LOCUS       NM_174914               2342 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens UDP glycosyltransferase family 3 member A2 (UGT3A2),
            transcript variant 1, mRNA.
ACCESSION   NM_174914
VERSION     NM_174914.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2342)
  AUTHORS   Meech,R., Rogers,A., Zhuang,L., Lewis,B.C., Miners,J.O. and
            Mackenzie,P.I.
  TITLE     Identification of residues that confer sugar selectivity to
            UDP-glycosyltransferase 3A (UGT3A) enzymes
  JOURNAL   J Biol Chem 287 (29), 24122-24130 (2012)
   PUBMED   22621930
  REMARK    GeneRIF: A phenylalanine (Phe-391) in UGT3A2 favors UDP-Glc use.
REFERENCE   2  (bases 1 to 2342)
  AUTHORS   Zhang,X., Yang,H., Lee,J.J., Kim,E., Lippman,S.M., Khuri,F.R.,
            Spitz,M.R., Lotan,R., Hong,W.K. and Wu,X.
  TITLE     MicroRNA-related genetic variations as predictors for risk of
            second primary tumor and/or recurrence in patients with early-stage
            head and neck cancer
  JOURNAL   Carcinogenesis 31 (12), 2118-2123 (2010)
   PUBMED   20819778
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   3  (bases 1 to 2342)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK075383.1, AC016612.6 and AY358416.1.
            
            On Nov 22, 2018 this sequence version replaced NM_174914.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075383.1, AY358416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282507.8/ ENSP00000282507.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-964               AK075383.1         1-964
            965-965             AC016612.6         44380-44380
            966-2274            AK075383.1         966-2274
            2275-2275           AC016612.6         48972-48972
            2276-2341           AK075383.1         2276-2341
            2342-2342           AY358416.1         2316-2316
FEATURES             Location/Qualifiers
     source          1..2342
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.2"
     gene            1..2342
                     /gene="UGT3A2"
                     /note="UDP glycosyltransferase family 3 member A2"
                     /db_xref="GeneID:167127"
                     /db_xref="HGNC:HGNC:27266"
                     /db_xref="MIM:616384"
     exon            1..187
                     /gene="UGT3A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1665
                     /gene="UGT3A2"
                     /EC_number="2.4.1.17"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; UDP-glucuronosyltransferase 3A2; UDPGT 3A2; UDP
                     glycosyltransferase 3 family, polypeptide A2"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 3A2 isoform 1
                     precursor"
                     /protein_id="NP_777574.2"
                     /db_xref="CCDS:CCDS3914.1"
                     /db_xref="GeneID:167127"
                     /db_xref="HGNC:HGNC:27266"
                     /db_xref="MIM:616384"
                     /translation="MAGQRVLLLVGFLLPGVLLSEAAKILTISTVGGSHYLLMDRVSQ
                     ILQDHGHNVTMLNHKRGPFMPDFKKEEKSYQVISWLAPEDHQREFKKSFDFFLEETLG
                     GRGKFENLLNVLEYLALQCSHFLNRKDIMDSLKNENFDMVIVETFDYCPFLIAEKLGK
                     PFVAILSTSFGSLEFGLPIPLSYVPVFRSLLTDHMDFWGRVKNFLMFFSFCRRQQHMQ
                     STFDNTIKEHFTEGSRPVLSHLLLKAELWFINSDFAFDFARPLLPNTVYVGGLMEKPI
                     KPVPQDLENFIAKFGDSGFVLVTLGSMVNTCQNPEIFKEMNNAFAHLPQGVIWKCQCS
                     HWPKDVHLAANVKIVDWLPQSDLLAHPSIRLFVTHGGQNSIMEAIQHGVPMVGIPLFG
                     DQPENMVRVEAKKFGVSIQLKKLKAETLALKMKQIMEDKRYKSAAVAASVILRSHPLS
                     PTQRLVGWIDHVLQTGGATHLKPYVFQQPWHEQYLLDVFVFLLGLTLGTLWLCGKLLG
                     MAVWWLRGARKVKET"
     exon            188..289
                     /gene="UGT3A2"
