LOCUS       NM_020121               4850 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens UDP-glucose glycoprotein glucosyltransferase 2
            (UGGT2), mRNA.
ACCESSION   NM_020121
VERSION     NM_020121.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4850)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 4850)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4850)
  AUTHORS   Adams,B.M., Canniff,N.P., Guay,K.P., Larsen,I.S.B. and Hebert,D.N.
  TITLE     Quantitative glycoproteomics reveals cellular substrate selectivity
            of the ER protein quality control sensors UGGT1 and UGGT2
  JOURNAL   Elife 9, e63997 (2020)
   PUBMED   33320095
  REMARK    GeneRIF: Quantitative glycoproteomics reveals cellular substrate
            selectivity of the ER protein quality control sensors UGGT1 and
            UGGT2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4850)
  AUTHORS   Takeda,Y., Seko,A., Fujikawa,K., Izumi,M., Kajihara,Y. and Ito,Y.
  TITLE     Effects of domain composition on catalytic activity of human
            UDP-glucose:glycoprotein glucosyltransferases
  JOURNAL   Glycobiology 26 (9), 999-1006 (2016)
   PUBMED   27496766
  REMARK    GeneRIF: In this study, we aimed to clarify the contribution of the
            noncatalytic domains by comparing activities of truncated forms of
            recombinant HUGT1/HUGT2 and HUGT1/HUGT2 chimeras with full-length
            enzymes.
REFERENCE   5  (bases 1 to 4850)
  AUTHORS   Takeda,Y., Seko,A., Hachisu,M., Daikoku,S., Izumi,M., Koizumi,A.,
            Fujikawa,K., Kajihara,Y. and Ito,Y.
  TITLE     Both isoforms of human UDP-glucose:glycoprotein glucosyltransferase
            are enzymatically active
  JOURNAL   Glycobiology 24 (4), 344-350 (2014)
   PUBMED   24415556
  REMARK    GeneRIF: The glucosyltransferase activity of UGGT2 has been
            lacking, leaving it unclear as to whether it has any function in
            the glycoprotein folding process.
REFERENCE   6  (bases 1 to 4850)
  AUTHORS   Caramelo,J.J. and Parodi,A.J.
  TITLE     Getting in and out from calnexin/calreticulin cycles
  JOURNAL   J Biol Chem 283 (16), 10221-10225 (2008)
   PUBMED   18303019
  REMARK    Review article
REFERENCE   7  (bases 1 to 4850)
  AUTHORS   Arnold,S.M. and Kaufman,R.J.
  TITLE     The noncatalytic portion of human UDP-glucose: glycoprotein
            glucosyltransferase I confers UDP-glucose binding and transferase
            function to the catalytic domain
  JOURNAL   J Biol Chem 278 (44), 43320-43328 (2003)
   PUBMED   12913004
  REMARK    GeneRIF: HUGT2 cannot activate the catalytic domain of UDP-glucose:
            glycoprotein glucosyltransferase I
REFERENCE   8  (bases 1 to 4850)
  AUTHORS   Christian,S.L., McDonough,J., Liu Cy,C.Y., Shaikh,S., Vlamakis,V.,
            Badner,J.A., Chakravarti,A. and Gershon,E.S.
  TITLE     An evaluation of the assembly of an approximately 15-Mb region on
            human chromosome 13q32-q33 linked to bipolar disorder and
            schizophrenia
  JOURNAL   Genomics 79 (5), 635-656 (2002)
   PUBMED   11991713
REFERENCE   9  (bases 1 to 4850)
  AUTHORS   Korotkov,K.V., Kumaraswamy,E., Zhou,Y., Hatfield,D.L. and
            Gladyshev,V.N.
  TITLE     Association between the 15-kDa selenoprotein and
            UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic
            reticulum of mammalian cells
  JOURNAL   J Biol Chem 276 (18), 15330-15336 (2001)
   PUBMED   11278576
REFERENCE   10 (bases 1 to 4850)
  AUTHORS   Arnold,S.M., Fessler,L.I., Fessler,J.H. and Kaufman,R.J.
