LOCUS       NM_015562              10521 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens UBX domain protein 7 (UBXN7), mRNA.
ACCESSION   NM_015562 XM_087353 XM_936412
VERSION     NM_015562.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10521)
  AUTHORS   Lin,Z., Lv,D., Liao,X., Peng,R., Liu,H., Wu,T., Wu,K., Sun,Y. and
            Zhang,Z.
  TITLE     CircUBXN7 promotes macrophage infiltration and renal fibrosis
            associated with the IGF2BP2-dependent SP1 mRNA stability in
            diabetic kidney disease
  JOURNAL   Front Immunol 14, 1226962 (2023)
   PUBMED   37744330
  REMARK    GeneRIF: CircUBXN7 promotes macrophage infiltration and renal
            fibrosis associated with the IGF2BP2-dependent SP1 mRNA stability
            in diabetic kidney disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10521)
  AUTHORS   Yuan,S., Xu,J., Wang,M., Huang,J., Ma,S., Liu,Y., Ke,Y., Zeng,X.,
            Wu,K., Wang,J., Tian,X., Zheng,D., Yousaf,T., Naz,W., Sun,J.,
            Chen,L., Guo,D., Guo,M. and Sun,G.
  TITLE     HBV X Protein Induces Degradation of UBXN7, a Novel Negative
            Regulator of NF-kappaB Signaling, to Promote HBV Replication
  JOURNAL   Cell Mol Gastroenterol Hepatol 15 (1), 179-195 (2023)
   PUBMED   36096451
  REMARK    GeneRIF: HBV X Protein Induces Degradation of UBXN7, a Novel
            Negative Regulator of NF-kappaB Signaling, to Promote HBV
            Replication.
REFERENCE   3  (bases 1 to 10521)
  AUTHORS   Xu,F., Chen,R., Shen,Y., Liu,H., Hu,L. and Zhu,L.
  TITLE     CircUBXN7 suppresses cell proliferation and facilitates cell
            apoptosis in lipopolysaccharide-induced cell injury by sponging
            miR-622 and regulating the IL6ST/JAK1/STAT3 axis
  JOURNAL   Int J Biochem Cell Biol 153, 106313 (2022)
   PUBMED   36257578
  REMARK    GeneRIF: CircUBXN7 suppresses cell proliferation and facilitates
            cell apoptosis in lipopolysaccharide-induced cell injury by
            sponging miR-622 and regulating the IL6ST/JAK1/STAT3 axis.
REFERENCE   4  (bases 1 to 10521)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 10521)
  AUTHORS   Di Gregorio,J., Cilenti,L., Ambivero,C.T., Andl,T., Liao,R. and
            Zervos,A.S.
  TITLE     UBXN7 cofactor of CRL3KEAP1 and CRL2VHL ubiquitin ligase complexes
            mediates reciprocal regulation of NRF2 and HIF-1alpha proteins
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (4), 118963 (2021)
   PUBMED   33444648
  REMARK    GeneRIF: UBXN7 cofactor of CRL3(KEAP1) and CRL2(VHL) ubiquitin
            ligase complexes mediates reciprocal regulation of NRF2 and
            HIF-1alpha proteins.
REFERENCE   6  (bases 1 to 10521)
  AUTHORS   Bandau,S., Knebel,A., Gage,Z.O., Wood,N.T. and Alexandru,G.
  TITLE     UBXN7 docks on neddylated cullin complexes using its UIM motif and
            causes HIF1alpha accumulation
  JOURNAL   BMC Biol 10, 36 (2012)
   PUBMED   22537386
  REMARK    GeneRIF: Study finds that UBXN7 over-expression converts CUL2 to
            its neddylated form and causes the accumulation of
            non-ubiquitylated HIF1alpha.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 10521)
  AUTHORS   den Besten,W., Verma,R., Kleiger,G., Oania,R.S. and Deshaies,R.J.
  TITLE     NEDD8 links cullin-RING ubiquitin ligase function to the p97
            pathway
  JOURNAL   Nat Struct Mol Biol 19 (5), 511-516,S1 (2012)
   PUBMED   22466964
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 10521)
  AUTHORS   Hanzelmann,P., Buchberger,A. and Schindelin,H.
