LOCUS       NM_001350842            5265 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens ubiquitin C-terminal hydrolase L5 (UCHL5), transcript
            variant 8, mRNA.
ACCESSION   NM_001350842 XM_005245244
VERSION     NM_001350842.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5265)
  AUTHORS   Wan,B., Cheng,M., He,T. and Zhang,L.
  TITLE     UCHL5 promotes hepatocellular carcinoma progression by promoting
            glycolysis through activating Wnt/beta-catenin pathway
  JOURNAL   BMC Cancer 24 (1), 618 (2024)
   PUBMED   38773433
  REMARK    GeneRIF: UCHL5 promotes hepatocellular carcinoma progression by
            promoting glycolysis through activating Wnt/beta-catenin pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5265)
  AUTHORS   Hashimoto,K., Miyagawa,Y., Watanabe,S., Takasaki,K., Nishizawa,M.,
            Yatsuki,K., Takahashi,Y., Kamata,H., Kihira,C., Hiraike,H.,
            Sasamori,Y., Kido,K., Ryo,E. and Nagasaka,K.
  TITLE     The TGF-beta/UCHL5/Smad2 Axis Contributes to the Pathogenesis of
            Placenta Accreta
  JOURNAL   Int J Mol Sci 24 (18), 13706 (2023)
   PUBMED   37762005
  REMARK    GeneRIF: The TGF-beta/UCHL5/Smad2 Axis Contributes to the
            Pathogenesis of Placenta Accreta.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5265)
  AUTHORS   Yang,Y., Cao,L., Guo,Z., Gu,H., Zhang,K. and Qiu,Z.
  TITLE     Deubiquitinase UCHL5 stabilizes ELK3 to potentiate cancer stemness
            and tumor progression in pancreatic adenocarcinoma (PAAD)
  JOURNAL   Exp Cell Res 421 (2), 113402 (2022)
   PUBMED   36328194
  REMARK    GeneRIF: Deubiquitinase UCHL5 stabilizes ELK3 to potentiate cancer
            stemness and tumor progression in pancreatic adenocarcinoma (PAAD).
REFERENCE   4  (bases 1 to 5265)
  AUTHORS   van der Wal,L., Bezstarosti,K. and Demmers,J.A.A.
  TITLE     A ubiquitinome analysis to study the functional roles of the
            proteasome associated deubiquitinating enzymes USP14 and UCH37
  JOURNAL   J Proteomics 262, 104592 (2022)
   PUBMED   35489684
  REMARK    GeneRIF: A ubiquitinome analysis to study the functional roles of
            the proteasome associated deubiquitinating enzymes USP14 and UCH37.
REFERENCE   5  (bases 1 to 5265)
  AUTHORS   Xiang,L., Zeng,Q., Liu,J., Xiao,M., He,D., Zhang,Q., Xie,D.,
            Deng,M., Zhu,Y., Liu,Y., Bo,H., Liu,X., Zhou,M., Xiong,W., Zhou,Y.,
            Zhou,J., Li,X. and Cao,K.
  TITLE     MAFG-AS1/MAFG positive feedback loop contributes to cisplatin
            resistance in bladder urothelial carcinoma through antagonistic
            ferroptosis
  JOURNAL   Sci Bull (Beijing) 66 (17), 1773-1788 (2021)
   PUBMED   36654385
  REMARK    GeneRIF: MAFG-AS1/MAFG positive feedback loop contributes to
            cisplatin resistance in bladder urothelial carcinoma through
            antagonistic ferroptosis.
REFERENCE   6  (bases 1 to 5265)
  AUTHORS   Rolen,U., Kobzeva,V., Gasparjan,N., Ovaa,H., Winberg,G.,
            Kisseljov,F. and Masucci,M.G.
  TITLE     Activity profiling of deubiquitinating enzymes in cervical
            carcinoma biopsies and cell lines
  JOURNAL   Mol Carcinog 45 (4), 260-269 (2006)
   PUBMED   16402389
  REMARK    GeneRIF: Upregulation of UCH37 is associated with Uterine Cervical
            Neoplasms
REFERENCE   7  (bases 1 to 5265)
  AUTHORS   Volik,S., Raphael,B.J., Huang,G., Stratton,M.R., Bignel,G.,
            Murnane,J., Brebner,J.H., Bajsarowicz,K., Paris,P.L., Tao,Q.,
            Kowbel,D., Lapuk,A., Shagin,D.A., Shagina,I.A., Gray,J.W.,
            Cheng,J.F., de Jong,P.J., Pevzner,P. and Collins,C.
