LOCUS       NP_001376485             520 aa            linear   PRI 22-SEP-2024
DEFINITION  UBX domain-containing protein 11 isoform 2 [Homo sapiens].
ACCESSION   NP_001376485
VERSION     NP_001376485.1
DBSOURCE    REFSEQ: accession NM_001389556.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 520)
  AUTHORS   Chen,X., Chen,C., He,R., Huang,Y. and Wang,Y.
  TITLE     UBXN11 Predicts as a Poor Index for Colorectal Cancer and
            Contributes to the Tumorigenesis by Activating NF-kappaB Signaling
  JOURNAL   Dig Dis Sci 69 (6), 2074-2082 (2024)
   PUBMED   38622461
  REMARK    GeneRIF: UBXN11 Predicts as a Poor Index for Colorectal Cancer and
            Contributes to the Tumorigenesis by Activating NF-kappaB Signaling.
REFERENCE   2  (residues 1 to 520)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 520)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 520)
  AUTHORS   Trepte,P., Kruse,S., Kostova,S., Hoffmann,S., Buntru,A.,
            Tempelmeier,A., Secker,C., Diez,L., Schulz,A., Klockmeier,K.,
            Zenkner,M., Golusik,S., Rau,K., Schnoegl,S., Garner,C.C. and
            Wanker,E.E.
  TITLE     LuTHy: a double-readout bioluminescence-based two-hybrid technology
            for quantitative mapping of protein-protein interactions in
            mammalian cells
  JOURNAL   Mol Syst Biol 14 (7), e8071 (2018)
   PUBMED   29997244
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 520)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (residues 1 to 520)
  AUTHORS   Maccalli,C., Di Cristanziano,V., Fodale,V., Corsi,D.,
            D'Agostino,G., Petrangeli,V., Laurenti,L., Guida,S., Mazzocchi,A.,
            Arienti,F., Perrone,M.P., Castelli,C., Rivoltini,L., Zagonel,V.,
            Tartaglia,M., Parmiani,G. and Belardelli,F.
  TITLE     Induction of both CD8+ and CD4+ T-cell-mediated responses in
            colorectal cancer patients by colon antigen-1
  JOURNAL   Clin Cancer Res 14 (22), 7292-7303 (2008)
   PUBMED   18974390
  REMARK    GeneRIF: Both CD4+ and CD8+ T-cell responses against COA-1 can
            occur in colorectal cancer patients with metastatic disease
REFERENCE   7  (residues 1 to 520)
  AUTHORS   Tateiwa,K., Katoh,H. and Negishi,M.
  TITLE     Socius, a novel binding partner of Galpha12/13, promotes the
            Galpha12-induced RhoA activation
  JOURNAL   Biochem Biophys Res Commun 337 (2), 615-620 (2005)
   PUBMED   16202387
  REMARK    GeneRIF: The rat homolog of UBXD5 promotes RhoA activation through
            G12/13 heterotrimeric G proteins
REFERENCE   8  (residues 1 to 520)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   9  (residues 1 to 520)
  AUTHORS   Maccalli,C., Li,Y.F., El-Gamil,M., Rosenberg,S.A. and Robbins,P.F.
  TITLE     Identification of a colorectal tumor-associated antigen (COA-1)
            recognized by CD4(+) T lymphocytes
  JOURNAL   Cancer Res 63 (20), 6735-6743 (2003)
   PUBMED   14583468
REFERENCE   10 (residues 1 to 520)
  AUTHORS   Katoh,H., Harada,A., Mori,K. and Negishi,M.
  TITLE     Socius is a novel Rnd GTPase-interacting protein involved in
            disassembly of actin stress fibers
  JOURNAL   Mol Cell Biol 22 (9), 2952-2964 (2002)
   PUBMED   11940653
  REMARK    GeneRIF: Socius is a novel Rnd GTPase-interacting protein involved
            in disassembly of actin stress fibers
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL451139.40.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a protein with a divergent C-terminal
            UBX domain. The homologous protein in the rat interacts with
            members of the Rnd subfamily of Rho GTPases at the cell periphery
            through its C-terminal region. It also interacts with several
            heterotrimeric G proteins through their G-alpha subunits and
            promotes Rho GTPase activation. It is proposed to serve a
            bidirectional role in the promotion and inhibition of Rho activity
            through upstream signaling pathways. The 3' coding sequence of this
            gene contains a polymoprhic region of 24 nt tandem repeats. Several
            transcripts containing between 1.5 and five repeat units have been
            reported. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.1952242.1,
                                           SRR14038194.1966227.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374222.6/ ENSP00000363339.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     Protein         1..520
                     /product="UBX domain-containing protein 11 isoform 2"
                     /note="colorectal tumor-associated antigen-1; socius; UBX
                     domain-containing protein 5; colorectal tumor-associated
                     antigen COA-1"
                     /calculated_mol_wt=57242
     Region          1..26
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5T124.2)"
     Region          <119..>256
                     /region_name="bchH"
                     /note="magnesium chelatase subunit H; Provisional;
                     PRK13405"
                     /db_xref="CDD:237377"
     Region          235..306
                     /region_name="SEP"
                     /note="SEP domain; pfam08059"
                     /db_xref="CDD:462348"
     Region          395..464
                     /region_name="UBX_UBXN11"
                     /note="Ubiquitin regulatory domain X (UBX) found in UBX
                     domain protein 11 (UBXN11) and similar proteins; cd17077"
                     /db_xref="CDD:340597"
     Region          476..520
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5T124.2)"
     Region          487..510
                     /region_name="3 X 8 AA tandem repeats of P-G-P-G-P-G-P-S"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5T124.2)"
     CDS             1..520
                     /gene="UBXN11"
                     /gene_synonym="COA-1; PP2243; SOC; SOCI; UBXD5"
                     /coded_by="NM_001389556.1:81..1643"
                     /note="isoform 2 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS41288.1"
                     /db_xref="GeneID:91544"
                     /db_xref="HGNC:HGNC:30600"
                     /db_xref="MIM:609151"
ORIGIN      
        1 mssplaslsk trkvplpsep mnpgrrgiri ygdedevdml sdgcgseeki svpscyggig
       61 apvsrqvpas hdselmafmt rklwdleqqv kaqtdeilsk dqkiaaledl vqtlrphpae
      121 atlqrqeele tmcvqlqrqv remerflsdy glqwvgepmd qedsesktvs ehgerdwmta
      181 kkfwkpgdsl appevdfdrl laslqdlsel vvegdtqvtp vpggarlrtl epiplklyrn
      241 gimmfdgpfq pfydpstqrc lrdildgffp selqrlypng vpfkvsdlrn qvyledgldp
      301 fpgegrvvgr qlmhkaldrv eehpgsrmta ekflnrlpkf virqgevidi rgpirdtlqn
      361 ccplpariqe ivvetptlaa erersqespn tpapplsmlr iksengeqaf llmmqpdnti
      421 gdvrallaqa rvmdasafei fstfpptlyq ddtltlqaag lvpkaalllr arrapksslk
      481 fspgpcpgpg pgpspgpgpg pspgpgpgps pcpgpspspq
//