  TITLE     Hierarchical binding of cofactors to the AAA ATPase p97
  JOURNAL   Structure 19 (6), 833-843 (2011)
   PUBMED   21645854
  REMARK    GeneRIF: FAF1 and UBXD7 only bind to p97-UFD1/NPL4, but not free
            p97, thus demonstrating for the first time a hierarchy in
            p97-cofactor interactions
REFERENCE   9  (bases 1 to 10521)
  AUTHORS   Bennett,E.J., Rush,J., Gygi,S.P. and Harper,J.W.
  TITLE     Dynamics of cullin-RING ubiquitin ligase network revealed by
            systematic quantitative proteomics
  JOURNAL   Cell 143 (6), 951-965 (2010)
   PUBMED   21145461
REFERENCE   10 (bases 1 to 10521)
  AUTHORS   Alexandru,G., Graumann,J., Smith,G.T., Kolawa,N.J., Fang,R. and
            Deshaies,R.J.
  TITLE     UBXD7 binds multiple ubiquitin ligases and implicates p97 in
            HIF1alpha turnover
  JOURNAL   Cell 134 (5), 804-816 (2008)
   PUBMED   18775313
  REMARK    GeneRIF: UBXD7 links p97 to the ubiquitin ligase CUL2/VHL and its
            substrate hypoxia-inducible factor 1alpha (HIF1alpha).
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA119173.1, BC047420.1, AB018337.1, BC028986.1, BG253663.1 and
            AC069257.28.
            
            On Nov 23, 2018 this sequence version replaced NM_015562.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.114482.1,
                                           SRR1660809.133266.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296328.9/ ENSP00000296328.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DA119173.1         48-50
            4-25                BC047420.1         1-22
            26-2142             AB018337.1         1-2117
            2143-2979           BC028986.1         2023-2859
            2980-4683           AB018337.1         2953-4656
            4684-4693           BG253663.1         438-447
            4694-10521          AC069257.28        26443-32270
FEATURES             Location/Qualifiers
     source          1..10521
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..10521
                     /gene="UBXN7"
                     /gene_synonym="UBXD7"
                     /note="UBX domain protein 7"
                     /db_xref="GeneID:26043"
                     /db_xref="HGNC:HGNC:29119"
                     /db_xref="MIM:616379"
     exon            1..101
                     /gene="UBXN7"
                     /gene_synonym="UBXD7"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1498
                     /gene="UBXN7"
                     /gene_synonym="UBXD7"
                     /note="UBX domain containing 7"
                     /codon_start=1
                     /product="UBX domain-containing protein 7"
                     /protein_id="NP_056377.1"
                     /db_xref="CCDS:CCDS43191.1"
                     /db_xref="GeneID:26043"
                     /db_xref="HGNC:HGNC:29119"
                     /db_xref="MIM:616379"
                     /translation="MAAHGGSAASSALKGLIQQFTTITGASESVGKHMLEACNNNLEM
                     AVTMFLDGGGIAEEPSTSSASVSTVRPHTEEEVRAPIPQKQEILVEPEPLFGAPKRRR
                     PARSIFDGFRDFQTETIRQEQELRNGGAIDKKLTTLADLFRPPIDLMHKGSFETAKEC