  TITLE     Two homologues encoding human UDP-glucose:glycoprotein
            glucosyltransferase differ in mRNA expression and enzymatic
            activity
  JOURNAL   Biochemistry 39 (9), 2149-2163 (2000)
   PUBMED   10694380
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC032302.1, BC017759.1, AL162500.15 and AF227906.2.
            
            On Nov 22, 2018 this sequence version replaced NM_020121.3.
            
            Summary: UDP-glucose:glycoprotein glucosyltransferase (UGT) is a
            soluble protein of the endoplasmic reticulum (ER) that selectively
            reglucosylates unfolded glycoproteins, thus providing quality
            control for protein transport out of the ER.[supplied by OMIM, Oct
            2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF227906.2, SRR1660803.182716.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376747.8/ ENSP00000365938.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BC032302.1         82-96
            16-1070             BC017759.1         1-1055
            1071-1071           AL162500.15        103467-103467       c
            1072-2467           AF227906.2         1054-2449
            2468-2550           AL162500.15        19980-20062         c
            2551-3068           AF227906.2         2533-3050
            3069-3069           AL162500.15        5035-5035           c
            3070-4850           AF227906.2         3052-4832
FEATURES             Location/Qualifiers
     source          1..4850
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.1"
     gene            1..4850
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /note="UDP-glucose glycoprotein glucosyltransferase 2"
                     /db_xref="GeneID:55757"
                     /db_xref="HGNC:HGNC:15664"
                     /db_xref="MIM:605898"
     exon            1..247
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..4640
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /note="UDP-glucose ceramide glucosyltransferase-like 2;
                     UDP-Glc:glycoprotein glucosyltransferase 2; UDP-glucose
                     ceramide glucosyltransferase-like 1"
                     /codon_start=1
                     /product="UDP-glucose:glycoprotein glucosyltransferase 2
                     precursor"
                     /protein_id="NP_064506.3"
                     /db_xref="CCDS:CCDS9480.1"
                     /db_xref="GeneID:55757"
                     /db_xref="HGNC:HGNC:15664"
                     /db_xref="MIM:605898"
                     /translation="MAPAKATNVVRLLLGSTALWLSQLGSGTVAASKSVTAHLAAKWP
                     ETPLLLEASEFMAEESNEKFWQFLETVQELAIYKQTESDYSYYNLILKKAGQFLDNLH
                     INLLKFAFSIRAYSPAIQMFQQIAADEPPPDGCNAFVVIHKKHTCKINEIKKLLKKAA
                     SRTRPYLFKGDHKFPTNKENLPVVILYAEMGTRTFSAFHKVLSEKAQNEEILYVLRHY
                     IQKPSSRKMYLSGYGVELAIKSTEYKALDDTQVKTVTNTTVEDETETNEVQGFLFGKL
                     KEIYSDLRDNLTAFQKYLIESNKQMMPLKVWELQDLSFQAASQIMSAPVYDSIKLMKD
                     ISQNFPIKARSLTRIAVNQHMREEIKENQKDLQVRFKIQPGDARLFINGLRVDMDVYD
                     AFSILDMLKLEGKMMNGLRNLGINGEDMSKFLKLNSHIWEYTYVLDIRHSSIMWINDL
                     ENDDLYITWPTSCQKLLKPVFPGSVPSIRRNFHNLVLFIDPAQEYTLDFIKLADVFYS
                     HEVPLRIGFVFILNTDDEVDGANDAGVALWRAFNYIAEEFDISEAFISIVHMYQKVKK
