LOCUS       NM_175866               8524 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens U2AF homology motif kinase 1 (UHMK1), transcript
            variant 1, mRNA.
ACCESSION   NM_175866
VERSION     NM_175866.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8524)
  AUTHORS   Moreno-Aguilera,M., Neher,A.M., Mendoza,M.B., Dodel,M.,
            Mardakheh,F.K., Ortiz,R. and Gallego,C.
  TITLE     KIS counteracts PTBP2 and regulates alternative exon usage in
            neurons
  JOURNAL   Elife 13, e96048 (2024)
   PUBMED   38597390
  REMARK    GeneRIF: KIS counteracts PTBP2 and regulates alternative exon usage
            in neurons.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8524)
  AUTHORS   Li,Y., Wang,S., Jin,K., Jin,W., Si,L., Zhang,H. and Tian,H.
  TITLE     UHMK1 promotes lung adenocarcinoma oncogenesis by regulating the
            PI3K/AKT/mTOR signaling pathway
  JOURNAL   Thorac Cancer 14 (12), 1077-1088 (2023)
   PUBMED   36919755
  REMARK    GeneRIF: UHMK1 promotes lung adenocarcinoma oncogenesis by
            regulating the PI3K/AKT/mTOR signaling pathway.
REFERENCE   3  (bases 1 to 8524)
  AUTHORS   Gao,X., Bao,W., Bai,J., Fan,K., Li,L. and Li,Y.
  TITLE     UHMK1 aids colorectal cancer cell proliferation and chemoresistance
            through augmenting IL-6/STAT3 signaling
  JOURNAL   Cell Death Dis 13 (5), 424 (2022)
   PUBMED   35501324
  REMARK    GeneRIF: UHMK1 aids colorectal cancer cell proliferation and
            chemoresistance through augmenting IL-6/STAT3 signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8524)
  AUTHORS   Niu,H., Zhao,M., Huang,J., Wang,J., Si,Y., Cheng,S. and Ding,W.
  TITLE     UHMK1-dependent phosphorylation of Cajal body protein coilin alters
            5-FU sensitivity in colon cancer cells
  JOURNAL   Cell Commun Signal 20 (1), 18 (2022)
   PUBMED   35151311
  REMARK    GeneRIF: UHMK1-dependent phosphorylation of Cajal body protein
            coilin alters 5-FU sensitivity in colon cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8524)
  AUTHORS   Petrovic,V., Costa,R.H., Lau,L.F., Raychaudhuri,P. and Tyner,A.L.
  TITLE     FoxM1 regulates growth factor-induced expression of
            kinase-interacting stathmin (KIS) to promote cell cycle progression
  JOURNAL   J Biol Chem 283 (1), 453-460 (2008)
   PUBMED   17984092
  REMARK    GeneRIF: Results show that KIS is a direct transcriptional target
            of FoxM1.
REFERENCE   6  (bases 1 to 8524)
  AUTHORS   Crook,M.F., Olive,M., Xue,H.H., Langenickel,T.H., Boehm,M.,
            Leonard,W.J. and Nabel,E.G.
  TITLE     GA-binding protein regulates KIS gene expression, cell migration,
            and cell cycle progression
  JOURNAL   FASEB J 22 (1), 225-235 (2008)
   PUBMED   17726090
  REMARK    GeneRIF: KIS promoter is activated by serum-responsive GABP binding
            to Ets-binding sites which leads to KIS gene expression, cell
            migration, and cell cycle progression
REFERENCE   7  (bases 1 to 8524)
  AUTHORS   Puri,V., McQuillin,A., Choudhury,K., Datta,S., Pimm,J.,
            Thirumalai,S., Krasucki,R., Lawrence,J., Quested,D., Bass,N.,
            Moorey,H., Morgan,J., Punukollu,B., Kandasami,G., Curtis,D. and
            Gurling,H.
  TITLE     Fine mapping by genetic association implicates the chromosome
            1q23.3 gene UHMK1, encoding a serine/threonine protein kinase, as a
            novel schizophrenia susceptibility gene
  JOURNAL   Biol Psychiatry 61 (7), 873-879 (2007)
   PUBMED   16978587
  REMARK    GeneRIF: These results provide preliminary evidence that the UHMK1
            gene increases susceptibility to schizophrenia. Further
            confirmation in adequately powered samples is needed.
