LOCUS       NM_021833               1621 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens uncoupling protein 1 (UCP1), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_021833
VERSION     NM_021833.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1621)
  AUTHORS   Musiol,E., Fromme,T., Hau,J., Di Pizio,A. and Klingenspor,M.
  TITLE     Comparative functional analysis reveals differential nucleotide
            sensitivity between human and mouse UCP1
  JOURNAL   Acta Physiol (Oxf) 240 (9), e14209 (2024)
   PUBMED   39072954
  REMARK    GeneRIF: Comparative functional analysis reveals differential
            nucleotide sensitivity between human and mouse UCP1.
REFERENCE   2  (bases 1 to 1621)
  AUTHORS   Kwok,T.C., Ramage,L.E., Kelman,A., Suchacki,K.J., Gray,C.,
            Boyle,L.D., Semple,S.I., MacGillivray,T., MacNaught,G., Patel,D.,
            van Beek,E.J.R., Semple,R.K., Wakelin,S.J. and Stimson,R.H.
  TITLE     UCP1 expression in human brown adipose tissue is inversely
            associated with cardiometabolic risk factors
  JOURNAL   Eur J Endocrinol 191 (1), 106-115 (2024)
   PUBMED   38917410
  REMARK    GeneRIF: UCP1 expression in human brown adipose tissue is inversely
            associated with cardiometabolic risk factors.
REFERENCE   3  (bases 1 to 1621)
  AUTHORS   Gyurina,K., Yarmak,M., Sasi-Szabo,L., Molnar,S., Mehes,G. and
            Roszer,T.
  TITLE     Loss of Uncoupling Protein 1 Expression in the Subcutaneous Adipose
            Tissue Predicts Childhood Obesity
  JOURNAL   Int J Mol Sci 24 (23), 16706 (2023)
   PUBMED   38069028
  REMARK    GeneRIF: Loss of Uncoupling Protein 1 Expression in the
            Subcutaneous Adipose Tissue Predicts Childhood Obesity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1621)
  AUTHORS   Kang,Y. and Chen,L.
  TITLE     Structural basis for the binding of DNP and purine nucleotides onto
            UCP1
  JOURNAL   Nature 620 (7972), 226-231 (2023)
   PUBMED   37336486
  REMARK    GeneRIF: Structural basis for the binding of DNP and purine
            nucleotides onto UCP1.
REFERENCE   5  (bases 1 to 1621)
  AUTHORS   Jones,S.A., Gogoi,P., Ruprecht,J.J., King,M.S., Lee,Y., Zogg,T.,
            Pardon,E., Chand,D., Steimle,S., Copeman,D.M., Cotrim,C.A.,
            Steyaert,J., Crichton,P.G., Moiseenkova-Bell,V. and Kunji,E.R.S.
  TITLE     Structural basis of purine nucleotide inhibition of human
            uncoupling protein 1
  JOURNAL   Sci Adv 9 (22), eadh4251 (2023)
   PUBMED   37256948
  REMARK    GeneRIF: Structural basis of purine nucleotide inhibition of human
            uncoupling protein 1.
REFERENCE   6  (bases 1 to 1621)
  AUTHORS   Fleury,C., Neverova,M., Collins,S., Raimbault,S., Champigny,O.,
            Levi-Meyrueis,C., Bouillaud,F., Seldin,M.F., Surwit,R.S.,
            Ricquier,D. and Warden,C.H.
  TITLE     Uncoupling protein-2: a novel gene linked to obesity and
            hyperinsulinemia
  JOURNAL   Nat Genet 15 (3), 269-272 (1997)
   PUBMED   9054939
REFERENCE   7  (bases 1 to 1621)
  AUTHORS   Clement,K., Ruiz,J., Cassard-Doulcier,A.M., Bouillaud,F.,
            Ricquier,D., Basdevant,A., Guy-Grand,B. and Froguel,P.
