LOCUS       NM_017859               1838 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens uridine-cytidine kinase 1 like 1 (UCKL1), transcript
            variant 1, mRNA.
ACCESSION   NM_017859
VERSION     NM_017859.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1838)
  AUTHORS   Matchett,E.C., Ambrose,E.C. and Kornbluth,J.
  TITLE     Characterization of uridine-cytidine kinase like-1 nucleoside
            kinase activity and its role in tumor growth
  JOURNAL   Biochem J 479 (11), 1149-1164 (2022)
   PUBMED   35583288
  REMARK    GeneRIF: Characterization of uridine-cytidine kinase like-1
            nucleoside kinase activity and its role in tumor growth.
REFERENCE   2  (bases 1 to 1838)
  AUTHORS   Buivydiene,A., Liakina,V., Kashuba,E., Norkuniene,J.,
            Jokubauskiene,S., Gineikiene,E. and Valantinas,J.
  TITLE     Impact of the UridineCytidine Kinase Like-1 Protein and IL28B
            rs12979860 and rs8099917 SNPs on the Development of Hepatocellular
            Carcinoma in Cirrhotic Chronic Hepatitis C Patients-A Pilot Study
  JOURNAL   Medicina (Kaunas) 54 (5), 67 (2018)
   PUBMED   30344298
  REMARK    GeneRIF: The presence of IL28B rs8099917 TT and rs12979860 CC SNPs,
            but not the intensity of UCKL-1 expression, is strongly associated
            with increased chances of Hepatocellular Carcinoma development in
            hepatitis C virus -positive cirrhotic patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1838)
  AUTHORS   Ambrose,E.C. and Kornbluth,J.
  TITLE     Downregulation of uridine-cytidine kinase like-1 decreases
            proliferation and enhances tumor susceptibility to lysis by
            apoptotic agents and natural killer cells
  JOURNAL   Apoptosis 14 (10), 1227-1236 (2009)
   PUBMED   19653100
  REMARK    GeneRIF: These results indicate a role for UCKL-1 in tumor cell
            survival.
REFERENCE   4  (bases 1 to 1838)
  AUTHORS   Fortier,J.M. and Kornbluth,J.
  TITLE     NK lytic-associated molecule, involved in NK cytotoxic function, is
            an E3 ligase
  JOURNAL   J Immunol 176 (11), 6454-6463 (2006)
   PUBMED   16709802
REFERENCE   5  (bases 1 to 1838)
  AUTHORS   Kashuba,E., Kashuba,V., Sandalova,T., Klein,G. and Szekely,L.
  TITLE     Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel
            human uridine kinase/uracil phosphoribosyltransferase
  JOURNAL   BMC Cell Biol 3, 23 (2002)
   PUBMED   12199906
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB193745.1, AK000524.1 and
            AK222559.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017859.3.
            
            Summary: The protein encoded by this gene is a uridine kinase.
            Uridine kinases catalyze the phosphorylation of uridine to uridine
            monophosphate. This protein has been shown to bind to Epstein-Barr
            nuclear antigen 3 as well as natural killer lytic-associated
            molecule. Ubiquitination of this protein is enhanced by the
            presence of natural killer lytic-associated molecule. In addition,
            protein levels decrease in the presence of natural killer
            lytic-associated molecule, suggesting that association with natural
            killer lytic-associated molecule results in ubiquitination and
            subsequent degradation of this protein. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Nov
            2014].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222559.1, AK000524.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354216.11/ ENSP00000346155.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DB193745.1         32-32
            2-911               AK000524.1         2-911
            912-1838            AK222559.1         914-1840
FEATURES             Location/Qualifiers
     source          1..1838
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..1838
                     /gene="UCKL1"
                     /gene_synonym="UCK1L; URKL1"
                     /note="uridine-cytidine kinase 1 like 1"
                     /db_xref="GeneID:54963"
                     /db_xref="HGNC:HGNC:15938"
                     /db_xref="MIM:610866"
     exon            1..157
                     /gene="UCKL1"
                     /gene_synonym="UCK1L; URKL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1691
                     /gene="UCKL1"
                     /gene_synonym="UCK1L; URKL1"
                     /EC_number="2.7.1.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uridine-cytidine kinase-like 1; UCK1-LIKE"
                     /codon_start=1
                     /product="uridine-cytidine kinase-like 1 isoform 1"
                     /protein_id="NP_060329.2"
                     /db_xref="CCDS:CCDS13547.1"
                     /db_xref="GeneID:54963"
                     /db_xref="HGNC:HGNC:15938"
                     /db_xref="MIM:610866"
                     /translation="MAAPPARADADPSPTSPPTARDTPGRQAEKSETACEDRSNAESL
                     DRLLPPVGTGRSPRKRTTSQCKSEPPLLRTSKRTIYTAGRPPWYNEHGTQSKEAFAIG
                     LGGGSASGKTTVARMIIEALDVPWVVLLSMDSFYKVLTEQQQEQAAHNNFNFDHPDAF
