LOCUS       NM_181713               6022 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens UBX domain protein 2A (UBXN2A), mRNA.
ACCESSION   NM_181713
VERSION     NM_181713.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6022)
  AUTHORS   Sane,S., Srinivasan,R., Potts,R.A., Eikanger,M., Zagirova,D.,
            Freeling,J., Reihe,C.A., Antony,R.M., Gupta,B.K., Lynch,D.,
            Bleeker,J., Turaihi,H., Pillatzki,A., Zhou,W., Luo,X.,
            Linnebacher,M., Agany,D., Zohim,E.G., Humphrey,L.E., Black,A.R. and
            Rezvani,K.
  TITLE     UBXN2A suppresses the Rictor-mTORC2 signaling pathway, an
            established tumorigenic pathway in human colorectal cancer
  JOURNAL   Oncogene 42 (21), 1763-1776 (2023)
   PUBMED   37037900
  REMARK    GeneRIF: UBXN2A suppresses the Rictor-mTORC2 signaling pathway, an
            established tumorigenic pathway in human colorectal cancer.
REFERENCE   2  (bases 1 to 6022)
  AUTHORS   Reihe,C.
  TITLE     UBXN2A, a Ubiquitin-Like Protein, Alters Proteins in mTORC2 Pathway
  JOURNAL   S D Med 75 (10), 456-458 (2022)
   PUBMED   36889268
  REMARK    GeneRIF: UBXN2A, a Ubiquitin-Like Protein, Alters Proteins in
            mTORC2 Pathway.
REFERENCE   3  (bases 1 to 6022)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 6022)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 6022)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 6022)
  AUTHORS   Wang,C.W. and Lee,S.C.
  TITLE     The ubiquitin-like (UBX)-domain-containing protein Ubx2/Ubxd8
            regulates lipid droplet homeostasis
  JOURNAL   J Cell Sci 125 (Pt 12), 2930-2939 (2012)
   PUBMED   22454508
  REMARK    GeneRIF: Ubx2 and Ubxd8 regulates lipid droplet homeostasis.
REFERENCE   7  (bases 1 to 6022)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   8  (bases 1 to 6022)
  AUTHORS   Vinayagam,A., Stelzl,U., Foulle,R., Plassmann,S., Zenkner,M.,
            Timm,J., Assmus,H.E., Andrade-Navarro,M.A. and Wanker,E.E.
  TITLE     A directed protein interaction network for investigating
            intracellular signal transduction
  JOURNAL   Sci Signal 4 (189), rs8 (2011)
   PUBMED   21900206
REFERENCE   9  (bases 1 to 6022)
  AUTHORS   Bhatnagar,P., Purvis,S., Barron-Casella,E., DeBaun,M.R.,
            Casella,J.F., Arking,D.E. and Keefer,J.R.
  TITLE     Genome-wide association study identifies genetic variants
            influencing F-cell levels in sickle-cell patients
  JOURNAL   J Hum Genet 56 (4), 316-323 (2011)
   PUBMED   21326311
REFERENCE   10 (bases 1 to 6022)
  AUTHORS   Lowe,J.K., Maller,J.B., Pe'er,I., Neale,B.M., Salit,J., Kenny,E.E.,
            Shea,J.L., Burkhardt,R., Smith,J.G., Ji,W., Noel,M., Foo,J.N.,
            Blundell,M.L., Skilling,V., Garcia,L., Sullivan,M.L., Lee,H.E.,
            Labek,A., Ferdowsian,H., Auerbach,S.B., Lifton,R.P.,
            Newton-Cheh,C., Breslow,J.L., Stoffel,M., Daly,M.J., Altshuler,D.M.
            and Friedman,J.M.
  TITLE     Genome-wide association studies in an isolated founder population
            from the Pacific Island of Kosrae
  JOURNAL   PLoS Genet 5 (2), e1000365 (2009)
   PUBMED   19197348
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC066692.3, AL832079.1 and BC016364.1.
