LOCUS       NM_001286077            1134 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens UBX domain protein 1 (UBXN1), transcript variant 2,
            mRNA.
ACCESSION   NM_001286077 XM_005274034
VERSION     NM_001286077.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1134)
  AUTHORS   Wang,H., Chen,W., Wang,Y., Gao,Y., Zhang,Z., Mi,S., Wang,L. and
            Xue,M.
  TITLE     SUB1 promotes colorectal cancer metastasis by activating NF-kappaB
            signaling via UBR5-mediated ubiquitination of UBXN1
  JOURNAL   Sci China Life Sci 67 (6), 1199-1211 (2024)
   PUBMED   38240906
  REMARK    GeneRIF: SUB1 promotes colorectal cancer metastasis by activating
            NF-kappaB signaling via UBR5-mediated ubiquitination of UBXN1.
REFERENCE   2  (bases 1 to 1134)
  AUTHORS   Jiao,K., Xu,G., Liu,Y., Yang,Z., Xiang,L., Chen,Z., Xu,C., Zuo,Y.,
            Wu,Z., Zheng,N., Xu,W., Zhang,L. and Liu,Y.
  TITLE     UBXN1 promotes liver tumorigenesis by regulating mitochondrial
            homeostasis
  JOURNAL   J Transl Med 22 (1), 485 (2024)
   PUBMED   38773518
  REMARK    GeneRIF: UBXN1 promotes liver tumorigenesis by regulating
            mitochondrial homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1134)
  AUTHORS   Chai,R.C., Chang,Y.Z., Chang,X., Pang,B., An,S.Y., Zhang,K.N.,
            Chang,Y.H., Jiang,T. and Wang,Y.Z.
  TITLE     YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated
            m6A modification to activate NF-kappaB and promote the malignant
            progression of glioma
  JOURNAL   J Hematol Oncol 14 (1), 109 (2021)
   PUBMED   34246306
  REMARK    GeneRIF: YTHDF2 facilitates UBXN1 mRNA decay by recognizing
            METTL3-mediated m(6)A modification to activate NF-kappaB and
            promote the malignant progression of glioma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1134)
  AUTHORS   Li,Y., Liu,X., Cui,X., Tan,Y., Wang,Q., Wang,Y., Xu,C., Fang,C. and
            Kang,C.
  TITLE     LncRNA PRADX-mediated recruitment of PRC2/DDX5 complex suppresses
            UBXN1 expression and activates NF-kappaB activity, promoting
            tumorigenesis
  JOURNAL   Theranostics 11 (9), 4516-4530 (2021)
   PUBMED   33754075
  REMARK    GeneRIF: LncRNA PRADX-mediated recruitment of PRC2/DDX5 complex
            suppresses UBXN1 expression and activates NF-kappaB activity,
            promoting tumorigenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1134)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1134)
  AUTHORS   LaLonde,D.P. and Bretscher,A.
  TITLE     The UBX protein SAKS1 negatively regulates endoplasmic
            reticulum-associated degradation and p97-dependent degradation
  JOURNAL   J Biol Chem 286 (6), 4892-4901 (2011)
   PUBMED   21135095
  REMARK    GeneRIF: SAKS1 inhibits protein degradation mediated by p97
            complexes in the cytosol with a component of the mechanism being
            the ability to shield polyubiquitin chains from
            ubiquitin-processing factors.
REFERENCE   7  (bases 1 to 1134)
  AUTHORS   Wu-Baer,F., Ludwig,T. and Baer,R.
  TITLE     The UBXN1 protein associates with autoubiquitinated forms of the
            BRCA1 tumor suppressor and inhibits its enzymatic function
  JOURNAL   Mol Cell Biol 30 (11), 2787-2798 (2010)
   PUBMED   20351172
  REMARK    GeneRIF: Data suggest that UBXN1 regulates the enzymatic function
            of BRCA1 in a manner that is dependent on its ubiquitination
            status.
REFERENCE   8  (bases 1 to 1134)
  AUTHORS   Alexandru,G., Graumann,J., Smith,G.T., Kolawa,N.J., Fang,R. and
            Deshaies,R.J.
  TITLE     UBXD7 binds multiple ubiquitin ligases and implicates p97 in
            HIF1alpha turnover
  JOURNAL   Cell 134 (5), 804-816 (2008)
   PUBMED   18775313
REFERENCE   9  (bases 1 to 1134)
  AUTHORS   Ishibashi,T., Ogawa,S., Hashiguchi,Y., Inoue,Y., Udo,H., Ohzono,H.,
            Kato,A., Minakami,R. and Sugiyama,H.
  TITLE     A novel protein specifically interacting with Homer2 regulates
            ubiquitin-proteasome systems
  JOURNAL   J Biochem 137 (5), 617-623 (2005)
   PUBMED   15944415
  REMARK    GeneRIF: Specific interaction of rat protein 2B28 with rat Homer2
            may play a role in regulation of protein degradation by
            ubiquitin-proteasome systems and that this function may be specific
            to Homer2 proteins among Homer family proteins.
REFERENCE   10 (bases 1 to 1134)
  AUTHORS   McNeill,H., Knebel,A., Arthur,J.S., Cuenda,A. and Cohen,P.
  TITLE     A novel UBA and UBX domain protein that binds polyubiquitin and VCP
            and is a substrate for SAPKs
  JOURNAL   Biochem J 384 (Pt 2), 391-400 (2004)
   PUBMED   15362974
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC040129.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001286077.1.
