LOCUS       NM_001015072             995 bp    mRNA    linear   PRI 22-AUG-2024
DEFINITION  Homo sapiens UFM1 specific peptidase 1 (UFSP1), transcript variant
            2, mRNA.
ACCESSION   NM_001015072 XM_380026
VERSION     NM_001015072.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 995)
  AUTHORS   Wang,X., Cao,L., Jiang,H., Zhou,L., Hu,Z. and Xu,G.
  TITLE     Proximity Proteomics and Biochemical Analysis Reveal a Noncanonical
            Function for UFM1-Specific Protease 1 in the p62 Body Formation
  JOURNAL   J Proteome Res 22 (7), 2352-2363 (2023)
   PUBMED   37285312
REFERENCE   2  (bases 1 to 995)
  AUTHORS   Lin,M., Zheng,X. and Jin,J.
  TITLE     Nontraditional translation is the key to UFMylation and beyond
  JOURNAL   J Biol Chem 298 (10), 102431 (2022)
   PUBMED   36037969
REFERENCE   3  (bases 1 to 995)
  AUTHORS   Millrine,D., Cummings,T., Matthews,S.P., Peter,J.J.,
            Magnussen,H.M., Lange,S.M., Macartney,T., Lamoliatte,F., Knebel,A.
            and Kulathu,Y.
  TITLE     Human UFSP1 is an active protease that regulates UFM1 maturation
            and UFMylation
  JOURNAL   Cell Rep 40 (5), 111168 (2022)
   PUBMED   35926457
  REMARK    GeneRIF: Human UFSP1 is an active protease that regulates UFM1
            maturation and UFMylation.
REFERENCE   4  (bases 1 to 995)
  AUTHORS   Liang,Q., Jin,Y., Xu,S., Zhou,J., Mao,J., Ma,X., Wang,M. and
            Cong,Y.S.
  TITLE     Human UFSP1 translated from an upstream near-cognate initiation
            codon functions as an active UFM1-specific protease
  JOURNAL   J Biol Chem 298 (6), 102016 (2022)
   PUBMED   35525273
  REMARK    GeneRIF: Human UFSP1 translated from an upstream near-cognate
            initiation codon functions as an active UFM1-specific protease.
REFERENCE   5  (bases 1 to 995)
  AUTHORS   Tutino,V.M., Lu,Y., Ishii,D., Poppenberg,K.E., Rajabzadeh-Oghaz,H.,
            Siddiqui,A.H. and Hasan,D.M.
  TITLE     Aberrant Whole Blood Gene Expression in the Lumen of Human
            Intracranial Aneurysms
  JOURNAL   Diagnostics (Basel) 11 (8), 1442 (2021)
   PUBMED   34441376
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 995)
  AUTHORS   Witting,K.F. and Mulder,M.P.C.
  TITLE     Highly Specialized Ubiquitin-Like Modifications: Shedding Light
            into the UFM1 Enigma
  JOURNAL   Biomolecules 11 (2), 255 (2021)
   PUBMED   33578803
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 995)
  AUTHORS   Huang,J., Sabater-Lleal,M., Asselbergs,F.W., Tregouet,D.,
            Shin,S.Y., Ding,J., Baumert,J., Oudot-Mellakh,T., Folkersen,L.,
            Johnson,A.D., Smith,N.L., Williams,S.M., Ikram,M.A., Kleber,M.E.,
            Becker,D.M., Truong,V., Mychaleckyj,J.C., Tang,W., Yang,Q.,
            Sennblad,B., Moore,J.H., Williams,F.M., Dehghan,A., Silbernagel,G.,
            Schrijvers,E.M., Smith,S., Karakas,M., Tofler,G.H., Silveira,A.,
            Navis,G.J., Lohman,K., Chen,M.H., Peters,A., Goel,A.,
            Hopewell,J.C., Chambers,J.C., Saleheen,D., Lundmark,P., Psaty,B.M.,
            Strawbridge,R.J., Boehm,B.O., Carter,A.M., Meisinger,C.,
            Peden,J.F., Bis,J.C., McKnight,B., Ohrvik,J., Taylor,K.,
            Franzosi,M.G., Seedorf,U., Collins,R., Franco-Cereceda,A.,
            Syvanen,A.C., Goodall,A.H., Yanek,L.R., Cushman,M.,
            Muller-Nurasyid,M., Folsom,A.R., Basu,S., Matijevic,N., van
            Gilst,W.H., Kooner,J.S., Hofman,A., Danesh,J., Clarke,R.,
            Meigs,J.B., Kathiresan,S., Reilly,M.P., Klopp,N., Harris,T.B.,
            Winkelmann,B.R., Grant,P.J., Hillege,H.L., Watkins,H.,
            Spector,T.D., Becker,L.C., Tracy,R.P., Marz,W., Uitterlinden,A.G.,
            Eriksson,P., Cambien,F., Morange,P.E., Koenig,W., Soranzo,N., van
            der Harst,P., Liu,Y., O'Donnell,C.J. and Hamsten,A.
  CONSRTM   DIAGRAM Consortium; CARDIoGRAM Consortium; C4D Consortium;
            CARDIOGENICS Consortium
  TITLE     Genome-wide association study for circulating levels of PAI-1
            provides novel insights into its regulation
  JOURNAL   Blood 120 (24), 4873-4881 (2012)
   PUBMED   22990020
REFERENCE   8  (bases 1 to 995)
  AUTHORS   Ha,B.H., Ahn,H.C., Kang,S.H., Tanaka,K., Chung,C.H. and Kim,E.E.
