LOCUS       NM_015902              10895 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ubiquitin protein ligase E3 component n-recognin 5
            (UBR5), transcript variant 1, mRNA.
ACCESSION   NM_015902
VERSION     NM_015902.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10895)
  AUTHORS   Zhang,S., Valenzuela,L.F., Zatulovskiy,E., Mangiante,L., Curtis,C.
            and Skotheim,J.M.
  TITLE     The G1-S transition is promoted by Rb degradation via the E3 ligase
            UBR5
  JOURNAL   Sci Adv 10 (43), eadq6858 (2024)
   PUBMED   39441926
  REMARK    GeneRIF: The G1-S transition is promoted by Rb degradation via the
            E3 ligase UBR5.
REFERENCE   2  (bases 1 to 10895)
  AUTHORS   Zhu,C., Cheng,Y., Yu,Y., Zhang,Y. and Ren,G.
  TITLE     VIRMA promotes the progression of head and neck squamous cell
            carcinoma by regulating UBR5 mRNA and m6A levels
  JOURNAL   Biomol Biomed 24 (5), 1244-1257 (2024)
   PUBMED   38577917
  REMARK    GeneRIF: VIRMA promotes the progression of head and neck squamous
            cell carcinoma by regulating UBR5 mRNA and m6A levels.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10895)
  AUTHORS   Du,Y., Yang,Z., Shi,H., Chen,Z., Chen,R., Zhou,F., Peng,X., Hong,T.
            and Jiang,L.
  TITLE     E3 ubiquitin ligase UBR5 promotes gemcitabine resistance in
            pancreatic cancer by inducing O-GlcNAcylation-mediated EMT via
            destabilization of OGA
  JOURNAL   Cell Death Dis 15 (5), 340 (2024)
   PUBMED   38755129
  REMARK    GeneRIF: E3 ubiquitin ligase UBR5 promotes gemcitabine resistance
            in pancreatic cancer by inducing O-GlcNAcylation-mediated EMT via
            destabilization of OGA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10895)
  AUTHORS   Hu,B. and Chen,S.
  TITLE     The role of UBR5 in tumor proliferation and oncotherapy
  JOURNAL   Gene 906, 148258 (2024)
   PUBMED   38331119
  REMARK    GeneRIF: The role of UBR5 in tumor proliferation and oncotherapy.
            Review article
REFERENCE   5  (bases 1 to 10895)
  AUTHORS   Chen,S.Y., Zhang,F.L., Zhang,Y.L., Liao,L., Deng,L., Shao,Z.M.,
            Liu,G.Y. and Li,D.Q.
  TITLE     Spermatid perinuclear RNA-binding protein promotes UBR5-mediated
            proteolysis of Dicer to accelerate triple-negative breast cancer
            progression
  JOURNAL   Cancer Lett 586, 216672 (2024)
   PUBMED   38280476
  REMARK    GeneRIF: Spermatid perinuclear RNA-binding protein promotes
            UBR5-mediated proteolysis of Dicer to accelerate triple-negative
            breast cancer progression.
REFERENCE   6  (bases 1 to 10895)
  AUTHORS   Eblen,S.T., Kumar,N.V., Shah,K., Henderson,M.J., Watts,C.K.,
            Shokat,K.M. and Weber,M.J.
  TITLE     Identification of novel ERK2 substrates through use of an
            engineered kinase and ATP analogs
  JOURNAL   J Biol Chem 278 (17), 14926-14935 (2003)
   PUBMED   12594221
REFERENCE   7  (bases 1 to 10895)
  AUTHORS   Henderson,M.J., Russell,A.J., Hird,S., Munoz,M., Clancy,J.L.,
            Lehrbach,G.M., Calanni,S.T., Jans,D.A., Sutherland,R.L. and
            Watts,C.K.
