LOCUS       NM_001076               2134 bp    mRNA    linear   PRI 25-MAR-2023
DEFINITION  Homo sapiens UDP glucuronosyltransferase family 2 member B15
            (UGT2B15), mRNA.
ACCESSION   NM_001076
VERSION     NM_001076.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2134)
  AUTHORS   Sarfstein R, Nagaraj K, Parikh S, Levy C, Laron Z, Benayahu D and
            Werner H.
  TITLE     Identification of UDP-Glucuronosyltransferase 2B15 (UGT2B15) as a
            Target for IGF1 and Insulin Action
  JOURNAL   Cells 11 (10), 1627 (2022)
   PUBMED   35626664
  REMARK    GeneRIF: Identification of UDP-Glucuronosyltransferase 2B15
            (UGT2B15) as a Target for IGF1 and Insulin Action.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2134)
  AUTHORS   Shafiee-Kermani F, Carney ST, Jima D, Utin UC, Farrar LB, Oputa MO,
            Hines MR, Kinyamu HK, Trotter KW, Archer TK, Hoyo C, Koller BH,
            Freedland SJ and Grant DJ.
  TITLE     Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is
            associated with methylation status in prostate cancer cells
  JOURNAL   Epigenetics 16 (3), 289-299 (2021)
   PUBMED   32660355
  REMARK    GeneRIF: Expression of UDP Glucuronosyltransferases 2B15 and 2B17
            is associated with methylation status in prostate cancer cells.
REFERENCE   3  (bases 1 to 2134)
  AUTHORS   Yu D, Chen J, Chen S, Xu L, Wu L, Li D, Luo J, Jin Y, Zhao Y, Knox
            B, Tolleson WH, Wang X, Guo L, Tong W and Ning B.
  TITLE     Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA
            LINC00574 and hsa-miR-129-5p in HepaRG Cells
  JOURNAL   Drug Metab Dispos 48 (4), 297-306 (2020)
   PUBMED   32086297
  REMARK    GeneRIF: Coordinated Regulation of UGT2B15 Expression by Long
            Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells.
            Erratum:[Drug Metab Dispos. 2020 May;48(5):386. PMID: 32273307]
REFERENCE   4  (bases 1 to 2134)
  AUTHORS   Luo Y, Nie Y, Tang L, Xu CC and Xu L.
  TITLE     The correlation between UDP-glucuronosyltransferase polymorphisms
            and environmental endocrine disruptors levels in polycystic ovary
            syndrome patients
  JOURNAL   Medicine (Baltimore) 99 (11), e19444 (2020)
   PUBMED   32176075
  REMARK    GeneRIF: Novel associations between the UGT polymorphisms and EEDs
            concentrations in patients with PCOS, supporting the relevance of
            genetic differences in EEDs metabolism, which might be considered
            as an etiology of PCOS.
REFERENCE   5  (bases 1 to 2134)
  AUTHORS   Chen X, Li D, Wang N, Yang M, Liao A, Wang S, Hu G, Zeng B, Yao Y,
            Liu D, Liu H, Zhou W, Xiao W, Li P, Ming C, Ping S, Chen P, Jing L,
            Bai Y and Yao J.
  TITLE     Bioinformatic analysis suggests that UGT2B15 activates the
            Hippo-YAP signaling pathway leading to the pathogenesis of gastric
            cancer
  JOURNAL   Oncol Rep 40 (4), 1855-1862 (2018)
   PUBMED   30066917
  REMARK    GeneRIF: High UGT2B15 expression is associated with the
            pathogenesis of gastric cancer.
REFERENCE   6  (bases 1 to 2134)
  AUTHORS   Green MD, Clarke DJ, Oturu EM, Styczynski PB, Jackson MR, Burchell
            B and Tephly TR.
  TITLE     Cloning and expression of a rat liver phenobarbital-inducible
            UDP-glucuronosyltransferase (2B12) with specificity for
            monoterpenoid alcohols
  JOURNAL   Arch Biochem Biophys 322 (2), 460-468 (1995)
   PUBMED   7574722
REFERENCE   7  (bases 1 to 2134)
  AUTHORS   Monaghan G, Clarke DJ, Povey S, See CG, Boxer M and Burchell B.
  TITLE     Isolation of a human YAC contig encompassing a cluster of UGT2
            genes and its regional localization to chromosome 4q13
  JOURNAL   Genomics 23 (2), 496-499 (1994)
   PUBMED   7835904
REFERENCE   8  (bases 1 to 2134)
  AUTHORS   Green MD, Oturu EM and Tephly TR.
