LOCUS       NM_001389556            1660 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens UBX domain protein 11 (UBXN11), transcript variant 4,
            mRNA.
ACCESSION   NM_001389556
VERSION     NM_001389556.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1660)
  AUTHORS   Chen,X., Chen,C., He,R., Huang,Y. and Wang,Y.
  TITLE     UBXN11 Predicts as a Poor Index for Colorectal Cancer and
            Contributes to the Tumorigenesis by Activating NF-kappaB Signaling
  JOURNAL   Dig Dis Sci 69 (6), 2074-2082 (2024)
   PUBMED   38622461
  REMARK    GeneRIF: UBXN11 Predicts as a Poor Index for Colorectal Cancer and
            Contributes to the Tumorigenesis by Activating NF-kappaB Signaling.
REFERENCE   2  (bases 1 to 1660)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1660)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1660)
  AUTHORS   Trepte,P., Kruse,S., Kostova,S., Hoffmann,S., Buntru,A.,
            Tempelmeier,A., Secker,C., Diez,L., Schulz,A., Klockmeier,K.,
            Zenkner,M., Golusik,S., Rau,K., Schnoegl,S., Garner,C.C. and
            Wanker,E.E.
  TITLE     LuTHy: a double-readout bioluminescence-based two-hybrid technology
            for quantitative mapping of protein-protein interactions in
            mammalian cells
  JOURNAL   Mol Syst Biol 14 (7), e8071 (2018)
   PUBMED   29997244
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1660)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 1660)
  AUTHORS   Maccalli,C., Di Cristanziano,V., Fodale,V., Corsi,D.,
            D'Agostino,G., Petrangeli,V., Laurenti,L., Guida,S., Mazzocchi,A.,
            Arienti,F., Perrone,M.P., Castelli,C., Rivoltini,L., Zagonel,V.,
            Tartaglia,M., Parmiani,G. and Belardelli,F.
  TITLE     Induction of both CD8+ and CD4+ T-cell-mediated responses in
            colorectal cancer patients by colon antigen-1
  JOURNAL   Clin Cancer Res 14 (22), 7292-7303 (2008)
   PUBMED   18974390
  REMARK    GeneRIF: Both CD4+ and CD8+ T-cell responses against COA-1 can
            occur in colorectal cancer patients with metastatic disease
REFERENCE   7  (bases 1 to 1660)
  AUTHORS   Tateiwa,K., Katoh,H. and Negishi,M.
  TITLE     Socius, a novel binding partner of Galpha12/13, promotes the
            Galpha12-induced RhoA activation
  JOURNAL   Biochem Biophys Res Commun 337 (2), 615-620 (2005)
   PUBMED   16202387
  REMARK    GeneRIF: The rat homolog of UBXD5 promotes RhoA activation through
            G12/13 heterotrimeric G proteins
REFERENCE   8  (bases 1 to 1660)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   9  (bases 1 to 1660)
  AUTHORS   Maccalli,C., Li,Y.F., El-Gamil,M., Rosenberg,S.A. and Robbins,P.F.
  TITLE     Identification of a colorectal tumor-associated antigen (COA-1)
            recognized by CD4(+) T lymphocytes
  JOURNAL   Cancer Res 63 (20), 6735-6743 (2003)
   PUBMED   14583468
REFERENCE   10 (bases 1 to 1660)
  AUTHORS   Katoh,H., Harada,A., Mori,K. and Negishi,M.
  TITLE     Socius is a novel Rnd GTPase-interacting protein involved in
            disassembly of actin stress fibers
  JOURNAL   Mol Cell Biol 22 (9), 2952-2964 (2002)
   PUBMED   11940653
  REMARK    GeneRIF: Socius is a novel Rnd GTPase-interacting protein involved
            in disassembly of actin stress fibers
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL451139.40.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a protein with a divergent C-terminal
            UBX domain. The homologous protein in the rat interacts with
            members of the Rnd subfamily of Rho GTPases at the cell periphery
            through its C-terminal region. It also interacts with several
            heterotrimeric G proteins through their G-alpha subunits and
            promotes Rho GTPase activation. It is proposed to serve a
            bidirectional role in the promotion and inhibition of Rho activity
            through upstream signaling pathways. The 3' coding sequence of this
            gene contains a polymoprhic region of 24 nt tandem repeats. Several
            transcripts containing between 1.5 and five repeat units have been
            reported. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.1952242.1,
                                           SRR14038194.1966227.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374222.6/ ENSP00000363339.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AL451139.40        42993-43037         c
            46-151              AL451139.40        39214-39319         c
            152-180             AL451139.40        38095-38123         c
            181-279             AL451139.40        37327-37425         c
            280-380             AL451139.40        34363-34463         c
            381-435             AL451139.40        33828-33882         c
            436-512             AL451139.40        33320-33396         c
            513-639             AL451139.40        30606-30732         c
            640-854             AL451139.40        22224-22438         c
            855-932             AL451139.40        21865-21942         c
            933-1053            AL451139.40        20763-20883         c
            1054-1157           AL451139.40        20543-20646         c
            1158-1231           AL451139.40        19265-19338         c
            1232-1372           AL451139.40        19050-19190         c
            1373-1660           AL451139.40        18683-18970         c
