LOCUS       NM_021027               2371 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens UDP glucuronosyltransferase family 1 member A9
            (UGT1A9), mRNA.
ACCESSION   NM_021027
VERSION     NM_021027.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2371)
  AUTHORS   Xu,C., Jiang,Z., Qian,M., Zuo,L., Xue,H. and Hu,N.
  TITLE     Influence of UDP-Glucuronosyltransferase Polymorphisms on
            Mycophenolic Acid Metabolism in Renal Transplant Patients
  JOURNAL   Transplant Proc 56 (6), 1280-1289 (2024)
   PUBMED   39054222
  REMARK    GeneRIF: Influence of UDP-Glucuronosyltransferase Polymorphisms on
            Mycophenolic Acid Metabolism in Renal Transplant Patients.
REFERENCE   2  (bases 1 to 2371)
  AUTHORS   Milne,G.L., Nogueira,M.S., Gao,B., Sanchez,S.C., Amin,W.,
            Thomas,S., Oger,C., Galano,J.M., Murff,H.J., Yang,G. and Durand,T.
  TITLE     Identification of novel F2-isoprostane metabolites by specific
            UDP-glucuronosyltransferases
  JOURNAL   Redox Biol 70, 103020 (2024)
   PUBMED   38211441
REFERENCE   3  (bases 1 to 2371)
  AUTHORS   Zhou,Y., Dong,H., Fan,J., Zhu,M., Liu,L., Wang,Y., Tang,P. and
            Chen,X.
  TITLE     Cytochrome P450 2B6 and UDP-Glucuronosyltransferase Enzyme-Mediated
            Clearance of Ciprofol (HSK3486) in Humans: The Role of Hepatic and
            Extrahepatic Metabolism
  JOURNAL   Drug Metab Dispos 52 (2), 106-117 (2024)
   PUBMED   38071562
  REMARK    GeneRIF: Cytochrome P450 2B6 and UDP-Glucuronosyltransferase
            Enzyme-Mediated Clearance of Ciprofol (HSK3486) in Humans: The Role
            of Hepatic and Extrahepatic Metabolism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2371)
  AUTHORS   Matsumoto,J., Nishimoto,A., Watari,S., Ueki,H., Shiromizu,S.,
            Iwata,N., Takeda,T., Ushio,S., Kajizono,M., Fujiyoshi,M.,
            Koyama,T., Araki,M., Wada,K., Zamami,Y., Nasu,Y. and Ariyoshi,N.
  TITLE     Significance of UGT1A6, UGT1A9, and UGT2B7 genetic variants and
            their mRNA expression in the clinical outcome of renal cell
            carcinoma
  JOURNAL   Mol Cell Biochem 478 (8), 1779-1790 (2023)
   PUBMED   36571650
  REMARK    GeneRIF: Significance of UGT1A6, UGT1A9, and UGT2B7 genetic
            variants and their mRNA expression in the clinical outcome of renal
            cell carcinoma.
REFERENCE   5  (bases 1 to 2371)
  AUTHORS   Li,J., Xu,Z. and Gu,J.
  TITLE     UGT1A1 and UGT1A9 Are Responsible for Phase II Metabolism of
            Tectorigenin and Irigenin In Vitro
  JOURNAL   Molecules 27 (13), 4104 (2022)
   PUBMED   35807350
  REMARK    GeneRIF: UGT1A1 and UGT1A9 Are Responsible for Phase II Metabolism
            of Tectorigenin and Irigenin In Vitro.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2371)
  AUTHORS   Bosma,P.J., Chowdhury,J.R., Huang,T.J., Lahiri,P., Elferink,R.P.,
            Van Es,H.H., Lederstein,M., Whitington,P.F., Jansen,P.L. and
            Chowdhury,N.R.
  TITLE     Mechanisms of inherited deficiencies of multiple
            UDP-glucuronosyltransferase isoforms in two patients with
            Crigler-Najjar syndrome, type I
  JOURNAL   FASEB J 6 (10), 2859-2863 (1992)
   PUBMED   1634050
REFERENCE   7  (bases 1 to 2371)
  AUTHORS   Ritter,J.K., Chen,F., Sheen,Y.Y., Tran,H.M., Kimura,S.,
            Yeatman,M.T. and Owens,I.S.
  TITLE     A novel complex locus UGT1 encodes human bilirubin, phenol, and
            other UDP-glucuronosyltransferase isozymes with identical carboxyl
            termini
  JOURNAL   J Biol Chem 267 (5), 3257-3261 (1992)
   PUBMED   1339448
REFERENCE   8  (bases 1 to 2371)
  AUTHORS   Wooster,R., Sutherland,L., Ebner,T., Clarke,D., Da Cruz e Silva,O.
            and Burchell,B.
  TITLE     Cloning and stable expression of a new member of the human liver
            phenol/bilirubin: UDP-glucuronosyltransferase cDNA family
  JOURNAL   Biochem J 278 (Pt 2) (Pt 2), 465-469 (1991)
   PUBMED   1910331
REFERENCE   9  (bases 1 to 2371)
  AUTHORS   Ritter,J.K., Crawford,J.M. and Owens,I.S.
