
            proliferation. This protein may also have a role in intranuclear
            degradation of polyglutamine aggregates. Alternative splicing
            results in multiple transcript variants some of which are
            non-protein coding. [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB071698.1, AF274049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276893.10/ ENSP00000276893.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               BG709183.1         54-177
            125-3573            AF274049.1         1-3449
            3574-3576           AB071698.1         3320-3322
FEATURES             Location/Qualifiers
     source          1..3576
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.1"
     gene            1..3576
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /note="ubiquitin like with PHD and ring finger domains 2"
                     /db_xref="GeneID:115426"
                     /db_xref="HGNC:HGNC:12557"
                     /db_xref="MIM:615211"
     exon            1..445
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..2701
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /EC_number="2.3.2.27"
                     /note="Np95-like ring finger protein; ubiquitin-like,
                     containing PHD and RING finger domains, 2; nuclear zinc
                     finger protein NP97; nuclear protein 97; RING finger
                     protein 107; np95/ICBP90-like RING finger protein;
                     ubiquitin-like PHD and RING finger domain-containing
                     protein 2; ubiquitin-like-containing PHD and RING finger
                     domains protein 2; ubiquitin-like with PHD and ring finger
                     domains 2, E3 ubiquitin protein ligase; RING-type E3
                     ubiquitin transferase UHRF2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UHRF2"
                     /protein_id="NP_690856.1"
                     /db_xref="CCDS:CCDS6469.1"
                     /db_xref="GeneID:115426"
                     /db_xref="HGNC:HGNC:12557"
                     /db_xref="MIM:615211"
                     /translation="MWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQR
                     LFYRGKQLENGYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKA
                     PRVGPSNQPSTSARARLIDPGFGIYKVNELVDARDVGLGAWFEAHIHSVTRASDGQSR
                     GKTPLKNGSSCKRTNGNIKHKSKENTNKLDSVPSTSNSDCVAADEDVIYHIQYDEYPE
                     SGTLEMNVKDLRPRARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTISR
                     TKKELRVKIFLGGSEGTLNDCKIISVDEIFKIERPGAHPLSFADGKFLRRNDPECDLC
                     GGDPEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIYCLNPPLDKVPEEEYWYCPSC
                     KTDSSEVVKAGERLKMSKKKAKMPSASTESRRDWGRGMACVGRTRECTIVPSNHYGPI
                     PGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFADEVDRGDEFTYT
                     GSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAESRNWRAGKPVRVIR
                     SFKGRKISKYAPEEGNRYDGIYKVVKYWPEISSSHGFLVWRYLLRRDDVEPAPWTSEG
                     IERSRRLCLRLQYPAGYPSDKEGKKPKGQSKKQPSGTTKRPISDDDCPSASKVYKASD
                     SAEAIEAFQLTPQQQHLIREDCQNQKLWDEVLSHLVEGPNFLKKLEQSFMCVCCQELV
                     YQPVTTECFHNVCKDCLQRSFKAQVFSCPACRHDLGQNYIMIPNEILQTLLDLFFPGY
                     SKGR"
     exon            446..676
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /inference="alignment:Splign:2.1.0"
     exon            677..936
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1155
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1265
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1452
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1576
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1684
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1789
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1896
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2059
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2200
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2297
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2455
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2554
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..3576
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3552..3557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /note="hexamer: AATAAA"
     polyA_site      3576
                     /gene="UHRF2"
                     /gene_synonym="NIRF; RNF107; TDRD23; URF2"
                     /note="major polyA site"