  TITLE     EDD, the human hyperplastic discs protein, has a role in
            progesterone receptor coactivation and potential involvement in DNA
            damage response
  JOURNAL   J Biol Chem 277 (29), 26468-26478 (2002)
   PUBMED   12011095
  REMARK    GeneRIF: ubiquitin-protein ligase EDD interacts with importin alpha
            5 through consensus basic nuclear localization signals and is
            localized in cell nuclei. EDD also binds progesterone receptor (PR)
            and potentiates progestin-mediated gene transactivation.
REFERENCE   8  (bases 1 to 10895)
  AUTHORS   Honda,Y., Tojo,M., Matsuzaki,K., Anan,T., Matsumoto,M., Ando,M.,
            Saya,H. and Nakao,M.
  TITLE     Cooperation of HECT-domain ubiquitin ligase hHYD and DNA
            topoisomerase II-binding protein for DNA damage response
  JOURNAL   J Biol Chem 277 (5), 3599-3605 (2002)
   PUBMED   11714696
REFERENCE   9  (bases 1 to 10895)
  AUTHORS   Deo,R.C., Sonenberg,N. and Burley,S.K.
  TITLE     X-ray structure of the human hyperplastic discs protein: an
            ortholog of the C-terminal domain of poly(A)-binding protein
  JOURNAL   Proc Natl Acad Sci U S A 98 (8), 4414-4419 (2001)
   PUBMED   11287654
REFERENCE   10 (bases 1 to 10895)
  AUTHORS   Callaghan,M.J., Russell,A.J., Woollatt,E., Sutherland,G.R.,
            Sutherland,R.L. and Watts,C.K.
  TITLE     Identification of a human HECT family protein with homology to the
            Drosophila tumor suppressor gene hyperplastic discs
  JOURNAL   Oncogene 17 (26), 3479-3491 (1998)
   PUBMED   10030672
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002981.2, AB020703.3,
            AP002907.2 and BX489192.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015902.5.
            
            Summary: This gene encodes a progestin-induced protein, which
            belongs to the HECT (homology to E6-AP carboxyl terminus) family.
            The HECT family proteins function as E3 ubiquitin-protein ligases,
            targeting specific proteins for ubiquitin-mediated proteolysis.
            This gene is localized to chromosome 8q22 which is disrupted in a
            variety of cancers. This gene potentially has a role in regulation
            of cell proliferation or differentiation. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.1052076.1, BC137234.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000520539.6/ ENSP00000429084.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AP002981.2         147228-147238       c
            12-7888             AB020703.3         1-7877
            7889-7891           AP002907.2         86853-86855         c
            7892-9155           AB020703.3         7878-9141
            9156-10323          AP002907.2         74422-75589         c
            10324-10895         BX489192.1         17-588              c
FEATURES             Location/Qualifiers
     source          1..10895
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.3"
     gene            1..10895
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /note="ubiquitin protein ligase E3 component n-recognin 5"
                     /db_xref="GeneID:51366"
                     /db_xref="HGNC:HGNC:16806"
                     /db_xref="MIM:608413"
     exon            1..528
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     CDS             467..8866
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /EC_number="2.3.2.26"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     identified by differential display; hyperplastic discs
                     protein homolog; progestin-induced protein; HECT-type E3
                     ubiquitin transferase UBR5; E3 ubiquitin-protein ligase,
                     HECT domain-containing 1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UBR5 isoform 1"
