LOCUS       NM_019093               2431 bp    mRNA    linear   PRI 13-DEC-2024
DEFINITION  Homo sapiens UDP glucuronosyltransferase family 1 member A3
            (UGT1A3), mRNA.
ACCESSION   NM_019093
VERSION     NM_019093.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2431)
  AUTHORS   Liu,Z., Martin,J.H., Liauw,W., McLachlan,S.A., Link,E., Matera,A.,
            Thompson,M., Jefford,M., Hicks,R.J., Cullinane,C., Hatzimihalis,A.,
            Campbell,I., Crowley,S., Beale,P.J., Karapetis,C.S., Price,T.,
            Burge,M.E. and Michael,M.
  TITLE     Evaluation of pharmacogenomics and hepatic nuclear imaging-related
            covariates by population pharmacokinetic models of irinotecan and
            its metabolites
  JOURNAL   Eur J Clin Pharmacol 78 (1), 53-64 (2022)
   PUBMED   34480602
  REMARK    GeneRIF: Evaluation of pharmacogenomics and hepatic nuclear
            imaging-related covariates by population pharmacokinetic models of
            irinotecan and its metabolites.
REFERENCE   2  (bases 1 to 2431)
  AUTHORS   Zheng,R., Du,M., Ge,Y., Gao,F., Xin,J., Lv,Q., Qin,C., Zhu,Y.,
            Gu,C., Wang,M., Zhu,Q., Guo,Z., Ben,S., Chu,H., Ye,D., Zhang,Z. and
            Wang,M.
  TITLE     Identification of low-frequency variants of UGT1A3 associated with
            bladder cancer risk by next-generation sequencing
  JOURNAL   Oncogene 40 (13), 2382-2394 (2021)
   PUBMED   33658628
  REMARK    GeneRIF: Identification of low-frequency variants of UGT1A3
            associated with bladder cancer risk by next-generation sequencing.
REFERENCE   3  (bases 1 to 2431)
  AUTHORS   Hirvensalo,P., Tornio,A., Launiainen,T., Paile-Hyvarinen,M.,
            Tapaninen,T., Neuvonen,M., Backman,J.T. and Niemi,M.
  TITLE     UGT1A3 and Sex Are Major Determinants of Telmisartan
            Pharmacokinetics-A Comprehensive Pharmacogenomic Study
  JOURNAL   Clin Pharmacol Ther 108 (4), 885-895 (2020)
   PUBMED   32498119
  REMARK    GeneRIF: UGT1A3 and Sex Are Major Determinants of Telmisartan
            Pharmacokinetics-A Comprehensive Pharmacogenomic Study.
REFERENCE   4  (bases 1 to 2431)
  AUTHORS   Wang,Y., Liu,S., Dong,W., Qu,X., Huang,C., Yan,T. and Du,J.
  TITLE     Combination of hesperetin and platinum enhances anticancer effect
            on lung adenocarcinoma
  JOURNAL   Biomed Pharmacother 113, 108779 (2019)
   PUBMED   30889488
  REMARK    GeneRIF: our study demonstrated that UGT1A3 functioned as an
            oncogenic factor in lung adenocarcinoma progression
REFERENCE   5  (bases 1 to 2431)
  AUTHORS   Wang,L., Hong,X., Yao,Z., Dai,Y., Zhao,G., Qin,Z., Wu,B.,
            Gonzalez,F.J. and Yao,X.
  TITLE     Glucuronidation of icaritin by human liver microsomes, human
            intestine microsomes and expressed UDP-glucuronosyltransferase
            enzymes: identification of UGT1A3, 1A9 and 2B7 as the main
            contributing enzymes
  JOURNAL   Xenobiotica 48 (4), 357-367 (2018)
   PUBMED   28443723
  REMARK    GeneRIF: Icaritin was subjected to significant glucuronidation,
            wherein UGT1A3, 1A7, 1A8, 1A9 and 2B7 were main contributing
            enzymes.
REFERENCE   6  (bases 1 to 2431)
  AUTHORS   Strassburg,C.P., Oldhafer,K., Manns,M.P. and Tukey,R.H.
  TITLE     Differential expression of the UGT1A locus in human liver, biliary,
            and gastric tissue: identification of UGT1A7 and UGT1A10
            transcripts in extrahepatic tissue
  JOURNAL   Mol Pharmacol 52 (2), 212-220 (1997)
   PUBMED   9271343
REFERENCE   7  (bases 1 to 2431)
  AUTHORS   Strassburg,C.P., Manns,M.P. and Tukey,R.H.
  TITLE     Differential down-regulation of the UDP-glucuronosyltransferase 1A
            locus is an early event in human liver and biliary cancer
  JOURNAL   Cancer Res 57 (14), 2979-2985 (1997)
   PUBMED   9230212
REFERENCE   8  (bases 1 to 2431)
  AUTHORS   Mojarrabi,B., Butler,R. and Mackenzie,P.I.
