LOCUS       XM_047416517           15883 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ubiquitin protein ligase E3 component
            n-recognin 4 (UBR4), transcript variant X42, mRNA.
ACCESSION   XM_047416517
VERSION     XM_047416517.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15883
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..15883
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /note="ubiquitin protein ligase E3 component n-recognin 4;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 13 mRNAs, 365 ESTs, 4855 long SRA reads, 8
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 56 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:23352"
                     /db_xref="HGNC:HGNC:30313"
                     /db_xref="MIM:609890"
     CDS             19..15561
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UBR4 isoform X42"
                     /protein_id="XP_047272473.1"
                     /db_xref="GeneID:23352"
                     /db_xref="HGNC:HGNC:30313"
                     /db_xref="MIM:609890"
                     /translation="MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAF
                     EMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAA
                     ACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKL
                     PQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVE
                     GENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDA
                     VLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSL
                     SCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAI
                     SSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
                     TKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGWETDGPPAA
                     LSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDS
                     NTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVK
                     SPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHH
                     MATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPF
                     SEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWDRFLSTMKQNALQGV
                     VPSETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQELSVNMDAQMRFVPLILA
                     RLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRATTPLYHGFKEV
                     EENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDSVACDVLFSKLVKYDELYAALTA
                     LLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYINQLSMNSPEM
                     SECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTTKCSSVKYDVE
                     IVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAET
                     DPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAAVLAI
                     GSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSESYI
                     SAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLE
                     SSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILE
                     ECLQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQ
                     LTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQL
                     LTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAG
                     HLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNAL
                     SQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQ
                     KEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLA
                     LVKRTPSSGMSSTMKESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPK
                     KSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQAL
                     SELHTVEKAVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMC
                     VLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLT
                     GNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELA
                     IVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQL
                     MEEASSAQQGPFYVTNVLEINHEDLKDSNSQVAGGGVSVYYSHVLQMLFFSYCQGKSF
                     AATISRTTLEVLQLFPINIKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVV
                     MVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVEN
                     TSYWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTDVEFGGN
