LOCUS       NM_053039               1857 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens UDP glucuronosyltransferase family 2 member B28
            (UGT2B28), transcript variant 1, mRNA.
ACCESSION   NM_053039
VERSION     NM_053039.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1857)
  AUTHORS   Lacombe,L., Hovington,H., Brisson,H., Mehdi,S., Beillevaire,D.,
            Emond,J.P., Wagner,A., Villeneuve,L., Simonyan,D., Ouellet,V.,
            Barres,V., Latour,M., Aprikian,A., Bergeron,A., Castonguay,V.,
            Couture,F., Chevalier,S., Brimo,F., Fazli,L., Fleshner,N.,
            Gleave,M., Karakiewicz,P.I., Lattouf,J.B., Trudel,D., van der
            Kwast,T., Mes-Masson,A.M., Pouliot,F., Fradet,Y., Audet-Walsh,E.,
            Saad,F., Guillemette,C. and Levesque,E.
  TITLE     UGT2B28 accelerates prostate cancer progression through
            stabilization of the endocytic adaptor protein HIP1 regulating AR
            and EGFR pathways
  JOURNAL   Cancer Lett 553, 215994 (2023)
   PUBMED   36343786
  REMARK    GeneRIF: UGT2B28 accelerates prostate cancer progression through
            stabilization of the endocytic adaptor protein HIP1 regulating AR
            and EGFR pathways.
REFERENCE   2  (bases 1 to 1857)
  AUTHORS   Rouleau,M., Nguyen Van Long,F., Turcotte,V., Caron,P., Lacombe,L.,
            Aprikian,A., Saad,F., Carmel,M., Chevalier,S., Levesque,E. and
            Guillemette,C.
  TITLE     Extensive metabolic consequences of human glycosyltransferase gene
            knockouts in prostate cancer
  JOURNAL   Br J Cancer 128 (2), 285-296 (2023)
   PUBMED   36347965
  REMARK    GeneRIF: Extensive metabolic consequences of human
            glycosyltransferase gene knockouts in prostate cancer.
REFERENCE   3  (bases 1 to 1857)
  AUTHORS   Ravindran,A., Krieger,K.L., Kaushik,A.K., Hovington,H., Mehdi,S.,
            Piyarathna,D.W.B., Putluri,V., Basil,P., Rasaily,U., Gu,F.,
            Dang,T., Choi,J.M., Sonavane,R., Jung,S.Y., Wang,L., Mehra,R.,
            Weigel,N.L., Putluri,N., Rowley,D.R., Palapattu,G.S.,
            Guillemette,C., Lacombe,L., Levesque,E. and Sreekumar,A.
  TITLE     Uridine Diphosphate Glucuronosyl Transferase 2B28 (UGT2B28)
            Promotes Tumor Progression and Is Elevated in African American
            Prostate Cancer Patients
  JOURNAL   Cells 11 (15), 2329 (2022)
   PUBMED   35954173
  REMARK    GeneRIF: Uridine Diphosphate Glucuronosyl Transferase 2B28
            (UGT2B28) Promotes Tumor Progression and Is Elevated in African
            American Prostate Cancer Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1857)
  AUTHORS   Le,P.H., Kuo,C.J., Hsieh,Y.C., Chen,T.H., Lin,C.L., Yeh,C.T. and
            Liang,K.H.
  TITLE     Ages of hepatocellular carcinoma occurrence and life expectancy are
            associated with a UGT2B28 genomic variation
  JOURNAL   BMC Cancer 19 (1), 1190 (2019)
   PUBMED   31805979
  REMARK    GeneRIF: Patients with UGT2B28-rs2132039 - TT variant type had an
            earlier presentation of hepatocellular carcinoma (HCC), earlier
            post-surgery recurrence, metastasis and HCC-related death.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1857)
  AUTHORS   Albertsen,H.M., Matalliotaki,C., Matalliotakis,M., Zervou,M.I.,
            Matalliotakis,I., Spandidos,D.A., Chettier,R., Ward,K. and
            Goulielmos,G.N.
  TITLE     Whole exome sequencing identifies hemizygous deletions in the
            UGT2B28 and USP17L2 genes in a three-generation family with
            endometriosis
  JOURNAL   Mol Med Rep 19 (3), 1716-1720 (2019)
   PUBMED   30628680
  REMARK    GeneRIF: further analysis revealed 2 hemizygous deletions in the
            grandmother that segregate in several of her affected offspring.
            The first deletion was found in the UGT2B28 locus, spanning 7
            informative sequence variants across at least 14 kb. The second
            deletion, located in USP17L2, spans 3 informative variants across
            at least 2 kb. On the whole, the findings of the presents study
            implicate 2 additional genes in the pathogenesis
REFERENCE   6  (bases 1 to 1857)
  AUTHORS   Ohno,S. and Nakajin,S.