                     GQMQNKWLMINIQNVQDFACQCLNRDVWSNEAVKNIIREHFIFWQVYHDSEEGQRYIQ
                     FYKLGDFPYVSILDPRTGQKLVEWHQLDVSSFLDQVTGFLGEHGQLDGLSSSPPKKCA
                     RSESLIDASEDSQLEAAIRASLQETHFDSTQTKQDSRSDEESESELFSGSEEFISVCG
                     SDEEEEVENLAKSRKSPHKDLGHRKEENRRPLTEPPVRTDPGTATNHQGLPAVDSEIL
                     EMPPEKADGVVEGIDVNGPKAQLMLRYPDGKREQITLPEQAKLLALVKHVQSKGYPNE
                     RFELLTNFPRRKLSHLDYDITLQEAGLCPQETVFVQERN"
     exon            102..249
                     /gene="UBXN7"
                     /gene_synonym="UBXD7"
                     /inference="alignment:Splign:2.1.0"
     exon            250..317
                     /gene="UBXN7"
                     /gene_synonym="UBXD7"
                     /inference="alignment:Splign:2.1.0"
     exon            318..383
                     /gene="UBXN7"
                     /gene_synonym="UBXD7"
                     /inference="alignment:Splign:2.1.0"
     exon            384..496
                     /gene="UBXN7"
                     /gene_synonym="UBXD7"
                     /inference="alignment:Splign:2.1.0"
     exon            497..643
                     /gene="UBXN7"
                     /gene_synonym="UBXD7"
                     /inference="alignment:Splign:2.1.0"
     exon            644..734
                     /gene="UBXN7"
                     /gene_synonym="UBXD7"
                     /inference="alignment:Splign:2.1.0"
     exon            735..862
                     /gene="UBXN7"
                     /gene_synonym="UBXD7"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1256
                     /gene="UBXN7"
                     /gene_synonym="UBXD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1336
                     /gene="UBXN7"
                     /gene_synonym="UBXD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..10521
                     /gene="UBXN7"
                     /gene_synonym="UBXD7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10498..10503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBXN7"
                     /gene_synonym="UBXD7"
                     /note="hexamer: AATAAA"
     polyA_site      10521
                     /gene="UBXN7"
                     /gene_synonym="UBXD7"
                     /note="major polyA site"
ORIGIN      
        1 gttgttcggc ggcggcggcg gcggtaagat ggctgcccac gggggctccg cggcgtcctc
       61 ggcgctgaag gggttaattc aacagttcac caccattacc ggtgcaagtg aaagtgtagg
      121 aaaacatatg cttgaagcgt gcaacaataa tctggaaatg gcagtcacta tgtttttgga
      181 tggtggagga atcgctgaag agcccagtac cagttcagca agtgtctcta ctgtcagacc
      241 acacacagaa gaagaagttc gtgccccaat tcctcaaaag caggaaatac tggtggaacc
      301 agaaccatta tttggtgctc ctaaaagacg acggcctgca cgttcaattt ttgatggttt
      361 ccgggatttt cagactgaaa ctattcggca agaacaagaa ttaagaaatg gaggagctat
      421 cgataagaaa ttaactaccc ttgcagatct attccggcca cccattgatt tgatgcataa
      481 aggcagcttt gaaacagcca aagagtgtgg ccagatgcaa aataagtggc tgatgataaa
      541 cattcaaaat gttcaagact ttgcatgtca gtgcctcaac cgcgatgtgt ggagcaacga
