LOCUS       NM_001074               1888 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens UDP glucuronosyltransferase family 2 member B7
            (UGT2B7), transcript variant 1, mRNA.
ACCESSION   NM_001074 XM_937808 XM_943434 XM_943440
VERSION     NM_001074.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1888)
  AUTHORS   Zhao,T., Zhang,H.L., Feng,J., Cui,L., Sun,L., Li,H.J. and Yu,L.H.
  TITLE     Impact of UGT1A4 and UGT2B7 polymorphisms on lamotrigine plasma
            concentration in patients with bipolar disorder
  JOURNAL   Pharmacogenet Genomics 34 (8), 261-267 (2024)
   PUBMED   39171428
  REMARK    GeneRIF: Impact of UGT1A4 and UGT2B7 polymorphisms on lamotrigine
            plasma concentration in patients with bipolar disorder.
REFERENCE   2  (bases 1 to 1888)
  AUTHORS   Xu,C., Jiang,Z., Qian,M., Zuo,L., Xue,H. and Hu,N.
  TITLE     Influence of UDP-Glucuronosyltransferase Polymorphisms on
            Mycophenolic Acid Metabolism in Renal Transplant Patients
  JOURNAL   Transplant Proc 56 (6), 1280-1289 (2024)
   PUBMED   39054222
  REMARK    GeneRIF: Influence of UDP-Glucuronosyltransferase Polymorphisms on
            Mycophenolic Acid Metabolism in Renal Transplant Patients.
REFERENCE   3  (bases 1 to 1888)
  AUTHORS   Milne,G.L., Nogueira,M.S., Gao,B., Sanchez,S.C., Amin,W.,
            Thomas,S., Oger,C., Galano,J.M., Murff,H.J., Yang,G. and Durand,T.
  TITLE     Identification of novel F2-isoprostane metabolites by specific
            UDP-glucuronosyltransferases
  JOURNAL   Redox Biol 70, 103020 (2024)
   PUBMED   38211441
REFERENCE   4  (bases 1 to 1888)
  AUTHORS   Bozina,N., Sporis,I.S., Domjanovic,I.K., Ganoci,L., Simicevic,L.,
            Lovric,M., Romic,Z.C., Gadze,Z.P. and Trkulja,V.
  TITLE     Bearing variant alleles at uridine glucuronosyltransferase
            polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G
            (rs2011425) has no relevant consequences for lamotrigine troughs in
            adults with epilepsy
  JOURNAL   Eur J Clin Pharmacol 79 (8), 1117-1129 (2023)
   PUBMED   37340142
  REMARK    GeneRIF: Bearing variant alleles at uridine glucuronosyltransferase
            polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G
            (rs2011425) has no relevant consequences for lamotrigine troughs in
            adults with epilepsy.
REFERENCE   5  (bases 1 to 1888)
  AUTHORS   Matsumoto,J., Nishimoto,A., Watari,S., Ueki,H., Shiromizu,S.,
            Iwata,N., Takeda,T., Ushio,S., Kajizono,M., Fujiyoshi,M.,
            Koyama,T., Araki,M., Wada,K., Zamami,Y., Nasu,Y. and Ariyoshi,N.
  TITLE     Significance of UGT1A6, UGT1A9, and UGT2B7 genetic variants and
            their mRNA expression in the clinical outcome of renal cell
            carcinoma
  JOURNAL   Mol Cell Biochem 478 (8), 1779-1790 (2023)
   PUBMED   36571650
  REMARK    GeneRIF: Significance of UGT1A6, UGT1A9, and UGT2B7 genetic
            variants and their mRNA expression in the clinical outcome of renal
            cell carcinoma.
REFERENCE   6  (bases 1 to 1888)
  AUTHORS   King,C.D., Rios,G.R., Assouline,J.A. and Tephly,T.R.
  TITLE     Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in
            the human brain and identification of 5-hydroxytryptamine as a
            substrate
  JOURNAL   Arch Biochem Biophys 365 (1), 156-162 (1999)
   PUBMED   10222050
REFERENCE   7  (bases 1 to 1888)
  AUTHORS   Strassburg,C.P., Strassburg,A., Nguyen,N., Li,Q., Manns,M.P. and
            Tukey,R.H.
  TITLE     Regulation and function of family 1 and family 2
            UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human
            oesophagus
  JOURNAL   Biochem J 338 (Pt 2) (Pt 2), 489-498 (1999)
   PUBMED   10024527
REFERENCE   8  (bases 1 to 1888)
  AUTHORS   Belanger,G., Beaulieu,M., Marcotte,B., Levesque,E., Guillemette,C.,
            Hum,D.W. and Belanger,A.