                     /protein_id="NP_056986.2"
                     /db_xref="CCDS:CCDS34933.1"
                     /db_xref="GeneID:51366"
                     /db_xref="HGNC:HGNC:16806"
                     /db_xref="MIM:608413"
                     /translation="MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLE
                     QATIKQCVVGPNHAAFLLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTS
                     RPGRTSDSPWFLSGSETLGRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRV
                     IRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNL
                     AVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDIS
                     YFGYPSFRRSSLSRLGSSRVLLLPLERDSELLRERESVLRLRERRWLDGASFDNERGS
                     TSKEGEPNLDKKNTPVQSPVSLGEDLQWWPDKDGTKFICIGALYSELLAVSSKGELYQ
                     WKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDET
                     LSSVASKLEHTAQTYSELQGERIVSLHCCALYTCAQLENSLYWWGVVPFSQRKKMLEK
                     ARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVW
                     NMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIA
                     SSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKF
                     PGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCI
                     PEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERN
                     VAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPA
                     NSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISH
                     RCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSN
                     GPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDP
                     PAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFI
                     LKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISS
                     SEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLES
                     LCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTAT
                     NLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLE
                     PPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTI
                     RLDCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVF
                     VILSVEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPT
                     APFTLASTSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQ
                     PVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGS
                     DMELDLLAAAETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQS
                     NDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRA
                     ASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSL
                     ARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWM
                     VSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRR
                     ATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWI
                     KAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAET
                     GQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGL
                     YSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEET
                     ESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWR
                     LSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDR
                     DLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSN
                     EKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDF
                     RRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLE
                     LSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKR
                     HGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGL
