LOCUS       NM_019075               2409 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens UDP glucuronosyltransferase family 1 member A10
            (UGT1A10), mRNA.
ACCESSION   NM_019075
VERSION     NM_019075.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2409)
  AUTHORS   Mubarokah,N., Hulin,J.A., Mackenzie,P.I., McKinnon,R.A.,
            Haines,A.Z., Hu,D.G. and Meech,R.
  TITLE     Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases
            1A8, -1A9, and 1A10 by CDX2 and HNF4alpha Is Mediated by a Novel
            Composite Regulatory Element
  JOURNAL   Mol Pharmacol 93 (5), 541-552 (2018)
   PUBMED   29519853
  REMARK    GeneRIF: studies lead to a model for the developmental patterning
            of UGT1A8, UGT1A9, and UGT1A10 in hepatic and/or extrahepatic
            tissues involving discrete regulatory modules that may function
            (independently and cooperatively) in a context-dependent manner
REFERENCE   2  (bases 1 to 2409)
  AUTHORS   Kallionpaa,R.A., Jarvinen,E. and Finel,M.
  TITLE     Glucuronidation of estrone and 16alpha-hydroxyestrone by human UGT
            enzymes: The key roles of UGT1A10 and UGT2B7
  JOURNAL   J Steroid Biochem Mol Biol 154, 104-111 (2015)
   PUBMED   26220143
  REMARK    GeneRIF: In further studies with UGT1A10, mutant F93G exhibited
            increased glucuronidation rates of 16alpha-hydroxyestrone, but not
            estrone
REFERENCE   3  (bases 1 to 2409)
  AUTHORS   DiStefano,J.K., Kingsley,C., Craig Wood,G., Chu,X.,
            Argyropoulos,G., Still,C.D., Done,S.C., Legendre,C., Tembe,W. and
            Gerhard,G.S.
  TITLE     Genome-wide analysis of hepatic lipid content in extreme obesity
  JOURNAL   Acta Diabetol 52 (2), 373-382 (2015)
   PUBMED   25246029
REFERENCE   4  (bases 1 to 2409)
  AUTHORS   Gramec Skledar,D., Troberg,J., Lavdas,J., Peterlin Masic,L. and
            Finel,M.
  TITLE     Differences in the glucuronidation of bisphenols F and S between
            two homologous human UGT enzymes, 1A9 and 1A10
  JOURNAL   Xenobiotica 45 (6), 511-519 (2015)
   PUBMED   25547628
  REMARK    GeneRIF: UGT1A10 exhibited somewhat higher BPA glucuronidation
            activity than UGT1A9, but it was lower than UGT2A1 and UGT2B15. 4.
REFERENCE   5  (bases 1 to 2409)
  AUTHORS   Lu,J., Zhang,Y., Li,H., Yu,J. and Liu,S.
  TITLE     Electrochemically driven drug metabolism via a CYP1A2-UGT1A10
            bienzyme confined in a graphene nano-cage
  JOURNAL   Chem Commun (Camb) 50 (90), 13896-13899 (2014)
   PUBMED   25264962
  REMARK    GeneRIF: A graphene nanocage with regulatable space for the
            assembly of a CYP1A2-UGT1A10 bienzyme complex has been constructed
            via a click reaction, and used to study drug sequential metabolism
            using an electrochemically-driven method.
REFERENCE   6  (bases 1 to 2409)
  AUTHORS   Mojarrabi,B. and Mackenzie,P.I.
  TITLE     The human UDP glucuronosyltransferase, UGT1A10, glucuronidates
            mycophenolic acid
  JOURNAL   Biochem Biophys Res Commun 238 (3), 775-778 (1997)
   PUBMED   9325166
REFERENCE   7  (bases 1 to 2409)
  AUTHORS   Mackenzie,P.I., Owens,I.S., Burchell,B., Bock,K.W., Bairoch,A.,
            Belanger,A., Fournel-Gigleux,S., Green,M., Hum,D.W., Iyanagi,T.,
            Lancet,D., Louisot,P., Magdalou,J., Chowdhury,J.R., Ritter,J.K.,
            Schachter,H., Tephly,T.R., Tipton,K.F. and Nebert,D.W.