FEATURES             Location/Qualifiers
     source          1..1660
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..1660
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /note="UBX domain protein 11"
                     /db_xref="GeneID:91544"
                     /db_xref="HGNC:HGNC:30600"
                     /db_xref="MIM:609151"
     exon            1..45
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /inference="alignment:Splign:2.1.0"
     exon            46..151
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1643
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /note="isoform 2 is encoded by transcript variant 4;
                     colorectal tumor-associated antigen-1; socius; UBX
                     domain-containing protein 5; colorectal tumor-associated
                     antigen COA-1"
                     /codon_start=1
                     /product="UBX domain-containing protein 11 isoform 2"
                     /protein_id="NP_001376485.1"
                     /db_xref="CCDS:CCDS41288.1"
                     /db_xref="GeneID:91544"
                     /db_xref="HGNC:HGNC:30600"
                     /db_xref="MIM:609151"
                     /translation="MSSPLASLSKTRKVPLPSEPMNPGRRGIRIYGDEDEVDMLSDGC
                     GSEEKISVPSCYGGIGAPVSRQVPASHDSELMAFMTRKLWDLEQQVKAQTDEILSKDQ
                     KIAALEDLVQTLRPHPAEATLQRQEELETMCVQLQRQVREMERFLSDYGLQWVGEPMD
                     QEDSESKTVSEHGERDWMTAKKFWKPGDSLAPPEVDFDRLLASLQDLSELVVEGDTQV
                     TPVPGGARLRTLEPIPLKLYRNGIMMFDGPFQPFYDPSTQRCLRDILDGFFPSELQRL
                     YPNGVPFKVSDLRNQVYLEDGLDPFPGEGRVVGRQLMHKALDRVEEHPGSRMTAEKFL
                     NRLPKFVIRQGEVIDIRGPIRDTLQNCCPLPARIQEIVVETPTLAAERERSQESPNTP
                     APPLSMLRIKSENGEQAFLLMMQPDNTIGDVRALLAQARVMDASAFEIFSTFPPTLYQ
                     DDTLTLQAAGLVPKAALLLRARRAPKSSLKFSPGPCPGPGPGPSPGPGPGPSPGPGPG
                     PSPCPGPSPSPQ"
     exon            152..180
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /inference="alignment:Splign:2.1.0"
     exon            181..279
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /inference="alignment:Splign:2.1.0"
     exon            280..380
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /inference="alignment:Splign:2.1.0"
     exon            381..435
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /inference="alignment:Splign:2.1.0"
     exon            436..512
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /inference="alignment:Splign:2.1.0"
     exon            513..639
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /inference="alignment:Splign:2.1.0"
     exon            640..854
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /inference="alignment:Splign:2.1.0"
     exon            855..932
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1053
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1157
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1231
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1372
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1660
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1639..1644
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /note="hexamer: AATAAA"
     polyA_site      1660
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /note="major polyA site"
ORIGIN      
        1 gacaacaaga tggcggcgct gcgggacggc tagcggccct gcgtgggagt tcctgacagc
       61 tggattctag aagtagaact atgagctcac ctttggcctc ccttagcaag acccgaaaag
      121 tgcccctgcc ctcggagcct atgaatcctg ggaggcgagg aatccgcatc tatggagatg
      181 aagatgaggt ggacatgttg agtgatgggt gtggctcaga agaaaagatc tcagtccctt
      241 cctgctatgg cggcataggt gcccctgtga gtcggcaagt ccctgcatcc catgactcgg
      301 agctgatggc cttcatgacg aggaagttgt gggacctgga gcagcaggtg aaggcccaga
      361 ctgatgagat actgtccaag gatcagaaga tagcggccct agaggacctg gtgcagaccc
      421 tccggccaca cccagccgag gcaaccctgc agcggcagga ggaactggag acgatgtgtg
      481 tgcagctgca gcggcaggtc agggagatgg agcggttcct cagtgactat ggcctgcagt
      541 gggtgggcga gcccatggac caggaggact cagagagcaa gacagtctca gagcatggcg
      601 agagggactg gatgacagcc aagaagttct ggaagccagg ggactcattg gcgccccctg
      661 aggtggactt tgacaggctg ctggccagcc tgcaggatct tagtgagctg gtggtagagg
      721 gtgacaccca agtgacacca gtgcccggcg gggcacggct gcgtaccctc gagcccatcc
      781 cgctgaagct ctaccggaat ggcatcatga tgttcgacgg gcccttccag cccttctacg
      841 atccctccac acagcgctgc ctccgagaca tattggatgg cttctttccc tcagagctcc
      901 agcgactgta ccccaatggg gtccccttta aggtgagtga cttgcgcaat caggtctacc
      961 tggaggatgg actggacccc ttcccaggcg agggccgtgt ggtgggcagg cagctgatgc
     1021 acaaggcctt ggacagggtg gaggagcacc caggctccag gatgactgct gagaaatttc
     1081 tgaacaggct ccccaagttt gtgatccggc aaggcgaggt gattgacatc cggggcccca
     1141 tcagggacac cttgcagaac tgctgcccat tgcctgcccg gatccaggag attgtggtgg
     1201 agacgcccac cttggccgct gagcgagaga ggagccagga gtcacccaac acgccggcac
     1261 ccccgctctc catgctgcgc atcaagtctg agaatgggga acaggccttc ctactgatga
     1321 tgcagcctga caacaccatt ggggacgtgc gagctctgct agcgcaggcc agggtcatgg
     1381 atgcctctgc ctttgagatc ttcagcacat tcccgcccac cctctaccag gacgatacac
     1441 tcacgctgca ggctgcaggc cttgtgccca aagcagcact gctgctgcgg gcacgccgag
     1501 ccccgaagtc cagcctgaaa ttcagtcctg gtccctgtcc cggtcccggt cccggcccca
     1561 gtcccggtcc cggtcccggc cccagtcccg gtcccggtcc cggccccagt ccctgtcctg
     1621 gacccagtcc cagcccccaa taaagcaccc gccccctcaa
//