  TITLE     Quantitative analysis of UGT2B28 mRNA expression by real-time
            RT-PCR and application to human tissue distribution study
  JOURNAL   Drug Metab Lett 5 (3), 202-208 (2011)
   PUBMED   21679149
  REMARK    GeneRIF: UGT2B28 was clearly detected in breast and adipose tissue;
            GT2B28 expression in the breast was comparatively low, about 1.6%
            of GAPDH mRNA levels, and was less than 5% of normalized (against
            GAPDH) UGT2B7 and 2B10 mRNA expression levels in the liver
REFERENCE   7  (bases 1 to 1857)
  AUTHORS   Setlur,S.R., Chen,C.X., Hossain,R.R., Ha,J.S., Van Doren,V.E.,
            Stenzel,B., Steiner,E., Oldridge,D., Kitabayashi,N., Banerjee,S.,
            Chen,J.Y., Schafer,G., Horninger,W., Lee,C., Rubin,M.A., Klocker,H.
            and Demichelis,F.
  TITLE     Genetic variation of genes involved in dihydrotestosterone
            metabolism and the risk of prostate cancer
  JOURNAL   Cancer Epidemiol Biomarkers Prev 19 (1), 229-239 (2010)
   PUBMED   20056642
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1857)
  AUTHORS   Ross,C.J., Katzov-Eckert,H., Dube,M.P., Brooks,B., Rassekh,S.R.,
            Barhdadi,A., Feroz-Zada,Y., Visscher,H., Brown,A.M., Rieder,M.J.,
            Rogers,P.C., Phillips,M.S., Carleton,B.C. and Hayden,M.R.
  CONSRTM   CPNDS Consortium
  TITLE     Genetic variants in TPMT and COMT are associated with hearing loss
            in children receiving cisplatin chemotherapy
  JOURNAL   Nat Genet 41 (12), 1345-1349 (2009)
   PUBMED   19898482
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Nat Genet. 2013 May;45(5):578]
REFERENCE   9  (bases 1 to 1857)
  AUTHORS   Menard,V., Eap,O., Harvey,M., Guillemette,C. and Levesque,E.
  TITLE     Copy-number variations (CNVs) of the human sex steroid metabolizing
            genes UGT2B17 and UGT2B28 and their associations with a UGT2B15
            functional polymorphism
  JOURNAL   Hum Mutat 30 (9), 1310-1319 (2009)
   PUBMED   19572376
  REMARK    GeneRIF: Copy-number variations (CNVs) of the human sex steroid
            metabolizing genes UGT2B28
REFERENCE   10 (bases 1 to 1857)
  AUTHORS   Levesque,E., Turgeon,D., Carrier,J.S., Montminy,V., Beaulieu,M. and
            Belanger,A.
  TITLE     Isolation and characterization of the UGT2B28 cDNA encoding a novel
            human steroid conjugating UDP-glucuronosyltransferase
  JOURNAL   Biochemistry 40 (13), 3869-3881 (2001)
   PUBMED   11300766
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC114786.4 and AF177272.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_053039.1.
            
            Summary: This gene encodes a member of the uridine
            diphosphoglucuronosyltransferase protein family. The encoded enzyme
            catalyzes the transfer of glucuronic acid from uridine
            diphosphoglucuronic acid to a diverse array of substrates including
            steroid hormones and lipid-soluble drugs. This process, known as
            glucuronidation, is an intermediate step in the metabolism of
            steroids. Two transcript variants encoding different isoforms have
            been found for this gene. While both isoforms are targeted to the
            endoplasmic reticulum, only the longer isoform appears to be
            active. [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF177272.1, AB451456.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2146982
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335568.10/ ENSP00000334276.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC114786.4         36715-36738
            25-1857             AF177272.1         1-1833
FEATURES             Location/Qualifiers
     source          1..1857
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.2"
     gene            1..1857
                     /gene="UGT2B28"
                     /note="UDP glucuronosyltransferase family 2 member B28"
                     /db_xref="GeneID:54490"
                     /db_xref="HGNC:HGNC:13479"
                     /db_xref="MIM:606497"
     exon            1..747
                     /gene="UGT2B28"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1616
                     /gene="UGT2B28"
                     /EC_number="2.4.1.17"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; UDP glycosyltransferase 2 family, polypeptide
