LOCUS       NM_003359               3037 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens UDP-glucose 6-dehydrogenase (UGDH), transcript variant
            1, mRNA.
ACCESSION   NM_003359
VERSION     NM_003359.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3037)
  AUTHORS   Jiang,L., Bi,S., Lin,L., He,F. and Deng,F.
  TITLE     Phenotypic and genetic characteristics of 24 cases of early
            infantile epileptic encephalopathy in East China, including a rare
            case of biallelic UGDH mutations
  JOURNAL   Mol Genet Genomic Med 11 (12), e2269 (2023)
   PUBMED   37593999
  REMARK    GeneRIF: Phenotypic and genetic characteristics of 24 cases of
            early infantile epileptic encephalopathy in East China, including a
            rare case of biallelic UGDH mutations.
REFERENCE   2  (bases 1 to 3037)
  AUTHORS   Harrington,B.S., Kamdar,R., Ning,F., Korrapati,S., Caminear,M.W.,
            Hernandez,L.F., Butcher,D., Edmondson,E.F., Traficante,N.,
            Hendley,J., Gough,M., Rogers,R., Lourie,R., Shetty,J., Tran,B.,
            Elloumi,F., Abdelmaksoud,A., Nag,M.L., Mazan-Mamczarz,K.,
            House,C.D., Hooper,J.D. and Annunziata,C.M.
  CONSRTM   Australian Ovarian Cancer Study
  TITLE     UGDH promotes tumor-initiating cells and a fibroinflammatory tumor
            microenvironment in ovarian cancer
  JOURNAL   J Exp Clin Cancer Res 42 (1), 270 (2023)
   PUBMED   37858159
  REMARK    GeneRIF: UGDH promotes tumor-initiating cells and a
            fibroinflammatory tumor microenvironment in ovarian cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3037)
  AUTHORS   Guo,B., Xu,X., Shao,M., Yang,X., He,G., Qi,K., Gu,J. and Wang,L.
  TITLE     UDP-glucose 6-dehydrogenase lessens sorafenib sensitivity via
            modulating unfolded protein response
  JOURNAL   Biochem Biophys Res Commun 613, 207-213 (2022)
   PUBMED   35617808
  REMARK    GeneRIF: UDP-glucose 6-dehydrogenase lessens sorafenib sensitivity
            via modulating unfolded protein response.
REFERENCE   4  (bases 1 to 3037)
  AUTHORS   Teoh,S.T., Ogrodzinski,M.P. and Lunt,S.Y.
  TITLE     UDP-glucose 6-dehydrogenase knockout impairs migration and
            decreases in vivo metastatic ability of breast cancer cells
  JOURNAL   Cancer Lett 492, 21-30 (2020)
   PUBMED   32768525
  REMARK    GeneRIF: UDP-glucose 6-dehydrogenase knockout impairs migration and
            decreases in vivo metastatic ability of breast cancer cells.
REFERENCE   5  (bases 1 to 3037)
  AUTHORS   Lin,L.H., Chou,H.C., Chang,S.J., Liao,E.C., Tsai,Y.T., Wei,Y.S.,
            Chen,H.Y., Lin,M.W., Wang,Y.S., Chien,Y.A., Yu,X.R. and Chan,H.L.
  TITLE     Targeting UDP-glucose dehydrogenase inhibits ovarian cancer growth
            and metastasis
  JOURNAL   J Cell Mol Med 24 (20), 11883-11902 (2020)
   PUBMED   32893977
  REMARK    GeneRIF: Targeting UDP-glucose dehydrogenase inhibits ovarian
            cancer growth and metastasis.
REFERENCE   6  (bases 1 to 3037)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   7  (bases 1 to 3037)
  AUTHORS   Bontemps,Y., Maquart,F.X. and Wegrowski,Y.
  TITLE     Human UDP-glucose dehydrogenase gene: complete cloning and
            transcription start mapping
  JOURNAL   Biochem Biophys Res Commun 275 (3), 981-985 (2000)
   PUBMED   10973831
REFERENCE   8  (bases 1 to 3037)
  AUTHORS   Marcu,O., Stathakis,D.G. and Marsh,J.L.
  TITLE     Assignment of the UGDH locus encoding UDP-glucose dehydrogenase to
            human chromosome band 4p15.1 by radiation hybrid mapping
  JOURNAL   Cytogenet Cell Genet 86 (3-4), 244-245 (1999)
   PUBMED   10575217
REFERENCE   9  (bases 1 to 3037)
  AUTHORS   Peng,H.L., Lou,M.D., Chang,M.L. and Chang,H.Y.
