LOCUS       NM_152376               5562 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens UBX domain protein 10 (UBXN10), mRNA.
ACCESSION   NM_152376
VERSION     NM_152376.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5562)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5562)
  AUTHORS   Trepte,P., Kruse,S., Kostova,S., Hoffmann,S., Buntru,A.,
            Tempelmeier,A., Secker,C., Diez,L., Schulz,A., Klockmeier,K.,
            Zenkner,M., Golusik,S., Rau,K., Schnoegl,S., Garner,C.C. and
            Wanker,E.E.
  TITLE     LuTHy: a double-readout bioluminescence-based two-hybrid technology
            for quantitative mapping of protein-protein interactions in
            mammalian cells
  JOURNAL   Mol Syst Biol 14 (7), e8071 (2018)
   PUBMED   29997244
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5562)
  AUTHORS   Raman,M., Sergeev,M., Garnaas,M., Lydeard,J.R., Huttlin,E.L.,
            Goessling,W., Shah,J.V. and Harper,J.W.
  TITLE     Systematic proteomics of the VCP-UBXD adaptor network identifies a
            role for UBXN10 in regulating ciliogenesis
  JOURNAL   Nat Cell Biol 17 (10), 1356-1369 (2015)
   PUBMED   26389662
  REMARK    GeneRIF: Data show that UBXN10 localizes to cilia in a AAA-ATPase
            VCP-dependent manner and both VCP and UBXN10 are required for
            ciliogenesis.
            Erratum:[Nat Cell Biol. 2016 Mar;18(3):347. doi: 10.1038/ncb3318..
            PMID: 26911913]
REFERENCE   4  (bases 1 to 5562)
  AUTHORS   Alexandru,G., Graumann,J., Smith,G.T., Kolawa,N.J., Fang,R. and
            Deshaies,R.J.
  TITLE     UBXD7 binds multiple ubiquitin ligases and implicates p97 in
            HIF1alpha turnover
  JOURNAL   Cell 134 (5), 804-816 (2008)
   PUBMED   18775313
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX648631.1 and Z98257.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152376.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA727065.1, BX648631.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375099.4/ ENSP00000364240.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3439              BX648631.1         9-3447
            3440-4328           Z98257.1           48427-49315
            4329-5560           BX648631.1         4338-5569
            5561-5562           Z98257.1           50548-50549
FEATURES             Location/Qualifiers
     source          1..5562
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..5562
                     /gene="UBXN10"
                     /gene_synonym="UBXD3"
                     /note="UBX domain protein 10"
                     /db_xref="GeneID:127733"
                     /db_xref="HGNC:HGNC:26354"
                     /db_xref="MIM:616783"
     exon            1..58
                     /gene="UBXN10"
                     /gene_synonym="UBXD3"
                     /inference="alignment:Splign:2.1.0"
     exon            59..5562
                     /gene="UBXN10"
                     /gene_synonym="UBXD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..916
