LOCUS       NM_016617               3168 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens ubiquitin fold modifier 1 (UFM1), transcript variant
            1, mRNA.
ACCESSION   NM_016617
VERSION     NM_016617.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3168)
  AUTHORS   Ke,D., Guo,H.H., Jiang,N., Shi,R.S. and Fan,T.Y.
  TITLE     Inhibition of UFM1 expression suppresses cancer progression and is
            linked to the dismal prognosis and immune infiltration in oral
            squamous cell carcinoma
  JOURNAL   Aging (Albany NY) 15 (22), 13059-13076 (2023)
   PUBMED   37980168
  REMARK    GeneRIF: Inhibition of UFM1 expression suppresses cancer
            progression and is linked to the dismal prognosis and immune
            infiltration in oral squamous cell carcinoma.
REFERENCE   2  (bases 1 to 3168)
  AUTHORS   Ishimura,R., Ito,S., Mao,G., Komatsu-Hirota,S., Inada,T., Noda,N.N.
            and Komatsu,M.
  TITLE     Mechanistic insights into the roles of the UFM1 E3 ligase complex
            in ufmylation and ribosome-associated protein quality control
  JOURNAL   Sci Adv 9 (33), eadh3635 (2023)
   PUBMED   37595036
  REMARK    GeneRIF: Mechanistic insights into the roles of the UFM1 E3 ligase
            complex in ufmylation and ribosome-associated protein quality
            control.
REFERENCE   3  (bases 1 to 3168)
  AUTHORS   Chung,C.H. and Yoo,H.M.
  TITLE     Emerging role of protein modification by UFM1 in cancer
  JOURNAL   Biochem Biophys Res Commun 633, 61-63 (2022)
   PUBMED   36344165
  REMARK    GeneRIF: Emerging role of protein modification by UFM1 in cancer.
            Review article
REFERENCE   4  (bases 1 to 3168)
  AUTHORS   Mao,M., Chen,Y., Yang,J., Cheng,Y., Xu,L., Ji,F., Zhou,J.,
            Zhang,X., Li,Z., Chen,C., Ju,S., Zhang,J. and Wang,L.
  TITLE     Modification of PLAC8 by UFM1 affects tumorous proliferation and
            immune response by impacting PD-L1 levels in triple-negative breast
            cancer
  JOURNAL   J Immunother Cancer 10 (12) (2022)
   PUBMED   36543379
  REMARK    GeneRIF: Modification of PLAC8 by UFM1 affects tumorous
            proliferation and immune response by impacting PD-L1 levels in
            triple-negative breast cancer.
REFERENCE   5  (bases 1 to 3168)
  AUTHORS   Millrine,D., Cummings,T., Matthews,S.P., Peter,J.J.,
            Magnussen,H.M., Lange,S.M., Macartney,T., Lamoliatte,F., Knebel,A.
            and Kulathu,Y.
  TITLE     Human UFSP1 is an active protease that regulates UFM1 maturation
            and UFMylation
  JOURNAL   Cell Rep 40 (5), 111168 (2022)
   PUBMED   35926457
  REMARK    GeneRIF: Human UFSP1 is an active protease that regulates UFM1
            maturation and UFMylation.
REFERENCE   6  (bases 1 to 3168)
  AUTHORS   Tatsumi,K., Yamamoto-Mukai,H., Shimizu,R., Waguri,S., Sou,Y.S.,
            Sakamoto,A., Taya,C., Shitara,H., Hara,T., Chung,C.H., Tanaka,K.,
            Yamamoto,M. and Komatsu,M.
  TITLE     The Ufm1-activating enzyme Uba5 is indispensable for erythroid
            differentiation in mice
  JOURNAL   Nat Commun 2, 181 (2011)
   PUBMED   21304510
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3168)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
REFERENCE   8  (bases 1 to 3168)
  AUTHORS   Tatsumi,K., Sou,Y.S., Tada,N., Nakamura,E., Iemura,S., Natsume,T.,
            Kang,S.H., Chung,C.H., Kasahara,M., Kominami,E., Yamamoto,M.,
            Tanaka,K. and Komatsu,M.
  TITLE     A novel type of E3 ligase for the Ufm1 conjugation system
  JOURNAL   J Biol Chem 285 (8), 5417-5427 (2010)
   PUBMED   20018847
  REMARK    GeneRIF: A novel type of E3 ligase for the Ufm1 conjugation system.
REFERENCE   9  (bases 1 to 3168)
  AUTHORS   Sasakawa,H., Sakata,E., Yamaguchi,Y., Komatsu,M., Tatsumi,K.,
            Kominami,E., Tanaka,K. and Kato,K.
  TITLE     Solution structure and dynamics of Ufm1, a ubiquitin-fold modifier
            1
  JOURNAL   Biochem Biophys Res Commun 343 (1), 21-26 (2006)
   PUBMED   16527251
  REMARK    GeneRIF: The solution structure and dynamics of human Ufm1 (hsUfm1)
            by nuclear magnetic resonance spectroscopy was analysed.
