LOCUS       NM_003353                795 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens urocortin (UCN), mRNA.
ACCESSION   NM_003353
VERSION     NM_003353.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 795)
  AUTHORS   Kavalakatt,S., Khadir,A., Kochumon,S., Madhu,D., Devarajan,S.,
            Hammad,M., Alam-Eldin,N., Warsame,S., Al-Kandari,H., AlMahdi,M.,
            Ahmad,R., Koistinen,H.A., Tuomilehto,J., Al-Mulla,F., Abubaker,J.
            and Tiss,A.
  TITLE     Urocortin Neuropeptide Levels Are Impaired in the PBMCs of
            Overweight Children
  JOURNAL   Nutrients 14 (3), 429 (2022)
   PUBMED   35276788
  REMARK    GeneRIF: Urocortin Neuropeptide Levels Are Impaired in the PBMCs of
            Overweight Children.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 795)
  AUTHORS   Gao,X., Yang,J. and Chen,Y.
  TITLE     Identification of a four immune-related genes signature based on an
            immunogenomic landscape analysis of clear cell renal cell carcinoma
  JOURNAL   J Cell Physiol 235 (12), 9834-9850 (2020)
   PUBMED   32452055
  REMARK    GeneRIF: Identification of a four immune-related genes signature
            based on an immunogenomic landscape analysis of clear cell renal
            cell carcinoma.
REFERENCE   3  (bases 1 to 795)
  AUTHORS   Maia,L.M., Rocha,A.L., Del Puerto,H.L., Petraglia,F. and Reis,F.M.
  TITLE     Plasma urocortin-1 as a preoperative marker of endometriosis in
            symptomatic women
  JOURNAL   Gynecol Endocrinol 34 (3), 202-205 (2018)
   PUBMED   28925754
  REMARK    GeneRIF: In women with chronic pelvic pain, infertility, or both
            symptoms, the probability of endometriosis (positive predictive
            value) increased consistently with the increase of plasma Ucn1
            levels.
REFERENCE   4  (bases 1 to 795)
  AUTHORS   Lawrence,K.M., Jones,R.C., Jackson,T.R., Baylie,R.L., Abbott,B.,
            Bruhn-Olszewska,B., Board,T.N., Locke,I.C., Richardson,S.M. and
            Townsend,P.A.
  TITLE     Chondroprotection by urocortin involves blockade of the
            mechanosensitive ion channel Piezo1
  JOURNAL   Sci Rep 7 (1), 5147 (2017)
   PUBMED   28698554
  REMARK    GeneRIF: Data report that Ucn1 is expressed in human articular
            chondrocytes (AC) and confirm that Ucn1 is essential for the
            survival of AC cells in the absence of pro-apoptotic stimuli.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 795)
  AUTHORS   Lawrence,K.M., Jackson,T.R., Jamieson,D., Stevens,A., Owens,G.,
            Sayan,B.S., Locke,I.C. and Townsend,P.A.
  TITLE     Urocortin--from Parkinson's disease to the skeleton
  JOURNAL   Int J Biochem Cell Biol 60, 130-138 (2015)
   PUBMED   25541373
  REMARK    Review article
REFERENCE   6  (bases 1 to 795)
  AUTHORS   Bamberger,C.M., Wald,M., Bamberger,A.M., Ergun,S., Beil,F.U. and
            Schulte,H.M.
  TITLE     Human lymphocytes produce urocortin, but not
            corticotropin-releasing hormone
  JOURNAL   J Clin Endocrinol Metab 83 (2), 708-711 (1998)
   PUBMED   9467598
REFERENCE   7  (bases 1 to 795)
  AUTHORS   Iino,K., Sasano,H., Oki,Y., Andoh,N., Shin,R.W., Kitamoto,T.,
            Totsune,K., Takahashi,K., Suzuki,H., Nagura,H. and Yoshimi,T.
  TITLE     Urocortin expression in human pituitary gland and pituitary adenoma
  JOURNAL   J Clin Endocrinol Metab 82 (11), 3842-3850 (1997)
   PUBMED   9360550
REFERENCE   8  (bases 1 to 795)
  AUTHORS   Gottowik,J., Goetschy,V., Henriot,S., Kitas,E., Fluhman,B.,
            Clerc,R.G., Moreau,J.L., Monsma,F.J. and Kilpatrick,G.J.
  TITLE     Labelling of CRF1 and CRF2 receptors using the novel radioligand,
            [3H]-urocortin
  JOURNAL   Neuropharmacology 36 (10), 1439-1446 (1997)
   PUBMED   9423932
REFERENCE   9  (bases 1 to 795)
  AUTHORS   Donaldson,C.J., Sutton,S.W., Perrin,M.H., Corrigan,A.Z.,
            Lewis,K.A., Rivier,J.E., Vaughan,J.M. and Vale,W.W.
