LOCUS       NM_016406                888 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens ubiquitin-fold modifier conjugating enzyme 1 (UFC1),
            mRNA.
ACCESSION   NM_016406
VERSION     NM_016406.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 888)
  AUTHORS   Makhlouf,L., Peter,J.J., Magnussen,H.M., Thakur,R., Millrine,D.,
            Minshull,T.C., Harrison,G., Varghese,J., Lamoliatte,F.,
            Foglizzo,M., Macartney,T., Calabrese,A.N., Zeqiraj,E. and
            Kulathu,Y.
  TITLE     The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER
            translocons
  JOURNAL   Nature 627 (8003), 437-444 (2024)
   PUBMED   38383789
REFERENCE   2  (bases 1 to 888)
  AUTHORS   Ishimura,R., Ito,S., Mao,G., Komatsu-Hirota,S., Inada,T., Noda,N.N.
            and Komatsu,M.
  TITLE     Mechanistic insights into the roles of the UFM1 E3 ligase complex
            in ufmylation and ribosome-associated protein quality control
  JOURNAL   Sci Adv 9 (33), eadh3635 (2023)
   PUBMED   37595036
REFERENCE   3  (bases 1 to 888)
  AUTHORS   Scavone,F., Gumbin,S.C., Da Rosa,P.A. and Kopito,R.R.
  TITLE     RPL26/uL24 UFMylation is essential for ribosome-associated quality
            control at the endoplasmic reticulum
  JOURNAL   Proc Natl Acad Sci U S A 120 (16), e2220340120 (2023)
   PUBMED   37036982
REFERENCE   4  (bases 1 to 888)
  AUTHORS   Peter,J.J., Magnussen,H.M., DaRosa,P.A., Millrine,D.,
            Matthews,S.P., Lamoliatte,F., Sundaramoorthy,R., Kopito,R.R. and
            Kulathu,Y.
  TITLE     A non-canonical scaffold-type E3 ligase complex mediates protein
            UFMylation
  JOURNAL   EMBO J 41 (21), e111015 (2022)
   PUBMED   36121123
REFERENCE   5  (bases 1 to 888)
  AUTHORS   Gupta,S. and Hashimoto,R.F.
  TITLE     Dynamical Analysis of a Boolean Network Model of the Oncogene Role
            of lncRNA ANRIL and lncRNA UFC1 in Non-Small Cell Lung Cancer
  JOURNAL   Biomolecules 12 (3), 420 (2022)
   PUBMED   35327612
  REMARK    GeneRIF: Dynamical Analysis of a Boolean Network Model of the
            Oncogene Role of lncRNA ANRIL and lncRNA UFC1 in Non-Small Cell
            Lung Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 888)
  AUTHORS   Zhang,Y., Zhang,M., Wu,J., Lei,G. and Li,H.
  TITLE     Transcriptional regulation of the Ufm1 conjugation system in
            response to disturbance of the endoplasmic reticulum homeostasis
            and inhibition of vesicle trafficking
  JOURNAL   PLoS One 7 (11), e48587 (2012)
   PUBMED   23152784
REFERENCE   7  (bases 1 to 888)
  AUTHORS   Tatsumi,K., Sou,Y.S., Tada,N., Nakamura,E., Iemura,S., Natsume,T.,
            Kang,S.H., Chung,C.H., Kasahara,M., Kominami,E., Yamamoto,M.,
            Tanaka,K. and Komatsu,M.
  TITLE     A novel type of E3 ligase for the Ufm1 conjugation system
  JOURNAL   J Biol Chem 285 (8), 5417-5427 (2010)
   PUBMED   20018847
REFERENCE   8  (bases 1 to 888)
  AUTHORS   Liu,G., Forouhar,F., Eletsky,A., Atreya,H.S., Aramini,J.M.,
            Xiao,R., Huang,Y.J., Abashidze,M., Seetharaman,J., Liu,J., Rost,B.,
            Acton,T., Montelione,G.T., Hunt,J.F. and Szyperski,T.
  TITLE     NMR and X-RAY structures of human E2-like ubiquitin-fold modifier
            conjugating enzyme 1 (UFC1) reveal structural and functional
            conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway
  JOURNAL   J Struct Funct Genomics 10 (2), 127-136 (2009)
   PUBMED   19101823
  REMARK    GeneRIF: The structure of human Ufc1 was solved by using both NMR
            spectroscopy and X-ray crystallography
REFERENCE   9  (bases 1 to 888)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   10 (bases 1 to 888)
  AUTHORS   Komatsu,M., Chiba,T., Tatsumi,K., Iemura,S., Tanida,I., Okazaki,N.,
            Ueno,T., Kominami,E., Natsume,T. and Tanaka,K.
