LOCUS       NM_014233               4795 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens upstream binding transcription factor (UBTF),
            transcript variant 1, mRNA.
ACCESSION   NM_014233
VERSION     NM_014233.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4795)
  AUTHORS   Han,D., Guan,L., Zhang,Y., Yang,H., Si,L., Jia,T., Wu,Y., Lv,K.,
            Song,T. and Yang,G.
  TITLE     FGF13A interacts with NPM1 and UBF and inhibits the invasion of
            bladder cancer cells
  JOURNAL   Biochem Biophys Res Commun 678, 1-10 (2023)
   PUBMED   37603967
  REMARK    GeneRIF: FGF13A interacts with NPM1 and UBF and inhibits the
            invasion of bladder cancer cells.
REFERENCE   2  (bases 1 to 4795)
  AUTHORS   Duployez,N., Vasseur,L., Kim,R., Largeaud,L., Passet,M.,
            L'Haridon,A., Lemaire,P., Fenwarth,L., Geffroy,S., Helevaut,N.,
            Celli-Lebras,K., Ades,L., Lebon,D., Berthon,C., Marceau-Renaut,A.,
            Cheok,M., Lambert,J., Recher,C., Raffoux,E., Micol,J.B.,
            Pigneux,A., Gardin,C., Delabesse,E., Soulier,J., Hunault,M.,
            Dombret,H., Itzykson,R., Clappier,E. and Preudhomme,C.
  TITLE     UBTF tandem duplications define a distinct subtype of adult de novo
            acute myeloid leukemia
  JOURNAL   Leukemia 37 (6), 1245-1253 (2023)
   PUBMED   37085611
  REMARK    GeneRIF: UBTF tandem duplications define a distinct subtype of
            adult de novo acute myeloid leukemia.
REFERENCE   3  (bases 1 to 4795)
  AUTHORS   Georgi,J.A., Stasik,S., Eckardt,J.N., Zukunft,S., Hartwig,M.,
            Rollig,C., Middeke,J.M., Oelschlagel,U., Krug,U., Sauer,T.,
            Scholl,S., Hochhaus,A., Brummendorf,T.H., Naumann,R., Steffen,B.,
            Einsele,H., Schaich,M., Burchert,A., Neubauer,A.,
            Schafer-Eckart,K., Schliemann,C., Krause,S.W., Hanel,M.,
            Noppeney,R., Kaiser,U., Baldus,C.D., Kaufmann,M., Muller-Tidow,C.,
            Platzbecker,U., Berdel,W.E., Serve,H., Ehninger,G., Bornhauser,M.,
            Schetelig,J., Kroschinsky,F. and Thiede,C.
  CONSRTM   Study Alliance Leukemia (SAL)
  TITLE     UBTF tandem duplications are rare but recurrent alterations in
            adult AML and associated with younger age, myelodysplasia, and
            inferior outcome
  JOURNAL   Blood Cancer J 13 (1), 88 (2023)
   PUBMED   37236968
  REMARK    GeneRIF: UBTF tandem duplications are rare but recurrent
            alterations in adult AML and associated with younger age,
            myelodysplasia, and inferior outcome.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4795)
  AUTHORS   Kaburagi,T., Shiba,N., Yamato,G., Yoshida,K., Tabuchi,K., Ohki,K.,
            Ishikita,E., Hara,Y., Shiraishi,Y., Kawasaki,H., Sotomatsu,M.,
            Takizawa,T., Taki,T., Kiyokawa,N., Tomizawa,D., Horibe,K.,
            Miyano,S., Taga,T., Adachi,S., Ogawa,S. and Hayashi,Y.
  TITLE     UBTF-internal tandem duplication as a novel poor prognostic factor
            in pediatric acute myeloid leukemia
  JOURNAL   Genes Chromosomes Cancer 62 (4), 202-209 (2023)
   PUBMED   36448876
  REMARK    GeneRIF: UBTF-internal tandem duplication as a novel poor
            prognostic factor in pediatric acute myeloid leukemia.
REFERENCE   5  (bases 1 to 4795)
  AUTHORS   Duhr,S., Torres-Montaner,A., Astola,A., Garcia-Cozar,F.J.,
            Pendon,C., Bolivar,J. and Valdivia,M.M.
  TITLE     Molecular analysis of the 5' region of human ribosomal
            transcription factor UBF
  JOURNAL   DNA Seq 12 (4), 267-272 (2001)
   PUBMED   11916260
REFERENCE   6  (bases 1 to 4795)
  AUTHORS   Matera,A.G., Wu,W., Imai,H., O'Keefe,C.L. and Chan,E.K.
