LOCUS       NP_777574                523 aa            linear   PRI 01-AUG-2024
DEFINITION  UDP-glucuronosyltransferase 3A2 isoform 1 precursor [Homo sapiens].
ACCESSION   NP_777574
VERSION     NP_777574.2
DBSOURCE    REFSEQ: accession NM_174914.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 523)
  AUTHORS   Meech,R., Rogers,A., Zhuang,L., Lewis,B.C., Miners,J.O. and
            Mackenzie,P.I.
  TITLE     Identification of residues that confer sugar selectivity to
            UDP-glycosyltransferase 3A (UGT3A) enzymes
  JOURNAL   J Biol Chem 287 (29), 24122-24130 (2012)
   PUBMED   22621930
  REMARK    GeneRIF: A phenylalanine (Phe-391) in UGT3A2 favors UDP-Glc use.
REFERENCE   2  (residues 1 to 523)
  AUTHORS   Zhang,X., Yang,H., Lee,J.J., Kim,E., Lippman,S.M., Khuri,F.R.,
            Spitz,M.R., Lotan,R., Hong,W.K. and Wu,X.
  TITLE     MicroRNA-related genetic variations as predictors for risk of
            second primary tumor and/or recurrence in patients with early-stage
            head and neck cancer
  JOURNAL   Carcinogenesis 31 (12), 2118-2123 (2010)
   PUBMED   20819778
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   3  (residues 1 to 523)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK075383.1, AC016612.6 and AY358416.1.
            
            On Dec 3, 2009 this sequence version replaced NP_777574.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075383.1, AY358416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282507.8/ ENSP00000282507.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.2"
     Protein         1..523
                     /product="UDP-glucuronosyltransferase 3A2 isoform 1
                     precursor"
                     /EC_number="2.4.1.17"
                     /note="UDP-glucuronosyltransferase 3A2; UDPGT 3A2; UDP
                     glycosyltransferase 3 family, polypeptide A2"
                     /calculated_mol_wt=57268
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2297
     mat_peptide     23..523
                     /product="UDP-glucuronosyltransferase 3A2.
                     /id=PRO_0000299153"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3SY77.1)"
                     /calculated_mol_wt=57268
     Region          23..491
                     /region_name="Glycosyltransferase_GTB-type"
                     /note="glycosyltransferase family 1 and related proteins
                     with GTB topology; cl10013"
                     /db_xref="CDD:471961"
     Site            order(34..35,37,196,199..200,204,243,302,369,371,373..374,
                     377)
                     /site_type="active"
                     /db_xref="CDD:340817"
     Site            order(34,302,369,371,373..374)
                     /site_type="active"
                     /note="TDP-binding site [active]"
                     /db_xref="CDD:340817"
     Site            35
                     /site_type="active"
                     /note="acceptor substrate-binding pocket [active]"
                     /db_xref="CDD:340817"
     Site            52
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q3SY77.1)"
     Site            484..504
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3SY77.1)"
     CDS             1..523
                     /gene="UGT3A2"
                     /coded_by="NM_174914.4:94..1665"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS3914.1"
                     /db_xref="GeneID:167127"
                     /db_xref="HGNC:HGNC:27266"
                     /db_xref="MIM:616384"
ORIGIN      
        1 magqrvlllv gfllpgvlls eaakiltist vggshyllmd rvsqilqdhg hnvtmlnhkr
       61 gpfmpdfkke eksyqviswl apedhqrefk ksfdffleet lggrgkfenl lnvleylalq
      121 cshflnrkdi mdslknenfd mvivetfdyc pfliaeklgk pfvailstsf gslefglpip
      181 lsyvpvfrsl ltdhmdfwgr vknflmffsf crrqqhmqst fdntikehft egsrpvlshl
      241 llkaelwfin sdfafdfarp llpntvyvgg lmekpikpvp qdlenfiakf gdsgfvlvtl
      301 gsmvntcqnp eifkemnnaf ahlpqgviwk cqcshwpkdv hlaanvkivd wlpqsdllah
      361 psirlfvthg gqnsimeaiq hgvpmvgipl fgdqpenmvr veakkfgvsi qlkklkaetl
      421 alkmkqimed kryksaavaa svilrshpls ptqrlvgwid hvlqtggath lkpyvfqqpw
      481 heqylldvfv fllgltlgtl wlcgkllgma vwwlrgarkv ket
//