  TITLE     Expression of transcripts encoding steroid
            UDP-glucuronosyltransferases in human prostate hyperplastic tissue
            and the LNCaP cell line
  JOURNAL   Mol Cell Endocrinol 113 (2), 165-173 (1995)
   PUBMED   8674824
REFERENCE   9  (bases 1 to 1888)
  AUTHORS   Monaghan,G., Clarke,D.J., Povey,S., See,C.G., Boxer,M. and
            Burchell,B.
  TITLE     Isolation of a human YAC contig encompassing a cluster of UGT2
            genes and its regional localization to chromosome 4q13
  JOURNAL   Genomics 23 (2), 496-499 (1994)
   PUBMED   7835904
REFERENCE   10 (bases 1 to 1888)
  AUTHORS   Ritter,J.K., Sheen,Y.Y. and Owens,I.S.
  TITLE     Cloning and expression of human liver UDP-glucuronosyltransferase
            in COS-1 cells. 3,4-catechol estrogens and estriol as primary
            substrates
  JOURNAL   J Biol Chem 265 (14), 7900-7906 (1990)
   PUBMED   2159463
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK313190.1, BC030974.1 and AW614236.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001074.3.
            
            Summary: The protein encoded by this gene belongs to the
            UDP-glycosyltransferase (UGT) family. UGTs serve a major role in
            the conjugation and subsequent elimination of potentially toxic
            xenobiotics and endogenous compounds. This protein is localized in
            the microsome membrane, and has unique specificity for 3,4-catechol
            estrogens and estriol, suggesting that it may play an important
            role in regulating the level and activity of these potent estrogen
            metabolites. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Mar 2017].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313190.1, J05428.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305231.12/ ENSP00000304811.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AK313190.1         1-1
            2-1750              BC030974.1         1-1749
            1751-1888           AW614236.1         13-150              c
FEATURES             Location/Qualifiers
     source          1..1888
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.2"
     gene            1..1888
                     /gene="UGT2B7"
                     /gene_synonym="UDPGT 2B7; UDPGT 2B9; UDPGT2B7; UDPGTh-2;
                     UDPGTH2; UGT2B9"
                     /note="UDP glucuronosyltransferase family 2 member B7"
                     /db_xref="GeneID:7364"
                     /db_xref="HGNC:HGNC:12554"
                     /db_xref="MIM:600068"
     exon            1..768
                     /gene="UGT2B7"
                     /gene_synonym="UDPGT 2B7; UDPGT 2B9; UDPGT2B7; UDPGTh-2;
                     UDPGTH2; UGT2B9"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1637
                     /gene="UGT2B7"
                     /gene_synonym="UDPGT 2B7; UDPGT 2B9; UDPGT2B7; UDPGTh-2;
                     UDPGTH2; UGT2B9"
                     /EC_number="2.4.1.17"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; UDP-glucuronyltransferase, family 2, beta-7;
                     3,4-catechol estrogen specific; UDP
                     glucuronosyltransferase 2 family, polypeptide B7;
                     UDP-glucuronosyltransferase 2B7;
                     UDP-glucuronosyltransferase 2B9; 3,4-catechol
                     estrogen-specific UDPGT"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 2B7 isoform 1
                     precursor"
                     /protein_id="NP_001065.2"
                     /db_xref="CCDS:CCDS3526.1"
                     /db_xref="GeneID:7364"
                     /db_xref="HGNC:HGNC:12554"
                     /db_xref="MIM:600068"
                     /translation="MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILD
                     ELIQRGHEVTVLASSASILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPK
                     DTFWLYFSQVQEIMSIFGDITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELL
                     AELFNIPFVYSLSFSPGYTFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVL
                     YFDFWFEIFDMKKWDQFYSEVLGRPTTLSETMGKADVWLIRNSWNFQFPYPLLPNVDF
                     VGGLHCKPAKPLPKEMEDFVQSSGENGVVVFSLGSMVSNMTEERANVIASALAQIPQK
                     VLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVG
                     IPLFADQPDNIAHMKARGAAVRVDFNTMSSTDLLNALKRVINDPSYKENVMKLSRIQH
                     DQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVATVIFIV
                     TKCCLFCFWKFARKAKKGKND"
     exon            769..917
                     /gene="UGT2B7"
                     /gene_synonym="UDPGT 2B7; UDPGT 2B9; UDPGT2B7; UDPGTh-2;
                     UDPGTH2; UGT2B9"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1049
                     /gene="UGT2B7"
                     /gene_synonym="UDPGT 2B7; UDPGT 2B9; UDPGT2B7; UDPGTh-2;
                     UDPGTH2; UGT2B9"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1137
                     /gene="UGT2B7"
                     /gene_synonym="UDPGT 2B7; UDPGT 2B9; UDPGT2B7; UDPGTh-2;
                     UDPGTH2; UGT2B9"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1357
                     /gene="UGT2B7"
                     /gene_synonym="UDPGT 2B7; UDPGT 2B9; UDPGT2B7; UDPGTh-2;
                     UDPGTH2; UGT2B9"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1888
                     /gene="UGT2B7"
                     /gene_synonym="UDPGT 2B7; UDPGT 2B9; UDPGT2B7; UDPGTh-2;
                     UDPGTH2; UGT2B9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1784..1789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGT2B7"
                     /gene_synonym="UDPGT 2B7; UDPGT 2B9; UDPGT2B7; UDPGTh-2;
                     UDPGTH2; UGT2B9"
                     /note="hexamer: AATAAA"
     polyA_site      1817
                     /gene="UGT2B7"
                     /gene_synonym="UDPGT 2B7; UDPGT 2B9; UDPGT2B7; UDPGTh-2;
                     UDPGTH2; UGT2B9"
                     /note="major polyA site"
     regulatory      1865..1870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGT2B7"
                     /gene_synonym="UDPGT 2B7; UDPGT 2B9; UDPGT2B7; UDPGTh-2;
                     UDPGTH2; UGT2B9"
                     /note="hexamer: AATAAA"
     polyA_site      1888
                     /gene="UGT2B7"
                     /gene_synonym="UDPGT 2B7; UDPGT 2B9; UDPGT2B7; UDPGTh-2;
                     UDPGTH2; UGT2B9"
                     /note="major polyA site"
ORIGIN      
        1 gacagaaagg aacagcaact ggaaaacaag cattgcattg caccaggatg tctgtgaaat
       61 ggacttcagt aattttgcta atacaactga gcttttgctt tagctctggg aattgtggaa
      121 aggtgctggt gtgggcagca gaatacagcc attggatgaa tataaagaca atcctggatg
      181 agcttattca gagaggtcat gaggtgactg tactggcatc ttcagcttcc attctttttg
      241 atcccaacaa ctcatccgct cttaaaattg aaatttatcc cacatcttta actaaaactg
      301 agttggagaa tttcatcatg caacagatta agagatggtc agaccttcca aaagatacat
      361 tttggttata tttttcacaa gtacaggaaa tcatgtcaat atttggtgac ataactagaa
      421 agttctgtaa agatgtagtt tcaaataaga aatttatgaa aaaagtacaa gagtcaagat
      481 ttgacgtcat ttttgcagat gctatttttc cctgtagtga gctgctggct gagctattta
      541 acataccctt tgtgtacagt ctcagcttct ctcctggcta cacttttgaa aagcatagtg
      601 gaggatttat tttccctcct tcctacgtac ctgttgttat gtcagaatta actgatcaaa
      661 tgactttcat ggagagggta aaaaatatga tctatgtgct ttactttgac ttttggttcg
      721 aaatatttga catgaagaag tgggatcagt tttatagtga agttctagga agacccacta
      781 cattatctga gacaatgggg aaagctgacg tatggcttat tcgaaactcc tggaattttc
      841 agtttccata tccactctta ccaaatgttg attttgttgg aggactccac tgcaaacctg
      901 ccaaacccct gcctaaggaa atggaagact ttgtacagag ctctggagaa aatggtgttg
      961 tggtgttttc tctggggtca atggtcagta acatgacaga agaaagggcc aacgtaattg
     1021 catcagccct ggcccagatc ccacaaaagg ttctgtggag atttgatggg aataaaccag
     1081 ataccttagg tctcaatact cggctctaca agtggatacc ccagaatgac cttctaggtc
     1141 atccaaagac cagagctttt ataactcatg gtggagccaa tggcatctac gaggcaatct
     1201 accatgggat ccctatggtg gggattccat tgtttgccga tcaacctgat aacattgctc
     1261 acatgaaggc caggggagca gctgttagag tggacttcaa cacaatgtcg agtacagact
     1321 tgctgaatgc attgaagaga gtaattaatg atccttcata taaagagaat gttatgaaat
     1381 tatcaagaat tcaacatgat caaccagtga agcccctgga tcgagcagtc ttctggattg
     1441 aatttgtcat gcgccacaaa ggagctaaac accttcgggt tgcagcccac gacctcacct
     1501 ggttccagta ccactctttg gatgtgattg ggttcctgct ggtctgtgtg gcaactgtga
     1561 tatttatcgt cacaaaatgt tgtctgtttt gtttctggaa gtttgctaga aaagcaaaga
     1621 agggaaaaaa tgattagtta tatctgagat ttgaagctgg aaaacctgat aggtgagact
     1681 acttcagttt attccagcaa gaaagattgt gatgcaagat ttctttcttc ctgagacaaa
     1741 aaaaaaaaaa gaaaaaaaaa tcttttcaaa atttactttg tcaaataaaa atttgttttt
     1801 cagagattta ccacccagtt catggttaga aatattttgt ggcaatgaag aaaacactac
     1861 ggaaaataaa aaataagata aagcctta
//