  TITLE     Molecular cloning of the RNA polymerase I transcription factor
            hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence
            in situ hybridization and radiation hybrid mapping
  JOURNAL   Genomics 41 (1), 135-138 (1997)
   PUBMED   9126496
REFERENCE   7  (bases 1 to 4795)
  AUTHORS   Chan,E.K., Imai,H., Hamel,J.C. and Tan,E.M.
  TITLE     Human autoantibody to RNA polymerase I transcription factor hUBF.
            Molecular identity of nucleolus organizer region autoantigen NOR-90
            and ribosomal RNA transcription upstream binding factor
  JOURNAL   J Exp Med 174 (5), 1239-1244 (1991)
   PUBMED   1940801
REFERENCE   8  (bases 1 to 4795)
  AUTHORS   O'Mahony,D.J. and Rothblum,L.I.
  TITLE     Identification of two forms of the RNA polymerase I transcription
            factor UBF
  JOURNAL   Proc Natl Acad Sci U S A 88 (8), 3180-3184 (1991)
   PUBMED   2014238
REFERENCE   9  (bases 1 to 4795)
  AUTHORS   Jantzen,H.M., Admon,A., Bell,S.P. and Tjian,R.
  TITLE     Nucleolar transcription factor hUBF contains a DNA-binding motif
            with homology to HMG proteins
  JOURNAL   Nature 344 (6269), 830-836 (1990)
   PUBMED   2330041
REFERENCE   10 (bases 1 to 4795)
  AUTHORS   Bell,S.P., Learned,R.M., Jantzen,H.M. and Tjian,R.
  TITLE     Functional cooperativity between transcription factors UBF1 and SL1
            mediates human ribosomal RNA synthesis
  JOURNAL   Science 241 (4870), 1192-1197 (1988)
   PUBMED   3413483
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004596.2, AK291733.1 and
            BC042297.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014233.3.
            
            Summary: This gene encodes a member of the HMG-box DNA-binding
            protein family. The encoded protein plays a critical role in
            ribosomal RNA transcription as a key component of the
            pre-initiation complex, mediating the recruitment of RNA polymerase
            I to rDNA promoter regions. The encoded protein may also play
            important roles in chromatin remodeling and pre-rRNA processing,
            and its activity is regulated by both phosphorylation and
            acetylation. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. Pseudogenes of
            this gene are located on the short arm of chromosomes 3, 11 and X
            and the long arm of chromosome 11. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.143562.1,
                                           SRR1803612.231454.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000436088.6/ ENSP00000390669.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AC004596.2         2151-2327
            178-2912            AK291733.1         1-2735
            2913-4795           BC042297.1         2705-4587
FEATURES             Location/Qualifiers
     source          1..4795
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..4795
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /note="upstream binding transcription factor"
                     /db_xref="GeneID:7343"
                     /db_xref="HGNC:HGNC:12511"
                     /db_xref="MIM:600673"
     exon            1..231
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     exon            232..356
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..2593
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /note="isoform a is encoded by transcript variant 1;
                     nucleolar transcription factor 1; autoantigen NOR-90;
                     90-kDa nucleolus organizer region autoantigen; upstream
                     binding transcription factor, RNA polymerase I"
                     /codon_start=1
                     /product="nucleolar transcription factor 1 isoform a"
                     /protein_id="NP_055048.1"
                     /db_xref="CCDS:CCDS11480.1"
                     /db_xref="GeneID:7343"
                     /db_xref="HGNC:HGNC:12511"
                     /db_xref="MIM:600673"
                     /translation="MNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSS
                     KFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTLTELILDAQEHVKNPYKG
                     KKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMK
                     YIQDFQREKQEFERNLARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVR
                     PDATTKEVKDSLGKQWSQLSDKKRLKWIHKALEQRKEYEEIMRDYIQKHPELNISEEG
                     ITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELMANMKDVPSTERMVLCSQQWKL
                     LSQKEKDAYHKKCDQKKKDYEVELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPAS
                     KKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMWNDLSE
                     KKKAKYKAREAALKAQSERKPGGEREERGKLPESPKRAEEIWQQSVIGDYLARFKNDR
                     VKALKAMEMTWNNMEKKEKLMWIKKAAEDQKRYERELSEMRAPPAATNSSKKMKFQGE
                     PKKPPMNGYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLAEEQQK
                     QYKVHLDLWVKSLSPQDRAAYKEYISNKRKSMTKLRGPNPKSSRTTLQSKSESEEDDE
                     EDEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESEDGDENEEDDEDEDDDEDDDED
                     EDNESEGSSSSSSSSGDSSDSDSN"
     exon            357..532
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     exon            533..616
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     exon            617..772
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     exon            773..837
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     exon            838..958
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1069
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1203
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1345
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1387
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1501
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1657
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1813
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1924
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2013
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2203
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2251
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2323
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2467
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..4795
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3242
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /note="major polyA site"
     regulatory      4778..4783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
                     /note="hexamer: AATAAA"
     polyA_site      4795
                     /gene="UBTF"
                     /gene_synonym="CONDBA; NOR-90; UBF; UBF-1; UBF1; UBF2"
ORIGIN      
        1 gtgcttttcg ccgcgaggag cagcaggcag cagccacagc cgccgccgcc gccgccgccg
       61 ccacagcagc agcagccgcc gccccagcgc cgccgcctcg cccggaggag gagccgctgc
      121 cgccgcggga gggagctgcg gctgtgcccg gccgagcggg ggagggcgcc gccactcaga
      181 gccagggagg gagccgctgg agcgggaagc ccggaggccg cgctgcgccg gggtgaggtg
      241 gctttgaccc cgggttgccc ggccagcacg accgaggagg tggctggaca gctggaggat
      301 gaacggagaa gccgactgcc ccacagacct ggaaatggcc gcccccaaag gccaagaccg
      361 ttggtcccag gaagacatgc tgactttgct ggaatgcatg aagaacaacc ttccatccaa
      421 tgacagctcc aagttcaaaa ccaccgaatc acacatggac tgggaaaaag tagcatttaa
      481 agacttttct ggagacatgt gcaagctcaa atgggtggag atttctaatg aggtgaggaa
      541 gttccgtaca ttgacagaat tgatcctcga tgctcaggaa catgttaaaa atccttacaa
      601 aggcaaaaaa ctcaagaaac acccagactt cccaaagaag cccctgaccc cttatttccg
      661 cttcttcatg gagaagcggg ccaagtatgc gaaactccac cctgagatga gcaacctgga
      721 cctaaccaag attctgtcca agaaatacaa ggagcttccg gagaagaaga agatgaaata
      781 tattcaggac ttccagagag agaaacagga gttcgagcga aacctggccc gattcaggga
      841 ggatcacccc gacctaatcc agaatgccaa gaaatcggac atcccagaga agcccaaaac
      901 cccccagcag ctgtggtaca cccacgagaa gaaggtgtat ctcaaagtgc ggccagatgc
      961 cactacgaag gaggtgaagg actccctggg gaagcagtgg tctcagctct cggacaaaaa
     1021 gaggctgaaa tggattcata aggccctgga gcagcggaag gagtacgagg agatcatgag
     1081 agactatatc cagaagcacc cagagctgaa catcagtgag gagggtatca ccaagtccac
     1141 cctcaccaag gccgaacgcc agctcaagga caagtttgac gggcgaccca ccaagccacc
     1201 tccgaacagc tactcgctgt actgcgcaga gctcatggcc aacatgaagg acgtgcccag
     1261 cacagagcgc atggtgctgt gcagccagca gtggaagctg ctgtcccaga aggagaagga
     1321 cgcctatcac aagaagtgtg atcagaaaaa gaaagattac gaggtggagc tgctccgttt