                     CLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFS
                     AMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAM
                     RKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKR
                     WFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCIS
                     RLYVPLYSSKQILKQKLLLAIKTKNFGFV"
     exon            529..573
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            574..655
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            656..732
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            733..852
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1042
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1202
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1352
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1564
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1681
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1792
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1947
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2065
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2250
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2360
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2473
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2617
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2729
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2884
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..3082
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3293
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            3294..3420
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            3421..3572
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            3573..3668
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            3669..3792
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            3793..3890
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            3891..4039
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            4040..4131
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            4132..4278
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            4279..4397
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            4398..4524
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            4525..4654
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            4655..4815
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            4816..5055
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            5056..5179
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            5180..5291
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            5292..5423
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            5424..5681
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            5682..5950
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            5951..6162
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            6163..6393
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            6394..6467
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            6468..6640
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            6641..6754
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            6755..6975
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            6976..7096
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            7097..7195
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            7196..7439
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            7440..7551
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            7552..7696
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            7697..7827
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            7828..7888
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            7889..8067
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            8068..8152
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            8153..8308
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            8309..8422
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            8423..8567
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            8568..8653
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     exon            8654..10895
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9247..9252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /note="hexamer: AATAAA"
     polyA_site      9264
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /note="major polyA site"
     regulatory      9815..9820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /note="hexamer: AAGAAA"
     polyA_site      9830
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /note="major polyA site"
     regulatory      10875..10880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
                     /note="hexamer: AATAAA"
     polyA_site      10895
                     /gene="UBR5"
                     /gene_synonym="DD5; EDD; EDD1; HYD"
ORIGIN      
        1 agaagtgaag atggcggcgg cagcttctcg ctagtgacgc gcggtgcggg ctcatctcct
       61 tcccctcctt cctcacctcc cctagtccgg accccgtccg ccgccgggac cagaccgtcc
      121 ccgtagcccg cagccagcag ccgcccctct cctcccccgg ccgcccctct cccaacgccc
      181 gtctgccgct ggccggcggc gcgcccctgg tcccggccgc ctgcctcgca ctccgcgctg
      241 tcgccggggg agcgggtggc gtgtggattc gccctcctgc ccgcccctcc gggccgcgga
      301 cacacgcccg gcagggaggc ggcggcggcc cctgcgtatt tgcttccctc catttgggga
      361 ctgggaggcg gcggcggctg tgggttttgg ggaggggtag agggctgggg ggcgggcgag
      421 agcgggaggg ggccgccctc gagtggagga cgagaaggaa agcaccatga cgtccatcca
      481 tttcgtggtt cacccgctgc cgggcaccga ggaccagctc aatgacaggt tacgagaagt
      541 ttctgagaag ctgaacaaat ataatttaaa cagccacccc cctttgaatg tattggaaca
      601 ggctactatt aaacagtgtg tggtgggacc aaatcatgct gcctttcttc ttgaggatgg
      661 tagagtttgc aggattggtt tttcagtaca gccagacaga ttggaattgg gtaaacctga
      721 taataatgat gggtcaaagt tgaacagcaa ctcgggggca gggaggacgt caaggcctgg
      781 taggacaagc gactctccat ggtttctctc aggttctgag actctaggca ggctggcagg
      841 caacacctta ggaagccgct ggagttctgg agtgggtgga agtggtggag gatcctctgg
      901 taggtcatca gctggagctc gagattcccg ccggcagact cgagttattc ggacaggacg
      961 ggatcgaggg tctgggcttt tgggcagtca gccccagcca gttattccag catctgtcat
     1021 tccagaggag ctgatttcac aggcccaagt tgttttacaa ggcaaatcca gaagtgtcat
     1081 tattcgagaa cttcagagaa caaatcttga tgtgaacctt gctgtaaata atttacttag
     1141 ccgggatgat gaagatggag atgatgggga tgatacagcc agcgaatctt atttgcctgg
     1201 agaggatctt atgtctctcc ttgatgccga cattcattct gcccacccaa gtgtcattat
     1261 tgatgcagat gccatgtttt ctgaagacat tagctatttt ggttaccctt cttttcgtcg
     1321 ttcatcactt tccaggctag gctcatctcg agttctcctt cttcccttag agagagactc
     1381 tgagctgttg cgtgaacgtg aatccgtttt acgtttacgt gaacgaaggt ggcttgatgg
     1441 agcctcattt gataatgaaa ggggttctac cagcaaggaa ggagagccaa acttggataa
     1501 gaagaataca cctgttcaaa gtccagtatc tctaggagaa gatttgcagt ggtggcctga
     1561 taaggatgga acaaaattca tctgtattgg ggctctgtat tctgaacttc tggctgtcag
     1621 cagtaaagga gaactttatc agtggaaatg gagtgaatct gagccttaca gaaatgccca
     1681 gaatccttca ttacatcatc cacgagcaac atttttgggg ttaaccaatg aaaagatagt
     1741 cctcctgtct gcaaatagca taagagcaac tgtagctaca gaaaataaca aggttgctac
     1801 atgggtggat gaaactttaa gttctgtggc ttctaaatta gagcacactg ctcagactta
     1861 ctctgaactt caaggagagc ggatagtttc tttacattgc tgtgcccttt acacctgcgc
