LOCUS       NM_001073               2105 bp    mRNA    linear   PRI 11-SEP-2020
DEFINITION  Homo sapiens UDP glucuronosyltransferase family 2 member B11
            (UGT2B11), mRNA.
ACCESSION   NM_001073
VERSION     NM_001073.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2105)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2105)
  AUTHORS   Li XAlpha, Zhou Y, Zhou SChi, Liu HR, Xu JM, Gao L, Yu XJ and Li
            XH.
  TITLE     Histopathology of melanosis coli and determination of its
            associated genes by comparative analysis of expression microarrays
  JOURNAL   Mol Med Rep 12 (4), 5807-5815 (2015)
   PUBMED   26238215
  REMARK    GeneRIF: CYP3A4, CYP3A7, UGT2B11 and UGT2B15 genes are
            significantly downregulated in melanosis coli.
REFERENCE   3  (bases 1 to 2105)
  AUTHORS   Ohno S and Nakajin S.
  TITLE     Quantitative analysis of UGT2B28 mRNA expression by real-time
            RT-PCR and application to human tissue distribution study
  JOURNAL   Drug Metab Lett 5 (3), 202-208 (2011)
   PUBMED   21679149
  REMARK    GeneRIF: significant expression of UGT2B11 was detected in the
            liver, breast and kidney, and was clearly different from the
            distribution of UGT2B28
REFERENCE   4  (bases 1 to 2105)
  AUTHORS   Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S,
            Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L,
            Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N,
            Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J and Ducar
            M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat. Biotechnol. 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   5  (bases 1 to 2105)
  AUTHORS   Beaulieu M, Levesque E, Hum DW and Belanger A.
  TITLE     Isolation and characterization of a human orphan
            UDP-glucuronosyltransferase, UGT2B11
  JOURNAL   Biochem. Biophys. Res. Commun. 248 (1), 44-50 (1998)
   PUBMED   9675083
REFERENCE   6  (bases 1 to 2105)
  AUTHORS   Jin CJ, Miners JO, Lillywhite KJ and Mackenzie PI.
  TITLE     cDNA cloning and expression of two new members of the human liver
            UDP-glucuronosyltransferase 2B subfamily
  JOURNAL   Biochem. Biophys. Res. Commun. 194 (1), 496-503 (1993)
   PUBMED   8333863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114797.5, AF016492.1, BG184936.1 and AC111000.3.
            
            On May 17, 2019 this sequence version replaced NM_001073.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF016492.1, BC107059.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2155590
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000446444.2/ ENSP00000387683.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC114797.5         12295-12311         c
            18-1739             AF016492.1         1-1722
            1740-1743           BG184936.1         139-142             c
            1744-1866           BG184936.1         15-137              c
            1867-2105           AC111000.3         152093-152331       c
FEATURES             Location/Qualifiers
     source          1..2105
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.2"
     gene            1..2105
                     /gene="UGT2B11"
                     /note="UDP glucuronosyltransferase family 2 member B11"
                     /db_xref="GeneID:10720"
                     /db_xref="HGNC:HGNC:12545"
                     /db_xref="MIM:603064"
     exon            1..747
                     /gene="UGT2B11"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1616
                     /gene="UGT2B11"
                     /EC_number="2.4.1.17"
                     /note="UDPGT 2B11; UDP glycosyltransferase 2 family,
                     polypeptide B11; UDP glycosyltransferase 2 family protein;
                     UDP glucuronosyltransferase 2 family, polypeptide B11;
                     UDP-glucuronosyltransferase 2B11"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 2B11 precursor"
                     /protein_id="NP_001064.1"
                     /db_xref="CCDS:CCDS3527.1"
                     /db_xref="GeneID:10720"
                     /db_xref="HGNC:HGNC:12545"
                     /db_xref="MIM:603064"
                     /translation="MTLKWTSVLLLIHLSCYFSSGSCGKVLVWAAEYSHWMNMKTILK