            GeneRIF: Evidence indicating that UHMK1 may be a candidate
            susceptibility gene for Schizophrenia in the British population.
            UHMK1 is situated between previously implicated genes RGS4 and
            NOS1AP.
REFERENCE   8  (bases 1 to 8524)
  AUTHORS   Bieche,I., Manceau,V., Curmi,P.A., Laurendeau,I., Lachkar,S.,
            Leroy,K., Vidaud,D., Sobel,A. and Maucuer,A.
  TITLE     Quantitative RT-PCR reveals a ubiquitous but preferentially neural
            expression of the KIS gene in rat and human
  JOURNAL   Brain Res Mol Brain Res 114 (1), 55-64 (2003)
   PUBMED   12782393
  REMARK    GeneRIF: KIS gene was overexpressed in NF1-associated plexiform
            neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs)
            as compared to dermal neurofibroma which suggests a possible
            implication of KIS in the genesis of NF1-associated tumors.
REFERENCE   9  (bases 1 to 8524)
  AUTHORS   Boehm,M., Yoshimoto,T., Crook,M.F., Nallamshetty,S., True,A.,
            Nabel,G.J. and Nabel,E.G.
  TITLE     A growth factor-dependent nuclear kinase phosphorylates p27(Kip1)
            and regulates cell cycle progression
  JOURNAL   EMBO J 21 (13), 3390-3401 (2002)
   PUBMED   12093740
  REMARK    GeneRIF: We identify the kinase responsible for S10 phosphorylation
            as human kinase interacting stathmin (hKIS) and show that it
            regulates cell cycle progression in response to mitogens.
REFERENCE   10 (bases 1 to 8524)
  AUTHORS   Caldwell,B.D., Darlington,D.N., Penzes,P., Johnson,R.C.,
            Eipper,B.A. and Mains,R.E.
  TITLE     The novel kinase peptidylglycine alpha-amidating monooxygenase
            cytosolic interactor protein 2 interacts with the cytosolic routing
            determinants of the peptide processing enzyme peptidylglycine
            alpha-amidating monooxygenase
  JOURNAL   J Biol Chem 274 (49), 34646-34656 (1999)
   PUBMED   10574929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359699.12 and AJ536197.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_175866.4.
            
            Summary: The gene encodes a serine/threonine protein kinase that
            promotes cell cycle progression through G1 by phosphorylation of
            the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes
            nuclear export and degradation. The encoded protein is also thought
            to function in the adult nervous system and the gene has been
            associated with schizophrenia. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.182523.1,
                                           SRR1660805.134760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000489294.2/ ENSP00000420270.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AL359699.12        70154-70200
            48-2111             AJ536197.1         10-2073
            2112-8524           AL359699.12        95555-101967
FEATURES             Location/Qualifiers
     source          1..8524
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..8524
                     /gene="UHMK1"
                     /gene_synonym="KIS; KIST; P-CIP2"
                     /note="U2AF homology motif kinase 1"
                     /db_xref="GeneID:127933"
                     /db_xref="HGNC:HGNC:19683"
                     /db_xref="MIM:608849"
     exon            1..451
                     /gene="UHMK1"