  TITLE     Decoding the fine-scale structure of a breast cancer genome and
            transcriptome
  JOURNAL   Genome Res 16 (3), 394-404 (2006)
   PUBMED   16461635
REFERENCE   8  (bases 1 to 5265)
  AUTHORS   Wicks,S.J., Haros,K., Maillard,M., Song,L., Cohen,R.E., Dijke,P.T.
            and Chantry,A.
  TITLE     The deubiquitinating enzyme UCH37 interacts with Smads and
            regulates TGF-beta signalling
  JOURNAL   Oncogene 24 (54), 8080-8084 (2005)
   PUBMED   16027725
  REMARK    GeneRIF: UCH37 interacts with Smads and regulates TGF-beta
            signalling.
REFERENCE   9  (bases 1 to 5265)
  AUTHORS   Li,T., Duan,W., Yang,H., Lee,M.K., Bte Mustafa,F., Lee,B.H. and
            Teo,T.S.
  TITLE     Identification of two proteins, S14 and UIP1, that interact with
            UCH37
  JOURNAL   FEBS Lett 488 (3), 201-205 (2001)
   PUBMED   11163772
REFERENCE   10 (bases 1 to 5265)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA255130.1, BC015521.1, DR760216.1, AL136370.4 and BP397519.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001350842.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.103629.1,
                                           SRR1660805.20748.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                DA255130.1         34-67
            35-729              BC015521.1         1-695
            730-810             DR760216.1         650-730
            811-1564            BC015521.1         696-1449
            1565-4996           AL136370.4         105665-109096
            4997-5265           BP397519.1         231-499
FEATURES             Location/Qualifiers
     source          1..5265
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31.2"
     gene            1..5265
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /note="ubiquitin C-terminal hydrolase L5"
                     /db_xref="GeneID:51377"
                     /db_xref="HGNC:HGNC:19678"
                     /db_xref="MIM:610667"
     exon            1..176
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1168
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /EC_number="3.4.19.12"
                     /note="isoform 7 is encoded by transcript variant 8;
                     ubiquitin C-terminal hydrolase UCH37; ubiquitin
                     carboxyl-terminal esterase L5; INO80 complex subunit R;
                     ubiquitin carboxyl-terminal hydrolase isozyme L5;
                     ubiquitin thioesterase L5; ubiquitin carboxyl-terminal
                     hydrolase L5"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase isozyme L5
                     isoform 7"
                     /protein_id="NP_001337771.1"
                     /db_xref="CCDS:CCDS86041.1"
                     /db_xref="GeneID:51377"
                     /db_xref="HGNC:HGNC:19678"
                     /db_xref="MIM:610667"
                     /translation="MTGNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFE
                     KLKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTH
                     QDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAKEE
                     DAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWISAVRPVIEKRIQKDGFSPCCP
                     GWSQTPELKPSACLDLPKWYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEPMDT
                     DQGNSMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQ
                     LIPLVEKAKEKQNAKKAQETK"
     exon            177..240
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /inference="alignment:Splign:2.1.0"
     exon            241..346
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /inference="alignment:Splign:2.1.0"
     exon            347..472
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /inference="alignment:Splign:2.1.0"
     exon            473..534
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /inference="alignment:Splign:2.1.0"
     exon            535..665
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /inference="alignment:Splign:2.1.0"
     exon            666..729
