LOCUS       NM_001105677            2568 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens UDP glucuronosyltransferase family 2 member A2
            (UGT2A2), transcript variant 1, mRNA.
ACCESSION   NM_001105677
VERSION     NM_001105677.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2568)
  AUTHORS   Shelton,J.F., Shastri,A.J., Fletez-Brant,K., Aslibekyan,S. and
            Auton,A.
  CONSRTM   23andMe COVID-19 Team
  TITLE     The UGT2A1/UGT2A2 locus is associated with COVID-19-related loss of
            smell or taste
  JOURNAL   Nat Genet 54 (2), 121-124 (2022)
   PUBMED   35039640
  REMARK    GeneRIF: The UGT2A1/UGT2A2 locus is associated with
            COVID-19-related loss of smell or taste.
REFERENCE   2  (bases 1 to 2568)
  AUTHORS   Perreault,M., Gauthier-Landry,L., Trottier,J., Verreault,M.,
            Caron,P., Finel,M. and Barbier,O.
  TITLE     The Human UDP-glucuronosyltransferase UGT2A1 and UGT2A2 enzymes are
            highly active in bile acid glucuronidation
  JOURNAL   Drug Metab Dispos 41 (9), 1616-1620 (2013)
   PUBMED   23756265
REFERENCE   3  (bases 1 to 2568)
  AUTHORS   Bushey,R.T., Dluzen,D.F. and Lazarus,P.
  TITLE     Importance of UDP-glucuronosyltransferases 2A2 and 2A3 in tobacco
            carcinogen metabolism
  JOURNAL   Drug Metab Dispos 41 (1), 170-179 (2013)
   PUBMED   23086198
REFERENCE   4  (bases 1 to 2568)
  AUTHORS   Sneitz,N., Court,M.H., Zhang,X., Laajanen,K., Yee,K.K., Dalton,P.,
            Ding,X. and Finel,M.
  TITLE     Human UDP-glucuronosyltransferase UGT2A2: cDNA construction,
            expression, and functional characterization in comparison with
            UGT2A1 and UGT2A3
  JOURNAL   Pharmacogenet Genomics 19 (12), 923-934 (2009)
   PUBMED   19858781
  REMARK    GeneRIF: Results show that UGT2A2 not only shares exons 2-6 with
            UGT2A1, it also shares with it a similar tissue expression pattern;
            both UGTs are primarily expressed in nasal epithelium. The 3rd
            member of UGT2A subfamily, UGT2A3 exhibited a different tissue
            expression pattern, found mainly in liver and small intestine.
REFERENCE   5  (bases 1 to 2568)
  AUTHORS   Mackenzie,P.I., Bock,K.W., Burchell,B., Guillemette,C.,
            Ikushiro,S., Iyanagi,T., Miners,J.O., Owens,I.S. and Nebert,D.W.
  TITLE     Nomenclature update for the mammalian UDP glycosyltransferase (UGT)
            gene superfamily
  JOURNAL   Pharmacogenet Genomics 15 (10), 677-685 (2005)
   PUBMED   16141793
  REMARK    Review article
REFERENCE   6  (bases 1 to 2568)
  AUTHORS   Jedlitschky,G., Cassidy,A.J., Sales,M., Pratt,N. and Burchell,B.
  TITLE     Cloning and characterization of a novel human olfactory
            UDP-glucuronosyltransferase
  JOURNAL   Biochem J 340 (Pt 3) (Pt 3), 837-843 (1999)
   PUBMED   10359671
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FJ664272.1 and AC093829.2.
            
            On May 21, 2011 this sequence version replaced NM_001105677.1.