      601 agctgtgaag aatattatcc gggaacattt cattttctgg caggtttatc atgacagtga
      661 ggaaggtcag agatacatac agttttataa gttaggggat ttcccctatg tttccatatt
      721 ggacccacgg acaggtcaga agctagtaga atggcaccag ttagatgtat cttctttctt
      781 ggaccaagtg acgggatttc tgggtgaaca tggacaactg gatggacttt ctagcagtcc
      841 ccccaaaaaa tgtgcccgtt cagagagcct tatagatgca agtgaagaca gccagctaga
      901 agctgccatc agagcctcct tacaagaaac acattttgat tcaacacaga caaaacagga
      961 tagccgctca gatgaagaat ctgaatctga acttttttct ggcagtgagg agttcatatc
     1021 cgtttgtggc tctgatgaag aagaagaggt agagaatctt gccaagtcca gaaagtctcc
     1081 ccacaaagat ttggggcata gaaaagagga gaatagaagg ccgctgactg agccaccagt
     1141 cagaactgat cctggaacag ccacaaacca ccaaggattg ccagctgtgg attcagagat
     1201 actggagatg ccacctgaaa aagcagatgg agtagtggag gggatagatg taaatggacc
     1261 aaaagcacag ctgatgttgc ggtatccaga tggaaaaagg gaacagatca ctcttccaga
     1321 gcaagctaaa ctgctagctt tggtgaagca cgtgcagtct aaaggatacc caaatgaacg
     1381 ttttgaactt ctcaccaact ttcctcgaag gaaattatct catctggact atgatattac
     1441 attgcaagag gcaggccttt gtcctcaaga gactgtcttt gtacaggaaa gaaattaaca
     1501 ccatggcttg acctctctca gcttacccct tttttccctt ttcctgtgag atacatgtca
     1561 ctaagtatgc attttggctc ataggaccac agagccaaag ttgggcaagc aagtcacctt
     1621 ccttctctta tttcttgatc tctcctataa tcagtctctt tctccccctt tgtttctttc
     1681 tcctcttctg ttttctcgct ccccactccg tacccttctg cctccccctc cccccacact
     1741 tttctttctt acctaatctg gtgaccaaac tgaagtgtaa ggataagacc tctcctagta
     1801 ctagcagcag gaattgtgtg ttccagtaag tggtctcttg cacggcactt ttttgggatc
     1861 aaatgttaac gttactcccc agactcttcg ggcaaaggaa tggctagatt cagagtaaga
     1921 acaaccctcc cttttttgta agtccccgtg tttagcaggg agaagaaatt ctctaacatg
     1981 ggtttggttt tgttgtgttc ttcatgtgga aatgtcgctt aacaaaatat ccaggctttt
     2041 gtttacgtgg aaaaagcatc ccttgtaatg attgctcatc atacttaaaa acctttttca
     2101 aaggattttc atgttcccag ctataaggac tatttccatg acatgtgtta ttggcagaat
     2161 gagtgttaaa tatggagcat atagcatggg gtgactttca ttgtcctaac ctgagacagt
     2221 tttccttatt actctgtatt gatcctgcta gtccaagaat ggacatgaag tgaacctatc
     2281 gtggtgactg ggataggaag gtgcttgcta tttttgccag cacagcatat tagttccttt
     2341 ggagccctcc attgtctgag tctgcagtga tctgtaggaa ggcagctggt caataatcat
     2401 gtagtacaat ggcttggaat tgtaaccact atggttattg attgtcctgt gttgtttcag
     2461 gcatacttag gtatgtccct ggggaaaaag aaaaccattc agctgagagt tgctaaccat
     2521 gttcttttgg ttagaaataa tggttcattt tttgcccctg gttggaatag tctctaaaag
     2581 gctctggtga ctgaattgaa catgagtccg catgctgttt tctttcaaaa ggtatcaaaa
     2641 cggaaagcct ctctaagggg aagacctttc aactccattc agaagacaac atttagtaag
     2701 gaggatggcg gaggttacta gtaattttca gatgtcttgg gctttttctg ccaacaaaac
     2761 ccaaaatcaa attagagttg gtgaaagctt tcttcagtgt ttttagaaga ggccatcttg
     2821 aatctgtaga ataccattta cacatcaact tcaccctatg ctcatttcgt attttgagct
     2881 taaatggagt cctctgaagg gggggtagtc gtgattctgg tggcaaaact agaactttta
     2941 acttgtaaaa tgaaaaatat taaatggacc tttttgtcag ttgaggattt agattgattc
     3001 ttttatctga ggagcgtatg ttcctcagat gttgcgtaga gacctttagg ttttcatcta
     3061 ctttaagatt gctctcttgg caattagggg atttgggaaa agaagaaaaa aagatgccat