     1921 tcagctggaa aacagtttat attggtgggg tgtagttcct tttagtcaaa ggaagaaaat
     1981 gttagagaaa gctagagcaa aaaataaaaa gcctaaatcc agtgctggta tttcttcaat
     2041 gccgaacatc actgttggta cccaggtatg cttgagaaat aatcctcttt atcatgctgg
     2101 agcagttgca ttttcaatta gtgctgggat tcctaaagtt ggtgtcttaa tggagtcagt
     2161 ttggaatatg aatgacagct gtagatttca acttagatct cctgaaagct tgaaaaacat
     2221 ggaaaaagct agcaaaacta ctgaagctaa gcctgaaagt aagcaggagc cagtgaaaac
     2281 agaaatgggt cctccaccat ctccagcatc cacgtgtagt gatgcatcct caattgccag
     2341 cagtgcatca atgccataca aacgacgacg gtcaacccct gcaccaaaag aagaggaaaa
     2401 ggtgaatgaa gagcagtggt ctcttcggga agtggttttt gtggaagatg tcaagaatgt
     2461 tcctgttggc aaggtgctaa aagtagatgg tgcctatgtt gctgtaaaat ttccaggaac
     2521 ctccagtaat actaactgtc agaacagctc tggtccagat gctgaccctt cttctctcct
     2581 gcaggattgt aggttactta gaattgatga attgcaggtt gtcaaaactg gtggaacacc
     2641 gaaggttccc gactgtttcc aaaggactcc taaaaagctt tgtatacctg aaaaaacaga
     2701 aatattagca gtgaatgtag attccaaagg tgttcatgct gttctgaaga ctggaaattg
     2761 ggtacgatac tgtatctttg atcttgctac aggaaaagca gaacaggaaa ataattttcc
     2821 tacaagcagc attgctttcc ttggtcagaa tgagaggaat gtagccattt tcactgctgg
     2881 acaggaatct cccattattc ttcgagatgg aaatggtacc atctacccaa tggccaaaga
     2941 ttgcatggga ggaataaggg atcccgattg gctggatctt ccacctatta gtagtcttgg
     3001 aatgggtgtg cattctttaa taaatcttcc tgccaattca acaatcaaaa agaaagctgc
     3061 tgttatcatc atggctgtag agaaacaaac cttaatgcaa cacattctgc gctgtgacta
     3121 tgaggcctgt cgacaatatc taatgaatct tgagcaagcg gttgttttag agcagaatct
     3181 acagatgctg cagacattca tcagccacag atgtgatgga aatcgaaata ttttgcatgc
     3241 ttgtgtatca gtttgctttc caaccagcaa taaagaaact aaagaagaag aggaagcgga
     3301 gcgttctgaa agaaatacat ttgcagaaag gctttctgct gttgaggcca ttgcaaatgc
     3361 aatatcagtt gtttcaagta atggcccagg taatcgggct ggatcatcaa gtagccgaag
     3421 tttgagatta cgggaaatga tgagacgttc gttgagagca gctggtttgg gtagacatga
     3481 agctggagct tcatccagtg accaccagga tccagtttca ccccccatag ctccccctag
     3541 ttgggttcct gaccctcctg cgatggatcc tgatggtgac attgatttta tcctggcccc
     3601 cgctgtggga tctcttacca cagcagcaac cggtactggt caaggaccaa gcacctccac
     3661 tattccaggt ccttccacag agccatctgt agtagaatcc aaggatcgaa aggcgaatgc
     3721 tcattttata ttgaaattgt tatgtgacag tgtggttctc cagccctatc tacgagaact
     3781 tctttctgcc aaggatgcaa gagggatgac cccatttatg tcagctgtaa gtggccgagc
     3841 ttatcctgct gcaattacca tcttagaaac tgctcagaaa attgcaaaag ctgaaatatc
     3901 ctcaagtgaa aaagaggaag atgtattcat gggaatggtt tgcccatcag gtaccaaccc
     3961 tgatgactct cctttatatg ttttatgttg taatgacact tgcagtttta catggactgg
     4021 agcagagcac attaaccagg atatttttga gtgtcgaact tgtggcttgc tggagtcact
     4081 gtgttgttgt acggaatgtg caagggtttg tcataaaggt catgattgca aactcaaacg
     4141 gacatcacca acagcctact gtgattgttg ggagaaatgt aaatgtaaaa ctcttattgc
     4201 tggacagaaa tctgctcgtc ttgatctact ttatcgcctg ctcactgcta ctaatctggt
     4261 tactctgcca aacagcaggg gagagcacct cttactattc ttagtacaga cagtcgcaag
     4321 gcagacggtg gagcattgtc aatacaggcc acctcgaatc agggaagatc gtaaccgaaa
     4381 aacagccagt cctgaagatt cagatatgcc agatcatgat ttagagcctc caagatttgc
     4441 ccagcttgca ttggagcgtg ttctacagga ctggaatgcc ttgaaatcta tgattatgtt
     4501 tgggtcgcag gagaataaag accctcttag tgccagcagt agaataggcc atcttttgcc
     4561 agaagagcaa gtatacctca atcagcaaag tggcacaatt cggctggact gtttcactca
     4621 ttgccttata gttaagtgta cagcagatat tttgctttta gatactctac taggtacact
     4681 agtgaaagaa ctccaaaaca aatatacacc tggacgtaga gaagaagcta ttgctgtgac
     4741 aatgaggttt ctacgttcag tggcaagagt ttttgttatt ctgagtgtgg aaatggcttc
     4801 atccaaaaag aaaaacaact ttattccaca gccaattgga aaatgcaagc gtgtattcca
     4861 agcattgcta ccttacgctg tggaagaatt gtgcaacgta gcagagtcac tgattgttcc