            
            Summary: The protein encoded by this gene belongs to the
            UDP-glycosyltransferase family. Members of this protein family play
            a role in the conjugation and subsequent elimination of potentially
            toxic xenobiotics and endogenous compounds. The encoded enzyme is
            expressed in the olfactory neuroepithelium, which lines the
            posterior nasal cavity and is exposed to a wide range of odorants
            and airborne toxic compounds. Hence, this protein has been
            suggested to be involved in clearing lipophilic odorant molecules
            from the sensory epithelium. This gene shares exon structure with
            the UDP glucuronosyltransferase 2A1 family member, which encodes
            N-terminally distinct isoforms. Polymorphisms in this gene may be
            associated with the loss of taste and smell that is reported by
            some individuals during SARS-CoV-2 infection. [provided by RefSeq,
            Jan 2022].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (UGT2A2_i1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ664272.1, SRR18074969.2737639.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2145774,
                                           SAMEA2155590 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: relevant for disease process
            MANE Ensembl match     :: ENST00000604629.6/ ENSP00000475028.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1641              FJ664272.1         1-1641
            1642-2568           AC093829.2         96337-97263         c
FEATURES             Location/Qualifiers
     source          1..2568
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..2568
                     /gene="UGT2A2"
                     /gene_synonym="UDPGT 2A2"
                     /note="UDP glucuronosyltransferase family 2 member A2"
                     /db_xref="GeneID:574537"
                     /db_xref="HGNC:HGNC:28183"
                     /db_xref="MIM:619809"
     exon            1..744
                     /gene="UGT2A2"
                     /gene_synonym="UDPGT 2A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..1613
                     /gene="UGT2A2"
                     /gene_synonym="UDPGT 2A2"
                     /EC_number="2.4.1.17"
                     /note="isoform UGT2A2_i1 precursor is encoded by
                     transcript variant 1; UDP-glucuronosyltransferase 2A2; UDP
                     glucuronosyltransferase 2 family, polypeptide A2"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 2A2 isoform
                     UGT2A2_i1 precursor"
                     /protein_id="NP_001099147.2"
                     /db_xref="CCDS:CCDS56331.1"
                     /db_xref="GeneID:574537"
                     /db_xref="HGNC:HGNC:28183"
                     /db_xref="MIM:619809"
                     /translation="MVSIRDFTMPKKFVQMLVFNLTLTEVVLSGNVLIWPTDGSHWLN
                     IKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHMIML
                     WIDHRPTPLTIWAFYKELGKLLDTFFQINIQLCDGVLKNPKLMARLQKGGFDVLVADP
                     VTICGDLVALKLGIPFMYTLRFSPASTVERHCGKIPAPVSYVPAALSELTDQMTFGER
                     IKNTISYSLQDYIFQSYWGEWNSYYSKILGRPTTLCETMGKAEIWLIRTYWDFEFPRP
                     YLPNFEFVGGLHCKPAKPLPKEMEEFIQSSGKNGVVVFSLGSMVKNLTEEKANLIASA
                     LAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIY
                     HGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAM
                     RLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCV
                     TTAIFLVIQCCLFSCQKFGKIGKKKKRE"
     exon            745..893
                     /gene="UGT2A2"
                     /gene_synonym="UDPGT 2A2"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1025
                     /gene="UGT2A2"
                     /gene_synonym="UDPGT 2A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1113
