LOCUS       NM_152404               4918 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens UDP glycosyltransferase family 3 member A1 (UGT3A1),
            transcript variant 1, mRNA.
ACCESSION   NM_152404
VERSION     NM_152404.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4918)
  AUTHORS   Vergara,A.G., Watson,C.J.W., Chen,G. and Lazarus,P.
  TITLE     UDP-Glycosyltransferase 3A Metabolism of Polycyclic Aromatic
            Hydrocarbons: Potential Importance in Aerodigestive Tract Tissues
  JOURNAL   Drug Metab Dispos 48 (3), 160-168 (2020)
   PUBMED   31836608
  REMARK    GeneRIF: UDP-Glycosyltransferase 3A Metabolism of Polycyclic
            Aromatic Hydrocarbons: Potential Importance in Aerodigestive Tract
            Tissues.
REFERENCE   2  (bases 1 to 4918)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   3  (bases 1 to 4918)
  AUTHORS   Meech,R., Rogers,A., Zhuang,L., Lewis,B.C., Miners,J.O. and
            Mackenzie,P.I.
  TITLE     Identification of residues that confer sugar selectivity to
            UDP-glycosyltransferase 3A (UGT3A) enzymes
  JOURNAL   J Biol Chem 287 (29), 24122-24130 (2012)
   PUBMED   22621930
  REMARK    GeneRIF: An asparagine (Asn-391) in the UGT signature sequence of
            UGT3A1 is necessary for utilization of UDP-GlcNAc.
REFERENCE   4  (bases 1 to 4918)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 4918)
  AUTHORS   Meech,R. and Mackenzie,P.I.
  TITLE     UGT3A: novel UDP-glycosyltransferases of the UGT superfamily
  JOURNAL   Drug Metab Rev 42 (1), 45-54 (2010)
   PUBMED   19814657
  REMARK    GeneRIF: UGT3A1 is involved in drug metabolism and uses UDP
            N-acetylglucosamine as a sugar donor
REFERENCE   6  (bases 1 to 4918)
  AUTHORS   Mackenzie,P.I., Rogers,A., Treloar,J., Jorgensen,B.R., Miners,J.O.
            and Meech,R.
  TITLE     Identification of UDP glycosyltransferase 3A1 as a UDP
            N-acetylglucosaminyltransferase
  JOURNAL   J Biol Chem 283 (52), 36205-36210 (2008)
   PUBMED   18981171
  REMARK    GeneRIF: UDP glycosyltransferase 3A1 is a UDP
            N-acetylglucosaminyltransferase
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK315851.1, AC112204.2 and AI244517.1.
            
            On May 17, 2019 this sequence version replaced NM_152404.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290809.1, AK057066.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA1970526 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274278.8/ ENSP00000274278.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1920              AK315851.1         8-1927
            1921-2812           AC112204.2         163052-163943       c
            2813-2835           AI244517.1         11-33               c
            2836-4918           AC112204.2         160946-163028       c
FEATURES             Location/Qualifiers
     source          1..4918
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.2"
     gene            1..4918
                     /gene="UGT3A1"
                     /note="UDP glycosyltransferase family 3 member A1"
                     /db_xref="GeneID:133688"
                     /db_xref="HGNC:HGNC:26625"
                     /db_xref="MIM:616383"
     exon            1..244
                     /gene="UGT3A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1722
                     /gene="UGT3A1"
                     /EC_number="2.4.1.17"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; UDP-glucuronosyltransferase 3A1; UDPGT 3A1; UDP
                     glycosyltransferase 3 family, polypeptide A1"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 3A1 isoform 1
                     precursor"
                     /protein_id="NP_689617.3"
                     /db_xref="CCDS:CCDS3913.1"
                     /db_xref="GeneID:133688"
                     /db_xref="HGNC:HGNC:26625"
                     /db_xref="MIM:616383"