     4921 tgtcagaatg gggattgctc gtccaactgc accatttacc ctggctagta ctagcataga
     4981 tgccatgcag ggcagtgaag aattattttc agtggaacca ctaccaccac gaccatcatc
     5041 tgatcagtct agcagctcca gtcagtctca gtcatcctac atcatcagga atccacagca
     5101 gaggcgcatc agccagtcac agcccgttcg gggcagagat gaagaacagg atgatattgt
     5161 ttcagcagat gtggaagagg ttgaggtggt ggagggtgtg gctggagaag aggatcatca
     5221 tgatgaacag gaagaacacg gggaagaaaa tgctgaggca gagggacaac atgatgagca
     5281 tgatgaagac gggagtgata tggagctgga cttgttagca gcagctgaaa cagaaagtga
     5341 tagtgaaagt aaccacagca accaagataa tgctagtggg cgcagaagcg ttgtcactgc
     5401 agcaactgct ggttcagaag caggagcaag cagtgttcct gccttctttt ctgaagatga
     5461 ttctcaatcg aatgactcaa gtgattctga tagcagtagt agtcagagtg acgacataga
     5521 acaggagacc tttatgcttg atgagccatt agaaagaacc acaaatagct cccatgccaa
     5581 tggtgctgcc caagctcccc gttcaatgca gtgggctgtc cgcaacaccc agcatcagcg
     5641 agcagccagt acagcccctt ccagtacatc tacaccagca gcaagttcag cgggtttgat
     5701 ttatattgat ccttcaaact tacgccggag tggtaccatc agtacaagtg ctgcagctgc
     5761 agcagctgct ttggaagcta gcaacgccag cagttaccta acatctgcaa gcagtttagc
     5821 cagggcttac agcattgtca ttagacaaat ctcggacttg atgggcctta ttcctaagta
     5881 taatcaccta gtatactctc agattccagc agctgtgaaa ttgacttacc aagatgcagt
     5941 aaacttacag aactatgtag aagaaaagct tattcccact tggaactgga tggtcagtat
     6001 tatggattct actgaagctc aattacgtta tggttctgca ttagcatctg ctggtgatcc
     6061 tggacatcca aatcatcctc ttcacgcttc tcagaattca gcgagaagag agaggatgac
     6121 tgcgcgagaa gaagctagct tacgaacact tgaaggcaga cgacgtgcca ccttgcttag
     6181 cgcccgtcaa ggaatgatgt ctgcacgagg agacttccta aattatgctc tgtctctaat
     6241 gcggtctcat aatgatgagc attctgatgt tcttccagtt ttggatgttt gctcattgaa
     6301 gcatgtggca tatgtttttc aagcacttat atactggatt aaggcaatga atcagcagac
     6361 aacattggat acacctcaac tagaacgcaa aaggacgcga gaactcttgg aactgggtat
     6421 tgataatgaa gattcagaac atgaaaatga tgatgacacc aatcaaagtg ctactttgaa
     6481 tgataaggat gatgactctc ttcctgcaga aactggccaa aaccatccat ttttccgacg
     6541 ttcagactcc atgacattcc ttgggtgtat acccccaaat ccatttgaag tgcctctggc
     6601 tgaagccatc cccttggctg atcagccaca tctgttgcag ccaaatgcta gaaaggagga
     6661 tctttttggc cgtccaagtc agggtcttta ttcttcatct gccagtagtg ggaaatgttt
     6721 aatggaggtt acagtggata gaaactgcct agaggttctt ccaacaaaaa tgtcttatgc
     6781 tgccaatctg aaaaatgtaa tgaacatgca aaaccggcaa aaaaaagaag gggaagaaca
     6841 gcccgtgctg ccagaagaaa ctgagagttc aaaaccaggg ccatctgctc atgatcttgc
     6901 tgcacaatta aaaagtagct tactagcaga aataggactt actgaaagtg aagggccacc
     6961 tctcacatct ttcaggccac agtgtagctt tatgggaatg gttatttccc atgatatgct
     7021 gctaggacgt tggcgccttt ctttagaact gttcggcagg gtattcatgg aagatgttgg
     7081 agcagaacct ggatcaatcc taactgaatt gggtggtttt gaggtaaaag aatcaaaatt
     7141 ccgcagagaa atggaaaaac tgagaaacca gcagtcaaga gatttgtcac tagaggttga
     7201 tcgggatcga gatcttctca ttcagcagac tatgaggcag cttaacaatc actttggtcg
     7261 aagatgtgct actacaccaa tggctgtaca cagagtaaaa gtcacattta aggatgagcc
     7321 aggagagggc agtggtgtag cacgaagttt ttatacagcc attgcacaag catttttatc
     7381 aaatgaaaaa ttgccaaatc tagagtgtat ccaaaatgcc aacaaaggca cccacacaag
     7441 tttaatgcag agattaagga accgaggaga gagagaccgg gaaagggaga gagaaaggga
     7501 aatgaggagg agtagtggtt tgcgagcagg ttctcggagg gaccgggata gagactttag
     7561 aagacagctt tccatcgaca ctaggccctt tagaccagcc tctgaaggga atcctagcga
     7621 tgatcctgag cctttgccag cacatcggca ggcacttgga gagaggcttt atcctcgtgt
     7681 acaagcaatg caaccagcat ttgcaagtaa aatcactggc atgttgttgg aattatcccc
     7741 agctcagctg cttctccttc tagcaagtga ggattctctg agagcaagag tggatgaggc
     7801 catggaactc attattgcac atggacggga aaatggagct gatagtatcc tggatcttgg
     7861 attagtagac tcctcagaaa aggtacagca ggaaaaccga aagcgccatg gctctagtcg
