LOCUS       NM_145314                870 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens upper zone of growth plate and cartilage matrix
            associated (UCMA), transcript variant 1, mRNA.
ACCESSION   NM_145314
VERSION     NM_145314.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 870)
  AUTHORS   Xiao,H., Chen,J., Duan,L. and Li,S.
  TITLE     Role of emerging vitamin K-dependent proteins: Growth
            arrest-specific protein 6, Gla-rich protein and periostin (Review)
  JOURNAL   Int J Mol Med 47 (3) (2021)
   PUBMED   33448308
  REMARK    GeneRIF: Role of emerging vitamin Kdependent proteins: Growth
            arrestspecific protein 6, Glarich protein and periostin (Review).
            Review article
REFERENCE   2  (bases 1 to 870)
  AUTHORS   Lee,S.H., Lee,Y.J., Park,S.I. and Kim,J.E.
  TITLE     Unique cartilage matrix-associated protein inhibits the migratory
            and invasive potential of triple-negative breast cancer
  JOURNAL   Biochem Biophys Res Commun 530 (4), 680-685 (2020)
   PUBMED   32768190
  REMARK    GeneRIF: Unique cartilage matrix-associated protein inhibits the
            migratory and invasive potential of triple-negative breast cancer.
REFERENCE   3  (bases 1 to 870)
  AUTHORS   Seuffert,F., Weidner,D., Baum,W., Schett,G. and Stock,M.
  TITLE     Upper zone of growth plate and cartilage matrix associated protein
            protects cartilage during inflammatory arthritis
  JOURNAL   Arthritis Res Ther 20 (1), 88 (2018)
   PUBMED   29720262
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 870)
  AUTHORS   Willems,B.A., Furmanik,M., Caron,M.M.J., Chatrou,M.L.L.,
            Kusters,D.H.M., Welting,T.J.M., Stock,M., Rafael,M.S.,
            Viegas,C.S.B., Simes,D.C., Vermeer,C., Reutelingsperger,C.P.M. and
            Schurgers,L.J.
  TITLE     Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell
            calcification via SMAD-dependent BMP signalling
  JOURNAL   Sci Rep 8 (1), 4961 (2018)
   PUBMED   29563538
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 870)
  AUTHORS   Rafael,M.S., Cavaco,S., Viegas,C.S., Santos,S., Ramos,A.,
            Willems,B.A., Herfs,M., Theuwissen,E., Vermeer,C. and Simes,D.C.
  TITLE     Insights into the association of Gla-rich protein and
            osteoarthritis, novel splice variants and gamma-carboxylation
            status
  JOURNAL   Mol Nutr Food Res 58 (8), 1636-1646 (2014)
   PUBMED   24867294
  REMARK    GeneRIF: Data suggest that novel splice variants of GRP are
            expressed in cartilage and other tissues (i.e. GRP-F5, GRP-F6);
            GRP-F1 is predominant splice variant expressed in adult tissues
            particularly in cartilage of patients with osteoarthritis.
REFERENCE   6  (bases 1 to 870)
  AUTHORS   Osman,A., Uhlin,F., Franlund,E., Fernstrom,A. and Magnusson,P.
  TITLE     Exon resequencing of the gene encoding UCma/GRP reveals a common
            carboxy-terminal 138Thr > Ser polymorphism
  JOURNAL   Clin Lab 59 (11-12), 1397-1401 (2013)
   PUBMED   24409676
  REMARK    GeneRIF: full exon resequencing of DNA samples from 17 chronic
            kidney disease patients (stage 5) and 121 healthy controls in a
            Swsedish population; the 138Thr > Ser polymorphism seems to be the
            only non-synonymous SNP found in the UCMA gene in a Swedish
            population
REFERENCE   7  (bases 1 to 870)
  AUTHORS   Le Jeune,M., Tomavo,N., Tian,T.V., Flourens,A., Marchand,N.,
            Camuzeaux,B., Mallein-Gerin,F. and Duterque-Coquillaud,M.
  TITLE     Identification of four alternatively spliced transcripts of the
            Ucma/GRP gene, encoding a new Gla-containing protein
  JOURNAL   Exp Cell Res 316 (2), 203-215 (2010)
   PUBMED   19819238
REFERENCE   8  (bases 1 to 870)
  AUTHORS   Viegas,C.S., Simes,D.C., Laize,V., Williamson,M.K., Price,P.A. and
            Cancela,M.L.
  TITLE     Gla-rich protein (GRP), a new vitamin K-dependent protein
            identified from sturgeon cartilage and highly conserved in
            vertebrates
  JOURNAL   J Biol Chem 283 (52), 36655-36664 (2008)
   PUBMED   18836183
  REMARK    GeneRIF: Gla-rich protein (GRP) is a new vitamin K-dependent
            protein that can bind calcium through Gla residues.
REFERENCE   9  (bases 1 to 870)
  AUTHORS   Surmann-Schmitt,C., Dietz,U., Kireva,T., Adam,N., Park,J.,
            Tagariello,A., Onnerfjord,P., Heinegard,D.,
            Schlotzer-Schrehardt,U., Deutzmann,R., von der Mark,K. and Stock,M.
  TITLE     Ucma, a novel secreted cartilage-specific protein with implications
            in osteogenesis
  JOURNAL   J Biol Chem 283 (11), 7082-7093 (2008)
   PUBMED   18156182
  REMARK    GeneRIF: Ucma may be involved in the negative control of osteogenic
            differentiation of osteochondrogenic precursor cells
REFERENCE   10 (bases 1 to 870)
  AUTHORS   Tagariello,A., Luther,J., Streiter,M., Didt-Koziel,L., Wuelling,M.,
            Surmann-Schmitt,C., Stock,M., Adam,N., Vortkamp,A. and
            Winterpacht,A.