                     /gene_synonym="KIS; KIST; P-CIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1443
                     /gene="UHMK1"
                     /gene_synonym="KIS; KIST; P-CIP2"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kinase interacting with leukemia-associated gene
                     (stathmin); KIS protein kinase; PAM COOH-terminal
                     interactor protein 2; U2AF homology motif (UHM) kinase 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Kist isoform 1"
                     /protein_id="NP_787062.1"
                     /db_xref="CCDS:CCDS1239.1"
                     /db_xref="GeneID:127933"
                     /db_xref="HGNC:HGNC:19683"
                     /db_xref="MIM:608849"
                     /translation="MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCG
                     NPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSP
                     NVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLK
                     PRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTE
                     CTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYH
                     LRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYL
                     ENEEEYEDVVEDVKEECQKYGPVVSLLVPKENPGRGQVFVEYANAGDSKAAQKLLTGR
                     MFDGKFVVATFYPLSAYKRGYLYQTLL"
     exon            452..744
                     /gene="UHMK1"
                     /gene_synonym="KIS; KIST; P-CIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            745..936
                     /gene="UHMK1"
                     /gene_synonym="KIS; KIST; P-CIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1031
                     /gene="UHMK1"
                     /gene_synonym="KIS; KIST; P-CIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1108
                     /gene="UHMK1"
                     /gene_synonym="KIS; KIST; P-CIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1207
                     /gene="UHMK1"
                     /gene_synonym="KIS; KIST; P-CIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1296
                     /gene="UHMK1"
                     /gene_synonym="KIS; KIST; P-CIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..8524
                     /gene="UHMK1"
                     /gene_synonym="KIS; KIST; P-CIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8484..8489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UHMK1"
                     /gene_synonym="KIS; KIST; P-CIP2"
                     /note="hexamer: AATAAA"
     regulatory      8498..8503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UHMK1"
                     /gene_synonym="KIS; KIST; P-CIP2"
                     /note="hexamer: AATAAA"
     polyA_site      8503
                     /gene="UHMK1"
                     /gene_synonym="KIS; KIST; P-CIP2"
                     /note="major polyA site"
     polyA_site      8524
                     /gene="UHMK1"
                     /gene_synonym="KIS; KIST; P-CIP2"
ORIGIN      
        1 gggactcggg tgcaccacgg cttccggtgt catggctgct tgaagtcccg ggagtcggtg
       61 aggcggctgc aggtccctcc ctgcggagcc gctggtccgg ctggcggaga tgtgaccgcg
      121 ggcccggccg gcctgcctca ggcgtcgcgt cagctcccgt gtccgtgccc ttaacccaca
      181 ccgatggcgg gatccggctg cgcctggggc gcggagccgc cgcgttttct ggaggccttc
      241 gggcggctgt ggcaggtaca gagccgtctg ggtagcggct cctccgcctc ggtgtatcgg
      301 gttcgctgct gcggcaaccc tggctcgccc cccggcgccc tcaagcagtt cttgccgcca