     3121 gtgttgctag tacacagtta taggatatgg tttctaatgg ttgaattttg aggaactctc
     3181 cctaaagaat gagttttata tctcctcaag gaaatcatgg aaaaatctgt ttattcttca
     3241 gtgagtcctt ttgaattaat gttcttaaat ttttttctaa gtctgtgtaa gtgcttatgt
     3301 ataagtatat aattgtataa atatttataa atatatttat ataattacgg tttcatttct
     3361 accttgagtc aaagttctgt ctttagattg gtgactgagt aatacttaca ctttggtgtt
     3421 ttttcttagg ttcttgaggc ttacttaact agcagcttct gatttattga gtgaaagatg
     3481 gttttcatgt taattcctca gttgcatctc tgaacttgga taacatactt gccgtttgaa
     3541 aaatagagct gtatactgtc aaaggtgcac tggagggtaa aacatttgtt ggtagtagac
     3601 aagctcagaa atccaaaaat tcagggaggg cacagggtaa gaagagaggt ttgctcagct
     3661 ttgtgctctg atggcaccca tctgtactcc agcaaagtca tagctgaagc ccaaatcgct
     3721 caaacgtgtg aagtcaatca tttttcctat agggctctgt ttccttttct ttaccttcta
     3781 gcttctcttg ataaaacagt tgggagaact gccaacgtgt tcatcagtga gagggtgtgg
     3841 ttctttccga tatgttcagc acgtgcatat tcatttatga gaaaccaaag taacttcttc
     3901 aactcgggtt actgtgggat gattaagtag atataaagtg atttaaaaga cagcatggta
     3961 ctttcactca gcttaacatg cagctgggat gtctacaata caagatgtgg tgggttttat
     4021 tttattttat tttgaggcag gagtgtaatt atcttagggt tgatataaag gcccatggga
     4081 agagttacgg attgtacatg ggaagaatcc ataaggagta ttgccttgct caagaattta
     4141 atccgctgac agtatgcttc ttccagtttg ccttacttcc tctgcaagtt tctttgctcc
     4201 ttagggcaga ggttttattg aatagattaa atgaggtcag taagattagt taaaaatagt
     4261 cattccttgt gggtgttgga cacagcttga aaggagtgtt taaaaaaaaa aagctaggga
     4321 ggaaaagaac aagaaagata gacttcgaga gtgataagag aaaaatacag ggagatggaa
     4381 tggaaactac caggaaggcc gggcgcggtg gctcatgcct gtaatcccaa cactttggga
     4441 ggcggaggtg ggcagatcac ctaaggtcag gagatcgagg ccagcctgag caacatggtg
     4501 aaaccccgtc tctactaaaa atacaaaaat tacctgggtg tggtggcgtg cacctgtaat
     4561 cccagctact cagaggctga ggcaggggaa tggcttgaac ctgggaggca gaggttgcag
     4621 tgagccaaga tcgcaccatt acactccagc ctgggcgaca aagcgacact ccatctcaaa
     4681 tttaaaaaaa aaaaagaaga agaagaagaa aactagtggg aaaaaagtga gaggaatact
     4741 tttttgaaat tggtatcgga aggaactgga gaagagaaaa caacagtgcc aaatgagaaa
     4801 agaacaggaa acttaatact aattggcatg caccagatac ttttgtgtac atttgcctct
     4861 tcaatctccc gaagaatcgt acaaaatgta tactttcttc ccatgttaag aaaacaggta
     4921 tagagaactt attcaggact catagctagt gagtggcaaa tcagaattgg aatccagagt
     4981 ccatgctgtg gtctccttca gcaagagaat caagctaccc agatgattct cttctcattg
     5041 tttggctttg taaagtgtca cttagttttg ttcccataaa tatagaggaa gtagttgggt
     5101 taaagttgtg ggatttgcac tatgcctata catttttatt tatgccatta ttttgagagg
     5161 ctgattattg cttttttaaa atgatgcact ggtgaagatg tgaaagtaaa attgccacgt
     5221 ggcattattt gccaagaata aatgaaaagg gtaaaaaaac aattttttct ttttttaaac
     5281 atttttcaga aaagatacaa ttaccttttt taataggtga gcgccaccac gcccggctaa
     5341 tttttgcatt tttagtagag acagggtttc accatgttgg ccaggatggt ctcgatctct
     5401 tgatctcgtg ttccgcccac ctcggcctcc taaagtgctg ggattacagg catgagccac
     5461 tgcgcccgat ctacaattct gttttctgtg tcccatccat accagattat tgaaccctct
     5521 gtgtgtatgt ttttaaatct tgtatataat tctacttcct tgacttacaa gtcaacaatt
