LOCUS       NM_001040697            4207 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens UEV and lactate/malate dehyrogenase domains (UEVLD),
            transcript variant 1, mRNA.
ACCESSION   NM_001040697
VERSION     NM_001040697.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4207)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4207)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 4207)
  AUTHORS   Kloor,M., Bork,P., Duwe,A., Klaes,R., von Knebel Doeberitz,M. and
            Ridder,R.
  TITLE     Identification and characterization of UEV3, a human cDNA with
            similarities to inactive E2 ubiquitin-conjugating enzymes
  JOURNAL   Biochim Biophys Acta 1579 (2-3), 219-224 (2002)
   PUBMED   12427560
  REMARK    GeneRIF: identification, sequencing and analysis of cDNA in various
            colon carcinoma cell lines as well as normal and tumor samples from
            colon
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112694.12 and AC027544.11.
            
            On Nov 23, 2018 this sequence version replaced NM_001040697.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.262348.1,
                                           SRR1660807.158026.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396197.8/ ENSP00000379500.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               AC112694.12        21235-21356         c
            123-207             AC112694.12        11346-11430         c
            208-273             AC112694.12        7969-8034           c
            274-437             AC112694.12        2836-2999           c
            438-573             AC027544.11        49405-49540
            574-692             AC027544.11        50877-50995
            693-795             AC027544.11        57557-57659
            796-966             AC027544.11        68837-69007
            967-1140            AC027544.11        71091-71264
            1141-1204           AC027544.11        79418-79481
            1205-1328           AC027544.11        81434-81557
            1329-4207           AC027544.11        83400-86278
FEATURES             Location/Qualifiers
     source          1..4207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..4207
                     /gene="UEVLD"
                     /gene_synonym="ATTP; UEV3"
                     /note="UEV and lactate/malate dehyrogenase domains"
                     /db_xref="GeneID:55293"
                     /db_xref="HGNC:HGNC:30866"
                     /db_xref="MIM:610985"
     exon            1..122
                     /gene="UEVLD"
                     /gene_synonym="ATTP; UEV3"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1496
                     /gene="UEVLD"
                     /gene_synonym="ATTP; UEV3"
                     /note="isoform a is encoded by transcript variant 1;
                     signaling molecule ATTP; UEV-3; EV and lactate/malate
                     dehydrogenase domain-containing protein"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 variant 3
                     isoform a"
                     /protein_id="NP_001035787.1"
                     /db_xref="CCDS:CCDS41624.1"
                     /db_xref="GeneID:55293"
                     /db_xref="HGNC:HGNC:30866"
                     /db_xref="MIM:610985"
                     /translation="MEFDCEGLRRLLGKYKFRDLTVEELRNVNVFFPHFKYSMDTYVF
                     KDSSQKDLLNFTGTIPVMYQGNTYNIPIRFWILDSHPFAPPICFLKPTANMGILVGKH
                     VDAQGRIYLPYLQNWSHPKSVIVGLIKEMIAKFQEELPMYSLSSSDEARQVDLLAYIA
                     KITEGVSDTNSKSWANHENKTVNKITVVGGGELGIACTLAISAKGIADRLVLLDLSEG
                     TKGATMDLEIFNLPNVEISKDLSASAHSKVVIFTVNSLGSSQSYLDVVQSNVDMFRAL
                     VPALGHYSQHSVLLVASQPVEIMTYVTWKLSTFPANRVIGIGCNLDSQRLQYIITNVL