      361 ggaaccaccg gggctgcggc ctctgccgcc gagtatggtt tccgcaaaga gagggcggcg
      421 ctggaacagt tgcagggtca cagaaacatc gtgactttgt atggagtgtt tacaatccac
      481 ttttctccaa atgtgccatc acgctgtctg ttgcttgaac tcctggatgt cagtgtttcg
      541 gaattgctct tatattccag tcaccagggt tgttccatgt ggatgataca gcattgtgcc
      601 cgagatgttt tggaggccct tgcttttctt catcatgagg gctatgtcca tgcggacctc
      661 aaaccacgta acatattgtg gagtgcagag aatgaatgtt ttaaactcat tgactttgga
      721 cttagcttca aagaaggcaa tcaggatgta aagtatattc agacagacgg gtatcgggct
      781 ccagaagcag aattgcaaaa ttgcttggcc caggctggcc tgcagagtga tacagaatgt
      841 acctcagctg ttgatctgtg gagcctagga atcattttac tggaaatgtt ctcaggaatg
      901 aaactgaaac atacagtcag atctcaggaa tggaaggcaa acagttctgc tattattgat
      961 cacatatttg ccagtaaagc agtggtgaat gccgcaattc cagcctatca cctaagagac
     1021 cttatcaaaa gcatgcttca tgatgatcca agcagaagaa ttcctgctga aatggcattg
     1081 tgcagcccat tctttagcat tccttttgcc cctcatattg aagatctggt catgcttccc
     1141 actccagtgc taagactgct gaatgtgctg gatgatgatt atcttgagaa tgaagaggaa
     1201 tatgaagatg ttgtagaaga tgtaaaagag gagtgtcaaa aatatggacc agtggtatct
     1261 ctacttgttc caaaggaaaa tcctggcaga ggacaagtct ttgttgagta tgcaaatgct
     1321 ggtgattcca aagctgcgca gaaattactg actggaagga tgtttgatgg gaagtttgtt
     1381 gtggctacat tctacccgct gagtgcctac aagaggggat atctgtatca aaccttgctt
     1441 taatcagtaa cctaaggact gtttcctttt tctcctcttc catttcttgg gttattccac
     1501 atatgaatgc aggactaccc ccttaccatt ttaagaaggt actttataca tttatttaat
     1561 cctactaatg tgcagccatt gcccaagcag tgactgcgtt gcatacattt ggcactgagt
     1621 aggacaagac ctctcagcta tacattgagg ggttttagag catccatgtg ggcaaccctt
     1681 ttttgtgcgg gagagcaggt gttgctcttc agtatgtagc ctaaaaaaat cttaattatt
     1741 tcatggatca tgaagcaagg atgaataata tcatgtcttg gtaaatacta acaaatttgt
     1801 taggtttggt gacatcattt acagattatt tctttatgtt gtccagtggt tcttccttat
     1861 tgttgatatc cataagctgg cactggatgc tctcagtaat gttaagtaat tgtcaagcag
     1921 cagttaccta ctgtgttctt aacactgagt tgtgaatttt ttcttaaagc agtactgtag
     1981 tactgaatat tcctttaaag gaactgcagt gagcctatct aagttttttt aaattaaggc
     2041 ttttaaaata gaaagctgat gcttgatctt gcacaatttt tatgtctagt atgtatgctt
     2101 gagtgaatgt gcgagtatga atgattagag aaaatttgag tcagtgtact ttatagtgtg
     2161 aatcctgtga gctaatacag tctatactta tttcttccct acctgtttca catccgtaag
     2221 atttaagata tacatttttt gagaggtagt ctgtctgata caatgtaaat gacaaaacat
     2281 aattcctgag aggcccagaa caaactggag tctagcctgg agttaaattg agacttctaa
     2341 aatgattgga acaaagacta agttgtgcca gatgtaaatc aacccctctt ttagtttact
     2401 ttagactttg tattagctca tcttttttgt agtaaatcta tagttttaag gtttctcaag
     2461 atgtggctct acctactatg atgaaaattg aagtgggtca aaagaattag atgtacagtg
     2521 aagggaaaag aaaaaaaatg ggcgaagaga gggtggaaaa taaaaggatt cttttttctt
     2581 cctttctgtt tctcgtatcc ctgctccctt tttcctcccc ttccctcatt ctttgcctct
     2641 atccttagct gaagacaaac tagaggagca gcatcccagg tagtttggct tttgactgca
     2701 aggtagttaa gaaaggtgta gatataatga ggtagaagta gaaaggaaga aaaactcaaa
     2761 gaattcttaa aaggattcat agcaacataa tgtgtccctg agtagaggat gctgctatgc
     2821 gtgagttcat ggacacaagt tgattacatg gtttttagaa ttataattat ggattcttct
     2881 tatttcatgg taggttgtct ttaaagatat aaaaattagg atgcctttat gaagcactga
     2941 ttataccaaa aaaaaaagac aagttatata caggttatta atttttttat ttatttattt
     3001 tttcctaagg aaaaagtctt ctatctttcc ctgctggaag cctcctcata tttccttatg
