LOCUS       NM_003355               1644 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens uncoupling protein 2 (UCP2), transcript variant 2,
            mRNA.
ACCESSION   NM_003355
VERSION     NM_003355.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1644)
  AUTHORS   Beikbaghban,T., Proietti,L., Ebner,J., Sango,R., Rattei,T.,
            Weichhart,T., Grebien,F., Sternberg,F. and Pohl,E.E.
  TITLE     Differential regulation of mitochondrial uncoupling protein 2 in
            cancer cells
  JOURNAL   Biochim Biophys Acta Bioenerg 1865 (4), 149486 (2024)
   PUBMED   38986826
  REMARK    GeneRIF: Differential regulation of mitochondrial uncoupling
            protein 2 in cancer cells.
REFERENCE   2  (bases 1 to 1644)
  AUTHORS   Sadeghi,S., Checchetto,V. and Varanita,T.
  TITLE     A Comprehensive Pan-Cancer Analysis of the Mitochondrial Uncoupling
            Protein UCP2, with a Focus on Sex and Gender-Related Aspects
  JOURNAL   Cell Physiol Biochem 58 (5), 630-653 (2024)
   PUBMED   39469880
  REMARK    GeneRIF: A Comprehensive Pan-Cancer Analysis of the Mitochondrial
            Uncoupling Protein UCP2, with a Focus on Sex and Gender-Related
            Aspects.
REFERENCE   3  (bases 1 to 1644)
  AUTHORS   Song,C., Liu,Q., Qin,J., Liu,L., Zhou,Z. and Yang,H.
  TITLE     UCP2 promotes NSCLC proliferation and glycolysis via the
            mTOR/HIF-1alpha signaling
  JOURNAL   Cancer Med 13 (3), e6938 (2024)
   PUBMED   38217303
  REMARK    GeneRIF: UCP2 promotes NSCLC proliferation and glycolysis via the
            mTOR/HIF-1alpha signaling.
REFERENCE   4  (bases 1 to 1644)
  AUTHORS   DU,W., Yin,F., Zhong,Y., Luo,M., Wang,Z., Lin,P., Liu,Q. and
            Yang,H.
  TITLE     CircUCP2 promotes the tumor progression of non-small cell lung
            cancer through the miR-149/UCP2 pathway
  JOURNAL   Oncol Res 31 (6), 929-936 (2023)
   PUBMED   37744277
  REMARK    GeneRIF: CircUCP2 promotes the tumor progression of non-small cell
            lung cancer through the miR-149/UCP2 pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1644)
  AUTHORS   Andreev,D.E., O'Connor,P.B., Fahey,C., Kenny,E.M., Terenin,I.M.,
            Dmitriev,S.E., Cormican,P., Morris,D.W., Shatsky,I.N. and
            Baranov,P.V.
  TITLE     Translation of 5' leaders is pervasive in genes resistant to eIF2
            repression
  JOURNAL   Elife 4, e03971 (2015)
   PUBMED   25621764
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1644)
  AUTHORS   Hurtaud,C., Gelly,C., Bouillaud,F. and Levi-Meyrueis,C.
  TITLE     Translation control of UCP2 synthesis by the upstream open reading
            frame
  JOURNAL   Cell Mol Life Sci 63 (15), 1780-1789 (2006)
   PUBMED   16845607
REFERENCE   7  (bases 1 to 1644)
  AUTHORS   Boss,O., Samec,S., Paoloni-Giacobino,A., Rossier,C., Dulloo,A.,
            Seydoux,J., Muzzin,P. and Giacobino,J.P.
  TITLE     Uncoupling protein-3: a new member of the mitochondrial carrier
            family with tissue-specific expression
  JOURNAL   FEBS Lett 408 (1), 39-42 (1997)
   PUBMED   9180264
REFERENCE   8  (bases 1 to 1644)
  AUTHORS   Gimeno,R.E., Dembski,M., Weng,X., Deng,N., Shyjan,A.W.,
            Gimeno,C.J., Iris,F., Ellis,S.J., Woolf,E.A. and Tartaglia,L.A.
