LOCUS       NM_003356               2277 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens uncoupling protein 3 (UCP3), transcript variant long,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_003356
VERSION     NM_003356.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2277)
  AUTHORS   De Leonardis,F., Ahmed,A., Vozza,A., Capobianco,L., Riley,C.L.,
            Barile,S.N., Di Molfetta,D., Tiziani,S., DiGiovanni,J.,
            Palmieri,L., Dolce,V. and Fiermonte,G.
  TITLE     Human mitochondrial uncoupling protein 3 functions as a metabolite
            transporter
  JOURNAL   FEBS Lett 598 (3), 338-346 (2024)
   PUBMED   38058167
  REMARK    GeneRIF: Human mitochondrial uncoupling protein 3 functions as a
            metabolite transporter.
REFERENCE   2  (bases 1 to 2277)
  AUTHORS   Huesca-Gomez,C., Torres-Paz,Y.E., Fuentevilla-Alvarez,G.,
            Gonzalez-Moyotl,N.J., Ramirez-Marroquin,E.S., Vasquez-Jimenez,X.,
            Sainz-Escarrega,V., Soto,M.E., Samano,R. and Gamboa,R.
  TITLE     Expressions of mRNA and encoded proteins of mitochondrial
            uncoupling protein genes (UCP1, UCP2, and UCP3) in epicardial and
            mediastinal adipose tissue and associations with coronary artery
            disease
  JOURNAL   Arch Endocrinol Metab 67 (2), 214-223 (2023)
   PUBMED   36651711
  REMARK    GeneRIF: Expressions of mRNA and encoded proteins of mitochondrial
            uncoupling protein genes (UCP1, UCP2, and UCP3) in epicardial and
            mediastinal adipose tissue and associations with coronary artery
            disease.
REFERENCE   3  (bases 1 to 2277)
  AUTHORS   Fortes,J.S., Pinto,R.M., de Souza,R.F., Godoy,F.R., da Cruz,R.S.,
            de M E Silva,D., Filho,H.P.L., da Cruz,A.D. and Minasi,L.B.
  TITLE     The influence of six polymorphisms of uncoupling protein 3 (UCP3)
            gene and childhood obesity: a case-control study
  JOURNAL   BMC Pediatr 23 (1), 87 (2023)
   PUBMED   36810017
  REMARK    GeneRIF: The influence of six polymorphisms of uncoupling protein 3
            (UCP3) gene and childhood obesity: a case-control study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2277)
  AUTHORS   Codella,R., Alves,T.C., Befroy,D.E., Choi,C.S., Luzi,L.,
            Rothman,D.L., Kibbey,R.G. and Shulman,G.I.
  TITLE     Overexpression of UCP3 decreases mitochondrial efficiency in mouse
            skeletal muscle in vivo
  JOURNAL   FEBS Lett 597 (2), 309-319 (2023)
   PUBMED   36114012
REFERENCE   5  (bases 1 to 2277)
  AUTHORS   Nikanorova,A.A., Barashkov,N.A., Pshennikova,V.G., Gotovtsev,N.N.,
            Romanov,G.P., Solovyev,A.V., Kuzmina,S.S., Sazonov,N.N. and
            Fedorova,S.A.
  TITLE     Relationships between Uncoupling Protein Genes UCP1, UCP2 and UCP3
            and Irisin Levels in Residents of the Coldest Region of Siberia
  JOURNAL   Genes (Basel) 13 (9), 1612 (2022)
   PUBMED   36140780
  REMARK    GeneRIF: Relationships between Uncoupling Protein Genes UCP1, UCP2
            and UCP3 and Irisin Levels in Residents of the Coldest Region of
            Siberia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2277)
  AUTHORS   Boss,O., Giacobino,J.P. and Muzzin,P.
  TITLE     Genomic structure of uncoupling protein-3 (UCP3) and its assignment
            to chromosome 11q13
  JOURNAL   Genomics 47 (3), 425-426 (1998)
   PUBMED   9480760
REFERENCE   7  (bases 1 to 2277)
  AUTHORS   Solanes,G., Vidal-Puig,A., Grujic,D., Flier,J.S. and Lowell,B.B.
  TITLE     The human uncoupling protein-3 gene. Genomic structure, chromosomal
            localization, and genetic basis for short and long form transcripts
  JOURNAL   J Biol Chem 272 (41), 25433-25436 (1997)
   PUBMED   9325252
REFERENCE   8  (bases 1 to 2277)
  AUTHORS   Gong,D.W., He,Y., Karas,M. and Reitman,M.