                     DLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGTQAIERA
                     PSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLNLFIGASVDPAGVTMIDAVKI
                     YGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTGDSDSAAPTTTSGTVLERLVV
                     SSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPASVQQQSKSLLASLHTSRSA
                     YHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSIAIMRPNNLVHFTESKL
                     PQMETEGMDEGKEPQKQLEGDCCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIE
                     ATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRR
                     HVTLPSSPRSNTPMDKDDDDDDDADEKMQSSGIPNGGHIRQESQEQSEVDHGDFEMVS
                     ESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQ
                     GSSSSALGLQSLGLSGQAPSSSSLDAGTLSDTTASASDDEGSTAATDGSTLRTSPADH
                     GGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTTTGHQ
                     EGDGSEGEGEGETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILM
                     LTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLSVFM
                     SRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPVAT
                     SQLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKITDTNS
                     RIPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHV
                     RGIKKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCI
                     KDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASSGSSSASSSSAPVA
                     ASSGQATTQSKSSTKKSKKEEKEKEKDGETSGSQEDQLCTALVNQLNKFADKETLIQF
                     LRCFLLESNSSSVRWQAHCLTLHIYRNSSKSQQELLLDLMWSIWPELPAYGRKAAQFV
                     DLLGYFSLKTPQTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYL
                     ESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTK
                     MVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIE
                     FADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCN
                     ACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQ
                     LENLLCKVNEAAPEKPQDDSGTAGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKI
                     IQKVFASRKELLEYDLQQREAATKSSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGC
                     ASAVTEHCITLLRALATNPALRHILVSQGLIRELFDYNLRRGAAAMREEVRQLMCLLT
                     RDNPEATQQMNDLIIGKVSTALKGHWANPDLASSLQYEMLLLTDSISKEDSCWELRLR
                     CALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYC
                     NEIHAQAQLWLKRDPKASYDAWKKCLPIRGIDGNGKAPSKSELRHLYLTEKYVWRWKQ
                     FLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALATIPSRKQQVLDL
                     LTSYLDELSIAGECAAEYLALYQKLITSAHWKVYLAARGVLPYVGNLITKEIARLLAL
                     EEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRT
                     KLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSII
                     YPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLV
                     ALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEF
                     IESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQGRHLLTVLLKLFS
                     YCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILD
                     ESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVE
                     KMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGI
                     TQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSI
                     PNLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMRQKA
                     LGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKR
                     VALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGL
                     LPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSAD
                     TGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGP
                     YYFTVLALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSS
                     LLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMP
                     VETFSEFLDVAGLLSEITDPESFLKDLLNSVP"
ORIGIN      
        1 gcagtagtac gacggaagat ggcgacgagc ggcggcgaag aggcggcggc agcggctccg
       61 gcgccgggga ccccggcaac gggggcggac acgaccccgg gctgggaggt ggctgtgcgg
      121 cccctgctgt ccgcgtccta ctccgccttc gagatgaagg agttgccgca gctggtggcc
      181 tcagtcatcg agagtgaatc agaaatcctg caccatgaga agcagtacga gccattctac