  TITLE     Additive effect of A-->G (-3826) variant of the uncoupling protein
            gene and the Trp64Arg mutation of the beta 3-adrenergic receptor
            gene on weight gain in morbid obesity
  JOURNAL   Int J Obes Relat Metab Disord 20 (12), 1062-1066 (1996)
   PUBMED   8968850
REFERENCE   8  (bases 1 to 1621)
  AUTHORS   Oppert,J.M., Vohl,M.C., Chagnon,M., Dionne,F.T.,
            Cassard-Doulcier,A.M., Ricquier,D., Perusse,L. and Bouchard,C.
  TITLE     DNA polymorphism in the uncoupling protein (UCP) gene and human
            body fat
  JOURNAL   Int J Obes Relat Metab Disord 18 (8), 526-531 (1994)
   PUBMED   7951471
REFERENCE   9  (bases 1 to 1621)
  AUTHORS   Cassard,A.M., Bouillaud,F., Mattei,M.G., Hentz,E., Raimbault,S.,
            Thomas,M. and Ricquier,D.
  TITLE     Human uncoupling protein gene: structure, comparison with rat gene,
            and assignment to the long arm of chromosome 4
  JOURNAL   J Cell Biochem 43 (3), 255-264 (1990)
   PUBMED   2380264
REFERENCE   10 (bases 1 to 1621)
  AUTHORS   Bouillaud,F., Villarroya,F., Hentz,E., Raimbault,S., Cassard,A.M.
            and Ricquier,D.
  TITLE     Detection of brown adipose tissue uncoupling protein mRNA in adult
            patients by a human genomic probe
  JOURNAL   Clin Sci (Lond) 75 (1), 21-27 (1988)
   PUBMED   3165741
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC108019.3 and BC098258.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_021833.4.
            
            Summary: Mitochondrial uncoupling proteins (UCP) are members of the
            family of mitochondrial anion carrier proteins (MACP). UCPs
            separate oxidative phosphorylation from ATP synthesis with energy
            dissipated as heat, also referred to as the mitochondrial proton
            leak. UCPs facilitate the transfer of anions from the inner to the
            outer mitochondrial membrane and the return transfer of protons
            from the outer to the inner mitochondrial membrane. They also
            reduce the mitochondrial membrane potential in mammalian cells.
            Tissue specificity occurs for the different UCPs and the exact
            methods of how UCPs transfer H+/OH- are not known. UCPs contain the
            three homologous protein domains of MACPs. This gene is expressed
            only in brown adipose tissue, a specialized tissue which functions
            to produce heat. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098168.1, U28480.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146411, SAMEA2151741
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000262999.4/
                                                  ENSP00000262999.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AC108019.3         13548-13703         c
            157-1156            BC098258.1         1-1000
            1157-1621           AC108019.3         4173-4637           c
FEATURES             Location/Qualifiers
     source          1..1621
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.1"
     gene            1..1621
                     /gene="UCP1"
                     /gene_synonym="SLC25A7; UCP"
                     /note="uncoupling protein 1"
                     /db_xref="GeneID:7350"
                     /db_xref="HGNC:HGNC:12517"
                     /db_xref="MIM:113730"
     exon            1..358
                     /gene="UCP1"
                     /gene_synonym="SLC25A7; UCP"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1156
                     /gene="UCP1"
                     /gene_synonym="SLC25A7; UCP"
                     /note="thermogenin; solute carrier family 25 member 7;
                     uncoupling protein 1 (mitochondrial, proton carrier)"
                     /codon_start=1
                     /product="mitochondrial brown fat uncoupling protein 1"
                     /protein_id="NP_068605.1"
                     /db_xref="CCDS:CCDS3753.1"
                     /db_xref="GeneID:7350"
                     /db_xref="HGNC:HGNC:12517"