     3061 tttgccatgc aggttgctga gagtccagtt agaatttgca ttttacagaa tgaaatactt
     3121 taccccattc aaacaattat tgtttgacat tttagttatt tataattgtc aaattcagga
     3181 ctctccttta atgtttatta tgaaaccaaa tttggcataa ggaggctgat ttatgaatta
     3241 ccaaagggtc ttgtggcatg ttccccaata catgccctta gaaggaagaa ctattatttt
     3301 ttattttggc cctttcagga gttgattata aattggtttg ttttcaagtc agaattcaag
     3361 tgggcagaac ccgtattgtg aagacctaaa ctttcctaaa tgttcatatg ggtagcagat
     3421 tttgtggtga ttagaaacat caggtcctta aatacgatga acatgggata caaaggaatt
     3481 ctttataagg gcaagtatcc taagttagca catttacttt tctctcccct ccgcccccaa
     3541 aagaaaaatc cttacaaata aactgcaggt aggcttctaa gcctagtcct gcagtatgct
     3601 gctaacatct tgatgccaat cttcacagca ttctttgatt gtcatcttat tgctgataca
     3661 ttcatacata tatttagtgc ttgacactgt agaattttgt tacagaagat ggttactaga
     3721 ttttaaggga gctgagggaa taattgatga gccttgaatt aaccatgcat ttaattagat
     3781 tttttgttgt tgttgttgtt gttttgagat gatgtcttgc tctgttgccc aggctggagt
     3841 gcagtggctc aatctcggct cactgcaacc tctgcctcgc aggtttgagc gattctcctg
     3901 tctcagcctc cccagtagct gggtttacag gcgcttgcca ccacacctgg ctagatgttt
     3961 tatattaaag ccagagaatt gaaaaagaaa tgcctcctgt gattgaaatt attttatagc
     4021 tcttagcccg ttctaccaaa gatcacatta gcagattacc cctccctcct gtgatattat
     4081 ctttcttaaa cctgaaccaa atatcaaaag atacaagttt catgattagg atgaaatata
     4141 tacataggga ttttggttta ttgaagttat tgaaagacct agaaattttc tttttgagag
     4201 aaagggtaaa gaggtgaggg ttcatgtcac ttaaccccta cccttttggg caaattttgt
     4261 ctcaggtagt gtttcattcc ctaaattaat acctgtgctt ccttgcctct caccttccca
     4321 gttacttctt tggggtatta ctgtggcaca ttgtacaccc agaaaaggca catacagtga
     4381 ttattttgtg ggaaatactt gattcttttg aaatatattt ggagggggta gctagctagc
     4441 cactgtcaaa actaatgctg tatttacagg acaaaaacaa gtagagttgg acacctcagt
     4501 aagagacagc attaactaaa agtactgact gccttttaaa ggaattttta aaactattct
     4561 cttgcaataa gagatccgca tttattacca ctggatgtct tccttttttg tggccaccaa
     4621 tatagcagct ctctttagag ggattccctt tctgctatgc cttgagccaa actggctgct
     4681 tttagaacaa aaaccataag tatggtttta ctcgaacttc tctttgtttt tattgagaga
     4741 aatattgcct tctttttggt actccagctg ctaaagagtg ctgagatatg ttaaattatt
     4801 ttttaaaaga aaatctccaa atacttattt aacttgtctt ctagattcat gttgcttata
     4861 ttttaactat tgagcaagtt tattataagg aatgctgcca tatagagaaa gctgaagaga
     4921 aaccatgggc agaaggcttt tttctgtctt attacactgg accttcactc tggtaagggc
     4981 atcagttact tttctggaat aaaaggcgga gttagagcac ttatcagatg ctgtttcatg
     5041 gcttgtttta gttaatttat catgcagata actaacattt gggtatcttt ttgttttagg
     5101 tcttattttc tgactgttag gcctatctta cacataagtt ctactatcag tatacttggc
     5161 agcatgactt tttttttttt ttacagttaa tttaatgaaa atcagcacca ttgtaaatga
     5221 tagtaattgt aacaacatag ttactgggtg aaggagtagg ggagacactc agtaaccatc
     5281 tatttaccta gacacttatg caggggtaca tgctaggtgg ctttattcag attcgggtac
     5341 attggaatca catcatgact ttgagtctga tggctgtgta gataaagatt taagcaagtg
     5401 ccttgtgttt gctggaaaat attaaaactc atttgggtga aagcttccca gatgatgata
     5461 attaatagca cttctgcctt tttcctggag taacttttag attgagtcac atatgatagt
     5521 ataaaagtcc aaaattttct gggtttacct ttgttttatt tttcatatat atattcactg
     5581 tctgcctgga aatagccttg gtttacctta tttttttgta tatgtaaaac tattcatatt
     5641 tgattttatt ccaatattat atatgatgga aaagccagaa ttgtctggca gaatttaatt
     5701 cttccttgga tctctagttc tgtttttaat atcaggttcc ttcatcaaat tttactactg
     5761 tagctctgtg atataatttc atttcttgtc aattatggtc acatatagac aagtacttgg