                     /gene="UGT2A2"
                     /gene_synonym="UDPGT 2A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1333
                     /gene="UGT2A2"
                     /gene_synonym="UDPGT 2A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..2568
                     /gene="UGT2A2"
                     /gene_synonym="UDPGT 2A2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2542..2547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGT2A2"
                     /gene_synonym="UDPGT 2A2"
                     /note="hexamer: AATAAA"
     polyA_site      2568
                     /gene="UGT2A2"
                     /gene_synonym="UDPGT 2A2"
                     /note="major polyA site"
ORIGIN      
        1 ggatggtttc cataagggat tttaccatgc ctaagaagtt tgtccagatg ctggttttta
       61 atttgactct gactgaagtt gttctaagtg ggaatgtgtt aatttggcct acagatggta
      121 gccattggtt aaatattaag attattctag aagagttgat tcaaagaaat cacaatgtga
      181 ctgtactggc ttcatcagca actctattca tcaactccaa tcccgattct cctgtgaatt
      241 ttgaagtgat acctgtttcc tacaagaaga gcaatataga ttccttaatt gagcatatga
      301 taatgctgtg gattgaccat agaccaactc ctctcacaat atgggctttc tacaaagaac
      361 taggaaaact tctagacact ttctttcaaa ttaacataca actctgtgat ggtgtactaa
      421 agaacccaaa gttgatggca agacttcaga aaggtggttt tgatgtgttg gtagcagacc
      481 cagtaacaat ctgtggtgat cttgttgctc tgaaattagg aattccattt atgtacacat
      541 tgaggttctc tccagcatca acagtggaga gacactgtgg gaaaatccca gcaccagtct
      601 cctatgtacc ggcagcctta tcagagctca ctgaccagat gacctttggt gaaaggatta
      661 aaaataccat atcttattct ctgcaagact atatatttca gtcctactgg ggagaatgga
      721 attcatacta tagcaaaatt ttaggaagac ccactacgtt atgtgagact atggggaaag
      781 ctgaaatttg gttaatccga acatattggg attttgaatt tcctcgtcca tacttaccta
      841 attttgagtt tgttggagga ttgcactgca aacctgccaa acctttacct aaggaaatgg
      901 aagaatttat ccagagctca ggtaaaaatg gtgttgtggt gttttctctg ggatcaatgg
      961 tcaaaaacct tacagaagaa aaggccaatc ttattgcctc agcccttgcc cagattccac
     1021 agaaggtttt atggagatac aaaggaaaga aaccagccac attaggaaac aatactcagc
     1081 tctttgattg gataccccag aatgatcttc ttggacatcc caaaaccaaa gcttttatca
     1141 ctcatggtgg aactaatggg atctacgaag ctatttacca cggagtccct atggtgggag
     1201 ttcccatgtt tgctgatcag cctgataaca ttgctcacat gaaggccaaa ggagcagctg
     1261 tggaagtgaa cctaaacaca atgacaagtg tggatttgct tagcgctttg agaacagtca
     1321 ttaatgaacc ttcttataaa gagaatgcta tgaggttatc aagaattcac catgatcaac
     1381 ctgtaaagcc cctggatcga gcagtcttct ggatcgagtt tgtcatgcgc cacaaaggag
     1441 ccaagcacct tcgggttgca gcccatgacc tcacctggtt ccagtaccac tctttggatg
     1501 taattgggtt cttgctggtc tgtgtgacaa cggctatatt tttggtcata caatgttgtt
     1561 tgttttcctg tcaaaaattt ggtaagatag gaaagaagaa aaaaagagaa taggtcaaga
     1621 aaaagaggaa atatatatat ttttaagttt ggcaaaatcc tgagtagtgt agtcctatta
     1681 attccagaca aaaggagttt aacaaaaaca cgtctcccat cctgtttcca aattttctat
     1741 ttctctacct gcgataagcc tactgataaa gcctagattt tggcatgatt attattaact
     1801 tgtgagttat agtcttctat ttttcctttg tctctccctg ctgactatac cctcttcctg
     1861 tcacttttct gacacaagga tactacctaa ttttaaatat gttctattca tagtatcaaa
     1921 ttattttatc gttaacctta attaatgatt aacaatatgc tgaatcctgg taatgcatac
     1981 agtgtagatg gaatttgata ggtgtaagga agagtcaaat tcacaaattt ccatatacca
     2041 aacaaatcag ggagccaccg taggagagta gtgtgttatg agaaaggtaa tgatttcctt
     2101 ttttaataaa aacaaactct tctgcttgct caatgtttca ggagttagag aatgaatttt
     2161 aagtgtgacg tgcgtcccta ttaaatgtct acaaaatttt cattaagcat atctagaaaa
     2221 tcacggcata acttgcctgc ctttcttcaa catatattct tatataacct gtagtggaag
     2281 atttgggtac tgtctttaat aaatcaatca atcgactctt ttatttcaag gagaaagttc
     2341 tatgttatat gttgaaggtg aacagatcat atttagagga tataacaatt agaaatctag
     2401 aaaataatta tcatttttat aaaattttta gtcaactgta caaataatta cataaaacat
     2461 caattaatta tgcttaaaaa tcactaatgt tcataatata taatcactat ttgtaatcaa
     2521 aagtttaatt ttatgccaaa aaataaaaaa tgcttacttg gaatttga
//