            
            On Nov 24, 2018 this sequence version replaced NM_181713.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.59218.1,
                                           SRR1803617.137813.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309033.5/ ENSP00000312107.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC066692.3         106521-106563
            44-1027             AL832079.1         2-985
            1028-1328           BC016364.1         916-1216
            1329-1939           AL832079.1         1287-1897
            1940-6022           AC066692.3         166885-170967
FEATURES             Location/Qualifiers
     source          1..6022
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..6022
                     /gene="UBXN2A"
                     /gene_synonym="UBXD4"
                     /note="UBX domain protein 2A"
                     /db_xref="GeneID:165324"
                     /db_xref="HGNC:HGNC:27265"
     exon            1..186
                     /gene="UBXN2A"
                     /gene_synonym="UBXD4"
                     /inference="alignment:Splign:2.1.0"
     exon            187..241
                     /gene="UBXN2A"
                     /gene_synonym="UBXD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..980
                     /gene="UBXN2A"
                     /gene_synonym="UBXD4"
                     /note="UBX domain containing 4; UBX domain-containing
                     protein 4"
                     /codon_start=1
                     /product="UBX domain-containing protein 2A"
                     /protein_id="NP_859064.2"
                     /db_xref="CCDS:CCDS1704.1"
                     /db_xref="GeneID:165324"
                     /db_xref="HGNC:HGNC:27265"
                     /translation="MKDVDNLKSIKEEWVCETGSDNQPLGNNQQSNCEYFVDSLFEEA
                     QKVSSKCVSPAEQKKQVDVNIKLWKNGFTVNDDFRSYSDGASQQFLNSIKKGELPSEL
                     QGIFDKEEVDVKVEDKKNEICLSTKPVFQPFSGQGHRLGSATPKIVSKAKNIEVENKN
                     NLSAVPLNNLEPITNIQIWLANGKRIVQKFNITHRVSHIKDFIEKYQGSQRSPPFSLA
                     TALPVLRLLDETLTLEEADLQNAVIIQRLQKTASFRELSEH"
     exon            242..380
                     /gene="UBXN2A"
                     /gene_synonym="UBXD4"
                     /inference="alignment:Splign:2.1.0"
     exon            381..487
                     /gene="UBXN2A"
                     /gene_synonym="UBXD4"
                     /inference="alignment:Splign:2.1.0"
     exon            488..625
                     /gene="UBXN2A"
                     /gene_synonym="UBXD4"
                     /inference="alignment:Splign:2.1.0"
     exon            626..784
                     /gene="UBXN2A"
                     /gene_synonym="UBXD4"
                     /inference="alignment:Splign:2.1.0"
     exon            785..6022
                     /gene="UBXN2A"
                     /gene_synonym="UBXD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1918..1923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBXN2A"
                     /gene_synonym="UBXD4"
                     /note="hexamer: AAGAAA"
     polyA_site      1939
                     /gene="UBXN2A"
                     /gene_synonym="UBXD4"
                     /note="major polyA site"
     polyA_site      4824
                     /gene="UBXN2A"
                     /gene_synonym="UBXD4"
     regulatory      6001..6006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBXN2A"
                     /gene_synonym="UBXD4"
                     /note="hexamer: ATTAAA"
     polyA_site      6022
                     /gene="UBXN2A"
                     /gene_synonym="UBXD4"
                     /note="major polyA site"
ORIGIN      
        1 gcttgggcgc ctggcgaaga ccgagagagg ctggcgggat ctcagcggcg cggccgcgga