     5821 tcacaattag ctcaaaagaa tccccatttc ttaaggtgct cagtcaatca cctttatttt
     5881 gagatggtag tttttcaagt tagtattact tactagcttt cttgatgaat ataaaaatgt
     5941 tgtctccatc atacagagct gagcctcttg tggtatatta agataagtcc cattcttaat
     6001 cacagaagaa catggatatt ttagtttttg gagtacccag aattgtaaag attttgtttc
     6061 attttgtttt aggatagctt ctctgcctaa tactatagga tatgtcatgt tcgttattgt
     6121 agccacctcc ctcagatgtt tttcactatt tttaaattat ataatgacca gtagattcac
     6181 agtagcatgt acttgacaag tgccatggat atttaagaag aaggtaaata attttaatat
     6241 tttttgctgt aattttatag gagcagtgga ctgtaagaga aatatctata aatcagagag
     6301 tatttaggaa actttgtatt ttataggtgg tcattaaagt gatcttcagg atataagata
     6361 gtttacacaa actttattct cctgatagga aatttttatt cattttccta ccactcagca
     6421 cttttgttct gccttgtact gcttatgagg attaatgttt taaatttgct ttatttgtgc
     6481 ttttcagaga gttgtcataa ttgtggcagt tgtgtttgtg gcactgtaaa tgctgaaatt
     6541 catgggaaac ttaccaaatg actgcttgag tgttatttcc cattaaattg ggtagctgtc
     6601 acaataacca gaagaaatct tgtggccctt ttgaagaaag ccatgtatgt tttgttacct
     6661 aggttcatag tattttaatt taaaggcaaa gagaagcatt ctacttattt gtcttataaa
     6721 ccattaatcg ttttttgtgc agaagagagc ttattttgtt atactgcttt gtataatgga
     6781 aataagtcac attctggggg aaaaaaactg gaattgtttg tattttgttt ttttgggggg
     6841 ggatctttat gtgaaaaatc agagctactt gttaccataa gcccttacta tcaacaagat
     6901 aattatttgt aatcactttt ttatcccagg ttggaattgc tttccccttc taagttatct
     6961 tcccttaata atatttatga taccaggaca gtgagggtat aagagcaaat gtagtgaggt
     7021 attcaaaaat cctgcatata tggactcaaa agttctttag ttatttgaat tatatatagc
     7081 tatattattt tattagcttg ggttgtcaga agattgccaa ttttaagagt aaagaggaga
     7141 gagataagta ataaaaatag aggaggggaa gaaaatggct cccttactgg tcttagtaat
     7201 cttctatata gttaatgagc taaaaaatga tacttaaagt tccaggtttg gtaccgctag
     7261 catagaaaca ttgcctttcc tacacattcc tcatcattgt ttcctcagaa aattatttta
     7321 agagtttgtg aaaccagatt aaatatctat attcagtttg gcctaatttt taaaaataaa
     7381 tatttatact ccagcttttg tgtatttggt gtacatcacc acttatgcaa atcaaggatc
     7441 agaaaactgg aggttagcca tctccattat ttccttttgc acattgggta cagtgggtgg
     7501 cattagtatg cactagctgc aaagtcacag caccttatgg aaataagtat gtttattata
     7561 ataaaaaaaa gttaagctgc atctctgtag attatttact ttgcagactg taaagctgcc
     7621 ctatcttttc cagcagaatt tactcttcca ttcttaattc ttttttgaaa tatcttaaat
     7681 aatttaacat tcctttataa cttcttaaca gtgtcaaaac tggggtagaa gggattttat
     7741 tttttcccaa aagggttcca tctttgctat ctgttgatca gccttagaaa atctaagtat
     7801 gatcaataaa ttttaatggt tgatggcatc ctgtgtcagc tggagtagtt ggttgtgaat
     7861 attaaaacct agtactattt tccctcagta acatgtaatt gctacatttt ttataagaag
     7921 gtatggttag aaaaaaatgt gaaagatcac ttaaaccaaa gccagttaca aggagtaatc
     7981 tctcctgttg gtttaccttc acctcagaac tacaagaata ttacaataca tagtgaatag
     8041 ttgtctgtaa catttctacc agttgtttca gtagcatatt ggtcttggca tttcttggca
     8101 ctgtggttct gctgtattat ttgtgatgtc ttattgtttg tgagcttttg tttttttttt
     8161 aaagaaaaaa caaaaactaa gtgggactat gtatgtagat gtgtgtcagt accaaaaagt
     8221 tattttctca aatccctaaa tttctgattt ccattcaagt cttttaaact ctttcctgct
     8281 gaatagcaaa gaacttttat tttccacttt cctatattcc taaaaagtgt gaacaatgcg
     8341 tttcagttga ctgtattgca tacttttttg ctgaagactt tttctgtaaa cacaattgcc
     8401 ttgttcagtt ttgttgtaaa ctgacttacc ataagatgca ctgttgataa tgctttctga
     8461 tgtgtgtttg ataagagtga taaaataaaa gcttaaaaat aaaggagttg ctttttaatt
     8521 tcaa
//