REFERENCE   10 (bases 1 to 3168)
  AUTHORS   Komatsu,M., Chiba,T., Tatsumi,K., Iemura,S., Tanida,I., Okazaki,N.,
            Ueno,T., Kominami,E., Natsume,T. and Tanaka,K.
  TITLE     A novel protein-conjugating system for Ufm1, a ubiquitin-fold
            modifier
  JOURNAL   EMBO J 23 (9), 1977-1986 (2004)
   PUBMED   15071506
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356863.12.
            
            On Nov 23, 2018 this sequence version replaced NM_016617.3.
            
            Summary: UFM1 is a ubiquitin-like protein that is conjugated to
            target proteins by E1-like activating enzyme UBA5 (UBE1DC1; MIM
            610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a
            manner analogous to ubiquitylation (see UBE2M; MIM 603173) (Komatsu
            et al., 2004 [PubMed 15071506]).[supplied by OMIM, Dec 2008].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK095490.1, SRR1803616.158504.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239878.9/ ENSP00000239878.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AL356863.12        24711-24781
            72-128              AL356863.12        24859-24915
            129-186             AL356863.12        29099-29156
            187-226             AL356863.12        32953-32992
            227-259             AL356863.12        34161-34193
            260-3168            AL356863.12        35571-38479
FEATURES             Location/Qualifiers
     source          1..3168
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q13.3"
     gene            1..3168
                     /gene="UFM1"
                     /gene_synonym="BM-002; C13orf20; HLD14"
                     /note="ubiquitin fold modifier 1"
                     /db_xref="GeneID:51569"
                     /db_xref="HGNC:HGNC:20597"
                     /db_xref="MIM:610553"
     exon            1..71
                     /gene="UFM1"
                     /gene_synonym="BM-002; C13orf20; HLD14"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..327
                     /gene="UFM1"
                     /gene_synonym="BM-002; C13orf20; HLD14"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="ubiquitin-fold modifier 1 isoform 1"
                     /protein_id="NP_057701.1"
                     /db_xref="CCDS:CCDS9366.1"
                     /db_xref="GeneID:51569"
                     /db_xref="HGNC:HGNC:20597"
                     /db_xref="MIM:610553"
                     /translation="MSKVSFKITLTSDPRLPYKVLSVPESTPFTAVLKFAAEEFKVPA
                     ATSAIITNDGIGINPAQTAGNVFLKHGSELRIIPRDRVGSC"
     exon            72..128
                     /gene="UFM1"
                     /gene_synonym="BM-002; C13orf20; HLD14"
                     /inference="alignment:Splign:2.1.0"
     exon            129..186
                     /gene="UFM1"
                     /gene_synonym="BM-002; C13orf20; HLD14"
                     /inference="alignment:Splign:2.1.0"
     exon            187..226
                     /gene="UFM1"
                     /gene_synonym="BM-002; C13orf20; HLD14"
                     /inference="alignment:Splign:2.1.0"
     exon            227..259
                     /gene="UFM1"
                     /gene_synonym="BM-002; C13orf20; HLD14"
                     /inference="alignment:Splign:2.1.0"
     exon            260..3168
                     /gene="UFM1"
                     /gene_synonym="BM-002; C13orf20; HLD14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2413..2418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UFM1"
                     /gene_synonym="BM-002; C13orf20; HLD14"
                     /note="hexamer: AACAAG"
     polyA_site      2441
                     /gene="UFM1"
                     /gene_synonym="BM-002; C13orf20; HLD14"
     regulatory      2530..2535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UFM1"
                     /gene_synonym="BM-002; C13orf20; HLD14"
                     /note="hexamer: AATACA"
     polyA_site      2552
                     /gene="UFM1"
                     /gene_synonym="BM-002; C13orf20; HLD14"
                     /note="major polyA site"
     regulatory      3148..3153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UFM1"
