LOCUS       NM_024743               2978 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens UDP glucuronosyltransferase family 2 member A3
            (UGT2A3), transcript variant 1, mRNA.
ACCESSION   NM_024743
VERSION     NM_024743.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2978)
  AUTHORS   Zhang,X., Yang,H., Lee,J.J., Kim,E., Lippman,S.M., Khuri,F.R.,
            Spitz,M.R., Lotan,R., Hong,W.K. and Wu,X.
  TITLE     MicroRNA-related genetic variations as predictors for risk of
            second primary tumor and/or recurrence in patients with early-stage
            head and neck cancer
  JOURNAL   Carcinogenesis 31 (12), 2118-2123 (2010)
   PUBMED   20819778
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   2  (bases 1 to 2978)
  AUTHORS   Sneitz,N., Court,M.H., Zhang,X., Laajanen,K., Yee,K.K., Dalton,P.,
            Ding,X. and Finel,M.
  TITLE     Human UDP-glucuronosyltransferase UGT2A2: cDNA construction,
            expression, and functional characterization in comparison with
            UGT2A1 and UGT2A3
  JOURNAL   Pharmacogenet Genomics 19 (12), 923-934 (2009)
   PUBMED   19858781
  REMARK    GeneRIF: Results show that UGT2A2 not only shares exons 2-6 with
            UGT2A1, it also shares with it a similar tissue expression pattern;
            both UGTs are primarily expressed in nasal epithelium. The 3rd
            member of UGT2A subfamily, UGT2A3 exhibited a different tissue
            expression pattern, found mainly in liver and small intestine.
REFERENCE   3  (bases 1 to 2978)
  AUTHORS   Court,M.H., Hazarika,S., Krishnaswamy,S., Finel,M. and
            Williams,J.A.
  TITLE     Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning,
            functional characterization of enzyme variants, comparative tissue
            expression, and gene induction
  JOURNAL   Mol Pharmacol 74 (3), 744-754 (2008)
   PUBMED   18523138
  REMARK    GeneRIF: This is the first report establishing UGT2A3 as a
            functional enzyme.
            GeneRIF: Describes initial cloning, expression and functional
            characterization of UGT2A3. Shows mRNA expression primarily in
            liver and intestines; and selective glucuronidation of bile acids,
            particularly hyodeoxycholic acid.
REFERENCE   4  (bases 1 to 2978)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021146.7, AY542891.1 and AK025587.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024743.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025587.1, AY358727.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151405, SAMEA2152474
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251566.9/ ENSP00000251566.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC021146.7         60654-60666
            14-208              AY542891.1         1-195
            209-2978            AK025587.1         1-2770
FEATURES             Location/Qualifiers
     source          1..2978
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.2"
     gene            1..2978
                     /gene="UGT2A3"
                     /note="UDP glucuronosyltransferase family 2 member A3"
                     /db_xref="GeneID:79799"
                     /db_xref="HGNC:HGNC:28528"
                     /db_xref="MIM:616382"
     exon            1..759
                     /gene="UGT2A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1628
                     /gene="UGT2A3"
                     /EC_number="2.4.1.17"
                     /note="UDP-glucuronosyltransferase 2A3; UDPGT 2A3; UDP
                     glucuronosyltransferase 2 family, polypeptide A3"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 2A3 precursor"
                     /protein_id="NP_079019.3"
                     /db_xref="CCDS:CCDS3525.1"
                     /db_xref="GeneID:79799"
                     /db_xref="HGNC:HGNC:28528"
                     /db_xref="MIM:616382"
                     /translation="MRSDKSALVFLLLQLFCVGCGFCGKVLVWPCDMSHWLNVKVILE
                     ELIVRGHEVTVLTHSKPSLIDYRKPSALKFEVVHMPQDRTEENEIFVDLALNVLPGLS
                     TWQSVIKLNDFFVEIRGTLKMMCESFIYNQTLMKKLQETNYDVMLIDPVIPCGDLMAE
                     LLAVPFVLTLRISVGGNMERSCGKLPAPLSYVPVPMTGLTDRMTFLERVKNSMLSVLF
                     HFWIQDYDYHFWEEFYSKALGRPTTLCETVGKAEIWLIRTYWDFEFPQPYQPNFEFVG
                     GLHCKPAKALPKEMENFVQSSGEDGIVVFSLGSLFQNVTEEKANIIASALAQIPQKVL
                     WRYKGKKPSTLGANTRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVP
                     IFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITDSSYKENAMRLSRIHHDQ
                     PVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYSIDVIGFLLACVATAIFLFTK
                     CFLFSCQKFNKTRKIEKRE"
