LOCUS       NM_025241               1915 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens UBX domain protein 6 (UBXN6), transcript variant 1,
            mRNA.
ACCESSION   NM_025241
VERSION     NM_025241.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1915)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1915)
  AUTHORS   Ketkar,H., Harrison,A.G., Graziano,V.R., Geng,T., Yang,L.,
            Vella,A.T. and Wang,P.
  TITLE     UBX Domain Protein 6 Positively Regulates JAK-STAT1/2 Signaling
  JOURNAL   J Immunol 206 (11), 2682-2691 (2021)
   PUBMED   34021047
  REMARK    GeneRIF: UBX Domain Protein 6 Positively Regulates JAK-STAT1/2
            Signaling.
REFERENCE   3  (bases 1 to 1915)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1915)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1915)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1915)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1915)
  AUTHORS   Alexandru,G., Graumann,J., Smith,G.T., Kolawa,N.J., Fang,R. and
            Deshaies,R.J.
  TITLE     UBXD7 binds multiple ubiquitin ligases and implicates p97 in
            HIF1alpha turnover
  JOURNAL   Cell 134 (5), 804-816 (2008)
   PUBMED   18775313
REFERENCE   8  (bases 1 to 1915)
  AUTHORS   Madsen,L., Andersen,K.M., Prag,S., Moos,T., Semple,C.A., Seeger,M.
            and Hartmann-Petersen,R.
  TITLE     Ubxd1 is a novel co-factor of the human p97 ATPase
  JOURNAL   Int J Biochem Cell Biol 40 (12), 2927-2942 (2008)
   PUBMED   18656546
  REMARK    GeneRIF: UBXD1 is a novel co-factor of the human p97 ATPase.
REFERENCE   9  (bases 1 to 1915)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 1915)
  AUTHORS   Carim-Todd,L., Escarceller,M., Estivill,X. and Sumoy,L.
  TITLE     Identification and characterization of UBXD1, a novel UBX
            domain-containing gene on human chromosome 19p13, and its mouse
            ortholog
  JOURNAL   Biochim Biophys Acta 1517 (2), 298-301 (2001)
   PUBMED   11342112
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM764980.1, BC008288.1 and BC007414.2.
            
            On Nov 23, 2018 this sequence version replaced NM_025241.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.278027.1,
                                           SRR1163655.68538.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153427 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301281.11/ ENSP00000301281.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               BM764980.1         1-270
            271-1761            BC008288.1         169-1659
            1762-1915           BC007414.2         1222-1375
FEATURES             Location/Qualifiers
     source          1..1915
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1915
                     /gene="UBXN6"
                     /gene_synonym="UBXD1; UBXDC2"
                     /note="UBX domain protein 6"
                     /db_xref="GeneID:80700"
                     /db_xref="HGNC:HGNC:14928"
                     /db_xref="MIM:611946"
     exon            1..180
                     /gene="UBXN6"
                     /gene_synonym="UBXD1; UBXDC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1423
                     /gene="UBXN6"
                     /gene_synonym="UBXD1; UBXDC2"
                     /note="isoform 1 is encoded by transcript variant 1; UBX
                     domain-containing 2; UBX domain containing 1; UBX
                     domain-containing protein 6; UBX domain-containing protein
                     1; CTB-50L17.16"
                     /codon_start=1
                     /product="UBX domain-containing protein 6 isoform 1"
                     /protein_id="NP_079517.1"
                     /db_xref="CCDS:CCDS12129.1"
                     /db_xref="GeneID:80700"
                     /db_xref="HGNC:HGNC:14928"
                     /db_xref="MIM:611946"
                     /translation="MKKFFQEFKADIKFKSAGPGQKLKESVGEKAHKEKPNQPAPRPP
                     RQGPTNEAQMAAAAALARLEQKQSRAWGPTSQDTIRNQVRKELQAEATVSGSPEAPGT
                     NVVSEPREEGSAHLAVPGVYFTCPLTGATLRKDQRDACIKEAILLHFSTDPVAASIMK
                     IYTFNKDQDRVKLGVDTIAKYLDNIHLHPEEEKYRKIKLQNKVFQERINCLEGTHEFF
                     EAIGFQKVLLPAQDQEDPEEFYVLSETTLAQPQSLERHKEQLLAAEPVRAKLDRQRRV
                     FQPSPLASQFELPGDFFNLTAEEIKREQRLRSEAVERLSVLRTKAMREKEEQRGLRKY