       61 acctgaggcg gtctggggcg gcggcgctcc ggctctgaag ggctccagcc aaacggagcc
      121 cgcggccaaa cggtgcctgc ggtgcctgag ctgagtgagg ccgaggccgg gaggccgtgc
      181 ccggagtaag gcgaaagaga atgaaagacg tagataacct caaaagtata aaagaagaat
      241 gggtttgtga aacaggatct gataatcaac ctcttggtaa taatcaacaa tcaaattgtg
      301 aatattttgt tgatagcctt tttgaggaag ctcagaaggt tagttccaaa tgtgtgtctc
      361 ccgctgaaca gaagaaacag gtagatgtaa atataaaatt atggaaaaac ggattcaccg
      421 tcaacgacga tttcagaagt tattccgatg gtgccagtca gcagtttttg aactccatca
      481 aaaaggggga attaccttca gaattacagg gaatttttga taaagaagag gtggacgtta
      541 aagttgaaga caagaaaaat gaaatatgtt tgtctacgaa gcctgtgttc cagccctttt
      601 caggacaggg tcacagacta ggaagtgcca caccaaaaat tgtttctaaa gcaaagaata
      661 ttgaagttga aaataaaaat aatttgtctg ctgttccact gaacaacttg gaacccatta
      721 ctaatataca gatctggttg gccaatggaa aaaggattgt ccagaaattt aacattactc
      781 atagagtaag ccatatcaaa gacttcattg aaaaatacca aggatctcaa agaagtcctc
      841 cgttttccct ggcaacagct cttcctgtcc tcaggttgct agatgagaca ctcacactgg
      901 aagaagcaga tttacagaat gctgtcatca ttcagagact ccaaaaaact gcatctttta
      961 gagaactttc agagcactga tttttgatag actaagtgga aaatttgcag agaaatgatg
     1021 gttgtaagtg gacatgcaaa ccaaaattgg ggattggaga agtcagactc actagacttt
     1081 tggttcgagt actattgaac tctctcctga tgagaagatg tttagataag tacaagttaa
     1141 gaaagtagca tatgactgga aactatattc agtgcacttt ctccaaaaga ctacccagaa
     1201 aaatagactt attttcaaat accagttatc aagatatatt aaatagctgt attgtttaga
     1261 atcttaatat ggtataaatt agcatatgta ttcacaatat tcattcagac atcattccca
     1321 gacagcaggg atttatttaa atgttagctg tctgagtttt taaatagcta atacgaccgg
     1381 gtacagtggt tcatgcctgt aatcccagaa cttcgggagg ccgagacagg cagatcacga
     1441 ggtcaacaga ttgagaccat cctggcaaac atggtgaaac cccatctcta gtaaaaatac
     1501 aaaaattagc tgggcgtggc ggtgcgcaac tgtagtccca gctactcggg aggctgaggc
     1561 aggagaatct cttgaacctg gcaagtgtag gttgcagtga gctgagattg agcaactgta
     1621 ctccagcttg gcgacagagc aagaccccct ctcaaaaata aataaaataa agtaaaataa
     1681 atataaataa ttgtggccgg gtgcaatggc tcatgcctgt aatcccagca ctttgggagg
     1741 ctgagatggg aggatcactt gaagccagga gtttaaaacc agaatgatca acagagtgag
     1801 acccctgtct atatattttt ttaatttaaa aaataaaaga ataaaattgt gtagctcagt
     1861 atagtatcaa gattaatctg cctactcaca tttctacact ttataaaaat gtaataaaag
     1921 aaaattatct ttctaaaaag cctattccct ttccatttta ttttctttca aaaattatgg
     1981 atttgttttt ggctaacatt tgggattagc cattcatttg ccaccactca cttagaatat
     2041 aatgccggtg tgtgtcacat tactagtatt ttttaaatgc atcatataaa gtatggtttt
     2101 ctgtttcttt ttcgtttgtt tgagatggag tttcgctctt gttgcccagg ctggagtgca
     2161 gtggcgcaat ctcagctcac cacaacctcc acctcccggg ttcaagagat tctcctgctc
     2221 agcctcccaa gtagctggga ttacaggcat gcgccaccat gcttggctaa ttttgcattt
     2281 ttagtagaca cgggatttca ccatgttggt caggctggtc tcgaactccc gacctcaggg
     2341 gatctgcctg cctaggcctc ctgaagtgct gggattacaa gtgtgaacca ccgtgcccag
     2401 ctggttttct gtttcataca tcagagtcaa cttgtgaata catttaaaga ttatttcatt
     2461 ttgatatcac gaagaaaaac aggctttata tctcagactt taactaaatc cagttagacc
     2521 tcaatttttc actgtcagat taaatcccca tacctgaaaa taagtttaac attttttttt
     2581 gcaaatgatc tattgaatca gatttaaaat gaagcatgca ttgagtgtgc caaggaacta
     2641 agtggtccat agcagcagta atgttcatag ggtgcgagat gcctgctatg aaacagcaac
     2701 tctcaaacat ttttatctca agaccatttg tttatgtgag ctatatatat tattatatta
     2761 aatattaaat ttttaaaata tttatttatg ggccaggcac ggtggcttac gcctgtaatc
     2821 ccagcacttt gggaggctga ggcaggcgga tcacaaggtc aagtgattga gaccatcctg
     2881 tccaacatgg tgaatccccg tctctactaa aaatacaaaa aaaattagct gggtgtggtg
     2941 gcatgcgcct gtagtcccag ctacgtggga ggctgaggga ggagaatggc ttgaacccgg
     3001 gaggtggagg tttcagtgag ccgagattgc gcccctgcac tccagcctgg tgacggagcg