  TITLE     Ucma--A novel secreted factor represents a highly specific marker
            for distal chondrocytes
  JOURNAL   Matrix Biol 27 (1), 3-11 (2008)
   PUBMED   17707622
  REMARK    GeneRIF: The present data strongly suggest an important function of
            Ucma in the early phase of chondrocyte differentiation.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL138764.21, BC018068.1 and
            AA628504.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145314.2.
            
            Summary: This gene encodes a chondrocyte-specific, highly charged
            protein that is abundantly expressed in the upper immature zone of
            fetal and juvenile epiphyseal cartilage. The encoded protein
            undergoes proteolytic processing to generate a mature protein that
            is secreted into the extracellular matrix. The glutamic acid
            residues in the encoded protein undergo gamma carboxylation in a
            vitamin K-dependent manner. Undercarboxylation of the encoded
            protein is associated with osteoarthritis in humans. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Jul 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018068.1, BG709040.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151741, SAMN03267763
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378681.8/ ENSP00000367952.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AL138764.21        63654-63699         c
            47-320              BC018068.1         4-277
            321-321             AL138764.21        62878-62878         c
            322-529             BC018068.1         279-486
            530-870             AA628504.1         5-345               c
FEATURES             Location/Qualifiers
     source          1..870
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p13"
     gene            1..870
                     /gene="UCMA"
                     /gene_synonym="C10orf49; GRP; GRP/UCMA"
                     /note="upper zone of growth plate and cartilage matrix
                     associated"
                     /db_xref="GeneID:221044"
                     /db_xref="HGNC:HGNC:25205"
     exon            1..174
                     /gene="UCMA"
                     /gene_synonym="C10orf49; GRP; GRP/UCMA"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..533
                     /gene="UCMA"
                     /gene_synonym="C10orf49; GRP; GRP/UCMA"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; unique cartilage matrix-associated protein;
                     Gla-rich protein"
                     /codon_start=1
                     /product="unique cartilage matrix-associated protein
                     isoform 1 preproprotein"
                     /protein_id="NP_660357.2"
                     /db_xref="CCDS:CCDS31147.1"
                     /db_xref="GeneID:221044"
                     /db_xref="HGNC:HGNC:25205"
                     /translation="MTWRQAVLLSCFSAVVLLSMLREGTSVSVGTMQMAGEEASEDAK
                     QKIFMQESDASNFLKRRGKRSPKSRDEVNVENRQKLRVDELRREYYEEQRNEFENFVE
                     EQNDEQEERSREAVEQWRQWHYDGLHPSYLYNRHHT"
     exon            175..240
                     /gene="UCMA"
                     /gene_synonym="C10orf49; GRP; GRP/UCMA"
                     /inference="alignment:Splign:2.1.0"
     exon            241..336
                     /gene="UCMA"
                     /gene_synonym="C10orf49; GRP; GRP/UCMA"
                     /inference="alignment:Splign:2.1.0"
     exon            337..435
                     /gene="UCMA"
                     /gene_synonym="C10orf49; GRP; GRP/UCMA"
                     /inference="alignment:Splign:2.1.0"
     exon            436..870
                     /gene="UCMA"
                     /gene_synonym="C10orf49; GRP; GRP/UCMA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      851..856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UCMA"
                     /gene_synonym="C10orf49; GRP; GRP/UCMA"
                     /note="hexamer: AATAAA"
     polyA_site      870
                     /gene="UCMA"
                     /gene_synonym="C10orf49; GRP; GRP/UCMA"
                     /note="major polyA site"
ORIGIN      
        1 ctcccccgcc ttccttcctc tcgcctgggc tgcctgcctc agaagtgggg acccaaaggg
       61 tgcaggacgc ctggtctgcc ttgtgggtcc tggacggagc ccctacctct gcaaagatga
      121 cttggagaca ggccgtcctg ctgtcttgct tctccgccgt ggtgctcctg tctatgctga
      181 gagagggaac cagtgtatct gtgggcacca tgcagatggc gggagaagag gcgagtgaag
      241 atgcaaaaca gaagattttc atgcaggaat cagatgcctc gaatttcctc aagaggcgcg
      301 gcaagcggtc ccccaagtcc agagatgagg tcaatgtgga aaacaggcag aagcttcggg
      361 ttgatgagct gcggagagaa tattacgagg aacaaaggaa tgaatttgag aacttcgtgg
      421 aggaacaaaa cgatgagcag gaagagagga gccgggaggc tgtggagcag tggcgccagt
      481 ggcactatga cggcctgcac ccatcctatc tctacaaccg ccaccacacc tgatcccatc
      541 ctgaagccgg ccaagaagac aaagcttgta gcaccattgg catccccgtg ttccagcaat
      601 ctttcccatg caaaccggcc cttcagaggg tctcagcttg gggtctgcag tggccagcag
      661 ctcttgaaaa gacgcatgcc tttccttcca gtgtgtgaaa gtgtcctgac tttcacctct
      721 ttgcagacca tcttctgagg tgagcaactg cctgcagggc ctcctagtac caaacctaca
      781 gtggcttccc ctggcttcgt tcccaagcaa aagaatcagt caagaatcac atgtttgctt
      841 atggcttaca aataaaaacg ctgaatcaac
//