  TITLE     The UDP glycosyltransferase gene superfamily: recommended
            nomenclature update based on evolutionary divergence
  JOURNAL   Pharmacogenetics 7 (4), 255-269 (1997)
   PUBMED   9295054
  REMARK    Review article
REFERENCE   8  (bases 1 to 2409)
  AUTHORS   Strassburg,C.P., Oldhafer,K., Manns,M.P. and Tukey,R.H.
  TITLE     Differential expression of the UGT1A locus in human liver, biliary,
            and gastric tissue: identification of UGT1A7 and UGT1A10
            transcripts in extrahepatic tissue
  JOURNAL   Mol Pharmacol 52 (2), 212-220 (1997)
   PUBMED   9271343
REFERENCE   9  (bases 1 to 2409)
  AUTHORS   van Es,H.H., Bout,A., Liu,J., Anderson,L., Duncan,A.M., Bosma,P.,
            Oude Elferink,R., Jansen,P.L., Chowdhury,J.R. and Schurr,E.
  TITLE     Assignment of the human UDP glucuronosyltransferase gene (UGT1A1)
            to chromosome region 2q37
  JOURNAL   Cytogenet Cell Genet 63 (2), 114-116 (1993)
   PUBMED   8467709
REFERENCE   10 (bases 1 to 2409)
  AUTHORS   Harding,D., Jeremiah,S.J., Povey,S. and Burchell,B.
  TITLE     Chromosomal mapping of a human phenol UDP-glucuronosyltransferase,
            GNT1
  JOURNAL   Ann Hum Genet 54 (1), 17-21 (1990)
   PUBMED   2108603
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC019072.8 and AC006985.2.
            
            On Jan 21, 2021 this sequence version replaced NM_019075.3.
            
            Summary: This gene encodes a UDP-glucuronosyltransferase, an enzyme
            of the glucuronidation pathway that transforms small lipophilic
            molecules, such as steroids, bilirubin, hormones, and drugs, into
            water-soluble, excretable metabolites. This gene is part of a
            complex locus that encodes several UDP-glucuronosyltransferases.
            The locus includes thirteen unique alternate first exons followed
            by four common exons. Four of the alternate first exons are
            considered pseudogenes. Each of the remaining nine 5' exons may be
            spliced to the four common exons, resulting in nine proteins with
            different N-termini and identical C-termini. Each first exon
            encodes the substrate binding site, and is regulated by its own
            promoter. The enzyme encoded by this gene has glucuronidase
            activity on mycophenolic acid, coumarins, and quinolines. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069210.1, AK025403.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344644.10/ ENSP00000343838.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-930               AC019072.8         38634-39563         c
            931-1062            AC006985.2         59278-59409         c
            1063-1150           AC006985.2         58507-58594         c
            1151-1370           AC006985.2         58004-58223         c
            1371-2409           AC006985.2         53143-54181         c
FEATURES             Location/Qualifiers
     source          1..2409
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..2409
                     /gene="UGT1A10"
                     /gene_synonym="GNT1; hUG-BR1; UDPGT; UGT-1A; UGT-1J; UGT1;
                     UGT1-01; UGT1-10; UGT1.1; UGT1.10; UGT1A; UGT1A1; UGT1J"
                     /note="UDP glucuronosyltransferase family 1 member A10"
                     /db_xref="GeneID:54575"
