LOCUS       NP_444267                529 aa            linear   PRI 04-APR-2024
DEFINITION  UDP-glucuronosyltransferase 2B28 isoform 1 precursor [Homo
            sapiens].
ACCESSION   NP_444267
VERSION     NP_444267.1
DBSOURCE    REFSEQ: accession NM_053039.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 529)
  AUTHORS   Lacombe,L., Hovington,H., Brisson,H., Mehdi,S., Beillevaire,D.,
            Emond,J.P., Wagner,A., Villeneuve,L., Simonyan,D., Ouellet,V.,
            Barres,V., Latour,M., Aprikian,A., Bergeron,A., Castonguay,V.,
            Couture,F., Chevalier,S., Brimo,F., Fazli,L., Fleshner,N.,
            Gleave,M., Karakiewicz,P.I., Lattouf,J.B., Trudel,D., van der
            Kwast,T., Mes-Masson,A.M., Pouliot,F., Fradet,Y., Audet-Walsh,E.,
            Saad,F., Guillemette,C. and Levesque,E.
  TITLE     UGT2B28 accelerates prostate cancer progression through
            stabilization of the endocytic adaptor protein HIP1 regulating AR
            and EGFR pathways
  JOURNAL   Cancer Lett 553, 215994 (2023)
   PUBMED   36343786
  REMARK    GeneRIF: UGT2B28 accelerates prostate cancer progression through
            stabilization of the endocytic adaptor protein HIP1 regulating AR
            and EGFR pathways.
REFERENCE   2  (residues 1 to 529)
  AUTHORS   Rouleau,M., Nguyen Van Long,F., Turcotte,V., Caron,P., Lacombe,L.,
            Aprikian,A., Saad,F., Carmel,M., Chevalier,S., Levesque,E. and
            Guillemette,C.
  TITLE     Extensive metabolic consequences of human glycosyltransferase gene
            knockouts in prostate cancer
  JOURNAL   Br J Cancer 128 (2), 285-296 (2023)
   PUBMED   36347965
  REMARK    GeneRIF: Extensive metabolic consequences of human
            glycosyltransferase gene knockouts in prostate cancer.
REFERENCE   3  (residues 1 to 529)
  AUTHORS   Ravindran,A., Krieger,K.L., Kaushik,A.K., Hovington,H., Mehdi,S.,
            Piyarathna,D.W.B., Putluri,V., Basil,P., Rasaily,U., Gu,F.,
            Dang,T., Choi,J.M., Sonavane,R., Jung,S.Y., Wang,L., Mehra,R.,
            Weigel,N.L., Putluri,N., Rowley,D.R., Palapattu,G.S.,
            Guillemette,C., Lacombe,L., Levesque,E. and Sreekumar,A.
  TITLE     Uridine Diphosphate Glucuronosyl Transferase 2B28 (UGT2B28)
            Promotes Tumor Progression and Is Elevated in African American
            Prostate Cancer Patients
  JOURNAL   Cells 11 (15), 2329 (2022)
   PUBMED   35954173
  REMARK    GeneRIF: Uridine Diphosphate Glucuronosyl Transferase 2B28
            (UGT2B28) Promotes Tumor Progression and Is Elevated in African
            American Prostate Cancer Patients.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 529)
  AUTHORS   Le,P.H., Kuo,C.J., Hsieh,Y.C., Chen,T.H., Lin,C.L., Yeh,C.T. and
            Liang,K.H.
  TITLE     Ages of hepatocellular carcinoma occurrence and life expectancy are
            associated with a UGT2B28 genomic variation
  JOURNAL   BMC Cancer 19 (1), 1190 (2019)
   PUBMED   31805979
  REMARK    GeneRIF: Patients with UGT2B28-rs2132039 - TT variant type had an
            earlier presentation of hepatocellular carcinoma (HCC), earlier
            post-surgery recurrence, metastasis and HCC-related death.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 529)
  AUTHORS   Albertsen,H.M., Matalliotaki,C., Matalliotakis,M., Zervou,M.I.,
            Matalliotakis,I., Spandidos,D.A., Chettier,R., Ward,K. and
            Goulielmos,G.N.
  TITLE     Whole exome sequencing identifies hemizygous deletions in the
            UGT2B28 and USP17L2 genes in a three-generation family with
            endometriosis
  JOURNAL   Mol Med Rep 19 (3), 1716-1720 (2019)
   PUBMED   30628680
  REMARK    GeneRIF: further analysis revealed 2 hemizygous deletions in the
            grandmother that segregate in several of her affected offspring.
            The first deletion was found in the UGT2B28 locus, spanning 7
            informative sequence variants across at least 14 kb. The second
            deletion, located in USP17L2, spans 3 informative variants across
            at least 2 kb. On the whole, the findings of the presents study
            implicate 2 additional genes in the pathogenesis
REFERENCE   6  (residues 1 to 529)
  AUTHORS   Ohno,S. and Nakajin,S.
  TITLE     Quantitative analysis of UGT2B28 mRNA expression by real-time
            RT-PCR and application to human tissue distribution study
  JOURNAL   Drug Metab Lett 5 (3), 202-208 (2011)
   PUBMED   21679149
  REMARK    GeneRIF: UGT2B28 was clearly detected in breast and adipose tissue;
            GT2B28 expression in the breast was comparatively low, about 1.6%
            of GAPDH mRNA levels, and was less than 5% of normalized (against
            GAPDH) UGT2B7 and 2B10 mRNA expression levels in the liver
REFERENCE   7  (residues 1 to 529)
  AUTHORS   Setlur,S.R., Chen,C.X., Hossain,R.R., Ha,J.S., Van Doren,V.E.,
            Stenzel,B., Steiner,E., Oldridge,D., Kitabayashi,N., Banerjee,S.,
            Chen,J.Y., Schafer,G., Horninger,W., Lee,C., Rubin,M.A., Klocker,H.
            and Demichelis,F.