      241 tcatcttttg ttgcactttc cacacactat attacaacag tttgcagtct cattccccgg
      301 aaccaacttc agtcagtggc agcagcctgt aaagttctaa ttgagttttc tctcctgcgt
      361 ctggagaatc cagatgaggc ttgtgctgtg tcccagaaac acttgattct cctaatcaag
      421 ggcctgtgca ctggctgtag ccgactagat agaactgaaa ttatcacatt tacagcaatg
      481 atgaaatccg ccaagctgcc ccaaacagtg aagacacttt cagacgtgga agatcagaaa
      541 gagctggcct caccagtaag ccctgagttg aggcaaaagg aggtacagat gaattttttg
      601 aaccagctga cctcagtttt taaccctaga actgtagcat cacaacctat cagtacacag
      661 actctggtgg aaggagaaaa tgatgagcag tcatctacag atcaagcctc agctatcaaa
      721 accaagaatg tgttcatagc tcagaacgtg gctagtcttc aagagcttgg tggctcggag
      781 aagctactgc gtgtatgttt gaacctgcca tatttcctac gctatatcaa tcggttccaa
      841 gatgcagttt tagctaattc cttcttcata atgcctgcaa cagtagcaga tgccactgct
      901 gttcgtaatg gctttcattc attggtgatt gatgtaacta tggcattgga taccctttct
      961 ctacctgtgt tggaacctct caatccttct cgtctacaag atgtgacagt cctcagccta
     1021 agttgtctgt atgcaggtgt gagtgtggca acgtgcatgg ccatcctcca tgtgggtagt
     1081 gcccagcaag tgcggacagg gtccacgagc tccaaagaag atgactatga aagtgacgca
     1141 gctacaattg tccagaaatg tctcgaaatc tatgacatga ttggacaagc aatcagcagt
     1201 tctcgccggg ctggtggtga gcactatcag aatttccaat tgctgggtgc ttggtgcttg
     1261 ttaaacagcc ttttcctcat actgaacctc agtcctactg cgttggctga taaggggaaa
     1321 gagaaggacc cactggctgc cctccgagtc agagacatcc tttctcgtac taaagaggga
     1381 gtgggctccc ctaaactggg gcctggaaaa gggcatcagg gatttggggt actctcagta
     1441 atattggcaa accatgccat caaactgcta acgtctctct ttcaagacct acaagtggag
     1501 gcccttcaca agggttggga gacagatggc ccccctgcag ccttgagcat tatggcccag
     1561 agcacctcca tacagaggat tcaacggctg attgactctg tcccactgat gaacctgctc
     1621 ttgacgttac tttcaacttc ctacagaaag gcatgtgtcc tgcagcggca gaggaagggc
     1681 tccatgagca gcgatgccag cgcctccacc gactccaata cttactatga ggacgatttc
     1741 agtagcacgg aggaggacag cagccaagac gatgacagtg agcctatttt ggggcaatgg
     1801 tttgaggaga ctatttctcc cagtaaagag aaagcagcac ctccgcctcc tcccccacct
     1861 cctccactgg aaagctctcc tcgggttaaa agccccagta agcaggcccc tggtgagaag
     1921 ggcaacattc tggcgagtcg caaagatcct gagttgttct taggtctggc ttccaacatt
     1981 ttgaacttca tcacctcttc catgctgaac tctcggaaca attttatccg aaactatctg
     2041 agtgtatctc tttcagaaca ccatatggcc accctagcca gtatcatcaa ggaggtggac
     2101 aaagatggac tcaagggttc atcagatgaa gagtttgctg cagctctcta tcacttcaac
     2161 cactcactgg taacctctga ccttcagtca cctaacctgc agaacacact gttgcagcag
     2221 ctaggagtgg ctcctttttc tgagggccct tggcccttgt acattcaccc tcaaagcctc
     2281 tctgtgcttt cacgcctcct gctcatctgg caacataaag ccagtgctca aggtgaccct
     2341 gacgtcccag aatgccttaa agtttgggac aggtttttgt ctacaatgaa gcagaatgcc
     2401 ctgcaaggtg tggtgcccag tgagacagag gatctgaatg tagaacacct gcagatgctc
     2461 ctcctcattt tccacaattt caccgagaca ggccggcggg ccatattgtc gctttttgtc
     2521 cagatcatcc aggagttgag cgtcaacatg gatgctcaga tgcgcttcgt gccgcttatc
     2581 ttggctcgcc tccttctcat ctttgattat ctgcttcatc agtactccaa agcccctgtg
     2641 tatctatttg agcaggtaca gcataacctg ctaagtcctc cctttgggtg ggcaagtgga
     2701 tcccaggaca gcaacagccg ccgggcaacc actcctctct atcatggatt caaagaagta
     2761 gaagaaaact ggtctaagca tttctcatca gatgctgtcc cacaccccag attctactgt
     2821 gtcctgtccc cagaagcctc agaggatgat ttgaaccgac ttgattctgt ggcatgtgac
     2881 gtccttttct ccaagcttgt caagtatgat gagctttatg ctgcactgac agccctgctt
     2941 gcagctgggt cccagcttga tacagttagg agaaaggaaa acaagaatgt aacagccttg
     3001 gaggcctgtg cccttcaata ttacttcttg atactgtgga ggatcctagg aattttacca
     3061 ccatcaaaga cttacattaa ccagctatcc atgaactcac ctgagatgag cgaatgtgac
     3121 atcttgcaca ctctgcgatg gtcttctcgg ctccggatca gctcctatgt caactggata
     3181 aaggatcacc ttatcaaaca gggaatgaag gctgagcatg ctagctcgct tctagaactg
     3241 gcatccacca ctaagtgtag ctcagtgaaa tatgatgttg aaatagtaga ggaatacttc
     3301 gctcgacaga tctcatcctt ctgtagtatc gactgtacca ccatcttgca gctgcatgaa
     3361 attcccagtc tgcagtccat ctacaccctt gatgccgcga tctcaaaggt ccaggtctct
     3421 ttggatgagc atttttctaa gatggctgct gagactgatc ctcataagtc gtctgagatt
     3481 accaagaacc tacttccagc cacgctgcaa ctcattgaca cctatgcatc gttcaccaga
     3541 gcctatttgc tgcaaaactt taatgaagag ggaacaactg agaaaccttc caaggagaaa
     3601 ctgcaaggct ttgctgctgt tttggctatt ggctctagca ggtgcaaggc aaatactctg
     3661 ggtccgacac tggttcagaa tttgccatcg tcagtgcaga ctgtgtgtga gtcctggaac