                     DQNILTVDNVKSVLQNTFPHANIWDILGIHSKYDEERKAGASFYKMTGLGPLPQALYN
                     GEPFKHEEMNIKELKMAVLQRMMDASVYLQREVFLGTLNDRTNAIDFLMDRNNVVPRI
                     NTLILRTNQQYLNLISTSVTADVEDFSTFFFLDSQDKSAVIAKNMYYLTQDDESIISA
                     VTLWIIADFDKPSGRKLLFNALKHMKTSVHSRLGIIYNPTSKINEENTAISRGILAAF
                     LTQKNMFLRSFLGQLAKEEIATAIYSGDKIKTFLIEGMDKNAFEKKYNTVGVNIFRTH
                     QLFCQDVLKLRPGEMGIVSNGRFLGPLDEDFYAEDFYLLEKITFSNLGEKIKGIVENM
                     GINANNMSDFIMKVDALMSSVPKRASRYDVTFLRENHSVIKTNPQENDMFFNVIAIVD
                     PLTREAQKMAQLLVVLGKIINMKIKLFMNCRGRLSEAPLESFYRFVLEPELMSGANDV
                     SSLGPVAKFLDIPESPLLILNMITPEGWLVETVHSNCDLDNIHLKDTEKTVTAEYELE
                     YLLLEGQCFDKVTEQPPRGLQFTLGTKNKPAVVDTIVMAHHGYFQLKANPGAWILRLH
                     QGKSEDIYQIVGHEGTDSQADLEDIIVVLNSFKSKILKVKVKKETDKIKEDILTDEDE
                     KTKGLWDSIKSFTVSLHKENKKEKDVLNIFSVASGHLYERFLRIMMLSVLRNTKTPVK
                     FWLLKNYLSPTFKEVIPHMAKEYGFRYELVQYRWPRWLRQQTERQRIIWGYKILFLDV
                     LFPLAVDKIIFVDADQIVRHDLKELRDFDLDGAPYGYTPFCDSRREMDGYRFWKTGYW
                     ASHLLRRKYHISALYVVDLKKFRRIGAGDRLRSQYQALSQDPNSLSNLDQDLPNNMIY
                     QVAIKSLPQDWLWCETWCDDESKQRAKTIDLCNNPKTKESKLKAAARIVPEWVEYDAE
                     IRQLLDHLENKKQDTILTHDEL"
     exon            248..330
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            331..461
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            462..574
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            575..749
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            750..846
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            847..919
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1020
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1120
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1181
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1273
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1424
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1544
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1630
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1766
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1901
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2066
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2190
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2289
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2384
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2591
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2723
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2848
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..2944
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2945..3047
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            3048..3127
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            3128..3317
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            3318..3476
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..3562
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            3563..3647
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            3648..3733
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            3734..3829
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            3830..3914
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            3915..4097