     3061 agactctttc tcaaaaaaaa aaaattattc atttaaaaat aacttctggc tggacatggt
     3121 gtctcacgcc tgtaatccta gcactttggg aggccaagac aggtggatca cttgagccca
     3181 ggagtttgag accagcctgg gcaacaaggc aaaactctat ctataaaaat tacaaaaatt
     3241 agtgcagtag ctcacacctg taatcccagc actttgggac actaaagcgg gcagatcacc
     3301 tgaggtcagg agttcgagac cagcctggtc aatgtggtga aaccatgtct gtactaaaaa
     3361 tacaaaaatt agcctggtgt ggtggcacat gcctgtaatc tcagctacta gggaggctga
     3421 gggaggagaa ttgcttgaac tcaggaggca gaggttgcag tgagccgaga ttgcgccact
     3481 gcactctagc ttaggcaaca gagtaagacc ctgccgtaat aataataact tttttttttt
     3541 tgagatagag ttttgctctt tcccccagac tagagtgcaa tggcgcgatc ttggctcact
     3601 gcaacttgtc cccccgggtt caagcgattc ttctgccaca gcctcccgag tagctgggat
     3661 tataggcgcc cactaccacg cctggctaat ttttgtattt ttagtagaga cggggtttcg
     3721 ccatgttggc ctggctggcc tctaactcgt aacctcaggt gatccgcccg ccttggcctc
     3781 ccaaagtgct aggattatag gcgtgagcca ctgtgcccag ccaataataa cttataaaac
     3841 atgaaacgat ttagtgagaa aagtggccgg ttttttgggg ggaattactt tctgtcataa
     3901 agaagataga tgggttctca tgtcttctac attcagtctg ttgtgcagtc acatatcatg
     3961 tagactctgg aaaacacctc tgtatactgg tgaaagaatg aaaagaagca aataatgcct
     4021 tagtatgatt atgaaaaacg ttttgacttc acagtgccct gaatgggtct tgggaatctc
     4081 cagggatccc tcaggcacac tttgagaacc aatctatata aagtgatggt tcacaatgat
     4141 tctgaagcct tagtttcaga atcatttggg gcagcttttc aaaaatgcca ttcctgccac
     4201 ctaccacaaa gattctgatt cactgtatct gtgatgggtc tcagatctct gcatttttaa
     4261 tctcacgtga ttcttaagta tgtggtggaa gtacctttct tcaggaaatt ctgtcctaag
     4321 cttttaccct gagaaaataa aacctgcatg ctttcaccat ggacggtggg agactccact
     4381 gaaacacatc tgctagacca ctaagtttat ccttgtcacc cagtttgctc ttggaaagag
     4441 tctgttccct tttgtcactg aaccaatcat gacataaact tgtgctttac ctcctatagc
     4501 acagccgaga caaggctgga acatttaatt aaggttttta ctaaggactc aggaataaca
     4561 acagggaaat atctatgtaa ctagatgacc tgacataaaa tctatcttct gattgcagtc
     4621 tattgtgaga atgctgcttt tcctagctcc cagccttcca tggggcagaa ggctctttta
     4681 attaggaaga gagggaggac aaaggagagc cttttctttt gtccattact cttagaaatg
     4741 aacaggtaca taatagaaaa taaataatta ttgttggtaa tgtttacaca gcagtgttag
     4801 agcctctctg tagtgaaaca aaaataatgt tcttaccaaa aaaaaaaaaa aaaaaaagag
     4861 gcaatgataa aatcaatgag cttatctttc tgatatagaa aataacagga tgacagttaa
     4921 tacatgttca ggaatctaag aaaatgtttc atataggcct atcatgtagc atttttattt
     4981 gcataattat agtcaacata tgattctcca tgtaggggtc tctcattgag aatgtttcct
     5041 gtgtacctat agaaaagcct ctttggtaga ttttccggtt tataattatt taaccagaag
     5101 atacatggga ggttcttttg tatgtacctg tagaatacat cccagtaagg gtcctatgga
     5161 gaaagacctg ttgtcatcaa taaccttcat tattctaact gtgaaacgtt cattaatgcg
     5221 aataatatcc tcaaagattt tctacaatga gaatcatcca gtaaagcttt ttaactgaga
     5281 atttaaaagt tgtaaaattg ttagttaaat gtgtataatt atcaaaagag gttgactttg
     5341 gaaaacaaac aatttgctaa gggaaggaaa acttgaaaat aatcacctta gatggggcat
     5401 acaatttgac ctaagcaatt gtttcaaaac tgtcttcagt ttcttgaaaa taattgttag
     5461 ggctgatata tagaaataca tatctaggcc aggcacggtg actcatgcct gcaatcccag
     5521 cactttggga ggctgaggtg gatggatcac gaggtcaaga gatcgagacc atcctggtca
     5581 acatggggaa accccgtcta tactaaaaat acaaaaatta gctgggtgta gtggtgtgcg
     5641 cctgtagtcc cagctactca ggaggctgag gcaggagaat cacctgagcc ccggaggcag
     5701 aggttgcagt gagccgagat cgtgccactg cactccagcc tgggcaacag agcgagactc
     5761 cgtctcaaaa aaaagaaaaa aagaaataca tatctaatgt tacagattgt ggtttattgg
     5821 ttaattacta tgcatttttt tcagtttaaa aaataatctt attttatata cttctctcgg
     5881 tataattttt catgacattt cagcatgttg ataatatgtg tgcatctatt tcagtgcctt
     5941 aaagtatttt gagagcaatc ttttgctgac agttgaagaa ctgttaatga aatactgttc
     6001 attaaaagga tctgtgaaat ca
//
