LOCUS       NM_019077               2371 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens UDP glucuronosyltransferase family 1 member A7
            (UGT1A7), mRNA.
ACCESSION   NM_019077
VERSION     NM_019077.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2371)
  AUTHORS   Milne,G.L., Nogueira,M.S., Gao,B., Sanchez,S.C., Amin,W.,
            Thomas,S., Oger,C., Galano,J.M., Murff,H.J., Yang,G. and Durand,T.
  TITLE     Identification of novel F2-isoprostane metabolites by specific
            UDP-glucuronosyltransferases
  JOURNAL   Redox Biol 70, 103020 (2024)
   PUBMED   38211441
REFERENCE   2  (bases 1 to 2371)
  AUTHORS   Ning,H.B., Jin,H.M., Liu,C.P., Peng,Z., Li,K., Xiao,E.H. and
            Shang,J.
  TITLE     [Gene mutation pattern of Gilbert's syndrome combined with viral
            hepatitis and its relationship with the exploration of clinical
            data]
  JOURNAL   Zhonghua Gan Zang Bing Za Zhi 28 (10), 855-860 (2020)
   PUBMED   33105931
  REMARK    GeneRIF: [Gene mutation pattern of Gilbert's syndrome combined with
            viral hepatitis and its relationship with the exploration of
            clinical data].
REFERENCE   3  (bases 1 to 2371)
  AUTHORS   Abudahab,S., Hakooz,N., Jarrar,Y., Al Shahhab,M., Saleh,A.,
            Zihlif,M. and Dajani,R.
  TITLE     Interethnic Variations of UGT1A1 and UGT1A7 Polymorphisms in the
            Jordanian Population
  JOURNAL   Curr Drug Metab 20 (5), 399-410 (2019)
   PUBMED   31132973
  REMARK    GeneRIF: We found that Circassians and Chechens have significantly
            higher allele frequencies of UGT1A7*2, UGT1A7*3 and UGT1A7*4 than
            the Jordanian-Arab population, but all three populations have
            similar frequencies of UGT1A1*28. Therefore, Circassians and
            Chechens are expected to have significantly lower levels of the
            UGT1A7 enzyme with almost 90% of these populations having genes
            that encode low or intermediate enzyme activity.
REFERENCE   4  (bases 1 to 2371)
  AUTHORS   Lacko,M., Voogd,A.C., van de Goor,R.C., Roelofs,H.M., Te
            Morsche,R.H., Bouvy,N.D., Peters,W.H. and Manni,J.J.
  TITLE     Genetic polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7
            and the risk for benign Warthin's tumors of the parotid gland
  JOURNAL   Head Neck 38 Suppl 1, E717-E723 (2016)
   PUBMED   25899702
  REMARK    GeneRIF: high activity UGT1A7 genotype is associated with an
            increased risk for Warthin's tumor.
REFERENCE   5  (bases 1 to 2371)
  AUTHORS   Yilmaz,L., Borazan,E., Aytekin,T., Baskonus,I., Aytekin,A.,
            Oztuzcu,S., Bozdag,Z. and Balik,A.
  TITLE     Increased UGT1A3 and UGT1A7 expression is associated with
            pancreatic cancer
  JOURNAL   Asian Pac J Cancer Prev 16 (4), 1651-1655 (2015)
   PUBMED   25743847
  REMARK    GeneRIF: Increased UGT1A7 expression is associated with pancreatic
            cancer.
REFERENCE   6  (bases 1 to 2371)
  AUTHORS   Guillemette,C., Ritter,J.K., Auyeung,D.J., Kessler,F.K. and
            Housman,D.E.
  TITLE     Structural heterogeneity at the UDP-glucuronosyltransferase 1
            locus: functional consequences of three novel missense mutations in
            the human UGT1A7 gene
  JOURNAL   Pharmacogenetics 10 (7), 629-644 (2000)
   PUBMED   11037804
REFERENCE   7  (bases 1 to 2371)
  AUTHORS   Tukey,R.H. and Strassburg,C.P.