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            4098..4258
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            4259..4373
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            4374..4490
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            4491..4617
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            4618..4850
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4825..4830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /note="hexamer: AATAAA"
     polyA_site      4850
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /note="major polyA site"
ORIGIN      
        1 agccgcgcag cgggaagagc cggccgaagc gtggcggcca cagactgtgg gtaccgggtc
       61 cgagggactc gcgcttttct ctccgtgcca tggcgccagc gaaagccacg aacgtggtgc
      121 ggctgctact aggctccaca gcgctgtggc tttcgcagct cggctccggg acggtcgccg
      181 cgtccaagtc ggtgactgcc cacttggccg cgaagtggcc cgagaccccg ctgctgctgg
      241 aggcaagtga atttatggca gaagaaagta atgaaaaatt ttggcagttt ttggaaactg
      301 tgcaagaatt agcaatttat aagcaaacag aatcagatta ttcttattac aacttaatcc
      361 tgaagaaagc tggacagttt ctagacaatt tacacatcaa ccttttaaag tttgctttct
      421 ctataagggc atactcccca gctattcaga tgtttcagca gattgcagct gatgagccac
      481 caccagatgg ttgtaatgca tttgtggtta ttcataagaa gcacacctgt aaaattaatg
      541 agattaaaaa gctgctgaag aaagctgctt caaggactag accttatcta tttaaaggag
      601 atcacaaatt tcctacaaac aaagagaact taccagtggt gattctctat gccgaaatgg
      661 gtactagaac atttagtgca tttcacaaag tattgtctga aaaagctcaa aatgaggaaa
      721 ttctgtatgt tcttcgccat tatattcaga aaccaagctc acggaaaatg tacttatctg
      781 ggtatggtgt ggagctagca attaagagta cagaatacaa agcactggat gatacccaag
      841 ttaaaactgt gactaatact actgtagagg atgagactga aacaaatgaa gttcaaggat
      901 ttctctttgg gaaactaaaa gaaatatatt cagatcttag agataatctg acagcattcc
      961 aaaaatacct gattgagagt aacaaacaaa tgatgccttt gaaagtctgg gaactacaag
     1021 atcttagttt tcaagcagct tctcaaataa tgtccgctcc agtttatgat tccattaaat
     1081 taatgaaaga catttcacag aacttcccca taaaagccag atctctaacc agaattgctg
     1141 taaatcaaca tatgagagaa gaaataaagg aaaatcaaaa ggatcttcaa gttagattta
     1201 aaattcagcc aggcgatgct cgtctattta taaatggcct tcgtgttgat atggatgttt
     1261 atgacgcttt tagtattttg gatatgctga aattagaagg aaaaatgatg aatggccttc
     1321 gcaatcttgg gatcaatggg gaagatatga gcaaattttt aaaattaaat tcacacattt
     1381 gggaatatac ttatgtatta gatattcgac attcttctat aatgtggatt aatgacttag
     1441 aaaatgatga tttgtatatt acatggccta caagttgcca gaaacttctg aagccagtat
     1501 ttcctggaag tgtaccttcc ataaggcgca attttcataa tttggttctg tttattgatc
     1561 cggcccaaga atataccttg gattttataa aacttgctga tgttttctat tctcacgaag
     1621 ttcctcttag aattggtttt gtgttcattc ttaatacaga tgatgaagtt gatggagcaa
     1681 atgatgctgg agttgctctc tggcgagctt tcaactatat tgcagaagaa tttgatatat
     1741 cagaagcatt tatttctata gtacacatgt accaaaaagt gaagaaggat caaaatatac
     1801 tcactgtgga caatgtgaag agtgttctcc aaaatacatt tcctcatgct aatatttggg
     1861 atattttggg aattcattct aaatatgatg aagaaagaaa ggctggagca agcttttata
     1921 agatgactgg cctgggtcct ttgcctcaag ctctttataa tggtgaaccc tttaaacatg
     1981 aagagatgaa tattaaagaa ctaaaaatgg ctgttcttca aagaatgatg gatgcatctg
     2041 tatatttaca aagagaagtt tttttgggca cattaaatga tcgcacgaat gcaattgatt
     2101 ttctaatgga taggaataat gttgtacccc gtataaatac tttgattttg cgtactaacc