                     /db_xref="HGNC:HGNC:12531"
                     /db_xref="MIM:606435"
     exon            1..930
                     /gene="UGT1A10"
                     /gene_synonym="GNT1; hUG-BR1; UDPGT; UGT-1A; UGT-1J; UGT1;
                     UGT1-01; UGT1-10; UGT1.1; UGT1.10; UGT1A; UGT1A1; UGT1J"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1668
                     /gene="UGT1A10"
                     /gene_synonym="GNT1; hUG-BR1; UDPGT; UGT-1A; UGT-1J; UGT1;
                     UGT1-01; UGT1-10; UGT1.1; UGT1.10; UGT1A; UGT1A1; UGT1J"
                     /EC_number="2.4.1.17"
                     /note="UDP glycosyltransferase 1 family, polypeptide A10;
                     UDP-glucuronosyltransferase 1A10;
                     UDP-glucuronosyltransferase 1-10;
                     UDP-glucuronosyltransferase 1-J; UDP
                     glucuronosyltransferase 1 family, polypeptide A10;
                     Bilirubin-specific UDPGT isozyme 1;
                     UDP-glucuronosyltransferase 1-A"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 1A10 precursor"
                     /protein_id="NP_061948.1"
                     /db_xref="CCDS:CCDS33403.1"
                     /db_xref="GeneID:54575"
                     /db_xref="HGNC:HGNC:12531"
                     /db_xref="MIM:606435"
                     /translation="MARAGWTSPVPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMQSV
                     VEKLILRGHEVVVVMPEVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQA
                     QSIFSLLMSSSSGFLDLFFSHCRSLFNDRKLVEYLKESSFDAVFLDPFDTCGLIVAKY
                     FSLPSVVFTRGIFCHHLEEGAQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHL
                     FCQYLFRNALEIASEILQTPVTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGIN
                     CHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRY
                     TGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFG
                     DQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVE
                     PLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCA
                     YGYRKCLGKKGRVKKAHKSKTH"
     exon            931..1062
                     /gene="UGT1A10"
                     /gene_synonym="GNT1; hUG-BR1; UDPGT; UGT-1A; UGT-1J; UGT1;
                     UGT1-01; UGT1-10; UGT1.1; UGT1.10; UGT1A; UGT1A1; UGT1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1150
                     /gene="UGT1A10"
                     /gene_synonym="GNT1; hUG-BR1; UDPGT; UGT-1A; UGT-1J; UGT1;
                     UGT1-01; UGT1-10; UGT1.1; UGT1.10; UGT1A; UGT1A1; UGT1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1370
                     /gene="UGT1A10"
                     /gene_synonym="GNT1; hUG-BR1; UDPGT; UGT-1A; UGT-1J; UGT1;
                     UGT1-01; UGT1-10; UGT1.1; UGT1.10; UGT1A; UGT1A1; UGT1J"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..2409
                     /gene="UGT1A10"
                     /gene_synonym="GNT1; hUG-BR1; UDPGT; UGT-1A; UGT-1J; UGT1;
                     UGT1-01; UGT1-10; UGT1.1; UGT1.10; UGT1A; UGT1A1; UGT1J"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2389..2394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGT1A10"
                     /gene_synonym="GNT1; hUG-BR1; UDPGT; UGT-1A; UGT-1J; UGT1;
                     UGT1-01; UGT1-10; UGT1.1; UGT1.10; UGT1A; UGT1A1; UGT1J"