  TITLE     cDNA cloning and characterization of the human UDP
            glucuronosyltransferase, UGT1A3
  JOURNAL   Biochem Biophys Res Commun 225 (3), 785-790 (1996)
   PUBMED   8780690
REFERENCE   9  (bases 1 to 2431)
  AUTHORS   Moghrabi,N., Sutherland,L., Wooster,R., Povey,S., Boxer,M. and
            Burchell,B.
  TITLE     Chromosomal assignment of human phenol and bilirubin
            UDP-glucuronosyltransferase genes (UGT1A-subfamily)
  JOURNAL   Ann Hum Genet 56 (2), 81-91 (1992)
   PUBMED   1503396
REFERENCE   10 (bases 1 to 2431)
  AUTHORS   Ritter,J.K., Chen,F., Sheen,Y.Y., Tran,H.M., Kimura,S.,
            Yeatman,M.T. and Owens,I.S.
  TITLE     A novel complex locus UGT1 encodes human bilirubin, phenol, and
            other UDP-glucuronosyltransferase isozymes with identical carboxyl
            termini
  JOURNAL   J Biol Chem 267 (5), 3257-3261 (1992)
   PUBMED   1339448
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC114812.5 and AC006985.2.
            
            On Jan 3, 2020 this sequence version replaced NM_019093.3.
            
            Summary: This gene encodes a UDP-glucuronosyltransferase, an enzyme
            of the glucuronidation pathway that transforms small lipophilic
            molecules, such as steroids, bilirubin, hormones, and drugs, into
            water-soluble, excretable metabolites. This gene is part of a
            complex locus that encodes several UDP-glucuronosyltransferases.
            The locus includes thirteen unique alternate first exons followed
            by four common exons. Four of the alternate first exons are
            considered pseudogenes. Each of the remaining nine 5' exons may be
            spliced to the four common exons, resulting in nine proteins with
            different N-termini and identical C-termini. Each first exon
            encodes the substrate binding site, and is regulated by its own
            promoter. Substrates of this enzyme include estrone,
            2-hydroxyestrone, and metabolites of benzo alpha-pyrene. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY435138.1, SRR11853562.20575.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMN04284274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000482026.6/ ENSP00000418532.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-952               AC114812.5         55032-55983
            953-1084            AC006985.2         59278-59409         c
            1085-1172           AC006985.2         58507-58594         c
            1173-1392           AC006985.2         58004-58223         c
            1393-2431           AC006985.2         53143-54181         c
FEATURES             Location/Qualifiers
     source          1..2431
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..2431
                     /gene="UGT1A3"
                     /gene_synonym="UDPGT; UDPGT 1-3; UGT-1C; UGT1-03; UGT1.3;
                     UGT1A3S; UGT1C"
                     /note="UDP glucuronosyltransferase family 1 member A3"
                     /db_xref="GeneID:54659"
                     /db_xref="HGNC:HGNC:12535"
                     /db_xref="MIM:606428"
     exon            1..952
                     /gene="UGT1A3"
                     /gene_synonym="UDPGT; UDPGT 1-3; UGT-1C; UGT1-03; UGT1.3;
                     UGT1A3S; UGT1C"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1690
                     /gene="UGT1A3"
                     /gene_synonym="UDPGT; UDPGT 1-3; UGT-1C; UGT1-03; UGT1.3;
                     UGT1A3S; UGT1C"
                     /EC_number="2.4.1.17"
                     /note="UDP glycosyltransferase 1 family, polypeptide A3;
                     UDP-glucuronosyltransferase 1-3;
                     UDP-glucuronosyltransferase 1 family polypeptide A3s;
                     UDP-glucuronosyltransferase 1A3;
                     UDP-glucuronosyltransferase 1-C; UDP
                     glucuronosyltransferase 1 family, polypeptide A3"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 1A3 precursor"
                     /protein_id="NP_061966.1"
                     /db_xref="CCDS:CCDS2509.1"
                     /db_xref="GeneID:54659"
                     /db_xref="HGNC:HGNC:12535"
                     /db_xref="MIM:606428"
                     /translation="MATGLQVPLPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSM
                     REVLRELHARGHQAVVLTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFE
                     TEHFLKKFFRSMAMLNNMSLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAV
                     LAKYLSIPTVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPL
                     ALSYICHAFSAPYASLASELFQREVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFI
                     GGINCANRKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTV
                     LWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMM
                     PLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKD
                     RPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITF
                     KCCAYGYRKCLGKKGRVKKAHKSKTH"
     exon            953..1084
                     /gene="UGT1A3"
                     /gene_synonym="UDPGT; UDPGT 1-3; UGT-1C; UGT1-03; UGT1.3;
                     UGT1A3S; UGT1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1172
                     /gene="UGT1A3"
                     /gene_synonym="UDPGT; UDPGT 1-3; UGT-1C; UGT1-03; UGT1.3;
                     UGT1A3S; UGT1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1392
                     /gene="UGT1A3"
                     /gene_synonym="UDPGT; UDPGT 1-3; UGT-1C; UGT1-03; UGT1.3;
                     UGT1A3S; UGT1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..2431
                     /gene="UGT1A3"
                     /gene_synonym="UDPGT; UDPGT 1-3; UGT-1C; UGT1-03; UGT1.3;
                     UGT1A3S; UGT1C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2411..2416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGT1A3"
                     /gene_synonym="UDPGT; UDPGT 1-3; UGT-1C; UGT1-03; UGT1.3;
                     UGT1A3S; UGT1C"
                     /note="hexamer: AATAAA"
     polyA_site      2431
                     /gene="UGT1A3"
                     /gene_synonym="UDPGT; UDPGT 1-3; UGT-1C; UGT1-03; UGT1.3;
                     UGT1A3S; UGT1C"
                     /note="major polyA site"
ORIGIN      
        1 agtgacaagg taattaagat gaagaaagca aatgtagcag gcacagcgtg gggtggacag
       61 tcagctgtcc gtgtcttctg ctgagatggc cacaggactc caggttcccc tgccgtggct
      121 ggccacagga ctgctgcttc tcctcagtgt ccagccctgg gctgagagtg gaaaggtgtt
      181 ggtggtgccc attgatggca gccactggct cagcatgcgg gaggtcttgc gggagctcca
      241 tgccagaggc caccaggcag tggtcctcac cccagaggtg aatatgcaca tcaaagaaga
      301 gaactttttc accctgacaa cctatgccat ttcgtggacc caggatgaat ttgatcgcca
      361 tgtgctgggc cacactcaac tgtactttga aacagaacat tttctgaaga aatttttcag
      421 aagtatggca atgttgaaca atatgtcttt ggtctatcat aggtcttgtg tggagctact
      481 acataatgag gccctgatca ggcacctgaa tgctacttcc tttgatgtgg ttttaacaga
      541 ccccgttaac ctctgcgcgg cagtgctggc taagtacctg tcgattccta ctgtgttttt
      601 tttgaggaac attccatgtg atttagactt taagggcaca cagtgtccaa acccttcctc
      661 ctatattcct agattactaa caaccaattc agaccacatg acattcatgc aaagggtcaa
      721 gaacatgctc taccctctgg ccctgtccta catttgccat gctttttctg ctccttatgc
      781 aagccttgcc tctgagcttt ttcagagaga ggtgtcagtg gtggatattc tcagtcatgc
      841 atctgtgtgg ctgttccgag gggactttgt gatggactac cccaggccaa tcatgcccaa
      901 catggtcttc attgggggca tcaactgtgc caacaggaag ccactatctc aggaatttga
      961 agcctacatt aatgcttctg gagaacatgg aattgtggtt ttctctttgg gatcaatggt
     1021 ctcagaaatt ccagagaaga aagctatggc aattgctgat gctttgggca aaatccctca
     1081 gacagtcctg tggcggtaca ctggaacccg accatcgaat cttgcgaaca acacgatact
     1141 tgttaagtgg ctaccccaaa acgatctgct tggtcacccg atgacccgtg cctttatcac
     1201 ccatgctggt tcccatggtg tttatgaaag catatgcaat ggcgttccca tggtgatgat
     1261 gcccttgttt ggtgatcaga tggacaatgc aaagcgcatg gagactaagg gagctggagt
     1321 gaccctgaat gttctggaaa tgacttctga agatttagaa aatgctctaa aagcagtcat
     1381 caatgacaaa agttacaagg agaacatcat gcgcctctcc agccttcaca aggaccgccc
     1441 ggtggagccg ctggacctgg ccgtgttctg ggtggagttt gtgatgaggc acaagggcgc
     1501 gccacacctg cgccccgcag cccacgacct cacctggtac cagtaccatt ccttggacgt
     1561 gattggtttc ctcttggccg tcgtgctgac agtggccttc atcaccttta aatgttgtgc
     1621 ttatggctac cggaaatgct tggggaaaaa agggcgagtt aagaaagccc acaaatccaa
     1681 gacccattga gaagtgggtg ggaaataagg taaaattttg aaccattccc tagtcatttc
     1741 caaacttgaa aacagaatca gtgttaaatt cattttattc ttattaagga aatactttgc
     1801 ataaattaat cagccccaga gtgctttaaa aaattctctt aaataaaaat aatagactcg
     1861 ctagtcagta aagatatttg aatatgtatc gtgccccctc tggtgtcttt gatcaggatg
     1921 acatgtgcca tttttcagag gacgtgcaga caggctggca ttctagatta cttttcttac
     1981 tctgaaacat ggcctgtttg ggagtgcggg attcaaaggt ggtcccacgg ctgcccctac
     2041 tgcaaatggc agttttaatc ttatcttttg gcttctgcag atggttgcaa ttgatcctta
     2101 accaataatg gtcagtcctc atctctgtcg tgcttcatag gtgccacctt gtgtgtttaa
     2161 agaagggaag ctttgtacct ttagagtgta ggtgaaatga atgaatggct tggagtgcac
     2221 tgagaacagc atatgatttc ttgctttggg gaaaaagaat gatgctatga aattggtggg
     2281 tggtgtattt gagaagataa tcattgctta tgtcaaatgg agctgaattt gataaaaacc
     2341 caaaatacag ctatgaagtg ctgggcaagt ttactttttt tctgatgttt cctacaacta
     2401 aaaataaatt aataaattta tataaattct a
//