                     DFDLIISTLKKLKQGKSVKVPIYDFTTHSRKKDWKTLYGANVIIFEGIMAFADKTLLE
                     LLDMKIFVDTDSDIRLVRRLRRDISERGRDIEGVIKQYNKFVKPSFDQYIQPTMRLAD
                     IVVPRGSGNTVAIDLIVQHVHSQLEERELSVRAALASAHQCHPLPRTLSVLKSTPQVR
                     GMHTIIRDKETSRDEFIFYSKRLMRLLIEHALSFLPFQDCVVQTPQGQDYAGKCYAGK
                     QITGVSILRAGETMEPALRAVCKDVRIGTILIQTNQLTGEPELHYLRLPKDISDDHVI
                     LMDCTVSTGAAAMMAVRVLLDHDVPEDKIFLLSLLMAEMGVHSVAYAFPRVRIITTAV
                     DKRVNDLFRIIPGIGNFGDRYFGTDAVPDGSDEEEVAYTG"
     exon            158..348
                     /gene="UCKL1"
                     /gene_synonym="UCK1L; URKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            349..455
                     /gene="UCKL1"
                     /gene_synonym="UCK1L; URKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            456..626
                     /gene="UCKL1"
                     /gene_synonym="UCK1L; URKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..698
                     /gene="UCKL1"
                     /gene_synonym="UCK1L; URKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..888
                     /gene="UCKL1"
                     /gene_synonym="UCK1L; URKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..950
                     /gene="UCKL1"
                     /gene_synonym="UCK1L; URKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            951..967
                     /gene="UCKL1"
                     /gene_synonym="UCK1L; URKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1066
                     /gene="UCKL1"
                     /gene_synonym="UCK1L; URKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1160
                     /gene="UCKL1"
                     /gene_synonym="UCK1L; URKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1223
                     /gene="UCKL1"
                     /gene_synonym="UCK1L; URKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1346
                     /gene="UCKL1"
                     /gene_synonym="UCK1L; URKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1454
                     /gene="UCKL1"
                     /gene_synonym="UCK1L; URKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1611
                     /gene="UCKL1"
                     /gene_synonym="UCK1L; URKL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1838
                     /gene="UCKL1"
                     /gene_synonym="UCK1L; URKL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1817..1822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UCKL1"
                     /gene_synonym="UCK1L; URKL1"
                     /note="hexamer: AATAAA"
     polyA_site      1838
                     /gene="UCKL1"
                     /gene_synonym="UCK1L; URKL1"
                     /note="major polyA site"
ORIGIN      
        1 atgcgcgccg cccggccagg cccgcaaaga ggcctccgag cgccatggct gcgcccccgg
       61 cccgcgcgga cgctgatcct tcgcccacgt cgccacctac ggcccgagac acaccaggcc
      121 ggcaggctga gaaaagcgag accgcgtgcg aggaccgcag caatgcagag tccctggaca
      181 ggctcctgcc acctgtgggc actgggcgct ctccccggaa gcggaccacc agccagtgca
      241 agtcagagcc tcccctgctg cgtacaagca agcgtaccat ctacaccgcc gggcggccgc
      301 cctggtacaa tgaacacggc acgcaatcca aagaggcctt cgccatcggc ttgggaggcg
      361 gcagtgcctc tgggaagacc actgtggcca gaatgatcat cgaggccctg gatgtgccct
      421 gggtggtctt gctgtccatg gactccttct acaaggtgct gactgagcag cagcaggaac
      481 aggccgcaca caacaacttc aacttcgacc acccagatgc ctttgacttc gacctcatca
      541 tttccaccct caagaagctg aagcagggga agagtgtcaa ggtgcccatt tatgacttca
      601 ccacgcacag ccggaagaag gactggaaaa cactgtatgg tgcaaacgtc atcatctttg
      661 agggcatcat ggcctttgct gacaagacac tgttggagct cctggacatg aagatctttg
      721 tggacacaga ctccgacatc cgcctggtac ggcggctgcg ccgggacatc agtgagcgcg
      781 gccgggacat cgagggtgtc atcaagcagt acaacaagtt tgtcaagccc tccttcgacc
      841 agtacatcca gcccaccatg cgcctggcag acatcgtggt ccccagaggg agcggcaaca
      901 cggtggccat cgacctgatt gtgcagcacg tgcacagcca gctggaggag cgtgaactca
      961 gcgtcagggc tgcgctggcc tcggcacacc agtgccaccc gctgccccgg acgctgagcg
     1021 tcctgaagag cacgccgcag gtacggggca tgcacaccat catcagggac aaggagacca
     1081 gtcgcgacga gttcatcttc tactccaaga gactgatgcg gctgctcatc gagcacgcgc
     1141 tctccttcct gccctttcag gactgcgtcg tacagacccc gcaggggcag gactatgcgg
     1201 gcaagtgcta tgcggggaag cagatcaccg gtgtgtccat tctgcgcgcc ggtgaaacca
     1261 tggagcccgc gctgcgcgct gtgtgcaaag acgtgcgcat cggcaccatc ctcatccaga
     1321 ccaaccagct taccggggag cccgagctcc actacctgag gctgcccaag gacatcagcg
     1381 atgaccacgt gatcctcatg gactgcaccg tgtccacggg cgcggcggcc atgatggcag
     1441 tgcgcgtgct cctggaccac gacgtgcctg aggacaagat ctttttgctg tcgctgctca
     1501 tggcagagat gggcgtgcac tcagtggcct atgcatttcc gcgagtgaga atcatcacca
     1561 cggcggtgga caagcgggtc aatgaccttt tccgcatcat cccaggcatt gggaactttg
     1621 gcgaccgcta ctttgggaca gacgcggtcc ccgatggcag tgacgaggag gaagtggcct
     1681 acacgggtta gctgcccagt gagccatccc gtccccacca ccctcctcct gcctcctgac
     1741 ccaggactgc tgaatacaaa gatgttaatt tttaaaatgt tactagtata atttattcta
     1801 tgcattttat aaaataaata aagctttaga aaaatgaa
//
