LOCUS       NM_001077               2481 bp    mRNA    linear   PRI 30-APR-2025
DEFINITION  Homo sapiens UDP glucuronosyltransferase family 2 member B17
            (UGT2B17), mRNA.
ACCESSION   NM_001077 XM_024454205 XM_936292
VERSION     NM_001077.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2481)
  AUTHORS   Ahire,D., Mariasoosai,C., Naji-Talakar,S., Natesan,S. and Prasad,B.
  TITLE     Promiscuity and Quantitative Contribution of UGT2B17 in Drug and
            Steroid Metabolism Determined by Experimental and Computational
            Approaches
  JOURNAL   J Chem Inf Model 64 (2), 483-498 (2024)
   PUBMED   38198666
  REMARK    GeneRIF: Promiscuity and Quantitative Contribution of UGT2B17 in
            Drug and Steroid Metabolism Determined by Experimental and
            Computational Approaches.
REFERENCE   2  (bases 1 to 2481)
  AUTHORS   Wagner,A., Rouleau,M., Villeneuve,L., Le,T., Peltier,C.,
            Allain,E.P., Beaudoin,C., Tremblay,S., Courtier,F., Nguyen Van
            Long,F., Laverdiere,I., Levesque,E., Banerji,V., Vanura,K. and
            Guillemette,C.
  TITLE     A Non-Canonical Role for the Glycosyltransferase Enzyme UGT2B17 as
            a Novel Constituent of the B Cell Receptor Signalosome
  JOURNAL   Cells 12 (9), 1295 (2023)
   PUBMED   37174695
  REMARK    GeneRIF: A Non-Canonical Role for the Glycosyltransferase Enzyme
            UGT2B17 as a Novel Constituent of the B Cell Receptor Signalosome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2481)
  AUTHORS   Rouleau,M., Nguyen Van Long,F., Turcotte,V., Caron,P., Lacombe,L.,
            Aprikian,A., Saad,F., Carmel,M., Chevalier,S., Levesque,E. and
            Guillemette,C.
  TITLE     Extensive metabolic consequences of human glycosyltransferase gene
            knockouts in prostate cancer
  JOURNAL   Br J Cancer 128 (2), 285-296 (2023)
   PUBMED   36347965
  REMARK    GeneRIF: Extensive metabolic consequences of human
            glycosyltransferase gene knockouts in prostate cancer.
REFERENCE   4  (bases 1 to 2481)
  AUTHORS   Yu,Y., Zhang,Z., Dong,X., Yang,R., Duan,Z., Xiang,Z., Li,J., Li,G.,
            Yan,F., Xue,H., Jiao,D., Lu,J., Lu,H., Zhang,W., Wei,Y., Fan,S.,
            Li,J., Jia,J., Zhang,J., Ji,J., Liu,P., Lu,H., Zhao,H., Chen,S.,
            Wei,C., Chen,H. and Zhu,Z.
  TITLE     Pangenomic analysis of Chinese gastric cancer
  JOURNAL   Nat Commun 13 (1), 5412 (2022)
   PUBMED   36109518
  REMARK    GeneRIF: Genes ACOT1, GSTM1, SIGLEC14 and UGT2B17 are identified as
            highly absent genes in gastric cancer population.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2481)
  AUTHORS   Salhab,H., Naughton,D.P. and Barker,J.
  TITLE     Potential Assessment of UGT2B17 Inhibition by Salicylic Acid in
            Human Supersomes In Vitro
  JOURNAL   Molecules 26 (15), 4410 (2021)
   PUBMED   34361561
  REMARK    GeneRIF: Potential Assessment of UGT2B17 Inhibition by Salicylic
            Acid in Human Supersomes In Vitro.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2481)
  AUTHORS   Collier,A.C., Ganley,N.A., Tingle,M.D., Blumenstein,M.,
            Marvin,K.W., Paxton,J.W., Mitchell,M.D. and Keelan,J.A.
  TITLE     UDP-glucuronosyltransferase activity, expression and cellular
            localization in human placenta at term
  JOURNAL   Biochem Pharmacol 63 (3), 409-419 (2002)
   PUBMED   11853692
REFERENCE   7  (bases 1 to 2481)
  AUTHORS   Beaulieu,M., Levesque,E., Tchernof,A., Beatty,B.G., Belanger,A. and
            Hum,D.W.
  TITLE     Chromosomal localization, structure, and regulation of the UGT2B17
            gene, encoding a C19 steroid metabolizing enzyme
  JOURNAL   DNA Cell Biol 16 (10), 1143-1154 (1997)
   PUBMED   9364925
REFERENCE   8  (bases 1 to 2481)
  AUTHORS   Beaulieu,M., Levesque,E., Hum,D.W. and Belanger,A.
  TITLE     Isolation and characterization of a novel cDNA encoding a human
            UDP-glucuronosyltransferase active on C19 steroids
  JOURNAL   J Biol Chem 271 (37), 22855-22862 (1996)
   PUBMED   8798464
REFERENCE   9  (bases 1 to 2481)
  AUTHORS   Moghissi,E., Ablan,F. and Horton,R.