                     NYTLLRVRLPDGCLLQGTFYARERLGAVYGFVREALQSDWLPFELLASGGQKLSEDEN
                     LALNECGLVPSALLTFSWDMAVLEDIKAAGAEPDSILKPELLSAIEKLL"
     exon            181..344
                     /gene="UBXN6"
                     /gene_synonym="UBXD1; UBXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            345..409
                     /gene="UBXN6"
                     /gene_synonym="UBXD1; UBXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            410..538
                     /gene="UBXN6"
                     /gene_synonym="UBXD1; UBXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            539..636
                     /gene="UBXN6"
                     /gene_synonym="UBXD1; UBXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            637..712
                     /gene="UBXN6"
                     /gene_synonym="UBXD1; UBXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            713..797
                     /gene="UBXN6"
                     /gene_synonym="UBXD1; UBXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            798..1017
                     /gene="UBXN6"
                     /gene_synonym="UBXD1; UBXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1148
                     /gene="UBXN6"
                     /gene_synonym="UBXD1; UBXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1297
                     /gene="UBXN6"
                     /gene_synonym="UBXD1; UBXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1915
                     /gene="UBXN6"
                     /gene_synonym="UBXD1; UBXDC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1893..1898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBXN6"
                     /gene_synonym="UBXD1; UBXDC2"
                     /note="hexamer: AATAAA"
     polyA_site      1915
                     /gene="UBXN6"
                     /gene_synonym="UBXD1; UBXDC2"
                     /note="major polyA site"
ORIGIN      
        1 attttcttcc ggtggctggt ctccggcggc cccgtccccg actgggcccc gtgccccccc
       61 gcccccgcgg ccccccgccg ccgggccagc cgccaccatg aagaaattct ttcaggagtt
      121 caaggccgac atcaagttca agagcgcggg acccggtcag aagctcaaag agtccgtggg
      181 ggaaaaggcc cacaaagaga agcccaacca gccagccccc aggccgcccc gccagggacc
      241 caccaatgag gcacagatgg cagccgctgc cgccctagcc cggctggagc agaagcagtc
      301 ccgggcctgg ggccccacat cgcaggacac catccgaaac caggtgagaa aggaacttca
      361 agccgaagcc accgtcagcg ggagccccga ggccccaggg accaacgtgg tatctgagcc
      421 cagagaggaa ggctctgccc acctggctgt gcctggcgtg tacttcacct gtccgctcac
      481 tggggccacc ctgaggaagg accagcggga cgcctgcatc aaggaggcca ttctcttgca
      541 cttctccacc gacccagtgg ccgcctccat catgaagatc tacacgttca acaaagacca
      601 ggaccgggtg aagctgggtg tggacaccat tgccaagtac ctggacaaca tccacctgca
      661 ccccgaggag gagaagtacc ggaagatcaa gctgcagaac aaggtgtttc aggagcgcat
      721 taactgcctg gaagggaccc acgagttttt tgaggccatt gggttccaga aggtgttgct
      781 tcccgcccag gatcaggagg accccgagga gttctacgtg ctgagcgaga ccaccttggc
      841 ccagccccag agcctggaga ggcacaagga acagctgctg gctgcggagc ccgtgcgcgc
      901 caagctggac aggcagcgcc gcgtcttcca gccctcgccc ctggcctcgc agttcgaact
      961 gcctggggac ttcttcaacc tcacagcaga ggagatcaag cgggagcaga ggctcaggtc
     1021 cgaggcggtg gagcggctga gcgtgctgcg gaccaaggcc atgcgggaga aggaggagca
     1081 gcgggggctg cgcaagtaca actacacgct gctgcgcgtg cgcctccccg atggctgcct
     1141 cctgcagggc actttctacg ctcgggagcg gctgggggcg gtgtacgggt tcgtccggga
     1201 ggccctgcag agcgactggc tgccttttga gctgctggcc tcgggagggc agaagctgtc
     1261 cgaggacgag aacctggcct tgaacgagtg cgggctggtg ccctctgccc tcctgacctt
     1321 ctcgtgggac atggctgtgc tggaggacat caaggccgcg ggggccgagc cggactccat
     1381 cctgaaaccc gagctcctgt cagccatcga gaagctcttg tgaaataaaa gcagggttgg
     1441 cctcagccct gtgggtctgt ctcatgctct ccctgttcct ctccccgcca ccccagggcc
     1501 tccaagccac ctctggaaat acttggctct gccccatggg cacgggaggg gcgccagccg
     1561 tggagctgtg gaattgggcc ccgtggcaga gcccccatcc cttgggggct gtggggatgc
     1621 gcccaagccc ccgagggaga ggcctgggga caccaacaaa tctaagccct ccctagctgc
     1681 ttggtaactg tgtcatgaag ctgccggaca gacacacgtg gcatctccct gggcaggaga
     1741 gcaggcctgc agcatgggtc ctgttcccgt gtgccgtggg tggcagtggc tgcacctggc
     1801 actagggctg ctctgtggat gtgggtgaca acggcaggag gggatgctgg ccttcctgca
     1861 catagacctg cagttagtaa atcataagcc caaataaaca ggttgtttga atata
//