     7921 aagtgtagta gatatggatt tagatgatac agatgatggt gatgacaatg cccctttgtt
     7981 ttaccaacct gggaaaagag gattttatac tccaaggcct ggcaagaaca cagaagcaag
     8041 gttgaattgt ttcagaaaca ttggcaggat tcttggacta tgtctgttac agaatgaact
     8101 atgtcctatc acattgaata gacatgtaat taaagtattg cttggtagaa aagtcaattg
     8161 gcatgatttt gctttttttg atcctgtaat gtatgagagt ttgcggcaac taatcctcgc
     8221 gtctcagagt tcagatgctg atgctgtttt ctcagcaatg gatttggcat ttgcaattga
     8281 cctgtgtaaa gaagaaggtg gaggacaggt tgaactcatt cctaatggtg taaatatacc
     8341 agtcactcca cagaatgtat atgagtatgt gcggaaatac gcagaacaca gaatgttggt
     8401 agttgcagaa cagcccttac atgcaatgag gaaaggtcta ctagatgtgc ttccaaaaaa
     8461 ttcattagaa gatttaacgg cagaagattt taggcttttg gtaaatggct gcggtgaagt
     8521 caatgtgcaa atgctgatca gttttacctc tttcaatgat gaatcaggag aaaatgctga
     8581 gaagcttctg cagttcaagc gttggttctg gtcaatagta gagaagatga gcatgacaga
     8641 acgacaagat cttgtttact tttggacatc aagcccatca ctgccagcca gtgaagaagg
     8701 attccagcct atgccctcaa tcacaataag accaccagat gaccaacatc ttcctactgc
     8761 aaatacttgc atttctcgac tttacgtccc actctattcc tctaaacaga ttctcaaaca
     8821 gaaattgtta ctcgccatta agaccaagaa ttttggtttt gtgtagagta taaaaagtgt
     8881 gtattgctgt gtaatattac tagcaaattt tgtagatttt tttccatttg tctataaaag
     8941 tttatggaag ttaatgctgt catacccccc tggtggtacc ttaaagagat aaaatgcaga
     9001 cattccttgc tgagtttata gcttaaaggc ctaaggagca ctagcaacat ttggctatat
     9061 tggtttgcta gtcaccaact tctgggtcta accccagcca aagatgacag cagaacaaca
     9121 taatttacac tgtgatttat ctttttgctg agggggaaaa aatgtaaatg ttctgaaaat
     9181 tcactgctgc ctttgtggaa actgtttcag caaaggttct tgtatagagg gaatagggaa
     9241 tttcaaaata aaaaattaag tatgttctgt gttttcattt taactttttt tatggtgttt
     9301 aatttgtggt tggctgcaac tgtgtatcat gtatatggaa cttgtaaaaa agttctcgac
     9361 attcagatct taagagatga aatcactttt acctataaaa accactttta ttgcggtttg
     9421 actgcattga gctctaggat attaaatgat atcactaata ttttgcatgt aatttgctca
     9481 tttgagtgag ggcacttttt ttgtacatat gatggggcca atgcacaata cttttatcac
     9541 aatcaacttt ttctttgtat ccctatttca atgagcagtc agtctcaaga ggttactgca
     9601 cttcagttct aactagacat ttgtactaag gtatttcagt tatgtaaact cagcctgggc
     9661 actttctgat aactgtaaaa tgttttataa gatcatgatt attgaagata cattttggaa
     9721 aattttaaat gttcgtgagc agcttaacta cttttgtatc tagccttttt taagtatctt
     9781 gttacattta cttttttaaa taaagaaatt acagaagaaa tgtcaagtaa tattgaagaa
     9841 acaatagttt ttatttatgt agttgtacat ttttaaacta agggcaatac actgacatgg
     9901 ttatgtgcat aaaaattttg acttaaagaa ctggaagttt atatacacct ggactataag
     9961 aaacagaaga aaatcagtcc acattttaca gttagcagag aatcctaaat ggcactggcc
    10021 tggccacctt ttcattttac aaatggggga agtgaagtgt gaccccttac ttggcatagg
    10081 aagttaactt acacctaata actgacaggt ttttgttttg atgacctatt aattatgtag
    10141 cctaggatta atatcccaaa attactctgg tttaagtagc tttattcagt ggcataataa
    10201 cactgttttc ttccttaagt cttcaatgaa gtgacttaaa acagtcactt tacatattaa
    10261 aaatgaggag agcaattctc tggaatctct cctttcagtt cctttgtagg atttctggcc
    10321 ttgaggatag tcttcatgtt caaaggcact atgcttttat tatataactt ccttcagaag
    10381 actgaaccac atgatattct cagccctgtt aacactaaaa atatttaaaa ctgaatgata
    10441 gtagtgactc attgtattac ttaaaactta tataacacgc tgtattagat gtgtgtaaat
    10501 tagccaaagg ttattttaca aagtgagaca ttggttttta tgtctaaatg ctatttctga
    10561 ataaatgaaa tagtaattag atcaagagct gattagcatc aatgtgtttg aaagatataa
    10621 aatttataca tcaccttaac ctctgtatgc acatgatggg attgataaaa tattaaatga
    10681 gaacaaacta gatatgatta ggacatttga aaccctaatt gtgaatttat ttttaatagt
    10741 tactgaaatg aaaatattta aaataatgca caatgtctta agtcttccta aatcaagatt
    10801 ttggttaaaa aatacttcta ataatagtaa aagatttttt ttttaagtaa atcataaaac
    10861 ggttctaaat gtaaaataaa gacatgtaaa ataaa
//