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /inference="alignment:Splign:2.1.0"
     exon            730..810
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /inference="alignment:Splign:2.1.0"
     exon            811..913
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1024
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1123
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..5265
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2015..2020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /note="hexamer: AATAAA"
     polyA_site      2036
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /note="major polyA site"
     regulatory      3167..3172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /note="hexamer: AATAAA"
     polyA_site      3187
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
     regulatory      3278..3283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /note="hexamer: AATAAA"
     polyA_site      3307
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
     regulatory      5126..5131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /note="hexamer: AATAAA"
     polyA_site      5153
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
     regulatory      5244..5249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
                     /note="hexamer: AATAAA"
     polyA_site      5265
                     /gene="UCHL5"
                     /gene_synonym="CGI-70; INO80R; UCH-L5; UCH37"
ORIGIN      
        1 gagctcggcg gcgggtttgc tgagatctgt ggccggcggc agctggtgcg gggggcagct
       61 gagagcgaga ggtggatcgg ggcggtgtgt ggccagggcc atgacgggca atgccgggga
      121 gtggtgcctc atggaaagcg accccggggt cttcaccgag ctcattaaag gattcggttg
      181 ccgaggagcc caagtagaag aaatatggag tttagagcct gagaattttg aaaaattaaa
      241 gccagttcat gggttaattt ttcttttcaa gtggcagcca ggagaagaac cagcaggctc
      301 tgtggttcag gactcccgac ttgacacgat attttttgct aagcaggtaa ttaataatgc
      361 ttgtgctact caagccatag tgagtgtgtt actgaactgt acccaccagg atgtccattt
      421 aggcgagaca ttatcagagt ttaaagaatt ttcacaaagt tttgatgcag ctatgaaagg
      481 cttggcactg agcaattcag atgtgattcg acaagtacac aacagtttcg ccagacagca
      541 aatgtttgaa tttgatacga agacatcagc aaaagaagaa gatgcttttc actttgtcag
      601 ttatgttcct gttaatggga gactgtatga attagatgga ttaagagaag gaccgattga
      661 tttaggtgca tgcaatcaag atgattggat cagtgcagta aggcctgtca tagaaaaaag
      721 gatacaaaaa gacgggtttt caccatgttg cccaggctgg tctcagactc ctgagctcaa
      781 gccatccgcc tgcctcgacc tcccaaagtg gtacagtgaa ggtgaaattc gatttaattt
      841 aatggccatt gtgtctgaca gaaaaatgat atatgagcag aagatagcag agttacaaag
      901 acaacttgca gaggaaccca tggatacaga tcaaggtaat agtatgttaa gtgctattca
      961 gtcagaagtt gccaaaaatc agatgcttat tgaagaagaa gtacagaaat taaaaagata
     1021 caagattgag aatatcagaa ggaagcataa ttatctgcct ttcattatgg aattgttaaa
     1081 gactttagca gaacaccagc agttaatacc actagtagaa aaggcaaaag aaaaacagaa
     1141 cgcaaagaaa gctcaggaaa ccaaatgaag atgttttcag atatgtacac atttctgctt
     1201 ctgcacatat tttcatggaa accattatgt ataaagaact tagagcaaca tcctaattgg
     1261 ctcagtgcac gtttggcaat agtgccagcc tgtcttgtct ttaatgcatg gattcataaa
     1321 cttcttccct acctgcatca tgtgcatgta gtgcatatta aatgaaagtg atattaagaa
     1381 tgctttccca aattccatta tttgacattg agtctgacaa ctgttagttt tctggttgtc
     1441 taactaccat atgaagctag aaaatgcaca aacgatattc cttatctgta atttaaatac
     1501 ttaaaatttg caattgtcag atcttgatta aactggttgt cttatttctt ctcatcatta
     1561 acggaaaaaa aatcagtatt tctatctttg atatctaagt gttttgagga ttttaaaact
     1621 gaattttatc tgctatacca gttatttgag aaagtatgat tttaatgtaa atcatttaaa
     1681 aaggacaaaa gtataatttc cagtgatttt cactgctgtc agtagaaaag taataaacat
     1741 ctcaatttta ttttagtaaa ttttcttcaa gtgtttgggg ttatttgttt atgtattaga
     1801 gaattgtttc aggaaggtct gagtattatg cttcaaagca aaatttcagg ttaagaagaa
     1861 attgtaaatc ttaaagaatg ttggtgttac tctcaatgga atattgtttc aagcttgtaa
     1921 gctgtgtata aaaaaactgg aggtctgaca gttcatgtta tctgcttttt taaaaagatg
     1981 gtagtggtga tgggggtctt tctatgccaa tttgaataaa tttcgtacag cctgcagttt