  TITLE     cDNA cloning and expression analysis of the human UDPglucose
            dehydrogenase
  JOURNAL   Proc Natl Sci Counc Repub China B 22 (4), 166-172 (1998)
   PUBMED   9850599
REFERENCE   10 (bases 1 to 3037)
  AUTHORS   Spicer,A.P., Kaback,L.A., Smith,T.J. and Seldin,M.F.
  TITLE     Molecular cloning and characterization of the human and mouse
            UDP-glucose dehydrogenase genes
  JOURNAL   J Biol Chem 273 (39), 25117-25124 (1998)
   PUBMED   9737970
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021148.8, AJ007702.1 and
            AF061016.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003359.3.
            
            Summary: The protein encoded by this gene converts UDP-glucose to
            UDP-glucuronate and thereby participates in the biosynthesis of
            glycosaminoglycans such as hyaluronan, chondroitin sulfate, and
            heparan sulfate. These glycosylated compounds are common components
            of the extracellular matrix and likely play roles in signal
            transduction, cell migration, and cancer growth and metastasis. The
            expression of this gene is up-regulated by transforming growth
            factor beta and down-regulated by hypoxia. Alternative splicing
            results in multiple transcript variants.[provided by RefSeq, May
            2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.197526.1,
                                           SRR1803614.167003.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316423.11/ ENSP00000319501.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC021148.8         93173-93256         c
            85-86               AJ007702.1         66-67
            87-112              AF061016.1         1-26
            113-661             AJ007702.1         94-642
            662-1686            AF061016.1         576-1600
            1687-3037           AC021148.8         64572-65922         c
FEATURES             Location/Qualifiers
     source          1..3037
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     gene            1..3037
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
                     /note="UDP-glucose 6-dehydrogenase"
                     /db_xref="GeneID:7358"
                     /db_xref="HGNC:HGNC:12525"
                     /db_xref="MIM:603370"
     exon            1..157
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            158..326
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1649
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
                     /EC_number="1.1.1.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UDP-glucose dehydrogenase; uridine diphospho-glucose
                     dehydrogenase; UDP-Glc dehydrogenase"
                     /codon_start=1
                     /product="UDP-glucose 6-dehydrogenase isoform 1"
                     /protein_id="NP_003350.1"
                     /db_xref="CCDS:CCDS3455.1"
                     /db_xref="GeneID:7358"
                     /db_xref="HGNC:HGNC:12525"
                     /db_xref="MIM:603370"
                     /translation="MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINA
                     WNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGR
                     AADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNP
                     EFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSEL
                     SKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSC
                     FQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAIL
                     GFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPGVSEDDQVS
                     RLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHN
                     ELQTIGFQIETIGKKVSSKRIPYAPSGEIPKFSLQDPPNKKPKV"
     exon            327..428
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            429..629
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            630..827
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            828..975
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1070
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1201
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1335
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1427
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1538
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..3037
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2442..2447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