  TITLE     Cloning and characterization of an uncoupling protein homolog: a
            potential molecular mediator of human thermogenesis
  JOURNAL   Diabetes 46 (5), 900-906 (1997)
   PUBMED   9133562
REFERENCE   9  (bases 1 to 1644)
  AUTHORS   Fleury,C., Neverova,M., Collins,S., Raimbault,S., Champigny,O.,
            Levi-Meyrueis,C., Bouillaud,F., Seldin,M.F., Surwit,R.S.,
            Ricquier,D. and Warden,C.H.
  TITLE     Uncoupling protein-2: a novel gene linked to obesity and
            hyperinsulinemia
  JOURNAL   Nat Genet 15 (3), 269-272 (1997)
   PUBMED   9054939
REFERENCE   10 (bases 1 to 1644)
  AUTHORS   Gillis,D.
  TITLE     Nonsyndromic Genetic Hyperinsulinism Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301549
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003717.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 20, 2020 this sequence version replaced NM_003355.2.
            
            Summary: Mitochondrial uncoupling proteins (UCP) are members of the
            larger family of mitochondrial anion carrier proteins (MACP). UCPs
            separate oxidative phosphorylation from ATP synthesis with energy
            dissipated as heat, also referred to as the mitochondrial proton
            leak. UCPs facilitate the transfer of anions from the inner to the
            outer mitochondrial membrane and the return transfer of protons
            from the outer to the inner mitochondrial membrane. They also
            reduce the mitochondrial membrane potential in mammalian cells.
            Tissue specificity occurs for the different UCPs and the exact
            methods of how UCPs transfer H+/OH- are not known. UCPs contain the
            three homologous protein domains of MACPs. This gene is expressed
            in many tissues, with the greatest expression in skeletal muscle.
            It is thought to play a role in nonshivering thermogenesis, obesity
            and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-6 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222557.1, BC011737.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000663595.2/
                                                  ENSP00000499695.1
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression,
                                                  longest protein
            regulatory uORF                    :: PMID: 16845607
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AP003717.3         42803-42925         c
            124-280             AP003717.3         41558-41714         c
            281-505             AP003717.3         38335-38559         c
            506-716             AP003717.3         37968-38178         c
            717-911             AP003717.3         36905-37099         c
            912-1013            AP003717.3         36723-36824         c
            1014-1194           AP003717.3         35573-35753         c
            1195-1644           AP003717.3         34754-35203         c
FEATURES             Location/Qualifiers
     source          1..1644
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..1644
                     /gene="UCP2"
                     /gene_synonym="BMIQ4; SLC25A8; UCPH"
                     /note="uncoupling protein 2"
                     /db_xref="GeneID:7351"
                     /db_xref="HGNC:HGNC:12518"
                     /db_xref="MIM:601693"
     exon            1..123
                     /gene="UCP2"
                     /gene_synonym="BMIQ4; SLC25A8; UCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            124..280
                     /gene="UCP2"
                     /gene_synonym="BMIQ4; SLC25A8; UCPH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      134..244
                     /regulatory_class="uORF"
                     /gene="UCP2"
                     /gene_synonym="BMIQ4; SLC25A8; UCPH"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:16845607]"
                     /note="this uORF is predicted to encode a 36 aa peptide
                     (PMID:16845607)"
     exon            281..505
                     /gene="UCP2"
                     /gene_synonym="BMIQ4; SLC25A8; UCPH"
                     /inference="alignment:Splign:2.1.0"
     CDS             380..1309
                     /gene="UCP2"