  TITLE     Stable expression of a human liver UDP-glucuronosyltransferase
            (UGT2B15) with activity toward steroid and xenobiotic substrates
  JOURNAL   Drug Metab Dispos 22 (5), 799-805 (1994)
   PUBMED   7835232
REFERENCE   9  (bases 1 to 2134)
  AUTHORS   Coffman BL, Tephly TR, Irshaid YM, Green MD, Smith C, Jackson MR,
            Wooster R and Burchell B.
  TITLE     Characterization and primary sequence of a human hepatic microsomal
            estriol UDPglucuronosyltransferase
  JOURNAL   Arch Biochem Biophys 281 (1), 170-175 (1990)
   PUBMED   2116769
REFERENCE   10 (bases 1 to 2134)
  AUTHORS   Irshaid,Y.M. and Tephly,T.R.
  TITLE     Isolation and purification of two human liver
            UDP-glucuronosyltransferases
  JOURNAL   Mol Pharmacol 31 (1), 27-34 (1987)
   PUBMED   3100939
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF180322.1, AC147055.2 and
            U06641.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001076.3.
            
            Summary: This gene encodes a glycosyltransferase that is invovled
            in the metabolism and elimination of toxic compounts, both
            endogenous and of xenobiotic origin. This gene plays a role in the
            regulation of estrogens and androgens. This locus is present in a
            cluster of similar genes and pseudogenes on chromosome 4. [provided
            by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF180322.1, AF548389.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338206.6/ ENSP00000341045.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1601              AF180322.1         5-1605
            1602-1797           AC147055.2         104769-104964       c
            1798-2102           AF180322.1         1803-2107
            2103-2134           U06641.1           2086-2117
FEATURES             Location/Qualifiers
     source          1..2134
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.2"
     gene            1..2134
                     /gene="UGT2B15"
                     /gene_synonym="HLUG4; UDPGT 2B8; UDPGT2B15; UDPGTH3;
                     UGT2B8"
                     /note="UDP glucuronosyltransferase family 2 member B15"
                     /db_xref="GeneID:7366"
                     /db_xref="HGNC:HGNC:12546"
                     /db_xref="MIM:600069"
     exon            1..758
                     /gene="UGT2B15"
                     /gene_synonym="HLUG4; UDPGT 2B8; UDPGT2B15; UDPGTH3;
                     UGT2B8"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1627
                     /gene="UGT2B15"
                     /gene_synonym="HLUG4; UDPGT 2B8; UDPGT2B15; UDPGTH3;
                     UGT2B8"
                     /EC_number="2.4.1.17"
                     /note="UDP-glucuronyltransferase, family 2, beta-15; UDP
                     glycosyltransferase 2B15; UDP-glucuronosyltransferase
                     2B15; UDP glucuronosyltransferase 2 family, polypeptide
                     B15; UDP-glucuronosyltransferase UGT2B15;
                     UDP-glucuronosyltransferase 2B8; uridine diphosphate
                     glucuronosyltransferase 2 family, member B8; uridine
                     diphosphate glycosyltransferase 2 family, member B15; UDP
                     gycosyltransferase 2 family, member B15; UDP
                     glucuronosyltransferase 2 family, member B8; UDP
                     glucuronosyltransferase 2 family, member 15"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 2B15 precursor"
                     /protein_id="NP_001067.2"
                     /db_xref="CCDS:CCDS3524.1"
                     /db_xref="GeneID:7366"
                     /db_xref="HGNC:HGNC:12546"
                     /db_xref="MIM:600069"
                     /translation="MSLKWTSVFLLIQLSCYFSSGSCGKVLVWPTEYSHWINMKTILE
                     ELVQRGHEVTVLTSSASTLVNASKSSAIKLEVYPTSLTKNYLEDSLLKILDRWIYGVS
                     KNTFWSYFSQLQELCWEYYDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGEL
                     LAELFNIPFLYSLRFSVGYTFEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHM
                     LYFDFWFQIYDLKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVD
                     FVGGLHCKPAKPLPKEMEEFVQSSGENGIVVFSLGSMISNMSEESANMIASALAQIPQ
                     KVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMV
                     GIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPVYKENVMKLSRIH
                     HDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVATVIFI
                     ITKFCLFCFRKLAKKGKKKKRD"
     exon            759..907
                     /gene="UGT2B15"
                     /gene_synonym="HLUG4; UDPGT 2B8; UDPGT2B15; UDPGTH3;
                     UGT2B8"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1039
                     /gene="UGT2B15"
                     /gene_synonym="HLUG4; UDPGT 2B8; UDPGT2B15; UDPGTH3;
                     UGT2B8"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1127
                     /gene="UGT2B15"
                     /gene_synonym="HLUG4; UDPGT 2B8; UDPGT2B15; UDPGTH3;
                     UGT2B8"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1347
                     /gene="UGT2B15"
                     /gene_synonym="HLUG4; UDPGT 2B8; UDPGT2B15; UDPGTH3;
                     UGT2B8"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..2134
                     /gene="UGT2B15"
                     /gene_synonym="HLUG4; UDPGT 2B8; UDPGT2B15; UDPGTH3;
                     UGT2B8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2112..2117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGT2B15"
                     /gene_synonym="HLUG4; UDPGT 2B8; UDPGT2B15; UDPGTH3;
                     UGT2B8"
                     /note="hexamer: AATAAA"
     polyA_site      2134
                     /gene="UGT2B15"
                     /gene_synonym="HLUG4; UDPGT 2B8; UDPGT2B15; UDPGTH3;
                     UGT2B8"
                     /note="major polyA site"
ORIGIN      
        1 aacaactgga aaagaagcat tgcataagac caggatgtct ctgaaatgga cgtcagtctt
       61 tctgctgata cagctcagtt gttactttag ctctggaagc tgtggaaagg tgctagtgtg
      121 gcccacagaa tacagccatt ggataaatat gaagacaatc ctggaagagc ttgttcagag
      181 gggtcatgag gtgactgtgt tgacatcttc ggcttctact cttgtcaatg ccagtaaatc
      241 atctgctatt aaattagaag tttatcctac atctttaact aaaaattatt tggaagattc
      301 tcttctgaaa attctcgata gatggatata tggtgtttca aaaaatacat tttggtcata
      361 tttttcacaa ttacaagaat tgtgttggga atattatgac tacagtaaca agctctgtaa
      421 agatgcagtt ttgaataaga aacttatgat gaaactacaa gagtcaaagt ttgatgtcat
      481 tctggcagat gcccttaatc cctgtggtga gctactggct gaactattta acataccctt
      541 tctgtacagt cttcgattct ctgttggcta cacatttgag aagaatggtg gaggatttct
      601 gttccctcct tcctatgtac ctgttgttat gtcagaatta agtgatcaaa tgattttcat
      661 ggagaggata aaaaatatga tacatatgct ttattttgac ttttggtttc aaatttatga
      721 tctgaagaag tgggaccagt tttatagtga agttctagga agacccacta cattatttga
      781 gacaatgggg aaagctgaaa tgtggctcat tcgaacctat tgggattttg aatttcctcg
      841 cccattctta ccaaatgttg attttgttgg aggacttcac tgtaaaccag ccaaacccct
      901 gcctaaggaa atggaagagt ttgtgcagag ctctggagaa aatggtattg tggtgttttc
      961 tctggggtcg atgatcagta acatgtcaga agaaagtgcc aacatgattg catcagccct
     1021 tgcccagatc ccacaaaagg ttctatggag atttgatggc aagaagccaa atactttagg
     1081 ttccaatact cgactgtaca agtggttacc ccagaatgac cttcttggtc atcccaaaac
     1141 caaagctttt ataactcatg gtggaaccaa tggcatctat gaggcgatct accatgggat
     1201 ccctatggtg ggcattccct tgtttgcgga tcaacatgat aacattgctc acatgaaagc
     1261 caagggagca gccctcagtg tggacatcag gaccatgtca agtagagatt tgctcaatgc
     1321 attgaagtca gtcattaatg accctgtcta taaagagaat gtcatgaaat tatcaagaat
     1381 tcatcatgac caaccaatga agcccctgga tcgagcagtc ttctggattg agtttgtcat
     1441 gcgccacaaa ggagccaagc accttcgagt cgcagctcac aacctcacct ggatccagta
     1501 ccactctttg gatgtgatag cattcctgct ggcctgcgtg gcaactgtga tatttatcat
     1561 cacaaaattt tgcctgtttt gtttccgaaa gcttgccaaa aaaggaaaga agaagaaaag
     1621 agattagtta tatcaaaagc ctgaagtgga atgactgaaa gatgggactc ctcctttatt
     1681 tcagcatgga gggttttaaa tggaggattt cctttttcct gtgacaaaac atcttttcac
     1741 aacttacctt gttaagacaa aatttatttt ccagggattt aatacgtact ttagctgaat
     1801 tattctatgt caatgatttt taagctatga aaaatacaat ggggggaagg atagcatttg
     1861 gagatatacc taatgttaaa tgacgagtta ctggatgcag cacgccaaca tggcacatgt
     1921 atacatatgt agctaacctg cacgttgtgc acatgtaccc taaaacttaa agtataattt
     1981 aaaaaaagca aaaaaaaaaa atacaactct tttttttaaa ccaggaagga aaatgtgaac
     2041 atggaaacaa cttctagtat tggatctgaa aataaagtgt catccaagcc ataaaaaaaa
     2101 aagaaaagaa aaataaaaat aatataaaac ctta
//