     1381 cctcgagagc ctgcctgagg aggagcagca gcgggtcttg ggggaagaga agatgctgaa
     1441 catcaacaag aagcaggcca ccagccccgc ctccaagaag ccagcccagg aagggggcaa
     1501 gggcggctcc gagaagccca agcggcccgt gtcggccatg ttcatcttct cggaggagaa
     1561 acggcggcag ctgcaggagg agcggcctga gctctccgag agcgagctga cccgcctgct
     1621 ggcccgaatg tggaacgacc tgtctgagaa gaagaaggcc aagtacaagg cccgagaggc
     1681 ggcgctcaag gctcagtcgg agaggaagcc cggcggggag cgcgaggaac ggggcaagct
     1741 gcccgagtcc cccaaaagag ctgaggagat ctggcaacag agcgttatcg gcgactacct
     1801 ggcccgcttc aagaatgacc gggtgaaggc cttgaaagcc atggaaatga cctggaataa
     1861 catggaaaag aaggagaaac tgatgtggat taagaaggca gccgaagacc aaaagcgata
     1921 tgagagagag ctgagtgaga tgcgggcacc tccagctgct acaaattctt ccaagaagat
     1981 gaaattccag ggagaaccca agaagcctcc catgaacggt taccagaagt tctcccagga
     2041 gctgctgtcc aatggggagc tgaaccacct gccgctgaag gagcgcatgg tggagatcgg
     2101 cagtcgctgg cagcgcatct cccagagcca gaaggagcac tacaaaaagc tggccgagga
     2161 gcagcaaaag cagtacaagg tgcacctgga cctctgggtt aagagcctgt ctccccagga
     2221 ccgtgcagca tataaagagt acatctccaa taaacgtaag agcatgacca agctgcgagg
     2281 cccaaacccc aaatccagcc ggactactct gcagtccaag tcggagtccg aggaggatga
     2341 tgaagaggat gaggatgacg aggacgagga tgaagaagag gaagatgatg agaatgggga
     2401 ctcctctgaa gatggcggcg actcctctga gtccagcagc gaggacgaga gcgaggatgg
     2461 ggatgagaat gaagaggatg acgaggacga agacgacgac gaggatgacg atgaggatga
     2521 agataatgag tccgagggca gcagctccag ctcctcctcc tcaggggact cctcagactc
     2581 tgactccaac tgaggctcag ccccacccca gggcagccag ggagagccca ggagctcccc
     2641 tccccaactg accacctttg tttctccccc atgttctgtc ccttgccccc ctggcctccc
     2701 ccactttctt tctttcttta aaaaaaaaaa aaaatacggt gggggtaggg ggctggagga
     2761 gcccaggcca ggactctgca gcctcagaga catcagccct tgggggtcct cctccaggga
     2821 cagcaactat cagactaagc cagcaccgga ccagcctggc ccaccccacc cacttctgca
     2881 cttgcggttc cggcatggac aatggaccgg agagtggggg tggggggtcc caaagagttt
     2941 gatgaggccc tccacacctg cggcccaatc caaggtgggg tggaagcttg gggaagaccc
     3001 attccttccc agaggggcct gccacctgga cccctgcatt ggaactggag gcagggaaca
     3061 tggggaggag gagggtcggt gccttcaaga aaacaggcac tgccctggtg gccctctccc
     3121 ctgccccctg caggaaggag ctgcctggac ccgttcatgg gggagggggc agaagtgttt
     3181 tttatatatg tgtatatatt tttttttaag ctctgagctg tcaacgagac gtttcctacc
     3241 gatctcggct gccgtctctg ttgtcatttc tgggagaggg agggtttagg ggtagatttg
     3301 gaacctttta aaaatggtct tgatgtatgt ggaagagagt atgtgtatgt gtgttcctgt
     3361 acatagcatg ggtgcagctg tggatgtgtg caaaagagtg tgagtgtgtg tgtgtgtgtg
     3421 taaaggggtc tgtcctagag cccacatcag tttgttgtga atctggaaaa agggtcggtg
     3481 agggccggga gatgttgacc ctggtgggag caggctgagg ctgccccgtt ctccacatcc
     3541 tctgttttgc ccagtctctg attccattag ggggagtgtg ctgaagccat tctcggatgc
     3601 ttcccagacc aggctccctc tgccagagtc acatgcatcc gagctgctgg tctccattgt
     3661 ccagcaggaa ggcggaaagg caggcaagat ggtgtgaagc ttaaagcttg tatttgatgg
     3721 aaaaggtctc ccctgttcat ctgagaggcc aagcctggcc accccaggct cagaacctgg
     3781 gcttcaagaa atgtgctggg agctcctaac ttacacatcc ctccagcctt ccttgaatcc
     3841 tcccaccacc ccctatttcc tttaatttct caggtctgct ccctcctccc ccaaccccac
     3901 agctgggcaa gaagtctgca aaagctgcat ctgcagctgt ctctaactct tcccagccat
     3961 ctcccgtatt ttttggtacc ttgattcctt gactcttaat aagccaagcc accttatctc
     4021 tgtagttctt atttttttgt tgactaaatt tggggggttc ttttttatgg tcatgtcact
     4081 gacctattaa attggggctt ggtgcttttc caccttcccc ctctgaatga aagccaagga
     4141 atgggggaag agcgggaact ctgccgcgga ggtggagcaa gaacggtgaa gggccctggt
     4201 cccagagagg ctggtgggtc cctctcccaa aggaaggcag acagtctctg ctttgccttg
     4261 gaccttggtg ctgggggtgg ggaggcctgg gggggacact ccccactccc attccccttc
     4321 ctttgtccta atcctggaat taagtacagg ggtttatagg ttctatttct tcccaagagc
     4381 cctgcaaaga accccagttt cctatttgga tgcccctaca ctgttgtgtt tcagtggaat
     4441 gtattttcat ttaaaaacaa ctttgaatgg ggcacttttt ctttcctgtt ttaaaaattg
     4501 aaaaattctt acagtacaaa caggactgtc agggtggggg tgttggtgct gtaagaggtc
     4561 actcttgagt gcattttggc actgggatgg gatggctggg gtgggaagac ccccatcccc
     4621 acccccaact tcttttctaa tatttaagga gtgttttgta ggattcaaca accaccacaa
     4681 cttgaatttg tatcatggga ggtgggaggg agtggcttag aggtgtctgc ctatgcttaa
     4741 agccaactgt ggaagttttg ttttcccttt tttgtataat aaagtgaaaa acaaa
//