  TITLE     A novel protein-conjugating system for Ufm1, a ubiquitin-fold
            modifier
  JOURNAL   EMBO J 23 (9), 1977-1986 (2004)
   PUBMED   15071506
  REMARK    GeneRIF: Identification of a novel enzyme called UFC1 for
            Ufm1-conjugating enzyme 1.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF151884.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016406.3.
            
            Summary: UFC1 is an E2-like conjugating enzyme for ubiquitin-fold
            modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed
            15071506]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF151884.1, AF161504.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368003.6/ ENSP00000356982.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-888               AF151884.1         202-1089
FEATURES             Location/Qualifiers
     source          1..888
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..888
                     /gene="UFC1"
                     /gene_synonym="HSPC155; NEDSG"
                     /note="ubiquitin-fold modifier conjugating enzyme 1"
                     /db_xref="GeneID:51506"
                     /db_xref="HGNC:HGNC:26941"
                     /db_xref="MIM:610554"
     exon            1..143
                     /gene="UFC1"
                     /gene_synonym="HSPC155; NEDSG"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..524
                     /gene="UFC1"
                     /gene_synonym="HSPC155; NEDSG"
                     /note="Ufm1-conjugating enzyme 1"
                     /codon_start=1
                     /product="ubiquitin-fold modifier-conjugating enzyme 1"
                     /protein_id="NP_057490.2"
                     /db_xref="CCDS:CCDS1220.1"
                     /db_xref="GeneID:51506"
                     /db_xref="HGNC:HGNC:26941"
                     /db_xref="MIM:610554"
                     /translation="MADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVE
                     NNKNADNDWFRLESNKEGTRWFGKCWYIHDLLKYEFDIEFDIPITYPTTAPEIAVPEL
                     DGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGLGPWLAVEIPDLIQKGVIQ
                     HKEKCNQ"
     exon            144..211
                     /gene="UFC1"
                     /gene_synonym="HSPC155; NEDSG"
                     /inference="alignment:Splign:2.1.0"
     exon            212..275
                     /gene="UFC1"
                     /gene_synonym="HSPC155; NEDSG"
                     /inference="alignment:Splign:2.1.0"
     exon            276..352
                     /gene="UFC1"
                     /gene_synonym="HSPC155; NEDSG"
                     /inference="alignment:Splign:2.1.0"
     exon            353..443
                     /gene="UFC1"
                     /gene_synonym="HSPC155; NEDSG"
                     /inference="alignment:Splign:2.1.0"
     exon            444..888
                     /gene="UFC1"
                     /gene_synonym="HSPC155; NEDSG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      866..871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UFC1"
                     /gene_synonym="HSPC155; NEDSG"
                     /note="hexamer: AATAAA"
     polyA_site      888
                     /gene="UFC1"
                     /gene_synonym="HSPC155; NEDSG"
                     /note="major polyA site"
ORIGIN      
        1 ctcttgcgcc ctggtccaag atggcggatg aagccacgcg acgtgttgtg tctgagatcc
       61 cggtgctgaa gactaacgcc ggaccccgag atcgtgagtt gtgggtgcag cgactgaagg
      121 aggaatatca gtcccttatc cggtatgtgg agaacaacaa gaatgctgac aacgattggt
      181 tccgactgga gtccaacaag gaaggaactc ggtggtttgg aaaatgctgg tatatccatg
      241 acctcctgaa atatgagttt gacatcgagt ttgacattcc tatcacatat cctactactg
      301 ccccagaaat tgcagttcct gagctggatg gaaagacagc aaagatgtac aggggtggca
      361 aaatatgcct gacggatcat ttcaaacctt tgtgggccag gaatgtgccc aaatttggac
      421 tagctcatct catggctctg gggctgggtc catggctggc agtggaaatc cctgatctga
      481 ttcagaaggg cgtcatccaa cacaaagaga aatgcaacca atgaagaatc aagccactga
      541 ggcagggcag agggaccttt gataggctac gatactattt tcctgtgcat cacacttaac
      601 tcatctaact gcttccccgg acaccctcca cctctagttg ttactaagta gctgcagtag
      661 gcattgctgg ggaagaaaca aacacacacc aaacagtact gctacttagt ttctaaggct
      721 gcacagggaa gggaaagact gggctttgga caatctagag gtaatttata tccgccccca
      781 ggtggagcaa catgcgattc tggaggcacg ggggtaactg aaagtgagta catatagtct
      841 ttctggtttc tggagataac ccatcaataa aagctgcttc ctctggta
//