     exon            760..908
                     /gene="UGT2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1040
                     /gene="UGT2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1128
                     /gene="UGT2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1348
                     /gene="UGT2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..2978
                     /gene="UGT2A3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2944..2949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGT2A3"
                     /note="hexamer: AATAAA"
     regulatory      2954..2959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGT2A3"
                     /note="hexamer: AATAAA"
     polyA_site      2963
                     /gene="UGT2A3"
                     /note="major polyA site"
     polyA_site      2978
                     /gene="UGT2A3"
                     /note="major polyA site"
ORIGIN      
        1 aactacaaaa ccattgcaga tcagtgtgtg agggaactgc catcatgagg tctgacaagt
       61 cagctttggt atttctgctc ctgcagctct tctgtgttgg ctgtggattc tgtgggaaag
      121 tcctggtgtg gccctgtgac atgagccatt ggcttaatgt caaggtcatt ctagaagagc
      181 tcatagtgag aggccatgag gtaacagtat tgactcactc aaagccttcg ttaattgact
      241 acaggaagcc ttctgcattg aaatttgagg tggtccatat gccacaggac agaacagaag
      301 aaaatgaaat atttgttgac ctagctctga atgtcttgcc aggcttatca acctggcaat
      361 cagttataaa attaaatgat ttttttgttg aaataagagg aactttaaaa atgatgtgtg
      421 agagctttat ctacaatcag acgcttatga agaagctaca ggaaaccaac tacgatgtaa
      481 tgcttataga ccctgtgatt ccctgtggag acctgatggc tgagttgctt gcagtccctt
      541 ttgtgctcac acttagaatt tctgtaggag gcaatatgga gcgaagctgt gggaaacttc
      601 cagctccact ttcctatgta cctgtgccta tgacaggact aacagacaga atgacctttc
      661 tggaaagagt aaaaaattca atgctttcag ttttgttcca cttctggatt caggattacg
      721 actatcattt ttgggaagag ttttatagta aggcattagg aaggcccact acattatgtg
      781 agactgtggg aaaagctgag atatggctaa tacgaacata ttgggatttt gaatttcctc
      841 aaccatacca acctaacttt gagtttgttg gaggattgca ctgtaaacct gccaaagctt
      901 tgcctaagga aatggaaaat tttgtccaga gttcagggga agatggtatt gtggtgtttt
      961 ctctggggtc actgtttcaa aatgttacag aagaaaaggc taatatcatt gcttcagccc
     1021 ttgcccagat cccacagaag gtgttatgga ggtacaaagg aaaaaaacca tccacattag
     1081 gagccaatac tcggctgtat gattggatac cccagaatga tcttcttggt catcccaaaa
     1141 ccaaagcttt tatcactcat ggtggaatga atgggatcta tgaagctatt taccatgggg
     1201 tccctatggt gggagttccc atatttggtg atcagcttga taacatagct cacatgaagg
     1261 ccaaaggagc agctgtagaa ataaacttca aaactatgac aagcgaagat ttactgaggg
     1321 ctttgagaac agtcattacc gattcctctt ataaagagaa tgctatgaga ttatcaagaa
     1381 ttcaccatga tcaacctgta aagcccctag atcgagcagt cttctggatc gagtttgtca
     1441 tgcgccacaa aggagccaag cacctgcgat cagctgccca tgacctcacc tggttccagc
     1501 actactctat agatgtgatt gggttcctgc tggcctgtgt ggcaactgct atattcttgt
     1561 tcacaaaatg ttttttattt tcctgtcaaa aatttaataa aactagaaag atagaaaaga
     1621 gggaatagat ctttccaaat tcaagaaaga cctgatgggg taatcctgtt aattccagcc
     1681 acatagaatt tggtgaaaac cttgctattt tcatattatc tattctgtta ttttatctta
     1741 gctatatagc ctagaattcc acgatcatga ggttgtgagt atatctcatt ctttcgttgt
     1801 attttcctag gtgtctttac tctcttctct cactttgtga cacaaggaca tgaatacatc
     1861 taaattttcc tatttctgat atgactgttt tgatgatgtc attacttcta taaccttaag
     1921 tgatagggtg acatgcaata tgattattcc tggtgtgcgc ccaaacacat ggatataaag
     1981 aggtaaaaaa cttaaaattc acaaaattca gtaaaccaca caaatcaggt aagtgttcta
     2041 tgagattagc tggctatgag aaacataatg atgtttcttt ttcaatttaa ataagccctt
     2101 ctacatagcc agcatcagtg atctcagaaa ataaattgct aataatgatg acatggcatt
     2161 atgcttagaa aagtttgctg tatttccata gacctcatct agatgtcatg gcctacattt
     2221 ctgccatcac tcaaccaata cttttttctg ttttcttgat gataaaaaga cctttctcat
     2281 gattgccatc aaataacaaa agaaactatt ttttttctca catagagaac atgtcagtaa
     2341 gatattcaag gtgaacagat tatttttggg attagtaact atttgaaata tgtggtgata
     2401 attactgagt ttataaaatt tatttgatag tacacttaaa gaagatttat atgtttattc
     2461 tttaaaaatg atgaatactc ataattctta tctctataat caaaagtata atttactgta
     2521 gaaaaataaa gagatgcttg ttctgaaagt aagatcagtg aactgctttt cagtctcaat
     2581 ctttgagaat tgtaaattca tcaaataatt gcttacatag taaaaattta aggtattaga
     2641 aaacctgcat aacaaatagt attatatatt aaatattttg atatgtaaag ctctacacaa
     2701 agctaaatat agtgtaataa tgtttacact aataagcaaa tatgttaatc ttctcatttt
     2761 tttactgtca tataatctta gtgatatgcc tattaatagt tttaaataaa taaattggct
     2821 catctggctt tttgaaaatt ttgaaattct tacagatgtt gattaggtat atctacaaat
     2881 taatttcaat tttaaaatga tgatataaaa ataaatataa gtatttttct tgtgtatgta
     2941 tacaataaat ataaataaaa ttgtttactg ttttgaaa
//