  TITLE     Uncoupling protein-3 is a mediator of thermogenesis regulated by
            thyroid hormone, beta3-adrenergic agonists, and leptin
  JOURNAL   J Biol Chem 272 (39), 24129-24132 (1997)
   PUBMED   9305858
REFERENCE   9  (bases 1 to 2277)
  AUTHORS   Vidal-Puig,A., Solanes,G., Grujic,D., Flier,J.S. and Lowell,B.B.
  TITLE     UCP3: an uncoupling protein homologue expressed preferentially and
            abundantly in skeletal muscle and brown adipose tissue
  JOURNAL   Biochem Biophys Res Commun 235 (1), 79-82 (1997)
   PUBMED   9196039
REFERENCE   10 (bases 1 to 2277)
  AUTHORS   Boss,O., Samec,S., Paoloni-Giacobino,A., Rossier,C., Dulloo,A.,
            Seydoux,J., Muzzin,P. and Giacobino,J.P.
  TITLE     Uncoupling protein-3: a new member of the mitochondrial carrier
            family with tissue-specific expression
  JOURNAL   FEBS Lett 408 (1), 39-42 (1997)
   PUBMED   9180264
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA876282.1, U84763.1,
            BC008392.1, BU618868.1, AW295096.1 and AP003717.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003356.3.
            
            Summary: Mitochondrial uncoupling proteins (UCP) are members of the
            larger family of mitochondrial anion carrier proteins (MACP). UCPs
            separate oxidative phosphorylation from ATP synthesis with energy
            dissipated as heat, also referred to as the mitochondrial proton
            leak. UCPs facilitate the transfer of anions from the inner to the
            outer mitochondrial membrane and the return transfer of protons
            from the outer to the inner mitochondrial membrane. They also
            reduce the mitochondrial membrane potential in mammalian cells. The
            different UCPs have tissue-specific expression; this gene is
            primarily expressed in skeletal muscle. This gene's protein product
            is postulated to protect mitochondria against lipid-induced
            oxidative stress. Expression levels of this gene increase when
            fatty acid supplies to mitochondria exceed their oxidation capacity
            and the protein enables the export of fatty acids from
            mitochondria. UCPs contain the three solcar protein domains
            typically found in MACPs. Two splice variants have been found for
            this gene.[provided by RefSeq, Nov 2008].
            
            Transcript Variant: This variant (long) encodes the full length
            isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279875.3233.1, ERR279867.2173.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000314032.9/
                                                  ENSP00000323740.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                DA876282.1         153-202
            51-1281             U84763.1           1-1231
            1282-1578           BC008392.1         973-1269
            1579-1579           BU618868.1         762-762
            1580-2121           BC008392.1         1271-1812
            2122-2273           AW295096.1         14-165              c
            2274-2277           AP003717.3         60359-60362         c
FEATURES             Location/Qualifiers
     source          1..2277
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..2277
                     /gene="UCP3"
                     /gene_synonym="SLC25A9"
                     /note="uncoupling protein 3"
                     /db_xref="GeneID:7352"
                     /db_xref="HGNC:HGNC:12519"
                     /db_xref="MIM:602044"
     exon            1..108
                     /gene="UCP3"
                     /gene_synonym="SLC25A9"
                     /inference="alignment:Splign:2.1.0"
     exon            109..329
                     /gene="UCP3"
                     /gene_synonym="SLC25A9"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1142
                     /gene="UCP3"
                     /gene_synonym="SLC25A9"
                     /note="isoform UCP3L is encoded by transcript variant
                     long; mitochondrial uncoupling protein 3; putative
                     mitochondrial transporter UCP3; solute carrier family 25
                     member 9; uncoupling protein 3 (mitochondrial, proton
                     carrier)"
                     /codon_start=1
                     /product="putative mitochondrial transporter UCP3 isoform
                     UCP3L"
                     /protein_id="NP_003347.1"
                     /db_xref="CCDS:CCDS8229.1"