                     /translation="MVGQRVLLLVAFLLSGVLLSEAAKILTISTLGGSHYLLLDRVSQ
                     ILQEHGHNVTMLHQSGKFLIPDIKEEEKSYQVIRWFSPEDHQKRIKKHFDSYIETALD
                     GRKESEALVKLMEIFGTQCSYLLSRKDIMDSLKNENYDLVFVEAFDFCSFLIAEKLVK
                     PFVAILPTTFGSLDFGLPSPLSYVPVFPSLLTDHMDFWGRVKNFLMFFSFSRSQWDMQ
                     STFDNTIKEHFPEGSRPVLSHLLLKAELWFVNSDFAFDFARPLLPNTVYIGGLMEKPI
                     KPVPQDLDNFIANFGDAGFVLVAFGSMLNTHQSQEVLKKMHNAFAHLPQGVIWTCQSS
                     HWPRDVHLATNVKIVDWLPQSDLLAHPSIRLFVTHGGQNSVMEAIRHGVPMVGLPVNG
                     DQHGNMVRVVAKNYGVSIRLNQVTADTLTLTMKQVIEDKRYKSAVVAASVILHSQPLS
                     PAQRLVGWIDHILQTGGATHLKPYAFQQPWHEQYLIDVFVFLLGLTLGTMWLCGKLLG
                     VVARWLRGARKVKKT"
     exon            245..346
                     /gene="UGT3A1"
                     /inference="alignment:Splign:2.1.0"
     exon            347..461
                     /gene="UGT3A1"
                     /inference="alignment:Splign:2.1.0"
     exon            462..993
                     /gene="UGT3A1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1225
                     /gene="UGT3A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1445
                     /gene="UGT3A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..4918
                     /gene="UGT3A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2817..2822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGT3A1"
                     /note="hexamer: AATAAA"
     polyA_site      2835
                     /gene="UGT3A1"
                     /note="major polyA site"
ORIGIN      
        1 agaagggcga gagaattggc aggatccgtc tcctacctct tcctaggccc acagccagtg
       61 cctttggagt actgaggcgc gcacagagtc cttagcccgg cgcagggcgc gcagcccagg
      121 ctgagatccg ctgcttctgt ggaagtgagc atggttgggc agcgggtgct gcttctagtg
      181 gccttccttc tttctggggt cctgctctca gaggctgcca aaatcctgac aatatctaca
      241 ctgggtggaa gccattacct actgttggac cgggtgtctc agattcttca agagcatggt
      301 cataatgtga ctatgcttca tcagagtgga aagtttttga tcccagatat taaagaggag
      361 gaaaaatcat accaagttat caggtggttt tcacctgaag atcatcaaaa aagaattaag
      421 aagcattttg atagctacat agaaacagca ttggatggca gaaaagaatc tgaagccctt
      481 gtaaagctaa tggaaatatt tgggactcaa tgtagttatt tgctaagcag aaaggatata
      541 atggattcct taaagaatga gaactatgat ctggtatttg ttgaagcatt tgatttctgt
      601 tctttcctga ttgctgagaa gcttgtgaaa ccatttgtgg ccattcttcc caccacattc
      661 ggctctttgg attttgggct accaagcccc ttgtcttatg ttccagtatt cccttccttg
      721 ctgactgatc acatggactt ctggggccga gtgaagaatt ttctgatgtt ctttagtttc
      781 tccaggagcc aatgggacat gcagtctaca tttgacaaca ccatcaagga gcatttccca
      841 gaaggctcta ggccagtttt gtctcatctt ctactgaaag cagagttgtg gtttgttaac
      901 tctgattttg cctttgattt tgcccggccc ctgcttccca acactgttta tattggaggc
      961 ttgatggaaa aacctattaa accagtacca caagacttgg acaacttcat tgccaacttt
     1021 ggggatgcag ggtttgtcct tgtggccttt ggctccatgt tgaacaccca tcagtcccag
     1081 gaagtcctca agaagatgca caatgccttt gcccacctcc ctcaaggagt gatatggaca
     1141 tgtcagagtt ctcattggcc cagagatgtt catttggcca caaatgtgaa aattgtggac
     1201 tggcttcctc agagtgacct cctggctcac cccagcatcc gtctttttgt cactcatggt
     1261 gggcagaaca gcgtaatgga ggccatccgt catggtgtgc ccatggtggg attaccagtc
     1321 aatggagacc agcatggaaa catggtccga gtagtagcca aaaattatgg tgtctctatc
     1381 cggttgaatc aggtcacagc cgacacactg acacttacaa tgaaacaagt catagaagac
     1441 aagaggtaca agtcggcagt ggtggcagcc agtgtcatcc tgcactctca gcccctgagc
     1501 cccgcacagc ggctggtggg ctggatcgac cacatcctcc agactggggg agcgacgcac
     1561 ctcaagccct atgccttcca gcagccttgg catgagcagt acctcattga tgtctttgtg
     1621 tttctgctgg ggctcactct gggcactatg tggctttgtg ggaagctgct gggtgtggtg
     1681 gccaggtggc tgcgtggggc caggaaggtg aagaagacat gaggctaggt gtagccttgg
     1741 gtgaggggag ggcatccctg gtcctttgaa ggttctcccc accccagcac acgccacccc
