LOCUS       NM_053049               1243 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens urocortin 3 (UCN3), mRNA.
ACCESSION   NM_053049
VERSION     NM_053049.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1243)
  AUTHORS   Flisher,M.F., Shin,D. and Huising,M.O.
  TITLE     Urocortin3: Local inducer of somatostatin release and bellwether of
            beta cell maturity
  JOURNAL   Peptides 151, 170748 (2022)
   PUBMED   35065098
  REMARK    GeneRIF: Urocortin3: Local inducer of somatostatin release and
            bellwether of beta cell maturity.
            Review article
REFERENCE   2  (bases 1 to 1243)
  AUTHORS   Alarslan,P., Unal Kocabas,G., Demir,I., Guler,A., Bozkaya,G.,
            Aslanipour,B. and Calan,M.
  TITLE     Increased urocortin 3 levels are associated with the risk of having
            type 2 diabetes mellitus
  JOURNAL   J Diabetes 12 (6), 474-482 (2020)
   PUBMED   31893569
  REMARK    GeneRIF: Increased urocortin 3 levels are associated with the risk
            of having type 2 diabetes mellitus.
REFERENCE   3  (bases 1 to 1243)
  AUTHORS   Pilbrow,A.P., Lewis,K.A., Perrin,M.H., Sweet,W.E., Moravec,C.S.,
            Tang,W.H., Huising,M.O., Troughton,R.W. and Cameron,V.A.
  TITLE     Cardiac CRFR1 Expression Is Elevated in Human Heart Failure and
            Modulated by Genetic Variation and Alternative Splicing
  JOURNAL   Endocrinology 157 (12), 4865-4874 (2016)
   PUBMED   27754786
  REMARK    GeneRIF: In summary, cardiac expression of CRFR1, CRF, and Ucn3
            genes is elevated in heart failure and may contribute to the
            activation of the CRF/Ucn system in these patients.
REFERENCE   4  (bases 1 to 1243)
  AUTHORS   Stirrat,C.G., Venkatasubramanian,S., Pawade,T., Mitchell,A.J.,
            Shah,A.S., Lang,N.N. and Newby,D.E.
  TITLE     Cardiovascular effects of urocortin 2 and urocortin 3 in patients
            with chronic heart failure
  JOURNAL   Br J Clin Pharmacol 82 (4), 974-982 (2016)
   PUBMED   27275843
  REMARK    GeneRIF: examination of the local and systemic cardiovascular
            effects of urocortin 2 and urocortin 3 in healthy subjects and
            patients with heart failure
REFERENCE   5  (bases 1 to 1243)
  AUTHORS   Telegdy,G., Kovacs,A.K., Rakosi,K., Zarandi,M. and Toth,G.K.
  TITLE     Antiamnesic properties of analogs and mimetics of the tripeptide
            human urocortin 3
  JOURNAL   Amino Acids 48 (9), 2261-2266 (2016)
   PUBMED   27262310
  REMARK    GeneRIF: Antiamnesic properties of analogs and mimetics of the
            tripeptide human urocortin 3
REFERENCE   6  (bases 1 to 1243)
  AUTHORS   Seres,J., Bornstein,S.R., Seres,P., Willenberg,H.S., Schulte,K.M.,
            Scherbaum,W.A. and Ehrhart-Bornstein,M.
  TITLE     Corticotropin-releasing hormone system in human adipose tissue
  JOURNAL   J Clin Endocrinol Metab 89 (2), 965-970 (2004)
   PUBMED   14764822
  REMARK    GeneRIF: CRH-R1:CRH-R2 ratio varied according to fat-depot type;
            whereas CRH-R1 expression was higher in sc fat than in visceral
            fat, the opposite was true for CRH-R2.
REFERENCE   7  (bases 1 to 1243)
  AUTHORS   Chanalaris,A., Lawrence,K.M., Stephanou,A., Knight,R.D., Hsu,S.Y.,
            Hsueh,A.J. and Latchman,D.S.
  TITLE     Protective effects of the urocortin homologues stresscopin (SCP)
            and stresscopin-related peptide (SRP) against hypoxia/reoxygenation
            injury in rat neonatal cardiomyocytes
  JOURNAL   J Mol Cell Cardiol 35 (10), 1295-1305 (2003)
   PUBMED   14519439
  REMARK    GeneRIF: SCP and UCN are potent activators of the p42/44 MAPK
            pathway, with SRP able to induce phosphorylation of p42/44 MAPK as
            well, albeit not as pronounced
REFERENCE   8  (bases 1 to 1243)
  AUTHORS   Hauger,R.L., Grigoriadis,D.E., Dallman,M.F., Plotsky,P.M.,
            Vale,W.W. and Dautzenberg,F.M.
  TITLE     International Union of Pharmacology. XXXVI. Current status of the
            nomenclature for receptors for corticotropin-releasing factor and
            their ligands
  JOURNAL   Pharmacol Rev 55 (1), 21-26 (2003)
   PUBMED   12615952
  REMARK    Review article
REFERENCE   9  (bases 1 to 1243)
  AUTHORS   Lewis,K., Li,C., Perrin,M.H., Blount,A., Kunitake,K., Donaldson,C.,
            Vaughan,J., Reyes,T.M., Gulyas,J., Fischer,W., Bilezikjian,L.,
            Rivier,J., Sawchenko,P.E. and Vale,W.W.
  TITLE     Identification of urocortin III, an additional member of the
            corticotropin-releasing factor (CRF) family with high affinity for
            the CRF2 receptor
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7570-7575 (2001)
   PUBMED   11416224
REFERENCE   10 (bases 1 to 1243)
  AUTHORS   Hsu,S.Y. and Hsueh,A.J.