  TITLE     Cloning and characterization of human urocortin
  JOURNAL   Endocrinology 137 (5), 2167-2170 (1996)
   PUBMED   8612563
  REMARK    Erratum:[Endocrinology. 1996 Sep;137(9):3896. doi:
            10.1210/endo.137.9.8756563.. PMID: 8756563]
REFERENCE   10 (bases 1 to 795)
  AUTHORS   Adachi,T., Schamel,W.W., Kim,K.M., Watanabe,T., Becker,B.,
            Nielsen,P.J. and Reth,M.
  TITLE     The specificity of association of the IgD molecule with the
            accessory proteins BAP31/BAP29 lies in the IgD transmembrane
            sequence
  JOURNAL   EMBO J 15 (7), 1534-1541 (1996)
   PUBMED   8612576
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AI857458.1, BC104470.1 and
            BU619919.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_003353.3.
            
            Summary: This gene encodes a member of the
            sauvagine/corticotropin-releasing factor/urotensin I family. The
            encoded preproprotein is proteolytically processed to generate the
            mature peptide, an endogenous ligand for both
            corticotropin-releasing factor receptor 1 and
            corticotropin-releasing factor receptor 2. In the brain this
            peptide may be responsible for the effects of stress on appetite.
            This peptide may also play a role in mood disorders,
            neurodegeneration, and skeletal system disorders. In spite of the
            gene family name similarity, the product of this gene has no
            sequence similarity to urotensin-2. [provided by RefSeq, Feb 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA430333.1, BU619919.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296099.2/ ENSP00000296099.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               AI857458.1         342-540             c
            200-765             BC104470.1         1-566
            766-795             BU619919.1         19-48               c
FEATURES             Location/Qualifiers
     source          1..795
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..795
                     /gene="UCN"
                     /gene_synonym="UCN1; UI; UROC"
                     /note="urocortin"
                     /db_xref="GeneID:7349"
                     /db_xref="HGNC:HGNC:12516"
                     /db_xref="MIM:600945"
     exon            1..286
                     /gene="UCN"
                     /gene_synonym="UCN1; UI; UROC"
                     /inference="alignment:Splign:2.1.0"
     exon            287..795
                     /gene="UCN"
                     /gene_synonym="UCN1; UI; UROC"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..674
                     /gene="UCN"
                     /gene_synonym="UCN1; UI; UROC"
                     /note="urocortin, preproprotein; prepro-urocortin"
                     /codon_start=1
                     /product="urocortin preproprotein"
                     /protein_id="NP_003344.1"
                     /db_xref="CCDS:CCDS1747.1"
                     /db_xref="GeneID:7349"
                     /db_xref="HGNC:HGNC:12516"
                     /db_xref="MIM:600945"
                     /translation="MRQAGRAALLAALLLLVQLCPGSSQRSPEAAGVQDPSLRWSPGA
                     RNQGGGARALLLLLAERFPRRAGPGRLGLGTAGERPRRDNPSLSIDLTFHLLRTLLEL
                     ARTQSQRERAEQNRIIFDSVGK"
     regulatory      776..781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UCN"
                     /gene_synonym="UCN1; UI; UROC"
                     /note="hexamer: AATAAA"
     polyA_site      795
                     /gene="UCN"
                     /gene_synonym="UCN1; UI; UROC"
                     /note="major polyA site"
ORIGIN      
        1 tgcgtccagt gctgcttcca gcgctagccc caggggcacg aaggctggtg tagggaggtg
       61 cgcccctccg ggggcccgcc agccgtcaga ctcgaagctg tggctgtcat tgcttctaca
      121 atcagtgcat gttcttcgct gacgtcagtc ggagctgtcc tggcactata taaggctggc
      181 gacagccccg ggacagaccc tgtgttcccc aaggcgtctt cagcctgccc cgagggacag
      241 agactggagc tcaatcttgg accgtacaga cgctcgccga caacctggcc ggcggcacca
      301 tgaggcaggc gggacgcgca gcgctgctgg ccgcgctgct gctcctggta cagctgtgcc
      361 ctgggagcag ccagaggagc cccgaggcgg ccggggtcca ggacccgagt ctgcgctgga
      421 gccccggggc acggaaccag ggtggcgggg cccgcgcgct cctcttgctg ctggcggagc
      481 gcttcccgcg ccgcgcgggg cccggccgat tgggactcgg gacggcaggc gagcggccgc
      541 ggcgggacaa cccttctctg tccattgacc tcacctttca cctgctgcgg accctgctgg
      601 agctggcgcg gacgcagagc cagcgggagc gcgccgagca gaaccgcatc atattcgact
      661 cggtgggcaa gtgatggccc ggtttggggc tgcgaaaacg ttgacccctt tcccccaccc
      721 cagagttggg atgcggggca gagccaccag ggcactgtct gcgtgactat tttttaataa
      781 aagtactgaa gaccc
//