                     /db_xref="GeneID:7352"
                     /db_xref="HGNC:HGNC:12519"
                     /db_xref="MIM:602044"
                     /translation="MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQ
                     GENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSV
                     KQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYS
                     GTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFP
                     CHFVSAFGAGFCATVVASPVDVVKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGF
                     TPSFLRLGSWNVVMFVTYEQLKRALMKVQMLRESPF"
     exon            330..540
                     /gene="UCP3"
                     /gene_synonym="SLC25A9"
                     /inference="alignment:Splign:2.1.0"
     exon            541..744
                     /gene="UCP3"
                     /gene_synonym="SLC25A9"
                     /inference="alignment:Splign:2.1.0"
     exon            745..846
                     /gene="UCP3"
                     /gene_synonym="SLC25A9"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1027
                     /gene="UCP3"
                     /gene_synonym="SLC25A9"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..2277
                     /gene="UCP3"
                     /gene_synonym="SLC25A9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2235..2240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UCP3"
                     /gene_synonym="SLC25A9"
                     /note="hexamer: AATAAA"
     polyA_site      2277
                     /gene="UCP3"
                     /gene_synonym="SLC25A9"
                     /note="major polyA site"
ORIGIN      
        1 agagacaaca gtgaatgaca aggaggggcc atccaatccc tgctgccacc tcctgggatg
       61 gagccctagg gagcccctgt gctgcccctg ccgtggcagg actcacagcc ccaccgctgc
      121 actgaagccc agggctgtgg agcagcctct ctccttggac ctcctctcgg ccctaaaggg
      181 actgggcaga gccttccagg actatggttg gactgaagcc ttcagacgtg cctcccacca
      241 tggctgtgaa gttcctgggg gcaggcacag cagcctgttt tgctgacctc gttacctttc
      301 cactggacac agccaaggtc cgcctgcaga tccaggggga gaaccaggcg gtccagacgg
      361 cccggctcgt gcagtaccgt ggcgtgctgg gcaccatcct gaccatggtg cggactgagg
      421 gtccctgcag cccctacaat gggctggtgg ccggcctgca gcgccagatg agcttcgcct
      481 ccatccgcat cggcctctat gactccgtca agcaggtgta cacccccaaa ggcgcggaca
      541 actccagcct cactacccgg attttggccg gctgcaccac aggagccatg gcggtgacct
      601 gtgcccagcc cacagatgtg gtgaaggtcc gatttcaggc cagcatacac ctcgggccat
      661 ccaggagcga cagaaaatac agcgggacta tggacgccta cagaaccatc gccagggagg
      721 aaggagtcag gggcctgtgg aaaggaactt tgcccaacat catgaggaat gctatcgtca
      781 actgtgctga ggtggtgacc tacgacatcc tcaaggagaa gctgctggac taccacctgc
      841 tcactgacaa cttcccctgc cactttgtct ctgcctttgg agccggcttc tgtgccacag
      901 tggtggcctc cccggtggac gtggtgaaga cccggtatat gaactcacct ccaggccagt
      961 acttcagccc cctcgactgt atgataaaga tggtggccca ggagggcccc acagccttct
     1021 acaagggatt tacaccctcc tttttgcgtt tgggatcctg gaacgtggtg atgttcgtaa
     1081 cctatgagca gctgaaacgg gccctgatga aagtccagat gttacgggaa tcaccgtttt
     1141 gaacaagaca agaaggccac tggtagctaa cgtgtccgaa accagttaag aatggaagaa
     1201 aacggtgcat ccacgcacac atggacacag acccacacat gtttacagaa ctgttgttta
     1261 cttgttgctg attcaagaaa cagaagtaga agaggaggag ggattctggt cttcactgcc
     1321 atgcctcaag aacacctttg ttttgcactg acaagatgga aaataaatta tattaatttt
     1381 tgaaacccat taggcatgcc taatatttag gcaagagaaa ataaaccaag atagatccat
     1441 ttggacaaaa tggaaggttg gagacgtgta tccccgtgaa atctggttag ataatgaatg
     1501 ataagcagga aggatggcaa gcacgggaca ggaggggccc acaatggagt gggagatcag
     1561 ccacggagcc tggagggatg ccacccagca acacagagct ggcgactgca gctgcaccat
     1621 cacacatgca tcatcagcct atttgtaata tgtctgccac agagagtcct ttgggattct
     1681 aggaaaccca aggaacaaga gaaaaaacta gagcctgtgc taaagaagcc ctgctgggcc
     1741 catgtgaggc tggggctcgt aaatattccc tgacgacact gaagaatcaa gagggcagcc
     1801 cccactttcc tacaaaatgg agggagccat cccttccctg tccacctcac caggggtgct
     1861 atgacatgca agtgagaagc tgggcatgaa cgcactttat aaaagcaaaa gctctgtgta
     1921 aatctaacta caaggacaat gccttgggag agattttgtc gggacagaga ggagttgcca
     1981 gggaagaagg tttgaaagat acggttgtct agaggtgaga ccaaaggatc cagagacttg
     2041 gggaccagag gtgacagtgg atgacgtgaa gccacaggag ccccaccccc atgcagcctc
     2101 ttccccaccc cccccaccac gtgctcaatc atgagtacct caaaggattg ttgggcttgg
     2161 gggaaaagag gtggattcct gggcaagaac ctaaagtagc aggactcgga attctcggga
     2221 aattattatg actcaataaa agaattcaca ccttaggtgt gggagtaaga acagcca
//