  TITLE     Cloning of two human liver bilirubin UDP-glucuronosyltransferase
            cDNAs with expression in COS-1 cells
  JOURNAL   J Biol Chem 266 (2), 1043-1047 (1991)
   PUBMED   1898728
REFERENCE   10 (bases 1 to 2371)
  AUTHORS   Harding,D., Jeremiah,S.J., Povey,S. and Burchell,B.
  TITLE     Chromosomal mapping of a human phenol UDP-glucuronosyltransferase,
            GNT1
  JOURNAL   Ann Hum Genet 54 (1), 17-21 (1990)
   PUBMED   2108603
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC058844.1, BC043491.1,
            AY435144.1 and S55985.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_021027.2.
            
            Summary: This gene encodes a UDP-glucuronosyltransferase, an enzyme
            of the glucuronidation pathway that transforms small lipophilic
            molecules, such as steroids, bilirubin, hormones, and drugs, into
            water-soluble, excretable metabolites. This gene is part of a
            complex locus that encodes several UDP-glucuronosyltransferases.
            The locus includes thirteen unique alternate first exons followed
            by four common exons. Four of the alternate first exons are
            considered pseudogenes. Each of the remaining nine 5' exons may be
            spliced to the four common exons, resulting in nine proteins with
            different N-termini and identical C-termini. Each first exon
            encodes the substrate binding site, and is regulated by its own
            promoter. The enzyme encoded by this gene is active on phenols.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058844.1, BC043491.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354728.5/ ENSP00000346768.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BC058844.1         7-19
            14-37               BC043491.1         1-24
            38-2370             AY435144.1         1-2333
            2371-2371           S55985.1           2368-2368
FEATURES             Location/Qualifiers
     source          1..2371
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..2371
                     /gene="UGT1A9"
                     /gene_synonym="HLUGP4; LUGP4; UDPGT; UDPGT 1-9; UGT-1I;
                     UGT1-09; UGT1-9; UGT1.9; UGT1A9S; UGT1AI; UGT1I"
                     /note="UDP glucuronosyltransferase family 1 member A9"
                     /db_xref="GeneID:54600"
                     /db_xref="HGNC:HGNC:12541"
                     /db_xref="MIM:606434"
     exon            1..892
                     /gene="UGT1A9"
                     /gene_synonym="HLUGP4; LUGP4; UDPGT; UDPGT 1-9; UGT-1I;
                     UGT1-09; UGT1-9; UGT1.9; UGT1A9S; UGT1AI; UGT1I"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1630
                     /gene="UGT1A9"
                     /gene_synonym="HLUGP4; LUGP4; UDPGT; UDPGT 1-9; UGT-1I;
                     UGT1-09; UGT1-9; UGT1.9; UGT1A9S; UGT1AI; UGT1I"
                     /EC_number="2.4.1.17"
                     /note="UDP glycosyltransferase 1 family, polypeptide A9;
                     UDP-glucuronosyltransferase 1A9;
                     UDP-glucuronosyltransferase 1-9;
                     UDP-glucuronosyltransferase 1-I;
                     UDP-glucuronosyltransferase 1 family polypeptide A9s; UDP
                     glucuronosyltransferase 1 family, polypeptide A9"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 1A9 precursor"
                     /protein_id="NP_066307.1"
                     /db_xref="CCDS:CCDS2505.1"
                     /db_xref="GeneID:54600"
                     /db_xref="HGNC:HGNC:12541"
                     /db_xref="MIM:606434"
                     /translation="MACTGWTSPLPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMRSV
                     VEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQV
                     RSIYSLLMGSYNDIFDLFFSNCRSLFKDKKLVEYLKESSFDAVFLDPFDNCGLIVAKY
                     FSLPSVVFARGILCHYLEEGAQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHL
                     LCHRFFKNALEIASEILQTPVTEYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGIN
                     CHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRY
                     TGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFG
                     DQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVE
                     PLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCA
                     YGYRKCLGKKGRVKKAHKSKTH"
     exon            893..1024