                     /gene="UBXN10"
                     /gene_synonym="UBXD3"
                     /note="UBX domain containing 3; UBX domain-containing
                     protein 3"
                     /codon_start=1
                     /product="UBX domain-containing protein 10"
                     /protein_id="NP_689589.1"
                     /db_xref="CCDS:CCDS205.1"
                     /db_xref="GeneID:127733"
                     /db_xref="HGNC:HGNC:26354"
                     /db_xref="MIM:616783"
                     /translation="MATEAPVNIAPPECSTVVSTAVDSLIWQPNSLNMHMIRPKSAKG
                     RTRPSLQKSQGVEVCAHHIPSPPPAIPYELPSSQKPGACAPKSPNQGASDEIPELQQQ
                     VPTGASSSLNKYPVLPSINRKNLEEEAVETVAKKASSLQLSSIRALYQDETGTMKTSE
                     EDSRARACAVERKFIVRTKKQGSSRAGNLEEPSDQEPRLLLAVRSPTGQRFVRHFRPT
                     DDLQTIVAVAEQKNKTSYRHCSIETMEVPRRRFSDLTKSLQECRIPHKSVLGISLEDG
                     EGWP"
     regulatory      1312..1317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBXN10"
                     /gene_synonym="UBXD3"
                     /note="hexamer: ATTAAA"
     polyA_site      1333
                     /gene="UBXN10"
                     /gene_synonym="UBXD3"
                     /note="major polyA site"
     regulatory      4185..4190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBXN10"
                     /gene_synonym="UBXD3"
                     /note="hexamer: AATAAA"
     polyA_site      4213
                     /gene="UBXN10"
                     /gene_synonym="UBXD3"
                     /note="major polyA site"
     regulatory      5397..5402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBXN10"
                     /gene_synonym="UBXD3"
                     /note="hexamer: AATACA"
     polyA_site      5415
                     /gene="UBXN10"
                     /gene_synonym="UBXD3"
     regulatory      5539..5544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBXN10"
                     /gene_synonym="UBXD3"
                     /note="hexamer: AATAAA"
     polyA_site      5562
                     /gene="UBXN10"
                     /gene_synonym="UBXD3"
ORIGIN      
        1 gttgtttacc agcaggacag agcccgggcg caggcggcgg atggagcgga acggctaggg
       61 gtcttgagaa gcaatggcca cagaagcccc tgtgaatata gcaccacctg agtgtagcac
      121 tgttgtcagc acagcagttg acagcctcat ttggcagcca aactcactaa atatgcacat
      181 gataaggccc aagtccgcca agggacggac aagaccgagt ctgcagaaat cccagggcgt
      241 ggaggtgtgc gctcatcata taccatctcc gcctccagcc attccctatg agttgccaag
      301 cagccaaaaa ccaggagcct gtgcacccaa atctccaaac cagggagctt ctgatgagat
      361 ccctgagctg cagcagcaag tacccactgg ggcttcctct tctctcaata agtatccagt
      421 ccttccttcc atcaacagaa agaacctgga ggaggaggct gtggaaaccg ttgccaaaaa
      481 ggccagctca ctgcaactga gcagtatccg ggctctttac caagacgaga cgggcaccat
      541 gaagacaagt gaagaagatt ccagagctcg agcttgtgcc gtggagagga aattcatcgt
      601 ccgaaccaag aaacagggct cttccagggc tggaaatctg gaggaaccat cggaccaaga
      661 accaaggttg ctgcttgctg ttagatcacc aacaggccaa aggtttgtac gccatttccg