     2041 tcaagagcca tatgtaattt gctcacaatt gatttttaaa aattgatttg ggagttgctt
     2101 tgtaataatc ttctgcttct aatcttcctt tgcaagtcag actttaaaga agactttata
     2161 aagctttctt ttttaaagga agtaacctac ttttttcttt atcaagaata tttctgaggt
     2221 tgatacatga ctttaacatt ttattattta ttgtaaaatc aatttagcat aatttatttt
     2281 attagggaga atgtgtaccc atcttccagc ttcagcacat ttttaaggat tgtttttaag
     2341 cttagtaatt gtggtattaa atgacttaga actaatggag aaaaacctga taggaaattg
     2401 atagaaaaac gaatgaaata tttttcatac ataatttcag ttggaggtaa tggaaaatat
     2461 gtagtctctc agttatttgt gggtaaatat gttttgctgt tgatacagta ataattatgg
     2521 agtgttttca aagccatgat ataattttta aaaatagatt tttaaggaag gctcatcttg
     2581 atctcattcg tttatttcag cttaatttat atattctttc ctattgaggc ttaaattttg
     2641 ttaagcaatg tgaggattat tgtggtaagt tgtatttagt aatcaataca gtgtgatact
     2701 ggcactagga ttgacaaata aagcaatgga acagaagaga gagcctgaaa acagatcaac
     2761 gtttatatga tcacttgatt tcgacaaagg tggcaaaaca attcaacaga gaaggaaagt
     2821 cttttcaaca aatggagcca gaatagaata gctgaatatc catatagaaa aaagtgaaca
     2881 atgaccccct acctcacaaa aatgactttg agatgaatca tagacctaaa tgtaatattt
     2941 taaaagtatg aagcttttta actgaaaaca gatgatattt ttgtgacttg gggggttagc
     3001 caaaggtttc ttaggtcaca gaaagcagta accataaaag atccaaaatt agagctcatc
     3061 agaattgtca ttgaaagtgt taacaaaagt aatatcaaat gacatttgaa aaatatcctt
     3121 gtaaaatgac tatattaata ggtataagga tttttcttat taatctaata aaattcctta
     3181 ataggaattt ccatagctta agagtggttt attttatctg catcttcttt ggtgattgca
     3241 aatcccttgt gatacttcat gattacttct gtctgtgaat aaagaagtgt gacttgtctg
     3301 ggtgctatat gttgctggtt tgaaattaag tcatgaagct agagggtaga gaaaatggaa
     3361 gaataaagag caacccataa atagataaat gctatttgga aagttttttt taaatgatat
     3421 tttatagaaa atcttgctca tttcatattt agtcttttct aaaattttat ttaattattg
     3481 ggtaggtgaa gtcgcttcca ttctatttta agccttcaaa atagccaatt ctaagggatg
     3541 tacttctgtt attatcaaca aaaaccttgc caacagctgc ggcactggct actctcacct
     3601 tatatgttta gttcccaaga tagcttgccc ttttccgaac agcagtcagc tcgactgtgc
     3661 cactaaaaca gacaaatatt tgctcgggaa tcacaaccac ggggacttgc tcccccagtt
     3721 aggaccatgg tacatatttg tgtgtatatt atggtgttac atgcagatta atactttcaa
     3781 ttaatcctcc tagttgcctg taacgttaac atttcaagat gcatttagat atttttatcc
     3841 tgtaggagga ttttgtttat ttgagggaaa aaaagggctt ttaatgtatt ctcctcaaaa
     3901 accatttaga gaaaacagat aagtaaaaat aaaatttaaa ttaccatatt tctatttaca
     3961 gggatgagca cattaacatt ttatgtattt agtgatcctt tttcctcatg tgtacacata
     4021 tgtttttgtg tgttagtctt gcttgccctc cccatagtct gaaatagttc tatgaagttt
     4081 atattatttt taaacttgat catatacaaa ttttcaggaa acaaaccact ctagctattt
     4141 gaagaggaat gcagatttat attgggagtt ttgaaactac atagtttctt acaaaatcat
     4201 tggaaggttt ggaggagcgg tttcaagctt aagtctccag agattactcc catccaaaca
     4261 tacagtattg gtgtacctag ggaactgctc acttttgcaa cagtcaggga gttcactgtt
     4321 ggaactatta atgttagaac atgttgcagt agttgtgttc aaggaatgag gaacctgctg
     4381 taacacttaa tgactgtgca ctggaatgca gaaaagttaa accttctatg cctaaatgcc
     4441 taaaacagac aaactggata gttatatttt tagaatgata ctgcgttttt tagagtagta
     4501 tgaattccta gatcagtcaa acatgcatgt tatttagttt gttctttagt atattgttaa
     4561 ctggcctaaa tccaatgact gacatggtaa agattcacca cttctagcat actgggcact
     4621 ttttattttt gacttgatta cattaacttt ttgaaaacta ttcagtgatt tattcagcca
     4681 atcttatgag gtacatctga gttgttctag atgctagagg atagtataac aggaaaaagc
     4741 ccctgctctc atggtgagac agataataag tatgtaatac aacttttcaa atagtagtat
     4801 gaatggtaaa aaaaataggg aaaaggggtg ggaggagctg aggtttgata gaatggtcat
     4861 ggaagatccc attaatgaga tgtactttaa gtagagacct aaatgaagat aattttttct
     4921 ctagtactga actagcactg tacaagtgga ttgcatatag gcatataggc agaacttctc
     4981 tagtactgaa ctaacactgt acaagtggat tgcatatagg catataggca gaaccaatgt
     5041 gcaataatta agaatattaa tttgcaatca tgtttgatgg ttaaatggtt tattaatgtt
     5101 ggagtgtcaa tatgaaaatg ggttgaataa aagatatatg gaaatgccta ggactactgc
     5161 tctatttact ttttagctta tccatatatt ttatgtaata tgcttctttg attctttctt
     5221 gtagcaatga taatataata ttgaataaac cataaaacca gtggg
//