     5581 agctattgag ttctttatag aagttggaag tattttgaaa tctgagatct aattcctggc
     5641 caggtgtggt ggctcatgcc tgtaatccca atattttggg aggccgaggt gggtggatca
     5701 cctgaggttg ggagttcgag atcagcctgg ccaacatggt gaaaccccat ctctactgaa
     5761 aaatacaaaa attagccagg catggtggct gtctgtaatc ccagctaatg gggaggctga
     5821 ggcacaagaa tctcttgaac ctgggaggcg gaggttgcag tgagccgaga tcacaccact
     5881 gcactccatc ctgggcaatg gagcgagact ctgtctcaaa aaataataaa taagatatga
     5941 ttcctgcctg ttttatccag ttagagagac acactacaca tgaaataatt ggagagcatg
     6001 taaatgttta cctattagtt caaacttaga aaaagggaag aatatgtttt agttagcaaa
     6061 gtcttaaaca agactgaagt ggcaagcact gtagctcacg ttttcttttg actcaccttt
     6121 ttctttagct ccaccttttg taacttctag atttggggca tgaagttctg ccactaaggc
     6181 ataaccagta cccaagtagg aaaggattat tgatccctgg agtaaagatt cctagcttgc
     6241 ggggatctca ctattgatcc cccggagtaa agattcctag ctcgcaggaa tcttacttgc
     6301 acacttaggg aaaataccag agggagccac tagcaaccga aaaatgaagg aaagatttaa
     6361 tttctctacc caggtacaaa tccaatgcat agtatagtat atgttatatg cagaaagggc
     6421 actggaggtg tgagagccct ttgggtaaca gctctgctag ttgttacctt cacacttctc
     6481 tttcttctta atctctggtt tctcgtctga aaaatgagat aattggacta gattaatagt
     6541 tctcagcctt ttctagaaca acaaattaga ttatctctga agtccttttc caaaatttca
     6601 tgcttccagt ctctccccgt gattgcgtat tatccctagg ctaattaaaa gtgtgctggt
     6661 taatcagttt ctttactttt tttttctctc ttttttttat tctgtgttca ggtatcattt
     6721 gaccaacaac ttgctcttaa tcttactgcg atgactgaaa tctccaaaga ggagagtata
     6781 gtagttatag gtctagtaat aataatcttg taaacaattc attatttttt aaaacttaat
     6841 gctgtgtgcc taatcagtgt tgagtatgac taaaatgtaa atgagaacca aatatgacac
     6901 taacgctggc actaaatttt atttttactt gtgtacttaa agtactttac tggcctgttg
     6961 ggaaattgat ttgtataaga ttcacacctg gttttggcag aaacagcttt ttaaagatac
     7021 aattaggctg acttaaaaat gttttttatt ccacagaatg tatctttatt atgtcattct
     7081 taccgtctct ctgccttttt tgaccatcat gtaactacgc agtagtaaat catggggtgc
     7141 aggctgatga attagtagtc tttgtaaaac taaaatgtaa tgagcatagg aagagacagc
     7201 tcttctggtg aacatggcag ttttccggta ataccagcct tgatgaatag gctaaagaca
     7261 gctgtgtact atggacattc aacttcactg gattgcctgg cttagctttt cagttattgt
     7321 cttgccgtga aacatggtgt tgcactgtac acattttaga atagtggcaa gaatgttctt
     7381 tagaactgca gataacccaa cagagaatac cataccaata tatcggtttc tcctgttaca
     7441 tagagatttg gtatttcagt gatggttatg gtttttgact cacctgtgtg tcagtcctgc
     7501 tagagagaca gtatagaatc aagaatttct tgatgtcttt ttaaaaatag agattataat
     7561 ggccttgcta gttgtcctgt gaagtgacag acccttaatt agaaatcttt taatcctgct
     7621 ttccatttta cttctccacc atttattttt aacattcatt ctctgaaaat agttatgatt
     7681 tttagtgtaa ttggctatgt ttaagaaatt ccatttcaaa gtcttaatat gtaacaatct
     7741 tcatttttta taaaattgaa ggacattttt gaggcaaact tacttttata gctcattttc
     7801 tccctagtta aggagaattc tctggtttca tatagagaat ggctagctct gtgatacccc
     7861 accctctttg tggcctacca gttgctgttg tgttgcttaa aattgcagat attctcataa
     7921 acatgatgat ttttggcaca ggcctttctt tgctattgat ttcaaaataa agttgggcaa
     7981 tccaatttga actactttaa taaacataat ttagcattcc tgtaatgaga aagtattttc
