LOCUS       NM_024954               1647 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ubiquitin domain containing 1 (UBTD1), mRNA.
ACCESSION   NM_024954
VERSION     NM_024954.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1647)
  AUTHORS   Zhao,Z., Yang,C., Geng,X., Yuan,C., Yang,R. and Yang,G.
  TITLE     UBTD1 is a potential prognostic biomarker in colorectal cancer
  JOURNAL   Sci Rep 14 (1), 17926 (2024)
   PUBMED   39095643
  REMARK    GeneRIF: UBTD1 is a potential prognostic biomarker in colorectal
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1647)
  AUTHORS   Zhao,L., Yu,N., Zhai,Y., Yang,Y., Wang,Y., Yang,Y., Gong,Z.,
            Zhang,Y., Zhang,X. and Guo,W.
  TITLE     The ubiquitin-like protein UBTD1 promotes colorectal cancer
            progression by stabilizing c-Myc to upregulate glycolysis
  JOURNAL   Cell Death Dis 15 (7), 502 (2024)
   PUBMED   39003255
  REMARK    GeneRIF: The ubiquitin-like protein UBTD1 promotes colorectal
            cancer progression by stabilizing c-Myc to upregulate glycolysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1647)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1647)
  AUTHORS   Torrino,S., Tiroille,V., Dolfi,B., Dufies,M., Hinault,C.,
            Bonesso,L., Dagnino,S., Uhler,J., Irondelle,M., Gay,A.S.,
            Fleuriot,L., Debayle,D., Lacas-Gervais,S., Cormont,M., Bertero,T.,
            Bost,F., Gilleron,J. and Clavel,S.
  TITLE     UBTD1 regulates ceramide balance and endolysosomal positioning to
            coordinate EGFR signaling
  JOURNAL   Elife 10, e68348 (2021)
   PUBMED   33884955
  REMARK    GeneRIF: UBTD1 regulates ceramide balance and endolysosomal
            positioning to coordinate EGFR signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1647)
  AUTHORS   Yang,N., Chen,T., Wang,L., Liu,R., Niu,Y., Sun,L., Yao,B., Wang,Y.,
            Yang,W., Liu,Q., Tu,K. and Liu,Z.
  TITLE     CXCR4 mediates matrix stiffness-induced downregulation of UBTD1
            driving hepatocellular carcinoma progression via YAP signaling
            pathway
  JOURNAL   Theranostics 10 (13), 5790-5801 (2020)
   PUBMED   32483419
  REMARK    GeneRIF: CXCR4 mediates matrix stiffness-induced downregulation of
            UBTD1 driving hepatocellular carcinoma progression via YAP
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1647)
  AUTHORS   Torrino,S., Roustan,F.R., Kaminski,L., Bertero,T., Pisano,S.,
            Ambrosetti,D., Dufies,M., Uhler,J.P., Lemichez,E., Mettouchi,A.,
            Gesson,M., Laurent,K., Gaggioli,C., Michiels,J.F., Lamaze,C.,
            Bost,F. and Clavel,S.
  TITLE     UBTD1 is a mechano-regulator controlling cancer aggressiveness
  JOURNAL   EMBO Rep 20 (4) (2019)
   PUBMED   30804013
  REMARK    GeneRIF: low levels of UBTD1 are associated with poor patient
            survival, suggesting that biological functions of UBTD1 could be
            beneficial in limiting cancer progression.
REFERENCE   7  (bases 1 to 1647)
  AUTHORS   Zhang,X.W., Wang,X.F., Ni,S.J., Qin,W., Zhao,L.Q., Hua,R.X.,
            Lu,Y.W., Li,J., Dimri,G.P. and Guo,W.J.
  TITLE     UBTD1 induces cellular senescence through an UBTD1-Mdm2/p53
            positive feedback loop
  JOURNAL   J Pathol 235 (4), 656-667 (2015)
   PUBMED   25382750
  REMARK    GeneRIF: Establish UBTD1 as a regulator of cellular senescence that
            mediates p53 function, and provide insights into the mechanism of
            Mdm2 inhibition that impacts p53 dynamics during cellular
            senescence and tumourigenesis.
REFERENCE   8  (bases 1 to 1647)
  AUTHORS   Uhler,J.P., Spahr,H., Farge,G., Clavel,S., Larsson,N.G.,
            Falkenberg,M., Samuelsson,T. and Gustafsson,C.M.
  TITLE     The UbL protein UBTD1 stably interacts with the UBE2D family of E2
            ubiquitin conjugating enzymes
  JOURNAL   Biochem Biophys Res Commun 443 (1), 7-12 (2014)
   PUBMED   24211586
  REMARK    GeneRIF: Biochemical characterization of recombinant UBTD1 and
            UBE2D demonstrated that the two proteins form a stable,
            stoichiometric complex that can be purified to near homogeneity.
REFERENCE   9  (bases 1 to 1647)
  AUTHORS   Markson,G., Kiel,C., Hyde,R., Brown,S., Charalabous,P., Bremm,A.,
            Semple,J., Woodsmith,J., Duley,S., Salehi-Ashtiani,K., Vidal,M.,
            Komander,D., Serrano,L., Lehner,P. and Sanderson,C.M.
  TITLE     Analysis of the human E2 ubiquitin conjugating enzyme protein
            interaction network
  JOURNAL   Genome Res 19 (10), 1905-1911 (2009)
   PUBMED   19549727
REFERENCE   10 (bases 1 to 1647)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM922594.1, BC007331.2,
            AL359388.32 and CB306542.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024954.4.