  TITLE     Human UDP-glucuronosyltransferases: metabolism, expression, and
            disease
  JOURNAL   Annu Rev Pharmacol Toxicol 40, 581-616 (2000)
   PUBMED   10836148
  REMARK    Review article
REFERENCE   8  (bases 1 to 2371)
  AUTHORS   Mackenzie,P.I., Owens,I.S., Burchell,B., Bock,K.W., Bairoch,A.,
            Belanger,A., Fournel-Gigleux,S., Green,M., Hum,D.W., Iyanagi,T.,
            Lancet,D., Louisot,P., Magdalou,J., Chowdhury,J.R., Ritter,J.K.,
            Schachter,H., Tephly,T.R., Tipton,K.F. and Nebert,D.W.
  TITLE     The UDP glycosyltransferase gene superfamily: recommended
            nomenclature update based on evolutionary divergence
  JOURNAL   Pharmacogenetics 7 (4), 255-269 (1997)
   PUBMED   9295054
  REMARK    Review article
REFERENCE   9  (bases 1 to 2371)
  AUTHORS   Strassburg,C.P., Oldhafer,K., Manns,M.P. and Tukey,R.H.
  TITLE     Differential expression of the UGT1A locus in human liver, biliary,
            and gastric tissue: identification of UGT1A7 and UGT1A10
            transcripts in extrahepatic tissue
  JOURNAL   Mol Pharmacol 52 (2), 212-220 (1997)
   PUBMED   9271343
REFERENCE   10 (bases 1 to 2371)
  AUTHORS   van Es,H.H., Bout,A., Liu,J., Anderson,L., Duncan,A.M., Bosma,P.,
            Oude Elferink,R., Jansen,P.L., Chowdhury,J.R. and Schurr,E.
  TITLE     Assignment of the human UDP glucuronosyltransferase gene (UGT1A1)
            to chromosome region 2q37
  JOURNAL   Cytogenet Cell Genet 63 (2), 114-116 (1993)
   PUBMED   8467709
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC114812.5 and AC006985.2.
            
            On Oct 19, 2020 this sequence version replaced NM_019077.2.
            
            Summary: This gene encodes a UDP-glucuronosyltransferase, an enzyme
            of the glucuronidation pathway that transforms small lipophilic
            molecules, such as steroids, bilirubin, hormones, and drugs, into
            water-soluble, excretable metabolites. This gene is part of a
            complex locus that encodes several UDP-glucuronosyltransferases.
            The locus includes thirteen unique alternate first exons followed
            by four common exons. Four of the alternate first exons are
            considered pseudogenes. Each of the remaining nine 5' exons may be
            spliced to the four common exons, resulting in nine proteins with
            different N-termini and identical C-termini. Each first exon
            encodes the substrate binding site, and is regulated by its own
            promoter. The enzyme encoded by this gene has moderate
            glucuronidase activity with phenols. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY435142.1, SRR11853566.16738.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373426.4/ ENSP00000362525.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-892               AC114812.5         7891-8782
            893-1024            AC006985.2         59278-59409         c
            1025-1112           AC006985.2         58507-58594         c
            1113-1332           AC006985.2         58004-58223         c
            1333-2371           AC006985.2         53143-54181         c
FEATURES             Location/Qualifiers
     source          1..2371
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..2371
                     /gene="UGT1A7"
                     /gene_synonym="GNT1; hUG-BR1; UDPGT; UDPGT 1-7; UGT-1A;
                     UGT-1G; UGT1; UGT1-01; UGT1-07; UGT1.1; UGT1.7; UGT1A;
                     UGT1A1; UGT1G"
                     /note="UDP glucuronosyltransferase family 1 member A7"