                     /note="hexamer: AATAAA"
     polyA_site      2409
                     /gene="UGT1A10"
                     /gene_synonym="GNT1; hUG-BR1; UDPGT; UGT-1A; UGT-1J; UGT1;
                     UGT1-01; UGT1-10; UGT1.1; UGT1.10; UGT1A; UGT1A1; UGT1J"
                     /note="major polyA site"
ORIGIN      
        1 gtgcctgtac ttcttccgcc tactgtatca tagcagctta gaatcccagc tgctggctcg
       61 ggctgcagtt ctctcatggc tcgcgcaggg tggaccagcc ccgttccttt atgtgtgtgt
      121 ctactgctga cctgtggctt tgccgaggca gggaagctgc tggtagtgcc catggatggg
      181 agtcactggt tcaccatgca gtcggtggtg gagaaactta tcctcagggg gcatgaggtg
      241 gttgtagtca tgccagaggt gagttggcaa ctggaaagat cactgaattg cacagtgaag
      301 acttactcaa cctcgtacac tctggaagat cagaaccggg aattcatggt tttcgcccat
      361 gctcaatgga aagcacaggc acaaagtata ttttctctat taatgagttc atccagtggt
      421 tttcttgact tatttttttc gcattgcagg agtttgttta atgaccgaaa attagtagaa
      481 tacttaaagg agagttcttt tgatgcagtg tttctggatc cttttgatac ctgtggctta
      541 attgttgcta aatatttctc cctcccctct gtggtcttca ccaggggaat attttgccac
      601 catcttgaag aaggtgcaca gtgccctgct cctctttcct atgtccccaa tgatctctta
      661 gggttctcag atgccatgac tttcaaggag agagtatgga accacatcgt gcacttggag
      721 gaccatttat tttgccagta tctttttaga aatgccctag aaatagcctc tgaaattctc
      781 caaacccctg tcacggcata tgatctctac agtcacacat caatttggtt gttgcgaacg
      841 gactttgttt tggactatcc caaacccgtg atgcccaaca tgatcttcat tggtggtatc
      901 aactgtcatc agggaaagcc attgcctatg gaatttgaag cctacattaa tgcttctgga
      961 gaacatggaa ttgtggtttt ctctttggga tcaatggtct cagaaattcc agagaagaaa
     1021 gctatggcaa ttgctgatgc tttgggcaaa atccctcaga cagtcctgtg gcggtacact
     1081 ggaacccgac catcgaatct tgcgaacaac acgatacttg ttaagtggct accccaaaac
     1141 gatctgcttg gtcacccgat gacccgtgcc tttatcaccc atgctggttc ccatggtgtt
     1201 tatgaaagca tatgcaatgg cgttcccatg gtgatgatgc ccttgtttgg tgatcagatg
     1261 gacaatgcaa agcgcatgga gactaaggga gctggagtga ccctgaatgt tctggaaatg
     1321 acttctgaag atttagaaaa tgctctaaaa gcagtcatca atgacaaaag ttacaaggag
     1381 aacatcatgc gcctctccag ccttcacaag gaccgcccgg tggagccgct ggacctggcc
     1441 gtgttctggg tggagtttgt gatgaggcac aagggcgcgc cacacctgcg ccccgcagcc
     1501 cacgacctca cctggtacca gtaccattcc ttggacgtga ttggtttcct cttggccgtc
     1561 gtgctgacag tggccttcat cacctttaaa tgttgtgctt atggctaccg gaaatgcttg
     1621 gggaaaaaag ggcgagttaa gaaagcccac aaatccaaga cccattgaga agtgggtggg
     1681 aaataaggta aaattttgaa ccattcccta gtcatttcca aacttgaaaa cagaatcagt
     1741 gttaaattca ttttattctt attaaggaaa tactttgcat aaattaatca gccccagagt
     1801 gctttaaaaa attctcttaa ataaaaataa tagactcgct agtcagtaaa gatatttgaa
     1861 tatgtatcgt gccccctctg gtgtctttga tcaggatgac atgtgccatt tttcagagga
     1921 cgtgcagaca ggctggcatt ctagattact tttcttactc tgaaacatgg cctgtttggg
     1981 agtgcgggat tcaaaggtgg tcccacggct gcccctactg caaatggcag ttttaatctt
     2041 atcttttggc ttctgcagat ggttgcaatt gatccttaac caataatggt cagtcctcat
     2101 ctctgtcgtg cttcataggt gccaccttgt gtgtttaaag aagggaagct ttgtaccttt
     2161 agagtgtagg tgaaatgaat gaatggcttg gagtgcactg agaacagcat atgatttctt
     2221 gctttgggga aaaagaatga tgctatgaaa ttggtgggtg gtgtatttga gaagataatc
     2281 attgcttatg tcaaatggag ctgaatttga taaaaaccca aaatacagct atgaagtgct
     2341 gggcaagttt actttttttc tgatgtttcc tacaactaaa aataaattaa taaatttata
     2401 taaattcta
//