     1801 tctgttctct cttcagctcc acctgccact gatcctgcaa cttgcttctt tctattctct
     1861 gcctctgttt agaaatcttc acgcaccact gaggcttctt gacttgcccc ttgtgacttg
     1921 aaaccccagc tcagatacaa attttcacct gccagccctg cctcctcctt tctccctttt
     1981 cctagacaca ggactctgac aacttcatcc tccttgttta gatgacttcc cagtttccag
     2041 tccccatttc tccttctatc acttttcata aaaaaactca ggaaatattt gacatatctt
     2101 ccatttcaaa ttcttccatt ttatgcagat atcttgccct tcctataagc tctcctcaaa
     2161 gctcaggaaa cctggtctgc tctcctgcat ttagggaagg agaacccctg ccaagacctt
     2221 tgctcactgc ctgagacccc ttccttagag agcacctcct ttgctggtca gacatggagc
     2281 ctgcagttgg tcacagatga tactgcttta tttcagtttt tacagttgtc ttcttaagat
     2341 tcccgtctta taaatggagt acagggaacc tcaagtagtg aagtggaaat ccatgtgtaa
     2401 ggctttgtgg cttcaggtac cagtggctaa ggtagtttta aagactttgt tgattttaga
     2461 aaaagtccat cttccatccc cgacatggca gttaataccc ttctatatgg taaaacctta
     2521 gagattacct taatctgcta ggaacagaag caagaaaaac catggcgtaa acacccccag
     2581 agtttttgtt catttgtttc atctttcttg ataaagcccg aaggtagccc attcagggct
     2641 gttgtggttg gttgctccat catgtcatca atagcccata tcttttcttt tttatcttcc
     2701 ttagtgtaac accaaactac ctctctgata gctggtgttc atgaaatatt ttaccttcaa
     2761 atgattgtac ctttttattt gctttagagt tctgaaataa aatgaaattc cactgtaata
     2821 aaactgtcaa atgcatggtg tctgatgagt taaaaacaca gagtagaaaa caggcatatg
     2881 gagaggccct ggatgaacca tagttttaga ttgtttaatt ctagaattgt gaaacagatc
     2941 ttgaaacaat tcagatcaaa agatgaaact gttacaaatg ctcctgcaga aatagagaat
     3001 gccccccacc aaaaactttg ccaattccat gaaaggattt gcttgcgagt ctgcagagct
     3061 gagtgctgga tgtctatcca ttttgtgagt tctcatgaca caagagccag aagcatgaag
     3121 cacgcagaag tacattagag tgtgtgtatc tgtgtgcgta taatacaagg ttttattgct
     3181 gtaattctta tgaaaccaca tgaattgatt gatggccata ctcccatgaa gggcagacat
     3241 ggatgcttcc ctgtgttttc tgttgaatca acagccatga tttcattccc ctcatgagca
     3301 acataaggtc ttagggataa gcctccctgg ccagtaactc ccccctcacc ccagaacata
     3361 gcctttctct aacacttggt aattcattga ggtcaacttt atgccacttg tataaacttg
     3421 catccctaaa atctgatcat aagcagccaa tgagccagaa tgatgcttct aatcttgctc
     3481 tgtccaagca ccctccacag ggctgcaagc atggctctga caacctagaa atctggtgtt
     3541 atccctcact gtttaaaatc tttgttccca ttgtgtggaa tataagggct ctatgatttg
     3601 gtcctggcta ccaatctagg cacacctgga gcagttctcc tcccactctt ttccaaatgt
     3661 tcgctacacc ccctcagaac acattttgct gtttttaacc tctgaggttt gtctatgccc
     3721 ttccttctct cagaaatacc atcctattct tgctggaatg agaaacttct gcttatctgt
     3781 cagtatccag tgtcattgtg ttcacattgg taagcctgtg cctgaccact acacctgaaa
     3841 tggagctcac tgcattctct tttgaagcat ttttcttact atatcgcaat tatttattac
     3901 aatatctgtt tcctatttag aaaccataag gtcataaaga cagggactgg ttcctattta
     3961 tcttgttata gaacctggca tagtgcctgg aacaaatact gctaggacaa ctggataata
     4021 ttgagaaaaa aggcaatatt tgatccagac ttcacactat atcaaaaact gaattcctat
     4081 acaccagata tctaggtaca aaaaatgata ccatgctgag tctaagagaa aaagtgaatt
     4141 tttccatagc ctgtgtatag ggagagactt tctaaatagg aagaaaaaat cctgatacaa
     4201 caagagaagt gtaaattaat ttgacacaaa aaactttggc atggcaaaaa tcatggtaag
     4261 aagattagcg atccaaatta aaaagttgga gaaacatagc tgcagcatat atcttacaca
     4321 tagacctaat atttctgata aactaagaac tattaaaatt gaagaaagaa cctatgatac
     4381 atatacatac tgaaataata ttcagcttta aactacaata aacaaaagca gaataagcta
     4441 atatggagca aattccaata tggttaagta aaaaatagca aagagtaaga gtaactatag
     4501 gatgtatcct tttttttata agaaaaagga aagtatgtgt atgggggata atgaaaaaaa
     4561 tacatatcta tgtgcattgc cttgcaaaaa cagtgcagag ggaataaacc agagtgtgat
     4621 agattatcta tgagggtggt gtttgaatag ggtggaagga tccatgtgtt tatgttttta
     4681 catagtttgg attttggaaa cgttaatatt ttgcatacca agtatatgtt taaataaaca
     4741 aggagagaaa agccaagaac tgaaatacaa acggaaacaa atgaaatcaa ttttttccaa
     4801 atgaaaatgt aactatactg tagtgaaaaa aattagcatc attacctttt aaacacagta
     4861 cttttactat atactgtata caatcaatca acagaaaaaa aaaagaactc caaacgaa
//