  TITLE     Genetic variation of genes involved in dihydrotestosterone
            metabolism and the risk of prostate cancer
  JOURNAL   Cancer Epidemiol Biomarkers Prev 19 (1), 229-239 (2010)
   PUBMED   20056642
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (residues 1 to 529)
  AUTHORS   Ross,C.J., Katzov-Eckert,H., Dube,M.P., Brooks,B., Rassekh,S.R.,
            Barhdadi,A., Feroz-Zada,Y., Visscher,H., Brown,A.M., Rieder,M.J.,
            Rogers,P.C., Phillips,M.S., Carleton,B.C. and Hayden,M.R.
  CONSRTM   CPNDS Consortium
  TITLE     Genetic variants in TPMT and COMT are associated with hearing loss
            in children receiving cisplatin chemotherapy
  JOURNAL   Nat Genet 41 (12), 1345-1349 (2009)
   PUBMED   19898482
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Nat Genet. 2013 May;45(5):578]
REFERENCE   9  (residues 1 to 529)
  AUTHORS   Menard,V., Eap,O., Harvey,M., Guillemette,C. and Levesque,E.
  TITLE     Copy-number variations (CNVs) of the human sex steroid metabolizing
            genes UGT2B17 and UGT2B28 and their associations with a UGT2B15
            functional polymorphism
  JOURNAL   Hum Mutat 30 (9), 1310-1319 (2009)
   PUBMED   19572376
  REMARK    GeneRIF: Copy-number variations (CNVs) of the human sex steroid
            metabolizing genes UGT2B28
REFERENCE   10 (residues 1 to 529)
  AUTHORS   Levesque,E., Turgeon,D., Carrier,J.S., Montminy,V., Beaulieu,M. and
            Belanger,A.
  TITLE     Isolation and characterization of the UGT2B28 cDNA encoding a novel
            human steroid conjugating UDP-glucuronosyltransferase
  JOURNAL   Biochemistry 40 (13), 3869-3881 (2001)
   PUBMED   11300766
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC114786.4 and AF177272.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of the uridine
            diphosphoglucuronosyltransferase protein family. The encoded enzyme
            catalyzes the transfer of glucuronic acid from uridine
            diphosphoglucuronic acid to a diverse array of substrates including
            steroid hormones and lipid-soluble drugs. This process, known as
            glucuronidation, is an intermediate step in the metabolism of
            steroids. Two transcript variants encoding different isoforms have
            been found for this gene. While both isoforms are targeted to the
            endoplasmic reticulum, only the longer isoform appears to be
            active. [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF177272.1, AB451456.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2146982
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335568.10/ ENSP00000334276.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..529
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.2"
     Protein         1..529
                     /product="UDP-glucuronosyltransferase 2B28 isoform 1
                     precursor"
                     /EC_number="2.4.1.17"
                     /note="UDP glycosyltransferase 2 family, polypeptide B28;
                     UDP glucuronosyltransferase 2 family, polypeptide B28;
                     UDPGT 2B28"
                     /calculated_mol_wt=58338
     sig_peptide     1..24
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9BY64.1)"
                     /calculated_mol_wt=2587
     Region          24..525
                     /region_name="UDPGT"
                     /note="UDP-glucoronosyl and UDP-glucosyl transferase;
                     pfam00201"
                     /db_xref="CDD:278624"
     mat_peptide     25..529
                     /product="UDP-glucuronosyltransferase 2B28.
                     /id=PRO_0000036046"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY64.1)"
                     /calculated_mol_wt=58338
     Site            order(34..35,37,206,209..210,214,256,311,374,376,378..379,
                     382)
                     /site_type="active"
                     /db_xref="CDD:340817"
     Site            order(34,311,374,376,378..379)
                     /site_type="active"
                     /note="TDP-binding site [active]"
                     /db_xref="CDD:340817"
     Site            35
                     /site_type="active"
                     /note="acceptor substrate-binding pocket [active]"
                     /db_xref="CDD:340817"
     Site            order(49,146,458..459,462)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:340817"
     Site            315
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9BY64.1)"
     Site            495..517
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY64.1)"
     CDS             1..529
                     /gene="UGT2B28"
                     /coded_by="NM_053039.2:27..1616"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS3528.1"
                     /db_xref="GeneID:54490"
                     /db_xref="HGNC:HGNC:13479"
                     /db_xref="MIM:606497"
ORIGIN      
        1 malkwtsvll lihlgcyfss gscgkvlvwt geyshwmnmk tilkelvqrg hevtvlassa
       61 silfdpndaf tlklevypts ltktefenii mqqvkrwsdi qkdsfwlyfs qeqeilwefh
      121 difrnfckdv vsnkkvmkkl qesrfdiifa daffpcgell aallnipfvy slcftpgyti
      181 erhsgglifp psyipvvmsk lsdqmtfmer vknmiyvlyf dfwfqmcdmk kwdqfysevl
      241 grpttlfetm gkadiwlmrn swsfqfphpf lpnidfvggl hckpakplpk emeefvqssg
      301 engvvvfslg svisnmtaer anviatalak ipqkvlwrfd gnkpdalgln trlykwipqn
      361 dllglpktra fithggangi yeaiyhgipm vgiplfwdqp dniahmkakg aavrldfhtm
      421 sstdllnalk tvindpsyke nvmklsiiqh dqpvkplhra vfwiefvmch kgakhlrvaa
      481 rdltwfqyhs ldvigfllac vatvifvvtk fclfcfwkfa rkgkkgkrd
//