                     /gene_synonym="BMIQ4; SLC25A8; UCPH"
                     /note="isoform a is encoded by transcript variant 2;
                     mitochondrial uncoupling protein 2; solute carrier family
                     25 member 8; uncoupling protein 2 (mitochondrial, proton
                     carrier); dicarboxylate carrier SLC25A8"
                     /codon_start=1
                     /product="dicarboxylate carrier SLC25A8 isoform a"
                     /protein_id="NP_003346.2"
                     /db_xref="CCDS:CCDS8228.1"
                     /db_xref="GeneID:7351"
                     /db_xref="HGNC:HGNC:12518"
                     /db_xref="MIM:601693"
                     /translation="MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQ
                     GESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDS
                     VKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTV
                     NAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHF
                     TSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPS
                     FLRLGSWNVVMFVTYEQLKRALMAACTSREAPF"
     exon            506..716
                     /gene="UCP2"
                     /gene_synonym="BMIQ4; SLC25A8; UCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            717..911
                     /gene="UCP2"
                     /gene_synonym="BMIQ4; SLC25A8; UCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1013
                     /gene="UCP2"
                     /gene_synonym="BMIQ4; SLC25A8; UCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1194
                     /gene="UCP2"
                     /gene_synonym="BMIQ4; SLC25A8; UCPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1644
                     /gene="UCP2"
                     /gene_synonym="BMIQ4; SLC25A8; UCPH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1624..1629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UCP2"
                     /gene_synonym="BMIQ4; SLC25A8; UCPH"
                     /note="hexamer: CATAAA"
     polyA_site      1644
                     /gene="UCP2"
                     /gene_synonym="BMIQ4; SLC25A8; UCPH"
                     /note="major polyA site"
ORIGIN      
        1 actgcgaagc ccagctgcgc gcgccttggg attgactgtc cacgctcgcc cggctcgtcc
       61 gacgcgccct ccgccagccg acagacacag ccgcacgcac tgccgtgttc tccctgcggc
      121 tcggacacat agtatgacca ttaggtgttt cgtctcccac ccattttcta tggaaaacca
      181 aggggatcgg gccatgatag ccactggcag ctttgaagaa cgggacacct ttagagaagc
      241 ttgatcttgg aggcctcacc gtgagacctt acaaagccgg attccggcag agttcctcta
      301 tctcgtcttg ttgctgatta aaggtgcccc tgtctccagt ttttctccat ctcctgggac
      361 gtagcaggaa atcagcatca tggttgggtt caaggccaca gatgtgcccc ctactgccac
      421 tgtgaagttt cttggggctg gcacagctgc ctgcatcgca gatctcatca cctttcctct
      481 ggatactgct aaagtccggt tacagatcca aggagaaagt caggggccag tgcgcgctac
      541 agccagcgcc cagtaccgcg gtgtgatggg caccattctg accatggtgc gtactgaggg
      601 cccccgaagc ctctacaatg ggctggttgc cggcctgcag cgccaaatga gctttgcctc
      661 tgtccgcatc ggcctgtatg attctgtcaa acagttctac accaagggct ctgagcatgc
      721 cagcattggg agccgcctcc tagcaggcag caccacaggt gccctggctg tggctgtggc
      781 ccagcccacg gatgtggtaa aggtccgatt ccaagctcag gcccgggctg gaggtggtcg
      841 gagataccaa agcaccgtca atgcctacaa gaccattgcc cgagaggaag ggttccgggg
      901 cctctggaaa gggacctctc ccaatgttgc tcgtaatgcc attgtcaact gtgctgagct
      961 ggtgacctat gacctcatca aggatgccct cctgaaagcc aacctcatga cagatgacct
     1021 cccttgccac ttcacttctg cctttggggc aggcttctgc accactgtca tcgcctcccc
     1081 tgtagacgtg gtcaagacga gatacatgaa ctctgccctg ggccagtaca gtagcgctgg
     1141 ccactgtgcc cttaccatgc tccagaagga ggggccccga gccttctaca aagggttcat
     1201 gccctccttt ctccgcttgg gttcctggaa cgtggtgatg ttcgtcacct atgagcagct
     1261 gaaacgagcc ctcatggctg cctgcacttc ccgagaggct cccttctgag cctctcctgc
     1321 tgctgacctg atcacctctg gctttgtctc tagccgggcc atgctttcct tttcttcctt
     1381 ctttctcttc cctccttccc ttctctcctt ccctctttcc ccacctcttc cttccgctcc
     1441 tttacctacc accttccctc tttctacatt ctcatctact cattgtctca gtgctggtgg
     1501 agttgacatt tgacagtgtg ggaggcctcg taccagccag gatcccaagc gtcccgtccc
     1561 ttggaaagtt cagccagaat cttcgtcctg cccccgacag cccagcctag cccacttgtc
     1621 atccataaag caagctcaac cttg
//