                     /db_xref="MIM:113730"
                     /translation="MGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQ
                     GECPTSSVIRYKGVLGTITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEF
                     LTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNA
                     YRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVS
                     ALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFL
                     RLGSWNVIMFVCFEQLKRELSKSRQTMDCAT"
     exon            359..557
                     /gene="UCP1"
                     /gene_synonym="SLC25A7; UCP"
                     /inference="alignment:Splign:2.1.0"
     exon            558..758
                     /gene="UCP1"
                     /gene_synonym="SLC25A7; UCP"
                     /inference="alignment:Splign:2.1.0"
     exon            759..860
                     /gene="UCP1"
                     /gene_synonym="SLC25A7; UCP"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1041
                     /gene="UCP1"
                     /gene_synonym="SLC25A7; UCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1621
                     /gene="UCP1"
                     /gene_synonym="SLC25A7; UCP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1547..1552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UCP1"
                     /gene_synonym="SLC25A7; UCP"
                     /note="hexamer: ATTAAA"
     polyA_site      1570
                     /gene="UCP1"
                     /gene_synonym="SLC25A7; UCP"
                     /note="major polyA site"
     regulatory      1595..1600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UCP1"
                     /gene_synonym="SLC25A7; UCP"
                     /note="hexamer: AATAAA"
     polyA_site      1621
                     /gene="UCP1"
                     /gene_synonym="SLC25A7; UCP"
                     /note="major polyA site"
ORIGIN      
        1 agagggtcct gctggcgcga gggtgggtag gaggggacgc ggggactcgg cccccaacac
       61 cgcgctccgt ctgcagccgc cgcctctgca ccgccgctgc ccggcggtcg gttcaaaaaa
      121 cagaaatcgg gtttgctgcc cggcggacag gcgtgaagag caagggaaag gaacttcctc
      181 caccttcggg gctggagccc ttttcctctg catctccagt ctctgagtga agatgggggg
      241 cctgacagcc tcggacgtac acccgaccct gggggtccag ctcttctcag ctggaatagc
      301 ggcgtgcttg gcggacgtga tcaccttccc gctggacacg gccaaagtcc ggctccaggt
      361 ccaaggtgaa tgcccgacgt ccagtgttat taggtataaa ggtgtcctgg gaacaatcac
      421 cgctgtggta aaaacagaag ggcggatgaa actctacagc gggctgcctg cggggcttca
      481 gcggcaaatc agctccgcct ctctcaggat cggcctctac gacacggtcc aggagttcct
      541 caccgcaggg aaagaaacag cacctagttt aggaagcaag attttagctg gtctaacgac
      601 tggaggagtg gcagtattca ttgggcaacc cacagaggtc gtgaaagtca gacttcaagc
      661 acagagccat ctccacggaa tcaaacctcg ctacacgggg acttataatg cgtacagaat
      721 aatagcaaca accgaaggct tgacgggtct ttggaaaggg actactccca atctgatgag
      781 aagtgtcatc atcaattgta cagagctagt aacatatgat ctaatgaagg aggcctttgt
      841 gaaaaacaac atattagcag atgacgtccc ctgccacttg gtgtcggctc ttatcgctgg
      901 attttgcgca acagctatgt cctccccggt ggatgtagta aaaaccagat ttattaattc
      961 tccaccagga cagtacaaaa gtgtgcccaa ctgtgcaatg aaagtgttca ctaacgaagg
     1021 accaacggct ttcttcaagg ggttggtacc ttccttcttg cgacttggat cctggaacgt
     1081 cattatgttt gtgtgctttg aacaactgaa acgagaactg tcaaagtcaa ggcagactat
     1141 ggactgtgcc acataatcag cttcaagaaa atgatgtaac ataccagtgg gaatcttgct
     1201 gactggatca taaaaacaaa caaaacttat tcacttattt taacctaaaa agataaagga
     1261 attttggcag agaattttgg acttttttat ataaaaaaga ggaaaattaa tgcctatttc
     1321 atataacttt ttttttttct cagtgtctta agaaggggaa agcaaaacat tcagcatata
     1381 ccctggcaaa tgtaatgcag ataagctact gcatttgacc atttctggag tgcaattgtg
     1441 tgaatgaatg tgaagaactt taacatgttt taattacaat tccaactggt ggaaaagaaa
     1501 ctgagtgaaa tgcagtttat atttataaat acttaaaaat gaagttatta aaaatattag
     1561 tttttattaa ccacagttgt cagttaatat attcaataaa gtattgctaa taccttttaa
     1621 a
//