                     ELVQRGHEVTVLASSASILFDPNDASTLKFEVYPTSLTKTEFENIIMQQVKRWSDIRK
                     DSFWLYFSQEQEILWELYDIFRNFCKDVVSNKKVMKKLQESRFDIVFADAVFPCGELL
                     AALLNIRFVYSLRFTPGYTIERHSGGLIFPPSYIPIVMSKLSDQMTFMERVKNMIYVL
                     YFDFWFQMSDMKKWDQFYSEVLGRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNVDF
                     VGGFHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSVISNMTAERANVIATALAKIPQK
                     VLWRFDGNKPDALGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVG
                     IPLFFDQPDNIAHMKAKGAAVRLDFNTMSSTDLLNALKTVINDPLYKENIMKLSRIQH
                     DQPVKPLDRAVFWIEFVMPHKGAKHLRVAAHDLTWFQYHSLDVIGFLLACVATVIFII
                     TKFCLFCFWKFARKGKKGKRD"
     exon            748..896
                     /gene="UGT2B11"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1028
                     /gene="UGT2B11"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1116
                     /gene="UGT2B11"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1336
                     /gene="UGT2B11"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..2105
                     /gene="UGT2B11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1845..1850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGT2B11"
                     /note="hexamer: ATTAAA"
     regulatory      1857..1862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGT2B11"
                     /note="hexamer: TATAAA"
     polyA_site      1866
                     /gene="UGT2B11"
                     /note="major polyA site"
     polyA_site      1884
                     /gene="UGT2B11"
ORIGIN      
        1 gaaaagaatg atcgcattgc accaggatga ctctgaaatg gacttcagtt cttctgctga
       61 tacatctcag ttgttacttt agctctggga gttgtggaaa agtgctggtg tgggccgcag
      121 aatacagcca ttggatgaat atgaagacaa tcctgaaaga gcttgttcag agaggtcatg
      181 aggtgactgt actggcatct tcagcttcca ttctttttga tcccaatgat gcatccactc
      241 ttaaatttga agtttatcct acatctttaa ctaaaactga atttgagaat atcatcatgc
      301 aacaggttaa gagatggtca gacattcgaa aagatagctt ttggttatat ttttcacaag
      361 aacaagaaat cctgtgggaa ttatatgaca tatttagaaa cttctgtaaa gatgtagttt
      421 caaataagaa agttatgaaa aaactacaag agtcaagatt tgacatcgtt tttgcagatg
      481 ctgtttttcc ctgtggtgag ctgctggctg cgctacttaa catacggttt gtgtacagtc
      541 tccgctttac tcctggctac acaattgaaa ggcacagtgg aggactgatt ttccctcctt
      601 cctacatacc tattgttatg tcaaaattaa gtgatcaaat gactttcatg gagagggtaa
      661 aaaatatgat ctatgtgctt tattttgact tttggttcca aatgtctgat atgaagaagt
      721 gggatcagtt ttacagtgaa gttttaggaa gacccactac cttatttgag acaatgggaa
      781 aagctgacat atggcttatg cgaaactcct ggagttttca atttcctcat ccattcttac
      841 caaacgttga ttttgttgga ggattccact gcaaacctgc caaaccccta cctaaggaaa
      901 tggaggagtt tgtacagagc tctggagaaa atggtgttgt ggtgttttct ctggggtcag
      961 tgataagtaa catgacagca gaaagggcca atgtaattgc aacagccctt gccaagatcc
     1021 cacaaaaggt tctgtggaga tttgacggga ataaaccaga tgccttaggt ctcaatactc
     1081 ggctgtacaa gtggataccc cagaatgacc ttctaggtca tccaaaaacc agagctttta
     1141 taactcatgg tggagccaat ggcatctatg aggcaatcta ccatgggatc cctatggtgg
     1201 gcattccatt gttttttgat caacctgata acattgctca catgaaggcc aagggagcag
     1261 ctgttagatt ggacttcaac acaatgtcga gtacagacct gctgaatgca ctgaagacag
     1321 taattaatga tcctttatat aaagagaata ttatgaaatt atcaagaatt caacatgatc
     1381 aaccagtaaa gcccctggat cgagcagtct tctggattga atttgtcatg ccccacaaag
     1441 gagccaaaca ccttcgagtt gcagcccatg acctcacctg gttccagtac cactctttgg
     1501 atgtgattgg gtttctgctg gcctgtgtgg caactgtgat atttatcatc acaaagtttt
     1561 gtctgttttg tttctggaag tttgctagaa aagggaagaa gggaaaaaga gattagttat
     1621 gtctgacatt tgaagctgga aaaccagata gataggacaa cttcagttta ttccagcaag
     1681 aaagaaaaga ttgttatgca agatttcttt cttcctgtga caaaaaaaaa aaaaaaaaaa
     1741 aaattttcaa atctaccttg tcaagtaaaa atttgttttt cagagattta ccacccaggt
     1801 aatggttaga aatattttgt ggcaatgaag aaaatactag gaaaattaaa aaataatata
     1861 aagccatttg agctcatatt gaaatttgtt gcacttatat tgagatttgt tgtttgaatt
     1921 cacaagttac atgaaaaaat ttactcagct taactatatt tcacacattt tacataaaca
     1981 caagaacatt aagaagtcta ctgacagtat cagtagtcac atcctcagaa taatttggct
     2041 tcattttgaa caggattctg ttgttttaac tgttgctaaa gaaactatta catagttaaa
     2101 ttgta
//