                     KAQTSGKEVWVIGEQGEDKVLTWSGQEEVVSHTSQVQLSNRAMELLRVKGQRSWSVGL
                     SVADMVDSIVNNKKKVHSVSALAKGYYDINSEVFLSLPCILGTNGVSEVIKTTLKEDT
                     VTEKLQSSASSIHSLQQQLKL"
     exon            123..207
                     /gene="UEVLD"
                     /gene_synonym="ATTP; UEV3"
                     /inference="alignment:Splign:2.1.0"
     exon            208..273
                     /gene="UEVLD"
                     /gene_synonym="ATTP; UEV3"
                     /inference="alignment:Splign:2.1.0"
     exon            274..437
                     /gene="UEVLD"
                     /gene_synonym="ATTP; UEV3"
                     /inference="alignment:Splign:2.1.0"
     exon            438..573
                     /gene="UEVLD"
                     /gene_synonym="ATTP; UEV3"
                     /inference="alignment:Splign:2.1.0"
     exon            574..692
                     /gene="UEVLD"
                     /gene_synonym="ATTP; UEV3"
                     /inference="alignment:Splign:2.1.0"
     exon            693..795
                     /gene="UEVLD"
                     /gene_synonym="ATTP; UEV3"
                     /inference="alignment:Splign:2.1.0"
     exon            796..966
                     /gene="UEVLD"
                     /gene_synonym="ATTP; UEV3"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1140
                     /gene="UEVLD"
                     /gene_synonym="ATTP; UEV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1204
                     /gene="UEVLD"
                     /gene_synonym="ATTP; UEV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1328
                     /gene="UEVLD"
                     /gene_synonym="ATTP; UEV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..4207
                     /gene="UEVLD"
                     /gene_synonym="ATTP; UEV3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4187..4192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UEVLD"
                     /gene_synonym="ATTP; UEV3"
                     /note="hexamer: AATAAA"
     polyA_site      4207
                     /gene="UEVLD"
                     /gene_synonym="ATTP; UEV3"
                     /note="major polyA site"
ORIGIN      
        1 agcggcttcc gtcctgcagc aagtccggaa gaaggtccgg gggctggagt cctgggacct
       61 agctcgggac cggcctggag atggagttcg actgcgaggg cctgagacgg ctgcttggca
      121 agtacaagtt cagggaccta actgtggaag aactaaggaa tgtaaatgta tttttcccac
      181 atttcaaata ttccatggac acctatgttt ttaaagatag ttctcagaaa gacctgctga
      241 attttactgg cacaattcct gtgatgtatc agggtaatac atataacata ccaattcgtt
      301 tctggatttt ggattctcac cctttcgctc cccctatttg cttcttgaag ccaactgcaa
      361 atatgggaat cttagtcgga aaacatgtgg atgctcaagg cagaatatat ttgccctatc
      421 tccaaaactg gagccatcct aaatctgtca ttgttggatt aattaaagaa atgattgcca
      481 agtttcaaga ggaacttccc atgtattctc tatcatcatc tgatgaggca cggcaggtag
      541 acttgctagc ctatattgca aaaatcactg aaggtgtttc agatacaaat tcaaagagct
      601 gggcaaatca tgagaataaa acagtcaata aaattactgt ggttggaggt ggagaactcg
      661 gtattgcctg cacattagca atttcagcaa agggtattgc agacaggctt gtcctcttag
      721 acctctcaga agggactaaa ggagccacga tggaccttga aatcttcaac cttcctaatg
      781 tggagatcag caaagatttg tctgcctctg ctcattccaa ggtggtgatc ttcacagtca
      841 actctttggg tagttctcag tcgtaccttg atgtggtaca gagcaatgtg gatatgttca
      901 gagcccttgt cccagctctg ggacattata gtcaacacag tgtcctgctc gttgcatctc
      961 aaccagtgga aatcatgacc tatgtaacat ggaaactgag tacatttcct gcaaatcgag
     1021 tgatcggaat tggatgtaat ctggattcac agagattaca gtatattatt acaaatgttt
     1081 tgaaggcaca gacttcaggc aaagaagtat gggttattgg cgagcaagga gaagacaaag
     1141 tgctcacatg gagtggccaa gaagaagtag tgagtcatac ctctcaagtg cagctgtcca