                     /db_xref="GeneID:54577"
                     /db_xref="HGNC:HGNC:12539"
                     /db_xref="MIM:606432"
     exon            1..892
                     /gene="UGT1A7"
                     /gene_synonym="GNT1; hUG-BR1; UDPGT; UDPGT 1-7; UGT-1A;
                     UGT-1G; UGT1; UGT1-01; UGT1-07; UGT1.1; UGT1.7; UGT1A;
                     UGT1A1; UGT1G"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1630
                     /gene="UGT1A7"
                     /gene_synonym="GNT1; hUG-BR1; UDPGT; UDPGT 1-7; UGT-1A;
                     UGT-1G; UGT1; UGT1-01; UGT1-07; UGT1.1; UGT1.7; UGT1A;
                     UGT1A1; UGT1G"
                     /EC_number="2.4.1.17"
                     /note="UDP glycosyltransferase 1 family, polypeptide A7;
                     UDP-glucuronosyltransferase 1A7;
                     UDP-glucuronosyltransferase 1-7;
                     UDP-glucuronosyltransferase 1-1; Bilirubin-specific UDPGT
                     isozyme 1; UDP-glucuronosyltransferase 1-A;
                     UDP-glucuronosyltransferase 1A1;
                     UDP-glucuronosyltransferase 1 family polypeptide A7s;
                     UDP-glucuronosyltransferase 1-G; UDP
                     glucuronosyltransferase 1 family, polypeptide A7"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 1A7 precursor"
                     /protein_id="NP_061950.2"
                     /db_xref="CCDS:CCDS2506.1"
                     /db_xref="GeneID:54577"
                     /db_xref="HGNC:HGNC:12539"
                     /db_xref="MIM:606432"
                     /translation="MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSV
                     VEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPL
                     RSAFSLLTSSSNGIFDLFFSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKY
                     FSLPSVVFARGIFCHYLEEGAQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHL
                     FCPYFFKNVLEIASEILQTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGIN
                     CHQGKPVPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRY
                     TGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFG
                     DQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVE
                     PLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCA
                     YGYRKCLGKKGRVKKAHKSKTH"
     exon            893..1024
                     /gene="UGT1A7"
                     /gene_synonym="GNT1; hUG-BR1; UDPGT; UDPGT 1-7; UGT-1A;
                     UGT-1G; UGT1; UGT1-01; UGT1-07; UGT1.1; UGT1.7; UGT1A;
                     UGT1A1; UGT1G"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1112
                     /gene="UGT1A7"
                     /gene_synonym="GNT1; hUG-BR1; UDPGT; UDPGT 1-7; UGT-1A;
                     UGT-1G; UGT1; UGT1-01; UGT1-07; UGT1.1; UGT1.7; UGT1A;
                     UGT1A1; UGT1G"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1332
                     /gene="UGT1A7"
                     /gene_synonym="GNT1; hUG-BR1; UDPGT; UDPGT 1-7; UGT-1A;
                     UGT-1G; UGT1; UGT1-01; UGT1-07; UGT1.1; UGT1.7; UGT1A;
                     UGT1A1; UGT1G"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..2371
                     /gene="UGT1A7"
                     /gene_synonym="GNT1; hUG-BR1; UDPGT; UDPGT 1-7; UGT-1A;
                     UGT-1G; UGT1; UGT1-01; UGT1-07; UGT1.1; UGT1.7; UGT1A;
                     UGT1A1; UGT1G"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2351..2356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGT1A7"