      721 gccaacagat gatttgcaaa ccattgttgc tgtggccgaa cagaaaaaca aaacctccta
      781 ccgacactgc agcattgaaa caatggaggt gcccaggagg cgattttctg acctcaccaa
      841 atctctgcaa gagtgcagaa tcccccacaa gtctgtgctg ggcatctcac tggaagatgg
      901 ggaagggtgg ccctgagtcc acagccaccc agctgaggtc ctgggtctct gagcaaagga
      961 gcatgcttgg gcgttgtggc ctcttaggca gcctgtttca agtgccatgt ggacctggtg
     1021 cagctgggaa gcttgggact ctcgtctgca ctgcgtgtcc tctgaagcag tgaagtctgt
     1081 gcctatgccg agcgcgctaa gaagtctccc ttccagctgt tccattctct ccaccaccag
     1141 cgtaactggc aagttaccaa ggttgttcct gaaacagcag tgatcatgac ttctcctttc
     1201 cagagttttg ggtccttctg aattaatggt ccttttcgaa caccggcttg cctttacagt
     1261 gaactgtgat tctctcgaag ccaatgcttt cctgtctgta tttgatgcag gattaaacac
     1321 ttcccagaga ggattctagt ctggtaaata accacagtgt aggaactatc taactggcat
     1381 ttgtgtttct tgcgagtatt ttgaagaaac aggccgttga ccccatcttt ggaagtagcc
     1441 ctttaccatg catggtcagt ttcttaggga tttactattt gtgtgaggtg gcatctaagg
     1501 gaagaatggg ttttcttccc caaaacatca gcatttctaa aatagtccta aagcttgaaa
     1561 gtaagttgct tccatgagca tggattaccc agtagctact ttttaataga gactgactag
     1621 gtttacaact tctgggagct actctgtggg ctgaattctt ccaaaaccga gaaaagccag
     1681 tgcagtctga tttcttttgc ttttgtcagt aatggaatct tttgttttta aaatgtacaa
     1741 acctataagt ttaaacaggt ttgtactgac aacctccttg gcttatttgg gggtggagca
     1801 attgttttat tccccagttt cagtgcgttg cccacttcaa acatggtgtg tcctttggag
     1861 ctgtgacaga ggtgcctgtt ctgacttaga acctctggag gaggaggggg gtgccttggt
     1921 ctcgtgttac tttgctgtgc ctgtgctgag agaccatgtg cccgagcatc tggttgaccg
     1981 gcatgaagta catcagcctg tcttagcctg agctgctttg aagaccatgg ggtcttgtgt
     2041 ttccaacttc gaagtgctga tgtggacagt ttgccaatgt tctcttctat tgcaagttca
     2101 gccagactcc atgactcatc tgatcccttt tatggccaaa tcatccttca gagtagggaa
     2161 cactcagaca ttctgtgcat gttgttcccc caaagcatgg tcatcacaaa gtcctgagtt
     2221 ctggtgtgtg ctcccgcctc ctgggtatac agagagaagg caggaatcag gagttccaga
     2281 agcatataca tgtggctacc ccagcaacaa gcgcatcctg tgctcagata agctgcatgg
     2341 ttgggagtgt tttttctcgc acgttgaggc ttagtggaga tgggcaccac tgccatttgc
     2401 tcagaagaag gctggtctgg tcctaactgc atcccacact gcccagatca ttctagaata
     2461 ggttatttct gaatgtttta tagaatttct taataccatc ctggtttggt cagccattcc
     2521 tttgattgga aaggtcagct ggggccagtg gtgcctcagg caggcccaca caactggcca
     2581 cctcttcccg ttaatgacca cagcagacag aatttgagcc cagcacctaa aagtacagga
     2641 atttcacttc ccaccaggac ttgagcacat aactctatgt ctgatctagg aggctggggg
     2701 aagagcctcc cataaaatca cacctactct gtggtaagaa taaaatccca cccacctggg
     2761 acttggtaat ttctccagac aggaaagctt tagaaaactt gagtgaaatg gagcaagctt
     2821 gaaggagtta gaatcttctg tgcttagggt ttgctgctgc tggtgagctt agaattttgg
     2881 ggttgggaaa aagtggaagg cataagcata gaaatatttt aggatatttt aggatatgtg
     2941 aataaagcta gactcaaacc atcataataa acattttttt tttggacaaa agatgatacg
     3001 ataaaaacca acttgtgtga aactgagtca gtggagaagt gcatctcgta ttttaaccta
     3061 aggcttcagc tcccacacac gactggacag aggggtgtgt tagcctgatc ttcagttttc