                     /note="hexamer: AATAAA"
     polyA_site      2474
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
                     /note="major polyA site"
     regulatory      2846..2851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
                     /note="hexamer: ATTAAA"
     polyA_site      2872
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
     regulatory      3012..3017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
                     /note="hexamer: AATAAA"
     polyA_site      3037
                     /gene="UGDH"
                     /gene_synonym="DEE84; EIEE84; GDH; UDP-GlcDH; UDPGDH; UGD"
                     /note="major polyA site"
ORIGIN      
        1 gtgtaacgcg tggcagcctg agggaggggc gtgcgccgag agggagctca gatcgagcgg
       61 ggcgcgggtg gagaagctgc ggcggcgcgg cccgtaggaa ggtgctgtcc gaacgatcgg
      121 gataggagcg gtccctgcgc ttgctgctgg gaagtggtac aatcatgttt gaaattaaga
      181 agatctgttg catcggtgca ggctatgttg gaggacccac atgtagtgtc attgctcata
      241 tgtgtcctga aatcagggta acggttgttg atgtcaatga atcaagaatc aatgcgtgga
      301 attctcctac acttcctatt tatgagccag gactaaaaga agtggtagaa tcctgtcgag
      361 gaaaaaatct ttttttttct accaatattg atgatgccat caaagaagct gatcttgtat
      421 ttatttctgt gaatactcca acaaaaacct atggaatggg gaaaggccgg gcagcagatc
      481 tgaagtatat tgaagcttgt gctagacgca ttgtgcaaaa ctcaaatggg tacaaaattg
      541 tgactgagaa aagcacagtt ccagtgcggg cagcagaaag tatccgtcgc atatttgatg
      601 caaacacaaa acccaacttg aatttacagg tgctgtccaa ccctgagttt ctggcagagg
      661 gaacagccat caaggaccta aagaacccag acagagtact gattggaggg gatgaaactc
      721 cagagggcca gagagctgtg caggccctgt gtgctgtata tgagcactgg gttcccagag
      781 aaaagatcct caccactaat acttggtctt cagagctttc caaactggca gcaaatgctt
      841 ttcttgccca gagaataagc agcattaact ccataagtgc tctgtgtgaa gcaacaggag
      901 ctgatgtaga agaggtagca acagcgattg gaatggacca gagaattgga aacaagtttc
      961 taaaagccag tgttgggttt ggtgggagct gtttccaaaa ggatgttctg aatttggttt
     1021 atctctgtga ggctctgaat ttgccagaag tagctcgtta ttggcagcag gtcatagaca
     1081 tgaatgacta ccagaggagg aggtttgctt cccggatcat agatagtctg tttaatacag
     1141 taactgataa gaagatagct attttgggat ttgcattcaa aaaggacact ggtgatacaa
     1201 gagaatcttc tagtatatat attagcaaat atttgatgga tgaaggtgca catctacata
     1261 tatatgatcc aaaagtacct agggaacaaa tagttgtgga tctttctcat ccaggtgttt
     1321 cagaggatga ccaagtgtcc cggctcgtga ccatttccaa ggatccatat gaagcatgtg
     1381 atggtgccca tgctgttgtt atttgcactg agtgggacat gtttaaggaa ttggattatg
     1441 aacgcattca taaaaaaatg ctaaagccag cctttatctt cgatggacgg cgtgtcctgg
     1501 atgggctcca caatgaacta caaaccattg gcttccagat tgaaacaatt ggcaaaaagg
     1561 tgtcttcaaa gagaattcca tatgctcctt ctggtgaaat tccgaagttt agtcttcaag
     1621 atccacctaa caagaaacct aaagtgtaga gattgccatt tttatttgtg attttttttt
     1681 tttttttttg gtacttcagg atagcaaata tctatctgct attaaatggt aaatgaacca
     1741 agtgtttttt tttgtttttt ttttgagaca gagtctcact gttgcccagg ctggagtgca
     1801 gtggtgcaat ctcggctcac tgcaagctct gcttcccagg ttcacgccat tctcctggct
     1861 cagcctccca agtagctggg actacaggca cccgccacag tgcctggcta attttttgta
     1921 tttttagtag agacagggtt tcaccatgtg agccaggatg gtctcaatct cctgaccttg
     1981 tgaaccaccc gtctcggcct cccaaagtgc tgggattaca ggtgtgagcc accacgcctg
     2041 gcccatgaac caagtgtttt taaggaaaca aaactatttt tttaatcatc agatttatac
     2101 tagctatatg gatattagca tatctggtaa ttatgaatct agaatttttt tacatatttt
     2161 tataatactg ttagctcagt tattggatga gtgaaagata atcatgttgg ttttaatagt
     2221 gtcaattttt gtaaaataaa aattaaactt caaactcttt actttataaa ttgtccatag
     2281 gccacacttt aatatcacat tataaaggga aggacagtct tcattcctcc tggttattgg
     2341 tttgtttgtc attaaagata tattttgaat ccatgaaatt gctatgctaa acagccttta
     2401 catgtatggt ctggttaaag ttcctttgtt ccttttgttt taataaaatg tgtcactgat
     2461 tttttagctc aaaatcatca ctgttaattt ccagtcaccc caaatatggt taaaagattt
     2521 tttttttaat catgaagaga aaattagtag catttctttc tctccccatt atttattggt
     2581 tttcctcact aatctttttt tttttagtcc aaaagccaaa aatatttatc ttggttttac
     2641 attttaattt ccattcttaa ttgtaatttt tttctttaaa taaggaaacc aatataatct
     2701 catgtataaa aacttaaata ttttacaagt tacatatagc atcattctaa aataagaatt
     2761 ttttttgttt tctgtctgct tttttcttat gtctcttgtt gagttttata ttttcagtgg
     2821 ttatttttgc ttgtgttaga tcattattaa aatatatcca atgtcccttt gatacttgtg
     2881 ctctgctgag aatgtacagt ttgcattaaa catcccaggt ctcatccttc aggaattttg
     2941 cagttcaatg agaagaggga gacaaatata aagatgagga cagaagcatc tctacagatg
     3001 aaaattacat aaataaaaca ttctccatca acaacta
//