     1201 acagagccat ggaactgcta agagtaaaag gtcaaagatc ctggtctgtt ggactatcag
     1261 tagctgacat ggttgacagt attgtaaaca ataagaagaa agtgcattct gtatcagctt
     1321 tagcaaaggg atattatgat ataaatagtg aagtgttttt aagtttgcct tgcatccttg
     1381 gaaccaatgg agtatctgaa gttatcaaaa ccacactgaa agaagataca gttactgaga
     1441 aactccaaag cagtgcatcc tcaatccaca gtctccaaca acagttaaaa ctttgattct
     1501 caaatgcaat ttgagaggct ggacttctac ctaaagggaa aagtcattta attttaccta
     1561 tatataggtt tgaggatttc tgtatcctgc tacttacttt tacaaactgc ttggttaaag
     1621 tagagggttt cttgattagc tttgtgatgt aaatccttaa ggagttatac aaggagggga
     1681 aaaattaatt ttatttgggg ttcttgagat atctatgctg ttctttaaat ctacagcagg
     1741 ggtaaacatt catctgcagt gtgcatcaat ttaaatcata tatcctaaac taaaagcaca
     1801 attcatactt cgggaatatt ttataagtaa tatatcttta aaagaaaatt accctttgac
     1861 ttttataatc aacataagtt ccaggcccag tatggattta caaaatctgt gtcagttgta
     1921 cattcacagg atccacagct taagttacta atgtttcttg tgtaaaatcc tgttggtagt
     1981 aatagtaaag cattgtattt cccttcttca aattaattac ctaccaaaaa atggaaaaga
     2041 attttacatg cactttaaaa tagtaaaatg gaaagtgaat ttttaaaata tatgcattaa
     2101 aagtttactt taatttccag tgggacttcc tttatgaaat tttccataac ctcttcctgg
     2161 agtattacaa gatctccaac atctcataaa ctaattgtga tattagtgga accataagca
     2221 aatatatatt tttagtggaa atagattatg aatgaaagcc aagcacctta ctttaaagcc
     2281 aaaatatgag attttcatta aaaacattgg tcataatagg gagaggtttt ttatttgttc
     2341 tgagcaaatc ctttaacctc tcctgatgat acagttcaga gtacacacac tttggtgatg
     2401 gatcaagagc aatattttct tatgtgaaag atagcttatt attactattg tgacatacaa
     2461 ctaatagtaa cagttaacat caacacttca tatataccag gcagcatgat aagcacttta
     2521 ttattttact gaatcctcac aacagaccac tgaggtaggg actattgcca tcatcatttt
     2581 ataaaaggaa attgaggttt agtcctcaag aagtcttggc tattaagggg cacttatcca
     2641 tacaacctct actttttcta ggcactaaaa gggggaaaag gcttaatagc caaaatagtt
     2701 atcaaaagac cctaaagctg gggtcctgta caccatgaaa ggattacttt cattctcatg
     2761 taagggcatg cttttataaa aaacaaacat gggctaggcg cagtgactca cgcctgtaat
     2821 cccagcacct tgggaggctg aggcgggcag atcacgaggt caggagattg agatcatcct
     2881 ggctaacatg gtgaaaccct gtctctacta aaaatacaaa aagttagcca ggcgtggtgg
     2941 caggtgcctg tagtcccagc tactcggaag gctgaggcaa gagaatggcg tgaacccggt
     3001 aggtggagct tgcagtgagc agagatcgcg ccactgcact ccagcctggg cgacagagca
     3061 agactccgtc tcaaaaaaaa aaaaaaaaag tttaaaaatt agccaggtgt ggtgatgtgc
     3121 acctgtagtt ccagctactc aggagggtga ggcaggagga tcacttgagc ccagaagttc
     3181 aagattgcaa tgagctatga tcatgctact gcactccagc ctaggcaaca gagtgagacc
     3241 ctgtctctaa aaaaataaaa ataaagcaag catataatag gttaatccag atggagttag
     3301 gagggtttat aagggcagac acatcctagt aaagaggaaa taggcaaact aatgctgttt
     3361 tagtgtaata aggaatgctt ataatgatga actttagtca taaagaaaag gtgaaattat
     3421 attcagtaac ccatgttagg aaagcagaaa actatttaat atgcttggaa agattccaac
     3481 cagagttaac tgaataaaaa ccttggacat ttgaagagaa aagcatttag ttctatctaa
     3541 tttcaatatg cacgtgaatt agttcatgtt actctaacaa tgtattctta ctgtcctttt
     3601 ttatgaaata ggaaagtaaa actgaaagaa ctatttcttg tgtttttaaa actagccttt
     3661 tctaatattt gatatctaat taaagttaga taatatgtaa tatgcttttg aacaataatc
     3721 taaccagaaa atattgtata ataaattacc aagaaatcat tacattaatt ataaaaggaa
     3781 catgtcaata caacaaatgt ttatttaaca cctactgtta ctccaaatac tgtgttagaa
     3841 tttgactatt cgaagatgaa taatagtctt tgccctctgg aaggccacaa tgtagaagta
     3901 attctctgta tcagatattt ccttgagtgt taagtgtatt agtaatcatg ttgtaaatcc
     3961 cagtgtaagt caagaagcaa tatcaccacc accacctccc tatgattttg tgataatttg
     4021 gcattttcaa tgcttgttaa ctttcatgtt ttcattttta tgaaatcatg cagagcttgt
     4081 tataattttt agtggggttt ggattaaaat gcttttttga tgtagcagaa gatacatttt
     4141 ttcccatttt acattgtttt ccttaaatat taagaataat gagtaaaata aactgatttt
     4201 aaaatca
//