ORIGIN      
        1 ataagtaaac actctgcgcg gcgcagacat ggcctcttcc tatctttgag gcggtgtctg
       61 cggcagcgcc tcagagtggt tccggtcgtc tctcctcaag tcggctagtc gggcgcgcgc
      121 gctgagagtc gtcgccgcct gtcgggcccg gcgtccggtc ggtccggtgg gcgcgctcgc
      181 ccgcctgccg ctgagggccc gagccgcagg gaaagcggcg cgggccgggc ggggcgcggc
      241 gcccagagct cagggggaga caaaggggac cggttcctct ctaggcgcca agatgtggat
      301 acaggttcgc accattgatg gctccaagac gtgcaccatt gaggacgtgt ctcgcaaagc
      361 cacgattgag gagctgcgcg agcgggtgtg ggcgctgttc gacgtgcggc ccgaatgcca
      421 gcgcctcttc taccggggca agcagttgga aaatggatat accttatttg attatgatgt
      481 tggactgaat gatataattc agctgctagt tcgcccagac cctgatcatc ttcctggcac
      541 atctacacag attgaggcta aaccctgttc taatagtcca cctaaagtaa agaaagctcc
      601 gagggtagga ccttccaatc agccatctac atcagctcgt gcccgtctta ttgatcctgg
      661 ctttggaata tataaggtaa atgaattggt ggatgccaga gatgtcggcc ttggtgcttg
      721 gtttgaagca cacatacata gtgttactag agcttctgat ggacagtcac gtggcaaaac
      781 tccactgaag aatggcagtt cttgtaaaag gactaatgga aatataaagc ataaatccaa
      841 agagaacaca aataaattgg acagtgtacc ctctacgtct aattcagact gtgttgctgc
      901 tgatgaagac gttatttacc atatccagta tgatgaatac ccagaaagcg gtactctaga
      961 aatgaatgtc aaggatctta gaccacgagc tagaaccatt ttgaaatgga atgaactaaa
     1021 tgttggtgat gtggtaatgg ttaattataa tgtagaaagt cctggacaaa gaggattctg
     1081 gtttgatgca gaaattacca cattgaagac aatctcaagg accaaaaaag aacttcgtgt
     1141 gaaaattttc ctggggggtt ctgaaggaac attaaatgac tgcaagataa tatctgtaga
     1201 tgaaatcttc aagattgaga gacctggagc ccatcccctt tcatttgcag atggaaagtt
     1261 tttaaggcga aatgaccctg aatgtgacct gtgtggtgga gacccagaaa agaaatgtca
     1321 ttcttgctcc tgtcgtgtat gtggtgggaa acatgaaccc aacatgcagc ttctgtgtga
     1381 tgaatgtaat gtggcttatc atatttactg tctgaatcca cctttggata aagtcccaga
     1441 agaggaatac tggtattgtc cttcttgtaa aactgattcc agtgaagttg taaaggctgg
     1501 tgaaagactc aagatgagta aaaagaaagc aaagatgccg tcagctagta ctgaaagccg
     1561 aagagactgg ggcaggggaa tggcttgtgt tggtcgtacg agagaatgta ctattgtccc
     1621 ttctaatcat tatggaccca ttcctggtat tcctgttgga tcaacttgga gatttagagt
     1681 tcaggtgagc gaagcaggtg ttcacagacc ccatgttggt ggaattcatg gtcgaagtaa
     1741 tgatggggct tattctcttg tactggctgg tggatttgcg gatgaagtcg accgaggtga
     1801 tgagttcaca tacactggaa gcggtggtaa aaatcttgct ggtaacaaaa gaattggtgc
     1861 accttcagct gatcaaacat taacaaacat gaacagggca ttggccctaa actgtgatgc
     1921 tccattggat gataaaattg gagcagagtc tcggaattgg agagctggta agccagtcag
     1981 agtgatacgc agttttaaag ggaggaagat cagcaaatat gctcctgaag aaggcaacag
     2041 atatgatggc atttataagg tggtgaaata ctggccagag atttcatcaa gccatggatt
     2101 cttggtttgg cgctatcttt taagaagaga tgatgttgaa cctgctcctt ggacctctga
     2161 aggaatagaa cggtcaagga gattatgtct acgtttacag tatccagcag gttacccttc
     2221 agataaagaa gggaagaagc ctaaaggaca gtcaaagaag cagcccagtg gaaccacaaa
     2281 aaggccaatt tcagatgatg actgtccaag tgcctccaaa gtgtacaaag catcagattc
     2341 agcagaagca attgaggctt ttcaactaac tcctcaacag caacatctca tcagagaaga
     2401 ttgtcaaaac cagaagctgt gggatgaagt gctttcacat cttgtggaag gaccaaattt
     2461 tctgaaaaaa ttggaacaat cttttatgtg cgtttgctgt caggagctag tttaccagcc
     2521 tgtgacaact gagtgcttcc acaatgtctg taaagattgc ctacagcgct cctttaaggc
     2581 acaggttttc tcctgccctg cttgccggca tgatcttggc cagaattaca tcatgattcc
     2641 caatgagatt ctgcagactc tacttgacct tttcttccct ggctacagca aaggacgatg
     2701 atctgcctgc tttcactgtg ttgttcatgg tggctttttg gacaataaag aatctaaaat
     2761 gggtggggag ggtggaagaa atggtggact gtatctctca cgttctgaag cagctaatcc
     2821 tctttcccac atagccatca tcttgtgtgt gtagtaagag gcccatttct caactgtctt
     2881 ttaaatatct aaaggtagtt cctgtaacaa ctagttttaa tgagtaaaaa gtcaaagcct
     2941 cagctctagt tgatatccaa gttatgattt attttgcaac tacctcagga cagaaaagat
     3001 ttatggggat tttaaaaatc attgaataac tagttaaatg aaattttagc tacacactgc
     3061 ctcccaaata ttagttgtgc ctggttcttg taatttgatt ttacagaaaa ggaaatgaca
     3121 cttgagatcc ttggaatgaa cacagcttct aaagtgtgca tatacttttt taacgtctct
     3181 tcttccatta caatgtgtgt tttgcaagga caggttcatt ttttttagcc cactttgtga
     3241 actccattgt gcttttttct ggtgttttat gcaagttgac tactaatgac taatgagaac
     3301 aataatgaat gcattgttgc tgcattagtg taatgtggtg tggttttgca cttaaaagag
     3361 gtattcatat gctctagttg taaatgttca tgaaaatcca cttctctact agtcgaactg
     3421 cttttagtgt ctcaccagtg gttttacatc tgcagagttt tgagggctgt gctgaccttt
     3481 gagaggattt gaaattgctt catattgtga tcctaaattt tatattcact atattcccta
     3541 aagtatacct taataaatat tttatgatca gaaaaa
//
