LOCUS       NP_060829                469 aa            linear   PRI 12-FEB-2025
DEFINITION  ufm1-specific protease 2 [Homo sapiens].
ACCESSION   NP_060829
VERSION     NP_060829.2
DBSOURCE    REFSEQ: accession NM_018359.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 469)
  AUTHORS   DaRosa,P.A., Penchev,I., Gumbin,S.C., Scavone,F., Wachalska,M.,
            Paulo,J.A., Ordureau,A., Peter,J.J., Kulathu,Y., Harper,J.W.,
            Becker,T., Beckmann,R. and Kopito,R.R.
  TITLE     UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from
            the ER
  JOURNAL   Nature 627 (8003), 445-452 (2024)
   PUBMED   38383785
REFERENCE   2  (residues 1 to 469)
  AUTHORS   Luo,H., Jiao,Q.B., Shen,C.B., Gong,W.Y., Yuan,J.H., Liu,Y.Y.,
            Chen,Z., Liu,J., Xu,X.L., Cong,Y.S. and Zhang,X.W.
  TITLE     UFMylation of HRD1 regulates endoplasmic reticulum homeostasis
  JOURNAL   FASEB J 37 (11), e23221 (2023)
   PUBMED   37795761
REFERENCE   3  (residues 1 to 469)
  AUTHORS   Zhou,J., Ma,X., He,X., Chen,B., Yuan,J., Jin,Z., Li,L., Wang,Z.,
            Xiao,Q., Cai,Y., Zou,Y. and Cong,Y.S.
  TITLE     Dysregulation of PD-L1 by UFMylation imparts tumor immune evasion
            and identified as a potential therapeutic target
  JOURNAL   Proc Natl Acad Sci U S A 120 (11), e2215732120 (2023)
   PUBMED   36893266
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2023 May 23;120(21):e2306087120.
            doi: 10.1073/pnas.2306087120.. PMID: 37186868]
REFERENCE   4  (residues 1 to 469)
  AUTHORS   Ishimura,R., El-Gowily,A.H., Noshiro,D., Komatsu-Hirota,S., Ono,Y.,
            Shindo,M., Hatta,T., Abe,M., Uemura,T., Lee-Okada,H.C.,
            Mohamed,T.M., Yokomizo,T., Ueno,T., Sakimura,K., Natsume,T.,
            Sorimachi,H., Inada,T., Waguri,S., Noda,N.N. and Komatsu,M.
  TITLE     The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3
  JOURNAL   Nat Commun 13 (1), 7857 (2022)
   PUBMED   36543799
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 469)
  AUTHORS   Wang,L., Xu,Y., Rogers,H., Saidi,L., Noguchi,C.T., Li,H.,
            Yewdell,J.W., Guydosh,N.R. and Ye,Y.
  TITLE     UFMylation of RPL26 links translocation-associated quality control
            to endoplasmic reticulum protein homeostasis
  JOURNAL   Cell Res 30 (1), 5-20 (2020)
   PUBMED   31595041
REFERENCE   6  (residues 1 to 469)
  AUTHORS   Ishimura,R., Obata,M., Kageyama,S., Daniel,J., Tanaka,K. and
            Komatsu,M.
  TITLE     A novel approach to assess the ubiquitin-fold modifier 1-system in
            cells
  JOURNAL   FEBS Lett 591 (1), 196-204 (2017)
   PUBMED   27926783
REFERENCE   7  (residues 1 to 469)
  AUTHORS   Watson,C.M., Crinnion,L.A., Gleghorn,L., Newman,W.G., Ramesar,R.,
            Beighton,P. and Wallis,G.A.