  TITLE     Origin of plasma androstanediol glucuronide in men
  JOURNAL   J Clin Endocrinol Metab 59 (3), 417-421 (1984)
   PUBMED   6746859
REFERENCE   10 (bases 1 to 2481)
  AUTHORS   Chung,L.W. and Coffey,D.S.
  TITLE     Androgen glucuronide. II. DIfferences in its formation by human
            normal and benign hyperplastic prostates
  JOURNAL   Invest Urol 15 (5), 385-388 (1978)
   PUBMED   76619
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC147055.2 and AC134921.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Jun 17, 2020 this sequence version replaced
            XM_024454205.1, NM_001077.3.
            
            Summary: This gene encodes a member of the uridine
            diphosphoglucuronosyltransferase protein family. The encoded enzyme
            catalyzes the transfer of glucuronic acid from uridine
            diphosphoglucuronic acid to a diverse array of substrates including
            steroid hormones and lipid-soluble drugs. This process, known as
            glucuronidation, is an intermediate step in the metabolism of
            steroids. Copy number variation in this gene is associated with
            susceptibility to osteoporosis.[provided by RefSeq, Apr 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.3138522.1,
                                           SRR1803613.246466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151358, SAMEA2153733
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317746.3/ ENSP00000320401.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-372               AC147055.2         33786-34157         c
            373-1160            AC147055.2         25596-26383         c
            1161-1309           AC147055.2         23407-23555         c
            1310-1441           AC147055.2         18372-18503         c
            1442-1529           AC147055.2         9659-9746           c
            1530-1749           AC147055.2         8512-8731           c
            1750-2481           AC134921.2         3010-3741           c
FEATURES             Location/Qualifiers
     source          1..2481
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.2"
     gene            1..2481
                     /gene="UGT2B17"
                     /gene_synonym="BMND12; UDPGT2B17"
                     /note="UDP glucuronosyltransferase family 2 member B17"
                     /db_xref="GeneID:7367"
                     /db_xref="HGNC:HGNC:12547"
                     /db_xref="MIM:601903"
     exon            1..372
                     /gene="UGT2B17"
                     /gene_synonym="BMND12; UDPGT2B17"
                     /inference="alignment:Splign:2.1.0"
     exon            373..1160
                     /gene="UGT2B17"
                     /gene_synonym="BMND12; UDPGT2B17"
                     /inference="alignment:Splign:2.1.0"
     CDS             437..2029
                     /gene="UGT2B17"
                     /gene_synonym="BMND12; UDPGT2B17"
                     /EC_number="2.4.1.17"
                     /note="UDP-glucuronyltransferase, family 2, beta-17;
                     UDP-glucuronosyltransferase 2B17; UDP glycosyltransferase
                     2 family, member B17; C19-steroid-specific
                     UDP-glucuronosyltransferase; C19-steroid-specific UDPGT;
                     UDP glucuronosyltransferase 2 family, polypeptide B17"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 2B17 precursor"
                     /protein_id="NP_001068.1"
                     /db_xref="CCDS:CCDS3523.1"
                     /db_xref="GeneID:7367"
                     /db_xref="HGNC:HGNC:12547"
                     /db_xref="MIM:601903"
                     /translation="MSLKWMSVFLLMQLSCYFSSGSCGKVLVWPTEYSHWINMKTILE
                     ELVQRGHEVIVLTSSASILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSIS
                     KNTFWSYFSQLQELCWEYSDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGEL
                     LAELLNIPFLYSLRFSVGYTVEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYM
                     LYFDFWFQAYDLKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVD
                     FVGGLHCKPAKPLPKEMEEFVQSSGENGIVVFSLGSMISNMSEESANMIASALAQIPQ
                     KVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMV
                     GIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPIYKENIMKLSRIH
                     HDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVATMIFM
                     ITKCCLFCFRKLAKTGKKKKRD"
     exon            1161..1309
                     /gene="UGT2B17"
                     /gene_synonym="BMND12; UDPGT2B17"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1441
                     /gene="UGT2B17"
                     /gene_synonym="BMND12; UDPGT2B17"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1529