     2161 agcagtacct caatttaata tctacatcag taactgctga tgttgaagat ttctctactt
     2221 tctttttctt ggattcacaa gataagagtg ctgtaattgc aaagaacatg tattatttaa
     2281 cccaagacga tgagagtata atttctgcag tcactctctg gattattgca gattttgata
     2341 agccttctgg gagaaaactt ctttttaatg cattaaagca catgaaaaca agtgttcata
     2401 gtcggttggg gattatttat aatcctacat caaaaataaa tgaagagaac acagctattt
     2461 ctagaggaat tttggcagct tttcttacac agaagaacat gtttttgaga agctttcttg
     2521 ggcaactggc aaaggaagaa attgctacag ctatttactc tggagataaa attaaaacat
     2581 tccttattga ggggatggat aagaatgctt ttgagaaaaa atataatact gttggagtga
     2641 atatttttcg aactcaccag ttgttctgtc aagatgtact taaattacgt cctggagaaa
     2701 tgggtattgt cagcaatggg agattcttag gacctttaga tgaagatttt tatgcagaag
     2761 atttttactt gttggaaaag ataacattta gtaatttagg agagaaaatt aaaggcattg
     2821 ttgaaaatat gggaatcaac gcaaataaca tgagtgactt tattatgaaa gttgatgccc
     2881 ttatgtcctc tgtgcctaag cgtgcatctc gatatgatgt cacatttctt agggagaatc
     2941 acagtgttat aaagacgaat cctcaagaga atgatatgtt cttcaatgtc attgctattg
     3001 ttgatccatt aacaagagaa gcacagaaaa tggcacagtt gttggttgta cttggcaaga
     3061 ttatcaacat gaagataaag ttgttcatga actgtagggg caggctttca gaagcccctt
     3121 tagaaagctt ttaccgtttt gttctggaac cagaactgat gtcaggggct aatgacgttt
     3181 cttctcttgg accagtggca aaatttttgg atattcctga atcacccctc ctaatcctca
     3241 acatgattac tccagaaggc tggttggttg aaacagtgca cagcaactgt gaccttgata
     3301 atattcactt aaaggatact gagaaaactg ttacagcaga atatgaacta gaatacttac
     3361 tactggaagg acaatgcttt gataaagtga cagaacagcc tcctcggggt ctgcagttca
     3421 cactaggcac aaaaaataaa cctgctgtgg ttgatacaat agtgatggca catcatgggt
     3481 attttcaatt aaaagcaaac ccaggtgctt ggatactgag gttacaccaa ggaaaatctg
     3541 aagatattta tcaaatagtt gggcatgaag gaactgactc tcaagcagac ctagaagata
     3601 tcattgttgt attaaacagc ttcaaaagca agatactcaa agtaaaagtg aaaaaagaaa
     3661 cagacaaaat taaggaagat atccttaccg atgaagatga aaaaacaaaa ggactgtggg
     3721 attccattaa aagtttcaca gtaagcttgc ataaagaaaa caaaaaggaa aaagatgtcc
     3781 taaacatttt ttcagttgct tctggtcatt tatatgaacg ttttttaaga attatgatgc
     3841 tttctgtttt gcgtaacacc aaaacaccag tgaaattctg gttgctaaaa aattatctct
     3901 caccgacatt taaagaagta attcctcaca tggctaaaga gtatggattc cgatatgaac
     3961 tagttcaata taggtggccc cgttggcttc gtcaacagac tgaaagacag aggattattt
     4021 ggggttacaa aattcttttc cttgatgttc ttttcccact agcagtggac aaaatcattt
     4081 ttgttgatgc tgaccagatt gtgagacatg atctaaaaga acttcgagat ttcgatctgg
     4141 atggagctcc ttatgggtat actccatttt gtgatagccg cagggaaatg gatggatatc
     4201 gtttctggaa aacaggatac tgggcatcac atcttttaag acggaaatac catatcagtg
     4261 ctttatatgt agtggatctc aagaagttca ggagaattgg agcaggtgac aggctcagga
     4321 gccagtatca agctctcagt caagatccaa acagtctttc aaacctagat caggatctcc
     4381 ccaataatat gatttaccaa gtcgccatta agtctcttcc tcaagactgg ctgtggtgtg
     4441 aaacctggtg tgatgatgaa tccaaacaaa gagccaaaac aattgatctg tgcaataatc
     4501 ccaaaacaaa agaatccaaa ctaaaagctg ctgccagaat tgtcccagaa tgggtggagt
     4561 atgatgctga gataagacaa ctattagatc atcttgaaaa caagaagcaa gatacaattt
     4621 tgacacatga tgaactctag cactggtgta tatgagaagg aaggcgaaag catgacagga
     4681 aacctgccgc ctgctgggga agtctggagc ccctgctgag acgatttgga agtctcgtta
     4741 agatcagtga catattcttt aattttaaaa aattgtaatt atttaaaaca gttatttaat
     4801 gtattgaatg agtttaagtt atataataaa tgaccattga gtatttaaaa
//