                     /inference="alignment:Splign:2.1.0"
     exon            290..404
                     /gene="UGT3A2"
                     /inference="alignment:Splign:2.1.0"
     exon            405..936
                     /gene="UGT3A2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1168
                     /gene="UGT3A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1388
                     /gene="UGT3A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..2342
                     /gene="UGT3A2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2307..2312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGT3A2"
                     /note="hexamer: AATAAA"
     polyA_site      2342
                     /gene="UGT3A2"
                     /note="major polyA site"
ORIGIN      
        1 agtgcctttg gcgcactgag gtgcacaggg tcccttagcc gggcgcaggg cgcgcagccc
       61 aggctgagat ccgcggcttc cgtagaagtg agcatggctg ggcagcgagt gcttcttcta
      121 gtgggcttcc ttctccctgg ggtcctgctc tcagaggctg ccaaaatcct gacaatatct
      181 acagtaggtg gaagccatta tctactgatg gaccgggttt ctcagattct tcaagatcac
      241 ggtcataatg tcaccatgct taaccacaaa agaggtcctt ttatgccaga ttttaaaaag
      301 gaagaaaaat catatcaagt tatcagttgg cttgcacctg aagatcatca aagagaattt
      361 aaaaagagtt ttgatttctt tctggaagaa actttaggtg gcagaggaaa atttgaaaac
      421 ttattaaatg ttctagaata cttggcgttg cagtgcagtc attttttaaa tagaaaggat
      481 atcatggatt ccttaaagaa tgagaacttc gacatggtga tagttgaaac ttttgactac
      541 tgtcctttcc tgattgctga gaagcttggg aagccatttg tggccattct ttccacttca
      601 ttcggctctt tggaatttgg gctaccaatc cccttgtctt atgttccagt attccgttcc
      661 ttgctgactg atcacatgga cttctggggc cgagtgaaga attttctgat gttctttagt
      721 ttctgcagga ggcaacagca catgcagtct acatttgaca acaccatcaa ggaacatttc
      781 acagaaggct ctaggccagt tttgtctcat cttctactga aagcagagtt gtggttcatt
      841 aactctgact ttgcctttga ttttgctcga cctctgcttc ccaacactgt ttatgttgga
      901 ggcttgatgg aaaaacctat taaaccagta ccacaagact tggagaactt cattgccaag
      961 tttggggact ctggttttgt ccttgtgacc ttgggctcca tggtgaacac ctgtcagaat
     1021 ccggaaatct tcaaggagat gaacaatgcc tttgctcacc taccccaagg ggtgatatgg
     1081 aagtgtcagt gttctcattg gcccaaagat gtccacctgg ctgcaaatgt gaaaattgtg
     1141 gactggcttc ctcagagtga cctcctggct cacccaagca tccgtctgtt tgtcacccac
     1201 ggcgggcaga atagcataat ggaggccatc cagcatggtg tgcccatggt ggggatccct
     1261 ctctttggag accagcctga aaacatggtc cgagtagaag ccaaaaagtt tggtgtttct
     1321 attcagttaa agaagctcaa ggcagagaca ttggctctta agatgaaaca aatcatggaa
     1381 gacaagagat acaagtccgc ggcagtggct gccagtgtca tcctgcgctc ccacccgctc
     1441 agccccacac agcggctggt gggctggatt gaccacgtcc tccagacagg gggcgcgacg
     1501 cacctcaagc cctatgtctt tcagcagccc tggcatgagc agtacctgct cgacgttttt
     1561 gtgtttctgc tggggctcac tctggggact ctatggcttt gtgggaagct gctgggcatg
     1621 gctgtctggt ggctgcgtgg ggccagaaag gtgaaggaga cataaggcca ggtgcagcct
     1681 tggcggggtc tgtttggtgg gcgatgtcac catttctagg gagcttccca ctagttctgg
     1741 cagccccatt ctctagtcct tctagttatc tcctgttttc ttgaagaaca ggaaaaatgg
     1801 ccaaaaatca tcctttccac ttgctaattt tgctacaaat tcatccttac tagctcctgc
     1861 ctgctagcag aattctttcc agtcctcttg tcctcctttg tttgccatca gcaagggcta
     1921 tgctgtgatt ctgtctctga gtgacttgga ccactgaccc tcagatttcc agccttaaaa
     1981 tccaccttcc ttctcatgcg cctctccgaa tcacaccctg actcttccag cctccatgtc
     2041 cagacctagt cagcctctct cactcctgcc cctactatct atcatggaat aacatccaag
     2101 aaagacacct tgcatattct ttcagtttct gttttgttct cccacatatt ctcttcaatg
     2161 ctcaggaagc ctgccctgtg cttgagagtt cagggccgga cacaggctca caggtctcca
     2221 cattgggtcc ctgtctctgg tgcccacagt gagctccttc ttggctgagc aggcttggag
     2281 actgtaggtt tccagatttc ctgaaaaata aaagtttaca gcgttatctc tccccaacct
     2341 ca
//