            
            Summary: The degradation of many proteins is carried out by the
            ubiquitin pathway in which proteins are targeted for degradation by
            covalent conjugation of the polypeptide ubiquitin. This gene
            encodes a protein that belongs to the ubiquitin family of proteins.
            The encoded protein is thought to regulate E2 ubiquitin conjugating
            enzymes belonging to the UBE2D family. [provided by RefSeq, Mar
            2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.82500.1,
                                           SRR3476690.423648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370664.4/ ENSP00000359698.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                BM922594.1         52-138
            88-1448             BC007331.2         1-1361
            1449-1497           AL359388.32        84082-84130
            1498-1644           BC007331.2         1411-1557
            1645-1647           CB306542.1         23-25               c
FEATURES             Location/Qualifiers
     source          1..1647
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1-q24.2"
     gene            1..1647
                     /gene="UBTD1"
                     /note="ubiquitin domain containing 1"
                     /db_xref="GeneID:80019"
                     /db_xref="HGNC:HGNC:25683"
                     /db_xref="MIM:616388"
     exon            1..350
                     /gene="UBTD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..964
                     /gene="UBTD1"
                     /codon_start=1
                     /product="ubiquitin domain-containing protein 1"
                     /protein_id="NP_079230.1"
                     /db_xref="CCDS:CCDS7465.1"
                     /db_xref="GeneID:80019"
                     /db_xref="HGNC:HGNC:25683"
                     /db_xref="MIM:616388"
                     /translation="MGNCVGRQRRERPAAPGHPRKRAGRNEPLKKERLKWKSDYPMTD
                     GQLRSKRDEFWDTAPAFEGRKEIWDALKAAAYAAEANDHELAQAILDGASITLPHGTL
                     CECYDELGNRYQLPIYCLSPPVNLLLEHTEEESLEPPEPPPSVRREFPLKVRLSTGKD
                     VRLSASLPDTVGQLKRQLHAQEGIEPSWQRWFFSGKLLTDRTRLQETKIQKDFVIQVI
                     INQPPPPQD"
     exon            351..578
                     /gene="UBTD1"
                     /inference="alignment:Splign:2.1.0"
     exon            579..1647
                     /gene="UBTD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1625..1630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBTD1"
                     /note="hexamer: AATAAA"
     polyA_site      1647
                     /gene="UBTD1"
                     /note="major polyA site"
ORIGIN      
        1 ctctccgccc ctccagcgga gctggtctcc ggccgggcac cgtcgcgggc ccccctggcc
       61 cggccacctg ggaccgtgct ggggagtctg ccacttccct ctctcccctg gcccgcaaag
      121 ttttggcgga gccatcgctg gggctgagcg cgcccccggg gggagatcgg ggagcgcccg
      181 atgccgggcg gccggagcca ttgacccggg acgccgccgt ccgctgagca gccgaccacc
      241 ccgccgcctc cggtgcatgg ggactggctg aggagccagc atgggcaact gcgtggggag
      301 acagcgccgg gagaggccgg cagccccggg acacccccgc aagcgagcag gacgcaatga
      361 gcccctgaag aaagagcggc ttaagtggaa gagcgactac cccatgactg acgggcagct
      421 gcggagcaaa cgggatgagt tctgggacac agcgcctgcc ttcgagggcc gcaaggagat
      481 ctgggatgcc ctcaaggctg ccgcctatgc tgctgaagcc aacgaccacg agctggccca
      541 ggccatcctg gatggagcca gcatcaccct gcctcatggc accctctgtg aatgctacga
      601 tgagctgggc aatcgctacc agctgcccat ctactgcctg tcaccgccgg tgaacctgct
      661 gctggagcac acggaggagg agagcctgga gccccccgag cctccaccca gcgtgcgccg
      721 tgagttcccg ctgaaggtgc gcctgtccac gggcaaggac gtgaggctca gcgccagcct
      781 gcccgacaca gtggggcagc tcaagaggca gctgcacgcc caggagggca tcgagccatc
      841 gtggcagcgg tggttcttct ccgggaagct gctcacagac cgcacacggc tccaggagac
      901 caagatccag aaagattttg tcatccaggt catcatcaac cagcccccac caccccagga
      961 ctgatgggcc cacggacccc tgggaagagg ccccgcctgg agcactaggc ccccaccctg
     1021 ctgctgcctt ccagtgctgt cattttcttc aggggccctc ccctcggtgt ggctggtggg
     1081 tgagccgtga agggaccctg cctttcaggg cactacgcgc caccagttcc cggtacccag
     1141 ggagcaggca gccacacacg ggccttgcaa ccttgtcaga gaaaaggcga acagggccct
     1201 caccctgcct gtctcccgaa gcaggttcga gccacaaggg ccaaccagga ggcccctgga
     1261 gcccagatct gtcatctggt gctgccagct gtgctcactc tggttttctg ctcagggtct
     1321 gaagcagctg ctgtctccct cctctgcccc catcccctgg ctctcccctg ggcacagtgc
     1381 cactcccttg gaagggaggg aaccacccgt gagccccagg gcttgggaag cctgaggcgg
     1441 gcctctgcct ctccctgccc ccagcacaat tggcagagat gaggcgggtg gtggacagct
     1501 gggctgtcgt ggcagggtct gcacagggcc atgtcctggc tgtaacccag gcagtgggag
     1561 gtctgcagcc tggtcatggc ctccacagca ggtccctgtg gacagacata tctgcatatt
     1621 tatcaataaa gccttttgct ccttctc
//