  TITLE     Structural basis for Ufm1 processing by UfSP1
  JOURNAL   J Biol Chem 283 (21), 14893-14900 (2008)
   PUBMED   18321862
REFERENCE   9  (bases 1 to 995)
  AUTHORS   Kang,S.H., Kim,G.R., Seong,M., Baek,S.H., Seol,J.H., Bang,O.S.,
            Ovaa,H., Tatsumi,K., Komatsu,M., Tanaka,K. and Chung,C.H.
  TITLE     Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases,
            UfSP1 and UfSP2
  JOURNAL   J Biol Chem 282 (8), 5256-5262 (2007)
   PUBMED   17182609
REFERENCE   10 (bases 1 to 995)
  AUTHORS   Wilson,M.D., Riemer,C., Martindale,D.W., Schnupf,P., Boright,A.P.,
            Cheung,T.L., Hardy,D.M., Schwartz,S., Scherer,S.W., Tsui,L.C.,
            Miller,W. and Koop,B.F.
  TITLE     Comparative analysis of the gene-dense ACHE/TFR2 region on human
            chromosome 7q22 with the orthologous region on mouse chromosome 5
  JOURNAL   Nucleic Acids Res 29 (6), 1352-1365 (2001)
   PUBMED   11239002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB073745.1, BC067904.1, BC017456.2 and AC011895.4.
            
            On Nov 22, 2018 this sequence version replaced NM_001015072.3.
            
            Summary: This gene encodes a protein that is similar to other
            Ufm1-specific proteases. Studies in mouse determined that Ufsp1
            releases Ufm1 (ubiquitin-fold modifier 1) from its bound conjugated
            complexes which also makes it into an active form. Because the
            human UFSP1 protein is shorter on the N-terminus and lacks a
            conserved Cys active site, it is predicted to be
            non-functional.[provided by RefSeq, Nov 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK292467.1, BC067904.1 [ECO:0000345]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                DB073745.1         4-37
            35-582              BC067904.1         1-548
            583-993             BC017456.2         521-931
            994-995             AC011895.4         130853-130854       c
FEATURES             Location/Qualifiers
     source          1..995
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..995
                     /gene="UFSP1"
                     /gene_synonym="UFSP"
                     /note="UFM1 specific peptidase 1"
                     /db_xref="GeneID:402682"
                     /db_xref="HGNC:HGNC:33821"
                     /db_xref="MIM:611481"
     exon            1..995
                     /gene="UFSP1"
                     /gene_synonym="UFSP"
                     /inference="alignment:Splign:2.1.0"
     CDS             445..873
                     /gene="UFSP1"
                     /gene_synonym="UFSP"
                     /note="isoform 2 is encoded by transcript variant 2;
                     inactive Ufm1-specific protease 1; UFM1 specific peptidase
                     1 (inactive); ufm1-specific protease 1"
                     /codon_start=1
                     /product="ufm1-specific protease 1 isoform 2"
                     /protein_id="NP_001015072.2"
                     /db_xref="CCDS:CCDS34710.1"
                     /db_xref="GeneID:402682"
                     /db_xref="HGNC:HGNC:33821"
                     /db_xref="MIM:611481"
                     /translation="MGDKPPGFRGSRDWIGCVEASLCLAHFGGPQGRLCHVPRGVGLH
                     GELERLYSHFAGGGGPVMVGGDADARSKALLGVCVGSGTEAYVLVLDPHYWGTPKSPS
                     ELQAAGWVGWQEVSAAFDPNSFYNLCLTSLSSQQQQRTLD"
     regulatory      970..975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UFSP1"
                     /gene_synonym="UFSP"
                     /note="hexamer: AATAAA"
     polyA_site      995
                     /gene="UFSP1"
                     /gene_synonym="UFSP"
                     /note="major polyA site"
ORIGIN      
        1 attgtgggag ctcctcggtc ggtgccggtc ggtggctgcc tattgcggcc tgcggtgatc
       61 aacgaggccc ggggagcgcg tccccagtct gcgcgccggt cctgcggcag ctggcccaag
      121 acccggagcc gaaaggaagt gttggagcct gaggtcgctc cgcgccgcta ggaggacgct
      181 gtgcctggcc tgggacctcc gctcccgccc accgccctgg agccgctgag ggacgtccac
      241 gtgggcctgt ccccgccgag ccgcggccct gtccgcctgg cgctgctctc gggccactac
      301 ctctactacc actacggctg cgacggcctg gacgaccgcg gctggggctg cggctaccgc
      361 actctgcaga cgctgtgctc gtggccagag ggccagcccg cgggcgtacc tggactggcc
      421 gccgtacagg cggccctgga ggacatgggc gacaagcccc ccggcttccg gggctcccgg
      481 gactggatcg gctgcgtgga ggccagcctc tgcctcgctc acttcggagg gccccaggga
      541 cgcctctgcc acgtaccccg gggagtgggg ctgcacgggg agctggagag gctttactcg
      601 cacttcgcag ggggtggggg cccagtcatg gttggggggg acgcagatgc caggtccaag
      661 gccttgctgg gagtctgcgt agggtcaggc acggaagcct atgtcctggt attggaccct
      721 cactactggg gcactccaaa aagccccagt gaactacagg ctgctgggtg ggtgggctgg
      781 caagaggtga gtgcagcctt tgaccccaac tccttctaca acctgtgctt gaccagcctt
      841 agctcccaac agcagcagcg caccttggac tgaggacgaa gttacagaac tgagattctc
      901 gggtcccaga cacgcaccta tgtacctccc actggtgtcc ctgcaaagcc tggcgctttt
      961 gacatcaata ataaaagtgg cagggctgag caaca
//