                     B28; UDP glucuronosyltransferase 2 family, polypeptide
                     B28; UDPGT 2B28"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 2B28 isoform 1
                     precursor"
                     /protein_id="NP_444267.1"
                     /db_xref="CCDS:CCDS3528.1"
                     /db_xref="GeneID:54490"
                     /db_xref="HGNC:HGNC:13479"
                     /db_xref="MIM:606497"
                     /translation="MALKWTSVLLLIHLGCYFSSGSCGKVLVWTGEYSHWMNMKTILK
                     ELVQRGHEVTVLASSASILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWSDIQK
                     DSFWLYFSQEQEILWEFHDIFRNFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELL
                     AALLNIPFVYSLCFTPGYTIERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVL
                     YFDFWFQMCDMKKWDQFYSEVLGRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDF
                     VGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSVISNMTAERANVIATALAKIPQK
                     VLWRFDGNKPDALGLNTRLYKWIPQNDLLGLPKTRAFITHGGANGIYEAIYHGIPMVG
                     IPLFWDQPDNIAHMKAKGAAVRLDFHTMSSTDLLNALKTVINDPSYKENVMKLSIIQH
                     DQPVKPLHRAVFWIEFVMCHKGAKHLRVAARDLTWFQYHSLDVIGFLLACVATVIFVV
                     TKFCLFCFWKFARKGKKGKRD"
     exon            748..896
                     /gene="UGT2B28"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1028
                     /gene="UGT2B28"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1116
                     /gene="UGT2B28"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1336
                     /gene="UGT2B28"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1857
                     /gene="UGT2B28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1836..1841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGT2B28"
                     /note="hexamer: AATAAA"
     polyA_site      1857
                     /gene="UGT2B28"
                     /note="major polyA site"
ORIGIN      
        1 gaaaagaatg attgcattgc accaggatgg ctctgaagtg gacttcagtt cttctgctga
       61 tacatctcgg ttgttacttt agctctggga gttgtggaaa ggtgctggtg tggaccggtg
      121 aatacagcca ttggatgaat atgaagacaa tcctgaaaga gcttgttcag agaggtcatg
      181 aggtgactgt actggcatct tcagcttcca ttctttttga tcccaatgac gcattcactc
      241 ttaaactcga agtttatcct acatctttaa ctaaaactga atttgagaat atcatcatgc
      301 aacaggttaa gagatggtca gacattcaaa aagatagctt ttggttatat ttttcacaag
      361 aacaagaaat cctgtgggaa tttcatgaca tatttagaaa cttctgtaaa gatgtagttt
      421 caaataagaa agttatgaaa aaactacaag agtcaagatt tgacatcatt tttgcagatg
      481 ctttttttcc ttgtggtgag ctgctggctg cgctacttaa cataccgttt gtgtacagtc
      541 tctgcttcac tcctggctac acaattgaaa ggcacagtgg aggactgatt ttccctcctt
      601 cctacatacc tgttgttatg tcaaaattaa gtgatcaaat gactttcatg gagagggtaa
      661 aaaacatgat ctatgtgctt tattttgact tttggttcca aatgtgtgat atgaagaagt
      721 gggatcagtt ttacagtgaa gttttaggaa gacccactac cttatttgag acaatgggga
      781 aagctgacat atggcttatg cgaaactcct ggagttttca atttcctcat ccattcttac
      841 caaacattga ttttgttgga ggactccact gcaaacctgc caaaccccta cctaaggaaa
      901 tggaggaatt tgtacagagc tctggtgaaa atggtgttgt ggtgttttct ctggggtcag
      961 tgataagtaa catgacagca gaaagggcca acgtaattgc aacagccctt gccaagatcc
     1021 cacaaaaggt tctgtggaga tttgatggga ataaaccaga tgccttaggt ctcaatactc
     1081 ggctgtataa gtggataccc cagaatgacc ttctaggtct tccaaaaacc agagctttta
     1141 taactcatgg tggagccaat ggcatctatg aggcaatcta ccatgggatc cctatggtag
     1201 gcattccatt gttttgggat caacctgata acattgctca catgaaggcc aagggagcag
     1261 ctgttagact ggacttccac acaatgtcga gtacagacct gctgaatgca ctgaagacag
     1321 taattaatga tccttcatat aaagagaatg ttatgaaatt atcaataatt caacatgatc
     1381 aaccagtaaa gcccctgcat cgagcagtct tctggattga atttgtgatg tgccacaaag
     1441 gagccaaaca ccttcgagtt gcagcccgtg acctcacctg gttccagtac cactctttgg
     1501 atgtgattgg gtttctgctg gcctgtgtgg caactgtgat atttgtcgtc acaaagtttt
     1561 gtctgttttg tttctggaag tttgctagaa aagggaagaa gggaaaaaga gattagttat
     1621 gtctgacatt tgaagctgga aaaccagata gatgggttga catcagttta ttccagcaag
     1681 aaagaaaaga ttgttatgca agatttcttt cttcctgtga caaaaaaaaa aacttttcaa
     1741 aatctacctt gtcaagtaaa aatttgtttt tcagagattt accacccagg taatggttag
     1801 aaatattctg tggcaatgaa gaaaacacta gggaaaataa aaaataatat aaagcca
//