                     /gene_synonym="BM-002; C13orf20; HLD14"
                     /note="hexamer: AATACA"
     polyA_site      3168
                     /gene="UFM1"
                     /gene_synonym="BM-002; C13orf20; HLD14"
ORIGIN      
        1 agcacactag aggaagtcgt gctacccccg cggagttgtc gtgtgttctg gattcattcc
       61 ggcaccacca tgtcgaaggt ttcctttaag atcacgctga cgtcggaccc acggctgccg
      121 tacaaagtac tcagtgttcc tgaaagtaca cctttcacag cagtcttaaa gtttgcagca
      181 gaagaattta aagttcctgc tgcaacaagt gcaattatta ccaatgatgg aataggaata
      241 aatcctgcac agactgctgg aaatgttttt ctaaaacatg gttcagaact gcggattatt
      301 cctagagatc gtgttggaag ttgttaatat ctgctacttg gaacatacga ttgcctttca
      361 gaataaatat tggtattttt tgttgttgta aaattgaaat caggcattta acatactatg
      421 aaaacaccag gagtcaatga ttaatgaaag gtgactcatc tgtccctttt tgttgtccat
      481 actcttccta tgaagaggga atgcgtatga attaaggcta ctactgtcac agaagatcat
      541 agtctttgat gctacctcac aacacaaaca ggtagttcgt tgggggcaaa tgaattagcc
      601 aactgttaac tggaagcttt tgataatttt tttttttaga acaatttgga acattaaaat
      661 ttactgaatc gtatatattc atctgagata aaaatataaa aagaattatg gaccctggat
      721 ggcaatttgc ttgatagcat ctgatttgca gactcataat ttgattttta attaaatata
      781 taggttgtga tgaagtgaat agacatatca gtgaacagtt aactatatta aatttttatc
      841 atttactttt tttaagattc agacctcagt tatataaatt tcagtttaat atcaaccaaa
      901 aaattaaaat tttaatctaa cccttatgtg tataaattgg tgtcccatac cagcttttaa
      961 tggtggacct atagaatcca gtacttttaa tggtgggaat ttacagtaga agcatccttt
     1021 gctgagttat acattccttt atcaatctct tttgatacaa catttaaaac aagtagcttc
     1081 aagaaaccac tggtgttttg aggatagtat ttctaaatag cattcaggaa cagagtatta
     1141 ttgcacagat ctgaagatca aaaaaaagct caaggaaata cagatcggaa gtgctgatga
     1201 gttatattta ttgaaaaccc aacttttaag gaagtgctaa gatcagtcac ccatgtgaat
     1261 aagaagccag gaaaggaaag atggggaagc ccagatcacc aggcttctat taaggaggaa
     1321 agcaacagag gaaacagtga aggggaacag aagggggtag caaagtgtta cagaaaagcg
     1381 gactggatag acaaaactgc agaaggtgta tgttggggag aactgaaagg gaaaacaaaa
     1441 tacttgacat agtcttaagt agaagaaggc agttagagaa aacaaagtat ctactggcct
     1501 tgtcaacata cagacttcaa aatacccctt atgagaatcc aaagaatgat gtgtgtaagg
     1561 gaagatttta tttgcccttc cggaagaaat cagtatctat gcaaatcttg aaagacgaaa
     1621 tcaaagccca ttaatgattc agaatcagtg cttgacctcc tgtattctga atggtgaact
     1681 ctggaagcag ggattgtgtc tggctctttt tagagctgga aatgtagtgg ctttcattaa
     1741 atacttgctg taaagtcttt ctaagaccaa ttattatctt agcatgtttc agtatcttct
     1801 ctatcatagg ccctaagttc attgggggaa aaaaaataag aagattcaac agaatcagca
     1861 tttgaagtgt accattggta gttgtttatg aaattaccag atattcataa atgtgacaaa
     1921 tgaacagcag gattatgaat tatcaaagga aaaagtattt gctgaggtga aaaaatctga
     1981 tgtttgagga agtttttatt tttatttatt tgttttgttt tttttttttt gaggcagact
     2041 ctctgtcgcc aggcttctcc tgcctcagcc tcacgagtag ctgggactac aggcatgcac
     2101 caccacgccc agctaatttt tgtattttta gcagagacag ggaggaagtt tttattttta
     2161 taaacaaaat ctgatgttca gaggccccgt ttcttacaat aaatgttgag tcttagttaa
     2221 gcaggaattt atgaacaccc atttcctgac tttttgcttt aatttagatt tttctccatc
     2281 ctgtttctag cacaaaaatt tgcctgctgt gttacaaaaa taaatttatg ttgtcctgtg
     2341 ccataaagtg atatatttaa tatttttatt ctttggtttt gaacattgta agttcctaaa
     2401 aacattttat taaacaagta gacattttgt tattaaaaaa atgtgatctg taatttcttt
     2461 gtgcagaatg atttgaagta ttgtattcag tttacatgcg ttattggttt ataattaata
     2521 tctaatgaaa atacatgttg ttatattgta aaccatattg tctgttctta ttattagagc
     2581 tcttaatcag cacacctttt gagtcagtat ataatacatg tagtaaagaa aaaaagggca
     2641 aagatgatta atgaccataa gtcagagaaa ttagtttata gtcatctgcc acagacatag
     2701 tagtgatgtt tcgtccaaca acagaccgca tatatgaccg tggtcccata ttactatatt
     2761 tttactgtgc tttatctatg tttggataca caagtactta ccatcatttt acagttgttt
     2821 acagtattag gtacagtaac atgctctaca ggtttgtagc ctaggagcaa taggccatac
     2881 caaatagcct aagtttgtag taggtgacat caactaggtt tgtacaagta cattctgatg
     2941 ttcacatagt gacaaaattg cctaaggaag catttctcag aatttgttcc tgtgattcag
     3001 tgatacataa cagtacttgc aaatgcctgt ccattttaca gacggaaaaa aaaaaaaaaa
     3061 aagttgagaa gaaaatgggg ttattgtaac tggctaggtt ggtaggttcc aaacctgggt
     3121 gataacagag tcgcctagga aattaaaaat acagattttt ggaaacca
//