     3121 tcattgggaa agcacttgtt ccactgttag aaccaagtcc tcctccccgg acacttctga
     3181 tgcccactgc agaagcgacg gggctcctgc tctcagcttc tgtcacagca cttagcttgt
     3241 ctggataaga gtcacctgaa tttttcctaa acatcattcc aagtactctg attttgggga
     3301 ttggcaagaa caaactaaat cagaattcag agttcctgat ggctccacat gttgcattgc
     3361 agctgaggcc ccctgtccta aatgggctca accggcctag cacactcctc ttggtggctt
     3421 tgggtgggtc agccttgccc agtttggggt catagacctc agttattcat ttaaccgatg
     3481 gccattgagg gcttacccag tgccacactt tgagacaagc atgggtgtcc tgaaaagaaa
     3541 gtgttggcaa gaaaacatga acccaccatt ggactctcaa ctcaaacctt actgaagtca
     3601 gtggctatag ctttatctgc aaaggacccc aaagtgagga tcccacattg ttactgctgg
     3661 ctcttcatcc caccctctgg agatgctaag gaagctcttg cccacctttt ctagtgatgg
     3721 agtaggaact ttgcatagga caaaccttca tgataggtta ctctagtata ttccctcata
     3781 aagtccaata ggtaaattag tcttggcagc agaaggaaca gcaggagaag taagtgattc
     3841 atcatctaga atccagaaaa tttgcaccaa cagatggcag gtggttataa cacaacagat
     3901 cttgccctga gaatatctgg ggacccagcc aacagccttc aaggcagggc actcctgcgg
     3961 aagagatggc ttgtgaacat gactgtggac ccagagtcac cccagagctc ccatataaaa
     4021 tgcttcacag agaaactaag agcagccttg gggcattcat tccaattaat aaccttaaag
     4081 actagagcca gatccacctg cattacaaaa gcaggcattc gaggaactaa actttgcttt
     4141 tgttcatgct cttacctgcc gttttaaatg ggtttctaat gtcaaataaa gccaccctgc
     4201 ctcttgggac aaagatgttt ctctttactt agttttaaaa ataaaatcct cataataagt
     4261 tcggataaaa gagactttta catggtaaga ggatctactt ttctaccttt taaacggaat
     4321 aaagaagaca gctatattat tttgctttag cattagttta gaagtcattc caagaattaa
     4381 gcaggaacat ctgttttctc agtccattaa ggcaacaccc cacagtaaag ttaaaagttc
     4441 acgagcctat tgactctcat ccagaaacca gaaccaacca aaccccacca tataacaggg
     4501 aaggcctgag gtcgcttcgg aggagttagc aatcaaagga gaacagactt ttggtgactc
     4561 agttaccaac acacaacact cataaaacta aaattaggtg ttttattttt tgtctacacg
     4621 ggtggcgtgc cactttcctt tcctgattag ggaagcttct cccagccctt tctgacgttc
     4681 atctgtgtgc ctttatgttc aaacagttta ggaagcagca gccctcctaa cagtcgacgc
     4741 ggaagcacaa atctctggag gtatttttgg acacacttaa atcctatccc aagagactga
     4801 acgactgtgg tgacaaatgc ccacgggtaa aactgagcaa gcctcattca gactgtcctg
     4861 ctcagaggcg ccctctggct gccgtgttga ggggctgggg tggaagatgg aagacttgag
     4921 tgctggaggt atgaaggtga ccagagagag gtgatggtgg ttcgggccag ggtggtagcc
     4981 agagatgtca tgagaggtgg ccagattctg gacatataat ccattttctt aaggagaaaa
     5041 aaaaggatag tttgacaagt tgggattcac ccaggtggac ttagcttgac caatatcgcc
     5101 aacgtggatt gtttctgcaa aaacaaacaa gcaaacaacc accacggcag caaagcacat
     5161 ggcaggcagg ggaaagacac tgaccagcag gaacattccc atcaaggaaa tgcacgagtg
     5221 tttttggaca aagtgtacag agaaaatcaa agctattcat tgttttaatt aagagataaa
     5281 actaaggtca ctgtttcact taatgttgag atataagtta aaagtatcat ctacctctag
     5341 gggtatgata tgactgctga ccaaggttac ttaataagaa atccttgttc tagttaaata
     5401 cactgtttat ctctatctcc tgtccttcat ccctcccttt cttgccaccc ttccctccat
     5461 ttattccagt ccagcagctg actggggatg catttcttct tgggaaggca aacaaagcca
     5521 tcattctggg gcttaattaa taaagctcct agtttcatag tt
//