            
            Transcript Variant: This variant (2) contains an alternate exon
            structure in the 3' region, compared to variant 1. The encoded
            isoform (2) has a distinct C-terminus and is shorter than isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.581711.1,
                                           SRR3476690.243126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301935.10/ ENSP00000303991.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1134              BC040129.1         20-1153
FEATURES             Location/Qualifiers
     source          1..1134
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..1134
                     /gene="UBXN1"
                     /gene_synonym="2B28; SAKS1; UBXD10"
                     /note="UBX domain protein 1"
                     /db_xref="GeneID:51035"
                     /db_xref="HGNC:HGNC:18402"
                     /db_xref="MIM:616378"
     exon            1..209
                     /gene="UBXN1"
                     /gene_synonym="2B28; SAKS1; UBXD10"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1044
                     /gene="UBXN1"
                     /gene_synonym="2B28; SAKS1; UBXD10"
                     /note="isoform 2 is encoded by transcript variant 2; SAPK
                     substrate protein 1; UBX domain-containing protein 1;
                     UBA/UBX 33.3 kDa protein"
                     /codon_start=1
                     /product="UBX domain-containing protein 1 isoform 2"
                     /protein_id="NP_001273006.1"
                     /db_xref="CCDS:CCDS66105.1"
                     /db_xref="GeneID:51035"
                     /db_xref="HGNC:HGNC:18402"
                     /db_xref="MIM:616378"
                     /translation="MAELTALESLIEMGFPRGRAEKALALTGNQGIEAAMDWLMEHED
                     DPDVDEPLETPLGHILGREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELV
                     AQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAA
                     RQRVREKIERDKAERAKKYGGSVGSQPPPVAPEPGPVPSSPSQEPPTKREYDQCRIQV
                     RLPDGTSLTQTFRAREQLAAVRLYVELHRGEELGGGQDPVQLLSGFPRRAFSEADMER
                     PLQELGLVPSAVLIVAKKCPS"
     exon            210..263
                     /gene="UBXN1"
                     /gene_synonym="2B28; SAKS1; UBXD10"
                     /inference="alignment:Splign:2.1.0"
     exon            264..370
                     /gene="UBXN1"
                     /gene_synonym="2B28; SAKS1; UBXD10"
                     /inference="alignment:Splign:2.1.0"
     exon            371..440
                     /gene="UBXN1"
                     /gene_synonym="2B28; SAKS1; UBXD10"
                     /inference="alignment:Splign:2.1.0"
     exon            441..632
                     /gene="UBXN1"
                     /gene_synonym="2B28; SAKS1; UBXD10"
                     /inference="alignment:Splign:2.1.0"
     exon            633..684
                     /gene="UBXN1"
                     /gene_synonym="2B28; SAKS1; UBXD10"
                     /inference="alignment:Splign:2.1.0"
     exon            685..801
                     /gene="UBXN1"
                     /gene_synonym="2B28; SAKS1; UBXD10"
                     /inference="alignment:Splign:2.1.0"
     exon            802..994
                     /gene="UBXN1"
                     /gene_synonym="2B28; SAKS1; UBXD10"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1134
                     /gene="UBXN1"
                     /gene_synonym="2B28; SAKS1; UBXD10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1111..1116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBXN1"
                     /gene_synonym="2B28; SAKS1; UBXD10"
                     /note="hexamer: AATAAA"
     polyA_site      1134
                     /gene="UBXN1"
                     /gene_synonym="2B28; SAKS1; UBXD10"
                     /note="major polyA site"
ORIGIN      
        1 cttctcgtcg gtgttcccgg ctgctataga gccgggtgag agagcgagcg cccgtcggcg
       61 ggtgtcgagg gcgggttgcc tcgcgctgac ccttcccgcc ctccttctcg tcacacacca
      121 ggtccccgcg gaagccgcgg tgtcggcgcc atggcggagc tgacggctct tgagagtctc
      181 atcgagatgg gcttccccag gggacgcgcg gagaaggctc tggccctcac agggaaccag
      241 ggcatcgagg ctgcgatgga ctggctgatg gagcacgaag acgaccccga tgtggacgag
      301 cctttagaga ctccccttgg acatatcctg ggacgggagc ccacttcctc agagcaaggc
      361 ggccttgaag gatctggttc tgctgccgga gaaggcaaac ccgctttgag tgaagaggaa
      421 agacaggaac aaactaagag gatgttggag ctggtggccc agaagcagcg ggagcgtgaa
      481 gaaagagagg aacgggaggc attggaacgg gaacggcagc gcaggagaca agggcaagag
      541 ttgtcagcag cacgacagcg gctacaggaa gatgagatgc gccgggctgc tgaggagagg
      601 cggagggaaa aggccgagga gttagcagcc agacaaagag ttagagaaaa gatcgagagg
      661 gacaaagcag agagagccaa gaagtatggt ggcagtgtgg gctctcagcc acccccagtg
      721 gcaccagagc caggtcctgt tccctcttct cccagccagg agcctcccac caagcgggag
      781 tatgaccagt gtcgcataca ggtcaggctg ccagatggga cctcactgac ccagacgttc
      841 cgggcccggg aacagctggc agctgtgagg ctctatgtgg agctccaccg tggggaggaa
      901 ctaggtgggg gccaggaccc tgtgcaattg ctcagtggct tccccagacg ggccttctca
      961 gaagctgaca tggagcggcc tctgcaggag ctgggactcg tgccttctgc tgttctcatt
     1021 gtggccaaga aatgtcccag ctgagggcct ttgtcccatt gtccctctgt gaccccttca
     1081 tctttgataa agcactgaca tctccttcct aataaataga ccctgagttc tgta
//