                     /gene_synonym="GNT1; hUG-BR1; UDPGT; UDPGT 1-7; UGT-1A;
                     UGT-1G; UGT1; UGT1-01; UGT1-07; UGT1.1; UGT1.7; UGT1A;
                     UGT1A1; UGT1G"
                     /note="hexamer: AATAAA"
     polyA_site      2371
                     /gene="UGT1A7"
                     /gene_synonym="GNT1; hUG-BR1; UDPGT; UDPGT 1-7; UGT-1A;
                     UGT-1G; UGT1; UGT1-01; UGT1-07; UGT1.1; UGT1.7; UGT1A;
                     UGT1A1; UGT1G"
                     /note="major polyA site"
ORIGIN      
        1 agaatcccag ctgctggctc tgggctgaag ttctctgatg gctcgtgcag ggtggactgg
       61 cctccttccc ctatatgtgt gtctactgct gacctgtggc tttgccaagg cagggaagct
      121 gctggtagtg cccatggatg ggagccactg gttcaccatg cagtcggtgg tggagaaact
      181 catcctcagg gggcatgagg tggtcgtagt catgccagag gtgagttggc aactgggaag
      241 atcactgaat tgcacagtga agacttactc aacctcatac actctggagg atcaggaccg
      301 ggagttcatg gtttttgccg atgctcgctg gacggcacca ttgcgaagtg cattttctct
      361 attaacaagt tcatccaatg gtatttttga cttatttttt tcaaattgca ggagtttgtt
      421 taatgaccga aaattagtag aatacttaaa ggagagttgt tttgatgcag tgtttctcga
      481 tccttttgat gcctgtggct taattgttgc caaatatttc tccctcccct ctgtggtctt
      541 cgccagggga atattttgcc actatcttga agaaggtgca cagtgccctg ctcctctttc
      601 ctatgtcccc agacttctct tagggttctc agacgccatg actttcaagg agagagtatg
      661 gaaccacatc atgcacttgg aggaacattt attttgcccc tattttttca aaaatgtctt
      721 agaaatagcc tctgaaattc tccaaacccc tgtcacggca tatgatctct acagccacac
      781 atcaatttgg ttgttgcgaa ctgactttgt tttggagtat cccaaacccg tgatgcccaa
      841 tatgatcttc attggtggta tcaactgtca tcagggaaag ccagtgccta tggaatttga
      901 agcctacatt aatgcttctg gagaacatgg aattgtggtt ttctctttgg gatcaatggt
      961 ctcagaaatt ccagagaaga aagctatggc aattgctgat gctttgggca aaatccctca
     1021 gacagtcctg tggcggtaca ctggaacccg accatcgaat cttgcgaaca acacgatact
     1081 tgttaagtgg ctaccccaaa acgatctgct tggtcacccg atgacccgtg cctttatcac
     1141 ccatgctggt tcccatggtg tttatgaaag catatgcaat ggcgttccca tggtgatgat
     1201 gcccttgttt ggtgatcaga tggacaatgc aaagcgcatg gagactaagg gagctggagt
     1261 gaccctgaat gttctggaaa tgacttctga agatttagaa aatgctctaa aagcagtcat
     1321 caatgacaaa agttacaagg agaacatcat gcgcctctcc agccttcaca aggaccgccc
     1381 ggtggagccg ctggacctgg ccgtgttctg ggtggagttt gtgatgaggc acaagggcgc
     1441 gccacacctg cgccccgcag cccacgacct cacctggtac cagtaccatt ccttggacgt
     1501 gattggtttc ctcttggccg tcgtgctgac agtggccttc atcaccttta aatgttgtgc
     1561 ttatggctac cggaaatgct tggggaaaaa agggcgagtt aagaaagccc acaaatccaa
     1621 gacccattga gaagtgggtg ggaaataagg taaaattttg aaccattccc tagtcatttc
     1681 caaacttgaa aacagaatca gtgttaaatt cattttattc ttattaagga aatactttgc
     1741 ataaattaat cagccccaga gtgctttaaa aaattctctt aaataaaaat aatagactcg
     1801 ctagtcagta aagatatttg aatatgtatc gtgccccctc tggtgtcttt gatcaggatg
     1861 acatgtgcca tttttcagag gacgtgcaga caggctggca ttctagatta cttttcttac
     1921 tctgaaacat ggcctgtttg ggagtgcggg attcaaaggt ggtcccacgg ctgcccctac
     1981 tgcaaatggc agttttaatc ttatcttttg gcttctgcag atggttgcaa ttgatcctta
     2041 accaataatg gtcagtcctc atctctgtcg tgcttcatag gtgccacctt gtgtgtttaa
     2101 agaagggaag ctttgtacct ttagagtgta ggtgaaatga atgaatggct tggagtgcac
     2161 tgagaacagc atatgatttc ttgctttggg gaaaaagaat gatgctatga aattggtggg
     2221 tggtgtattt gagaagataa tcattgctta tgtcaaatgg agctgaattt gataaaaacc
     2281 caaaatacag ctatgaagtg ctgggcaagt ttactttttt tctgatgttt cctacaacta
     2341 aaaataaatt aataaattta tataaattct a
//
