LOCUS       NM_152277               2988 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ubiquitin domain containing 2 (UBTD2), mRNA.
ACCESSION   NM_152277
VERSION     NM_152277.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2988)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2988)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2988)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 2988)
  AUTHORS   Song,A.X., Yang,H., Gao,Y.G., Zhou,C.J., Zhang,Y.H. and Hu,H.Y.
  TITLE     A ubiquitin shuttle DC-UbP/UBTD2 reconciles protein ubiquitination
            and deubiquitination via linking UbE1 and USP5 enzymes
  JOURNAL   PLoS One 9 (9), e107509 (2014)
   PUBMED   25207809
  REMARK    GeneRIF: A ubiquitin shuttle DC-UbP reconciles protein
            ubiquitination and deubiquitination via linking UbE1 and USP5
            enzymes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2988)
  AUTHORS   Song,A.X., Zhou,C.J., Guan,X., Sze,K.H. and Hu,H.Y.
  TITLE     Solution structure of the N-terminal domain of DC-UbP/UBTD2 and its
            interaction with ubiquitin
  JOURNAL   Protein Sci 19 (5), 1104-1109 (2010)
   PUBMED   20440844
  REMARK    GeneRIF: The results show that DC-UbP_N holds a novel structural
            fold and acts as a Ub-binding domain (UBD) but with low affinity.
REFERENCE   6  (bases 1 to 2988)
  AUTHORS   Gao,Y.G., Song,A.X., Shi,Y.H., Chang,Y.G., Liu,S.X., Yu,Y.Z.,
            Cao,X.T., Lin,D.H. and Hu,H.Y.
  TITLE     Solution structure of the ubiquitin-like domain of human DC-UbP
            from dendritic cells
  JOURNAL   Protein Sci 14 (8), 2044-2050 (2005)
   PUBMED   15987890
  REMARK    GeneRIF: Solution NMR structure of the ubiquitin-like domain of
            DC-UbP is very similar to that of ubiquitin despite low similarity
            (<30%) in amino-acid sequence.
REFERENCE   7  (bases 1 to 2988)
  AUTHORS   Liu,S., An,H., Li,N., Yu,Y., Lin,N., Wan,T., Zhang,M., Wang,W. and
            Cao,X.
  TITLE     Cloning and identification of a novel human ubiquitin-like protein,
            DC-UbP, from dendritic cells
  JOURNAL   Biochem Biophys Res Commun 300 (3), 800-805 (2003)
   PUBMED   12507522
  REMARK    GeneRIF: cloning and identification; DC-UbP might be downregulated
            during cellular differentiation and apoptosis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008671.6 and AC024561.5.
            
            On Nov 23, 2018 this sequence version replaced NM_152277.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.211197.1,
                                           SRR1660805.138323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393792.3/ ENSP00000377381.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AC008671.6         43920-44088         c
            170-406             AC024561.5         25391-25627
            407-2988            AC024561.5         47522-50103
FEATURES             Location/Qualifiers
     source          1..2988
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.1"
     gene            1..2988
                     /gene="UBTD2"
                     /gene_synonym="DCUBP"
                     /note="ubiquitin domain containing 2"
                     /db_xref="GeneID:92181"
                     /db_xref="HGNC:HGNC:24463"
                     /db_xref="MIM:610174"
     exon            1..169
                     /gene="UBTD2"
                     /gene_synonym="DCUBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..804
                     /gene="UBTD2"
                     /gene_synonym="DCUBP"
                     /note="ubiquitin-like protein SB72"
                     /codon_start=1
                     /product="ubiquitin domain-containing protein 2"
                     /protein_id="NP_689490.2"
                     /db_xref="CCDS:CCDS4379.2"
                     /db_xref="GeneID:92181"
                     /db_xref="HGNC:HGNC:24463"
                     /db_xref="MIM:610174"
                     /translation="MGGCVGAQHDSSGSLNENSEGTGVALGRNQPLKKEKPKWKSDYP
                     MTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAHAFESNDHELAQAIIDGANITLPH
                     GALTECYDELGNRYQLPVYCLAPPINMIEEKSDIETLDIPEPPPNSGYECQLRLRLST
                     GKDLKLVVRSTDTVFHMKRRLHAAEGVEPGSQRWFFSGRPLTDKMKFEELKIPKDYVV
                     QVIVSQPVQNPTPVEN"
     exon            170..406
                     /gene="UBTD2"
                     /gene_synonym="DCUBP"
                     /inference="alignment:Splign:2.1.0"
     exon            407..2988
                     /gene="UBTD2"