                     /gene="UGT2B17"
                     /gene_synonym="BMND12; UDPGT2B17"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1749
                     /gene="UGT2B17"
                     /gene_synonym="BMND12; UDPGT2B17"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..2481
                     /gene="UGT2B17"
                     /gene_synonym="BMND12; UDPGT2B17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2236..2241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGT2B17"
                     /gene_synonym="BMND12; UDPGT2B17"
                     /note="hexamer: AATAAT"
     regulatory      2244..2249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGT2B17"
                     /gene_synonym="BMND12; UDPGT2B17"
                     /note="hexamer: TATAAA"
     polyA_site      2255
                     /gene="UGT2B17"
                     /gene_synonym="BMND12; UDPGT2B17"
                     /note="major polyA site"
     polyA_site      2263
                     /gene="UGT2B17"
                     /gene_synonym="BMND12; UDPGT2B17"
     regulatory      2449..2454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGT2B17"
                     /gene_synonym="BMND12; UDPGT2B17"
                     /note="hexamer: AATGAA"
     regulatory      2465..2470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGT2B17"
                     /gene_synonym="BMND12; UDPGT2B17"
                     /note="hexamer: ATTAAA"
     polyA_site      2470
                     /gene="UGT2B17"
                     /gene_synonym="BMND12; UDPGT2B17"
     polyA_site      2481
                     /gene="UGT2B17"
                     /gene_synonym="BMND12; UDPGT2B17"
ORIGIN      
        1 gagctcagat tttaaggcag tatcttgcca atgttcccag ctgaataaag cccttccttc
       61 tacaactcga tgtctgagag gttttgtctg tggctcgtcc tgctacattt cttggctccc
      121 tgacccagaa gcaaggtgac tgacggaagg ctgaggcagc cccttaggtg gcttaagcct
      181 gccctgtgga gcatccctgt ggggtactcc gggcagcctg agtgatgaga tccaaagagc
      241 gctcctgggt aggaaattgc cccagtggaa cacctcacca gatcaacacg tagcaggccc
      301 ccgtggagga ttaacacagt ggctgaacac cgggaaggaa ctggcacttg gagtctggac
      361 atctggaact tgatataagt atgagaaatg acagaaagaa acaacaactg gaaaagaagc
      421 actgcataag accaggatgt ctctgaaatg gatgtcagtc tttctgctga tgcagctcag
      481 ttgttacttt agctctggga gttgtggaaa ggtgctggtg tggcccacag aatacagcca
      541 ttggataaat atgaagacaa tcctggaaga gcttgttcag aggggtcatg aggtgattgt
      601 gttgacatct tcggcttcta ttcttgtcaa tgccagtaaa tcatctgcta ttaaattaga
      661 agtttatcct acatctttaa ctaaaaatga tttggaagat ttttttatga aaatgttcga
      721 tagatggaca tatagtattt caaaaaatac attttggtca tatttttcac aactacaaga
      781 attgtgttgg gaatattctg actataatat aaagctctgt gaagatgcag ttttgaacaa
      841 gaaacttatg agaaaactac aagagtcaaa atttgatgtc cttctggcag atgccgttaa
      901 tccctgtggt gagctgctgg ctgagctact taacataccc tttctgtaca gtctccgctt
      961 ctctgttggc tacacagttg agaagaatgg tggaggattt ctgttccctc cttcctatgt
     1021 acctgttgtt atgtcagaat taagtgatca aatgattttc atggagagga taaaaaatat
     1081 gatatatatg ctttattttg acttttggtt tcaagcatat gatctgaaga agtgggacca
     1141 gttttatagt gaagttctag gaagacccac tacattattt gagacaatgg ggaaagctga
     1201 aatgtggctc attcgaacct attgggattt tgaatttcct cgcccattct taccaaatgt
     1261 tgattttgtt ggaggacttc actgtaaacc agccaaaccc ttgcctaagg aaatggaaga
     1321 gtttgtgcag agctctggag aaaatggtat tgtggtgttt tctctggggt cgatgatcag
     1381 taacatgtca gaagaaagtg ccaacatgat tgcatcagcc cttgcccaga tcccacaaaa
     1441 ggttctatgg agatttgatg gcaagaagcc aaatacttta ggttccaata ctcgactgta
     1501 taagtggtta ccccagaatg accttcttgg tcatcccaaa accaaagctt ttataactca
     1561 tggtggaacc aatggcatct atgaggcaat ctaccatggg atccctatgg tgggcattcc
     1621 cttgtttgcg gatcaacatg ataacattgc tcacatgaaa gccaagggag cagccctcag
     1681 tgtggacatc aggaccatgt caagtagaga tttgctcaat gcattgaagt cagtcattaa
     1741 tgaccctatc tataaagaga atatcatgaa attatcaaga attcatcatg atcaaccggt
     1801 gaagcccctg gatcgagcag tcttctggat tgagtttgtc atgcgccata aaggagccaa
     1861 gcaccttcgg gtcgcagccc acaacctcac ctggatccag taccactctt tggatgtgat
     1921 agcattcctg ctggcctgcg tggcaactat gatatttatg atcacaaaat gttgcctgtt
     1981 ttgtttccga aagcttgcca aaacaggaaa gaagaagaaa agggattagt tatatcaaaa
     2041 gcctgaagtg gaatgaccaa aagatgggac tcctccttta ttccagcatg gagggtttta
     2101 aatggaggat ttcctttttc ctgcgacaaa acgtcttttc acaacttacc ctgttaagtc
     2161 aaaatttatt ttccaggaat ttaatatgta ctttagttgg aattattcta tgtcaatgat
     2221 ttttaagcta tgaaaaataa taatataaaa ccttatgggc ttatattgaa atttattatt
     2281 ctaatccaaa agttacccca cacaaaagtt actgagcttc cttatgtttc acacattgta
     2341 tttgaacaca aaacattaac aactccactc atagtatcaa cattgttttg caaatactca
     2401 gaatattttg gcttcatttt gagcagaatt tttgttttta attttgccaa tgaaatcttc
     2461 aataattaaa ttatgtaaaa a
//