                     /gene="UGT1A9"
                     /gene_synonym="HLUGP4; LUGP4; UDPGT; UDPGT 1-9; UGT-1I;
                     UGT1-09; UGT1-9; UGT1.9; UGT1A9S; UGT1AI; UGT1I"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1112
                     /gene="UGT1A9"
                     /gene_synonym="HLUGP4; LUGP4; UDPGT; UDPGT 1-9; UGT-1I;
                     UGT1-09; UGT1-9; UGT1.9; UGT1A9S; UGT1AI; UGT1I"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1332
                     /gene="UGT1A9"
                     /gene_synonym="HLUGP4; LUGP4; UDPGT; UDPGT 1-9; UGT-1I;
                     UGT1-09; UGT1-9; UGT1.9; UGT1A9S; UGT1AI; UGT1I"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..2371
                     /gene="UGT1A9"
                     /gene_synonym="HLUGP4; LUGP4; UDPGT; UDPGT 1-9; UGT-1I;
                     UGT1-09; UGT1-9; UGT1.9; UGT1A9S; UGT1AI; UGT1I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2351..2356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGT1A9"
                     /gene_synonym="HLUGP4; LUGP4; UDPGT; UDPGT 1-9; UGT-1I;
                     UGT1-09; UGT1-9; UGT1.9; UGT1A9S; UGT1AI; UGT1I"
                     /note="hexamer: AATAAA"
     polyA_site      2371
                     /gene="UGT1A9"
                     /gene_synonym="HLUGP4; LUGP4; UDPGT; UDPGT 1-9; UGT-1I;
                     UGT1-09; UGT1-9; UGT1.9; UGT1A9S; UGT1AI; UGT1I"
                     /note="major polyA site"
ORIGIN      
        1 agattcccag ctgcttgctc tcagctgcag ttctctgatg gcttgcacag ggtggaccag
       61 cccccttcct ctatgtgtgt gtctgctgct gacctgtggc tttgccgagg cagggaagct
      121 actggtagtg cccatggatg ggagccactg gttcaccatg aggtcggtgg tggagaaact
      181 cattctcagg gggcatgagg tggttgtagt catgccagag gtgagttggc aactgggaag
      241 atcactgaat tgcacagtga agacttattc aacttcatat accctggagg atctggaccg
      301 ggagttcaag gcttttgccc atgctcaatg gaaagcacaa gtacgaagta tatattctct
      361 attaatgggt tcatacaatg acatttttga cttatttttt tcaaattgca ggagtttgtt
      421 taaagacaaa aaattagtag aatacttaaa ggagagttct tttgatgcag tgtttctcga
      481 tccttttgat aactgtggct taattgttgc caaatatttc tccctcccct ccgtggtctt
      541 cgccagggga atactttgcc actatcttga agaaggtgca cagtgccctg ctcctctttc
      601 ctatgtcccc agaattctct tagggttctc agatgccatg actttcaagg agagagtacg
      661 gaaccacatc atgcacttgg aggaacattt attatgccac cgttttttca aaaatgccct
      721 agaaatagcc tctgaaattc tccaaacacc tgttacggag tatgatctct acagccacac
      781 atcaatttgg ttgttgcgaa cggactttgt tttggactat cccaaacccg tgatgcccaa
      841 catgatcttc attggtggta tcaactgcca tcagggaaag ccgttgccta tggaatttga
      901 agcctacatt aatgcttctg gagaacatgg aattgtggtt ttctctttgg gatcaatggt
      961 ctcagaaatt ccagagaaga aagctatggc aattgctgat gctttgggca aaatccctca
     1021 gacagtcctg tggcggtaca ctggaacccg accatcgaat cttgcgaaca acacgatact
     1081 tgttaagtgg ctaccccaaa acgatctgct tggtcacccg atgacccgtg cctttatcac
     1141 ccatgctggt tcccatggtg tttatgaaag catatgcaat ggcgttccca tggtgatgat
     1201 gcccttgttt ggtgatcaga tggacaatgc aaagcgcatg gagactaagg gagctggagt
     1261 gaccctgaat gttctggaaa tgacttctga agatttagaa aatgctctaa aagcagtcat
     1321 caatgacaaa agttacaagg agaacatcat gcgcctctcc agccttcaca aggaccgccc
     1381 ggtggagccg ctggacctgg ccgtgttctg ggtggagttt gtgatgaggc acaagggcgc
     1441 gccacacctg cgccccgcag cccacgacct cacctggtac cagtaccatt ccttggacgt
     1501 gattggtttc ctcttggccg tcgtgctgac agtggccttc atcaccttta aatgttgtgc
     1561 ttatggctac cggaaatgct tggggaaaaa agggcgagtt aagaaagccc acaaatccaa
     1621 gacccattga gaagtgggtg ggaaataagg taaaattttg aaccattccc tagtcatttc
     1681 caaacttgaa aacagaatca gtgttaaatt cattttattc ttattaagga aatactttgc
     1741 ataaattaat cagccccaga gtgctttaaa aaattctctt aaataaaaat aatagactcg
     1801 ctagtcagta aagatatttg aatatgtatc gtgccccctc tggtgtcttt gatcaggatg
     1861 acatgtgcca tttttcagag gacgtgcaga caggctggca ttctagatta cttttcttac
     1921 tctgaaacat ggcctgtttg ggagtgcggg attcaaaggt ggtcccacgg ctgcccctac
     1981 tgcaaatggc agttttaatc ttatcttttg gcttctgcag atggttgcaa ttgatcctta
     2041 accaataatg gtcagtcctc atctctgtcg tgcttcatag gtgccacctt gtgtgtttaa
     2101 agaagggaag ctttgtacct ttagagtgta ggtgaaatga atgaatggct tggagtgcac
     2161 tgagaacagc atatgatttc ttgctttggg gaaaaagaat gatgctatga aattggtggg
     2221 tggtgtattt gagaagataa tcattgctta tgtcaaatgg agctgaattt gataaaaacc
     2281 caaaatacag ctatgaagtg ctgggcaagt ttactttttt tctgatgttt cctacaacta
     2341 aaaataaatt aataaattta tataaattct a
//