     8041 aaaagataac cagatttatt tctaggatta gagatggcaa ataccaatga tagtattttt
     8101 cccaagagca atcacagatt aatctataaa tatgagaagt cgcattattg tacttaattc
     8161 tttggcaaca aacagcaagt ttttattgtt taattgtatt tcctctctag agatcacaat
     8221 actctgggta ttttatatcc cttctaaagg tcatttgggt tttcaaatgg gaagaatagt
     8281 caagctaagc tggactaaac ctaagtaata ttttttctca tcaaaagaag ttattaatct
     8341 aactgggtta gcatgagtca ttcatttttt agacatgata aatgggaaac atatcaaatc
     8401 attagataaa ttctgacctg gaattgaatt ccccctttct taaaatcttt ttaatttgct
     8461 tttttcatag actcagtatg gaactcttaa ctgataaggg agagattctt gatctggaac
     8521 cgttccctgc cattctcctt ttttctctct atctaggtag ctggttccat agtgcccgtc
     8581 acgagggtcc atttcagttt gatgacatta gactgcttac actcagctgg atgccttgct
     8641 gtttgcagca acatgatttt acagtatgct tttctcaaag ctttgcattc ttaatggaga
     8701 tatcaaatgg tgtaattcca aatataaata tgtttatgac actaatcata tgcttttaac
     8761 aataactttt tgataactta ttgccctgta agttaaacct tacacggagt gactgttgcc
     8821 atcagaaaat cccctttcac ctgctagaga gagtgaaagt agtgcgtggc ctccactttt
     8881 cagttaacga gtagcaagct tctagtaggg gctgcttatc tgacccatgt ggggtcttgg
     8941 gccttgttac tttcctgggt tcgtcccttc agctggaaag gctgttgaaa acacttgcca
     9001 ggaaacagta aagctgtgag agaatcttct agtcttagat atagagaaat gagtaccagt
     9061 tgatgctaac acgatactta gactttgagg ggcttccatc caagctttgg catgaatctg
     9121 ttagacacgg ttttcttcac tcctctgata atcttttttt ccagaatggt tttttgttgt
     9181 tgttgttgtt aacaaattct aaacatccag tgttactttt tgttttgttt gttttgtttt
     9241 gttttgtttt gttttgtttg cccttcagga aagtcctttt tcgagtaggt attgattgtt
     9301 ccctggaaac tctcagcagt gtctgtgcag gctctgtgca tgctttgtat gagttcggct
     9361 tgaacaatgc atttgaagtc acctgggatg tccagttctg gcatgtcttc attgattgtg
     9421 tttttaaaca tgtttcatgt ttcatgtcat tttccaaacc tcactttaca tcttactcag
     9481 agaagttaat caaggaatga aatttctagg gggataggga tgatgagggt gggttggggg
     9541 cttgagtgaa gtcaacttgg ggtatttgct ttaaagtgtt ttctaaagca gttcctaaca
     9601 gtatttagag attccctggg atgtttgtgg ctcaacttat tctggacaaa gtgtgtgtgg
     9661 gggtggtctt actgagattt gcattcttaa tgcaggacag gctctaaatt tcatctgtac
     9721 tctaaatttg tgattgaatc caagaagata acagagacag tgctcctgtt gtaatgtttc
     9781 tggcaagtgc tccctaaaat gcacatcgaa ttctgttttc tgggcctttt ctccaatggt
     9841 gctaggagat accgttgatt tctgcagctc ttctcagtgg tgggaagaag tctttgggat
     9901 tgttgagcaa ggggcagctg gaccatccac taaatttttt tgttcaagac acattagaga
     9961 ccctcctgta tatctagtaa gtcataataa aggtgcttgg gaaagcctta aatttgaaga
    10021 cacatggagg cggtagaaaa ttaaacttgt aagaggagaa aaacatgcca ttaggtaacg
    10081 cagagttgta actactggct aagactcaat ggaacttcca cttgctctaa aaccagggaa
    10141 atcttagata actgggtgtg atctacctat agatctacct agtctatagg taataatttc
    10201 cagaaggagg atcttgctgt cagttgggga tcctctggtt tggtctgtac caaattgtga
    10261 atactcttgc tgtgttgtac ccagttgctt tatattaata ctgcaacttg aaacggggag
    10321 ggtgggggga caatggggtg ggggagggaa gggagtggga cgataagtct tttgaagaca
    10381 tcagctcact gtgctgagag agggaccaaa ctcaaggaaa cctctgatct atacattcaa
    10441 ctgctgcatt tttttataaa tacatgtaaa tgtcctgttg taatatttga tcttggaaat
    10501 aaaaacaaaa acttttcagt a
//