  TITLE     Identification of a mutation in the ubiquitin-fold modifier
            1-specific peptidase 2 gene, UFSP2, in an extended South African
            family with Beukes hip dysplasia
  JOURNAL   S Afr Med J 105 (7), 558-563 (2015)
   PUBMED   26428751
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 469)
  AUTHORS   Yoo,H.M., Kang,S.H., Kim,J.Y., Lee,J.E., Seong,M.W., Lee,S.W.,
            Ka,S.H., Sou,Y.S., Komatsu,M., Tanaka,K., Lee,S.T., Noh,D.Y.,
            Baek,S.H., Jeon,Y.J. and Chung,C.H.
  TITLE     Modification of ASC1 by UFM1 is crucial for ERalpha transactivation
            and breast cancer development
  JOURNAL   Mol Cell 56 (2), 261-274 (2014)
   PUBMED   25219498
REFERENCE   9  (residues 1 to 469)
  AUTHORS   Kang,S.H., Kim,G.R., Seong,M., Baek,S.H., Seol,J.H., Bang,O.S.,
            Ovaa,H., Tatsumi,K., Komatsu,M., Tanaka,K. and Chung,C.H.
  TITLE     Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases,
            UfSP1 and UfSP2
  JOURNAL   J Biol Chem 282 (8), 5256-5262 (2007)
   PUBMED   17182609
REFERENCE   10 (residues 1 to 469)
  AUTHORS   Jiang,L.Q., Wen,S.J., Wang,H.Y. and Chen,L.Y.
  TITLE     Screening the proteins that interact with calpain in a human heart
            cDNA library using a yeast two-hybrid system
  JOURNAL   Hypertens Res 25 (4), 647-652 (2002)
   PUBMED   12358155
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC106897.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 25, 2009 this sequence version replaced NP_060829.1.
            
            Summary: This gene encodes a highly conserved cysteine protease.
            The protein cleaves two C-terminal residues from ubiquitin-fold
            modifier 1, a ubiquitin-like post-translational modifier protein.
            Activation of ubiquitin-fold modifier 1 by the encoded protein
            exposes a C-terminal glycine residue that allows interaction with
            other proteins and transfer to its target protein. An allelic
            variant of this gene has been associated with Beukes hip dysplasia.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.577870.1,
                                           SRR18074968.1423294.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264689.11/ ENSP00000264689.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.1"
     Protein         1..469
                     /product="ufm1-specific protease 2"
                     /EC_number="3.4.22.-"
                     /calculated_mol_wt=53130
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000269|PubMed:25732826; propagated from
                     UniProtKB/Swiss-Prot (Q9NUQ7.3)"
     Region          276..461
                     /region_name="Peptidase_C78"
                     /note="Peptidase family C78; pfam07910"
                     /db_xref="CDD:400318"
     CDS             1..469
                     /gene="UFSP2"
                     /gene_synonym="BHD; C4orf20; DEE106; SEMDDR"
                     /coded_by="NM_018359.5:97..1506"
                     /db_xref="CCDS:CCDS3842.1"
                     /db_xref="GeneID:55325"
                     /db_xref="HGNC:HGNC:25640"
                     /db_xref="MIM:611482"
ORIGIN      
        1 mvisesmdil frirggldla fqlatpneif lkkalkhvls dlstklssna lvfrichssv
       61 yiwpssdint ipgeltdasa cknilrfiqf epeedikrkf mrkkdkklsd mhqivnidlm
      121 lemstslaav tpiieresgg hhyvnmtlpv davisvapee twgkvrkllv daihnqltdm
      181 ekcilkymkg tsivvpeplh fllpgkknlv tisypsgipd gqlqayrkel hdlfnlphdr
      241 pyfkrsnayh fpdepykdgy irnphtylnp pnmetgmiyv vqgiygyhhy mqdriddngw
      301 gcayrslqti cswfkhqgyt ersipthrei qqalvdagdk patfvgsrqw igsievqlvl
      361 nqligitski lfvsqgseia sqgrelanhf qsegtpvmig ggvlahtilg vawneitgqi
      421 kflildphyt gaedlqvile kgwcgwkgpd fwnkdayynl clpqrpnmi
//