  TITLE     Human stresscopin and stresscopin-related peptide are selective
            ligands for the type 2 corticotropin-releasing hormone receptor
  JOURNAL   Nat Med 7 (5), 605-611 (2001)
   PUBMED   11329063
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL683826.14, BQ777111.1,
            BQ776877.1, BQ778217.1, AY026949.1 and CK821206.1.
            
            On Nov 23, 2018 this sequence version replaced NM_053049.3.
            
            Summary: This gene encodes a member of the
            sauvagine/corticotropin-releasing factor/urotensin I family of
            proteins. The encoded preproprotein is proteolytically processed to
            generate the mature peptide hormone, which is secreted by
            pancreatic beta and alpha cells. This hormone is an endogenous
            ligand for corticotropin-releasing factor receptor 2 and may
            regulate insulin secretion in response to plasma glucose levels.
            Patients with type 2 diabetes exhibit reduced levels of the encoded
            protein in beta cells. In the brain, the encoded protein may be
            responsible for the effects of stress on appetite. [provided by
            RefSeq, May 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100867.2, BQ777111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380433.5/ ENSP00000369798.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AL683826.14        60438-60480
            44-105              BQ777111.1         4-65
            106-601             BQ776877.1         56-551
            602-678             BQ778217.1         1-77                c
            679-757             AY026949.1         408-486
            758-826             AL683826.14        69679-69747
            827-1152            CK821206.1         1-326
            1153-1153           AL683826.14        70074-70074
            1154-1243           CK821206.1         328-417
FEATURES             Location/Qualifiers
     source          1..1243
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.1"
     gene            1..1243
                     /gene="UCN3"
                     /gene_synonym="SCP; SPC; UCNIII"
                     /note="urocortin 3"
                     /db_xref="GeneID:114131"
                     /db_xref="HGNC:HGNC:17781"
                     /db_xref="MIM:605901"
     exon            1..265
                     /gene="UCN3"
                     /gene_synonym="SCP; SPC; UCNIII"
                     /inference="alignment:Splign:2.1.0"
     exon            266..1243
                     /gene="UCN3"
                     /gene_synonym="SCP; SPC; UCNIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..757
                     /gene="UCN3"
                     /gene_synonym="SCP; SPC; UCNIII"
                     /note="urocortin III; stresscopin; ucn III;
                     prepro-urocortin 3"
                     /codon_start=1
                     /product="urocortin-3 preproprotein"
                     /protein_id="NP_444277.2"
                     /db_xref="CCDS:CCDS7065.1"
                     /db_xref="GeneID:114131"
                     /db_xref="HGNC:HGNC:17781"
                     /db_xref="MIM:605901"
                     /translation="MLMPVHFLLLLLLLLGGPRTGLPHKFYKAKPIFSCLNTALSEAE
                     KGQWEDASLLSKRSFHYLRSRDASSGEEEEGKEKKTFPISGARGGARGTRYRYVSQAQ
                     PRGKPRQDTAKSPHRTKFTLSLDVPTNIMNLLFNIAKAKNLRAQAAANAHLMAQIGRK
                     K"
     regulatory      1222..1227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UCN3"
                     /gene_synonym="SCP; SPC; UCNIII"
                     /note="hexamer: ATTAAA"
     polyA_site      1243
                     /gene="UCN3"
                     /gene_synonym="SCP; SPC; UCNIII"
                     /note="major polyA site"
ORIGIN      
        1 aaatgaaatc tcatcccagc gtagacacca cgtctggaat tacgatccac cctgtgatct
       61 gtcactttta tatacacaca ggggagggga ccgtttccat agagagggaa tatcacagcc
      121 cacttaggaa caataccgga gaagcaggag ccgagacccc ggagcagcca caagttcatg
      181 gggacgtgca cggggccgcc ctcctggccc tgaagctgcg ccggcctccc tgagcgtttc
      241 gctgcggagg gaagtccact ctcggggaga gatgctgatg ccggtccact tcctgctgct
      301 cctgctgctg ctcctggggg gccccaggac aggcctcccc cacaagttct acaaagccaa
      361 gcccatcttc agctgcctca acaccgccct gtctgaggct gagaagggcc agtgggagga
      421 tgcatccctg ctgagcaaga ggagcttcca ctacctgcgc agcagagacg cctcttcggg
      481 agaggaggag gagggcaaag agaaaaagac tttccccatc tctggggcca ggggtggagc
      541 cagaggcacc cggtacagat acgtgtccca agcacagccc aggggaaagc cacgccagga
      601 cacggccaag agtccccacc gcaccaagtt caccctgtcc ctcgacgtcc ccaccaacat
      661 catgaacctc ctcttcaaca tcgccaaggc caagaacctg cgtgcccagg cggccgccaa
      721 tgcccacctg atggcgcaaa ttgggaggaa gaagtagagg cggaggctgg acgggagggc
      781 agcggggtgg ggagggggag gggaggggga ggggagggcg agggggggag gggaggggga
      841 gggtgctgtc tgctggtttg tgttttgtgg gatcagtcag ttttacaggt tgctgcactg
      901 ctgagcccct ctgatctctt ctggcctttg accctgtctc cctcctgctc tgtctgtaca
      961 cacagaagtg cagtattgtc caaccttccc agacacaaag cagctaacgt tcctccctgt
     1021 actcagcgtc tccttcctcc ctccccacag caagaggcaa agttcatgca ttcctcctct
     1081 ccagtcttct ctctgttgac cccatgcctg agaagagagc gttcagggct cctctcccac
     1141 acatcaactt cttccagggc agaaagagga gctgcagcac tcgccttcct gccaccgaat
     1201 ccttccctac ctcctcaccc cattaaaaca atggcttctt caa
//