                     /gene_synonym="DCUBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1218..1223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBTD2"
                     /gene_synonym="DCUBP"
                     /note="hexamer: AATAAT"
     polyA_site      1238
                     /gene="UBTD2"
                     /gene_synonym="DCUBP"
                     /note="major polyA site"
     regulatory      2401..2406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBTD2"
                     /gene_synonym="DCUBP"
                     /note="hexamer: AATATA"
     polyA_site      2419
                     /gene="UBTD2"
                     /gene_synonym="DCUBP"
                     /note="major polyA site"
     polyA_site      2988
                     /gene="UBTD2"
                     /gene_synonym="DCUBP"
ORIGIN      
        1 gtccggagct cggcggtggc gccggaggag gctgcagcgg cggcggcggc gggcccggac
       61 gagcgtccgg aggtggcgga cgaggcgccg ggggccccca tgggcgggtg tgtgggcgcc
      121 cagcacgact cctcgggcag cctcaacgag aactcggagg gcaccggagt tgctctaggt
      181 cgtaaccagc ctttgaaaaa ggagaaacca aaatggaaaa gcgattatcc tatgacagat
      241 ggacaactac gcagcaagag ggatgaattt tgggatacag caccagcttt tgaaggccgg
      301 aaagagattt gggatgcctt gaaggctgct gcacatgctt ttgagagcaa tgatcatgaa
      361 ctggcacaag caatcattga tggtgcaaac ataacattac cacatggtgc acttacagag
      421 tgctacgatg aactggggaa cagatatcag cttccagtgt attgcttggc accgccaatc
      481 aacatgatag aggaaaagag cgacatagag actctggata ttcctgagcc accacccaat
      541 tctggatatg aatgtcagct tcgtttgcgc ctttccacag gcaaagacct caagcttgtg
      601 gttcgcagca cagacacagt attccacatg aagagacggt tgcatgcagc agagggagtg
      661 gaaccaggta gtcagcggtg gtttttttct ggcagacctc tcactgacaa aatgaagttc
      721 gaagagctga agatcccaaa ggactatgtt gtacaggtta tagtgagcca acctgtgcag
      781 aacccaacac cagtggagaa ctgaactgag ccctgttggc cagctcccac atccctctgc
      841 tcctttttat ggttcttgtt gtcatttcct actctgcggc gtgaaatcta tttcactgct
      901 ctaaattccc tatgaatgga tttagttctg aggaattacc agtgaaaaat tccatctgtg
      961 atggagacca acaaaaataa taaaacacaa agagccaggc tttgagactc atgtaattac
     1021 aatttctaat ttgaaaggca gttaagaaat agataaccat ttattttaga acactcaaca
     1081 actatgtaat ggctatattt cagtgacttg gactgtaaat gaaacattgc atccatgaag
     1141 gacagcacca agcacctttt tgaatacaga atttttttag aaaaatatat caaattatat
     1201 aatttccaga aaccataaat aatggatata aaacttaacc tttttgtttt gttttgtttt
     1261 gttttgtttt gttttgtttt gttttggtta atggaaactg aaaagagcag tatttgaggt
     1321 tgcttctatt ctggtttttt attcttagct caattaatat ttagccataa atgagtagag
     1381 actggcaaat tgtgctttag tgttgctttc ctcatcccca catcttgagc tccttattta
     1441 cattcacact aaattttggt gccttccagc acattagtgg caggcaccct tctggaacac
     1501 taggcaataa tttcatcaat acagtcaggt ctcttgagtt tcaacagata ctcagttgaa
     1561 aagtcgctgt catcttgctg cataagtatt ttgaaaggtc tgtataacga agccattttt
     1621 atatccaggc ttagaaggtc actactatat agtaccttca ttgatctatc tattctgctt
     1681 ggaacttttc atagctaagt ataaccccca aatgcatggt tcctgggtca ggagacacca
     1741 aaatcaatta tagctgttcc cactcaagtt aataaagtaa atgatttcct ccactttgca
     1801 tggaggggtg taaggaaagc ctattttatc tgtgcctggg agaactgtgc ctattttcag
     1861 tcttttagag gaaatttcaa ctcaaaattt ttaagtgtga aagatttact ggtgtcacat
     1921 aaacattagc agtgagacca aataatgaaa cattgcttta taccttagtg ctttccagtt
     1981 cactgttacc tctagtcatg gtagatgaca attttcctcc ctcatctttt gtagcaaaga
     2041 agcaaattaa gagccttttg caagttagat taggggactg aaaaatccag ggagataacc
     2101 tgattcttct atactatgac tggagtaaag ctgccaagag ttaggttgaa tttggagcct
     2161 tttaaaagtt ggttccataa gtgagaaggg gggctaacat gtgaccactg tgcccctgag
     2221 aatccatgag atggaaaagt acagacaaga aggcacttaa cgctgttctc agttggaaaa
     2281 tgtcagccct ccacacctgt ttggatgtga agtgcattat taattttaat gacaaaatga
     2341 aactgctaat tagtttaaat gtaatgttta aatggtattg aatttcctat tgcctgatta
     2401 aatatatctg taattgtaac atcatgtttc tgagagcttt aactacttcc ttatttttat
     2461 gcaatcattt taaagattgt ggctatatct aatttaaatt tgctgatgat tgaatctaaa
     2521 ttcaagtgaa gaccacagca ttaatcccaa aggagatttt ttttatgttt agaggtggag
     2581 atattagggt aaatcagtat attgctcctg tcatcaaagt ttttgttcat ttgtgtgcca
     2641 catcgaatag cagcacttct caaagtttgt caactggaaa aaagtgttta aaactgtttt
     2701 tttcttaagc agatttggtg atgtcatcaa tatctatgat atcgattggt aaaaggtctt
     2761 tctttgttga ggatttgagc tctcttttta agagtttatt ttattttaaa ggaacatatg
     2821 ctttgaataa caattctctg ggcatgttta actaacctag gtgggaaaac catggtgctg
     2881 tttaattgta aatagattga tataagattg gaccagtact tgatgtgtat aattttagta
     2941 tgtagggttt atgtgctttt tttaaaaaaa aaaaaaaggt tcaatttt
//