     3721 aacatcaata ccaatgaatt tcccaatatt ggatcctggc gcaatgcctt tgccaatgac
     3781 accatccctt cagagagtta tattagtgca gtgcaggctg cacacctggg gactctctgt
     3841 agccaaagtc tgcccctggc tgcttccctg aagcataccc tcctctcact ggtcaggttg
     3901 actggagatc ttattgtttg gtcagatgag atgaacccac cacaggtaat tcggacactg
     3961 ctacctcttc ttttggaatc aagcactgag agtgttgccg agatcagtag caactccctg
     4021 gaacgcatct tgggccctgc tgagtctgat gagttcttgg ctcgtgttta tgagaagctg
     4081 atcactggtt gttacaacat tctggccaat catgcagatc ctaacagtgg actggatgaa
     4141 tccatcctgg aggaatgtct ccagtacttg gaaaagcagc tggaaagtag ccaggctcgt
     4201 aaagctatgg aggagttttt ctctgacagt ggagaacttg tacagatcat gatggcaaca
     4261 gccaatgaga acctctctgc taaattctgt aaccgagttt tgaaattctt caccaaactc
     4321 ttccagctga ctgagaagag ccctaacccg agcctgttgc atctctgtgg ctccctggca
     4381 caactggcct gtgtggaacc tgtgcgcctg caggcctggc tcacccgcat gactacatcg
     4441 cccccaaaag attctgatca gctggatgta attcaggaga accggcagct gctgcagtta
     4501 ctgaccacat acattgttcg ggaaaacagc caagttgggg aaggtgtgtg tgctgttctt
     4561 ctgggcaccc tgactcccat ggcaacagag atgctggcca acggtgatgg gactggcttc
     4621 cctgaactta tggttgtgat ggccactctg gccagtgcag gtcaaggtgc tggtcacctt
     4681 cagcttcata atgctgctgt ggattggctg agcagatgca agaaatacct gtcacagaag
     4741 aatgtagttg aaaaactgaa tgccaatgta atgcatggaa agcatgtgat gatcttggag
     4801 tgcacatgcc atatcatgtc ttacttggct gatgtcacga atgccctgag ccagagtaat
     4861 ggtcaaggcc caagtcatct ctcagtggat ggggaagagc gggccattga agtagactca
     4921 gactgggtgg aggagttggc ggtggaagag gaagattccc aggctgagga ttcagatgaa
     4981 gattctcttt gcaataaact ctgcactttt acgatcacac agaaagaatt catgaaccag
     5041 cattggtacc actgtcacac ctgtaaaatg gtggatggcg tgggtgtctg cacagtgtgt
     5101 gctaaggtgt gccacaagga tcatgagatt tcctatgcca agtatggatc cttcttctgt
     5161 gactgtggag ccaaggaaga tggcagctgt ttggctctgg tgaagagaac tcctagcagt
     5221 ggcatgagct ctaccatgaa ggagtcggca tttcagagtg aacccaggat ttcagagagt
     5281 ctagtgcgtc atgccagcac ctcctcgcca gctgacaaag ccaaggttac catcagtgat
     5341 ggaaaggttg ctgacgaaga gaagcccaag aagagcagcc tctgccgcac agtagagggc
     5401 tgccgggagg aattacagaa ccaggccaat ttctccttcg ctcctctcgt gttagacatg
     5461 cttaatttcc ttatggatgc cattcagacc aacttccagc aagcttcagc cgtcgggagc
     5521 agcagccgtg ctcagcaagc cctcagtgag ctacacactg tggagaaggc agtggagatg
     5581 acagaccagc tgatggttcc caccttaggg tcccaggaag gtgcctttga gaatgtgcgg
     5641 atgaattaca gtggagacca gggccagacc atccggcagc tgatcagtgc tcatgtgctc
     5701 aggcgggtgg ctatgtgtgt gctctcctct ccccatgggc gccgccaaca tttggctgtc
     5761 agccatgaga agggcaagat caccgttctg cagctctctg cactcctgaa gcaagcagat
     5821 tccagcaaaa ggaagttaac tctgacccgc ttggcttctg ccccagttcc ttttactgtg
     5881 ttgagcctca caggaaatcc ctgcaaggaa gactacttgg cggtttgtgg gctaaaggac
     5941 tgtcatgtgc tcacctttag tagctcaggc tctgtttcgg atcacttggt tttgcaccct
     6001 cagttggcaa cggggaactt catcatcaaa gccgtgtggt tacctggttc acagaccgag
     6061 ttagcaattg tcaccgcaga ctttgttaag atttatgacc tgtgtgttga tgccttgagt
     6121 ccaaccttct attttctcct gccaagctca aagataagag atgttacctt ccttttcaat
     6181 gaggagggaa agaacatcat tgttataatg tcttcggctg ggtacatcta tactcagctt
     6241 atggaagagg ccagcagtgc ccagcaggga cccttctatg tcactaatgt gttggaaatc
     6301 aatcatgagg acctgaagga cagtaacagc caggtggcgg gcggtggtgt gtccgtgtac
     6361 tactcccacg tgttgcagat gttgttcttc agctattgtc aaggcaaatc attcgcagcc
     6421 accatcagca ggacaaccct ggaggtgttg caactcttcc ccatcaacat caaaagttcc
     6481 aatggtggca gtaagacttc tcctgctctt tgccagtggt ctgaggtgat gaaccaccct
     6541 ggcttggtgt gctgtgtcca gcaaactaca ggggtgccgc tggtagttat ggtgaaacca
     6601 gacacttttc ttatccagga gattaagact cttcctgcta aagcgaagat ccaagacatg
     6661 gttgctatta ggcacacggc ctgcaatgag cagcagcgga caacaatgat tctgctgtgt
     6721 gaggatggca gcctgcgcat ttacatggcc aacgtggaga acacctccta ctggctgcag
     6781 ccatccctgc agcccagcag tgtcatcagc atcatgaagc ctgttcgaaa gcgcaaaaca
     6841 gctacaatca caacccgcac gtctagccag gtgactttcc ccattgactt ttttgaacac
     6901 aaccagcagc tgacagatgt ggagtttggt ggtaacgacc tcctacaggt ctataatgca
     6961 caacagataa aacaccggct gaattccact ggcatgtatg tggccaacac caagcccgga
     7021 ggcttcacca ttgagattag taacaacaat agcactatgg tgatgacagg catgcggatc
     7081 cagattggga ctcaagcaat agaacgggcc ccgtcatata tcgagatctt cggcagaact
     7141 atgcagctca acctgagtcg ctcacgctgg tttgacttcc ccttcaccag agaagaagcc
     7201 ctgcaggctg ataagaagct gaacctcttc attggggcct cggtggatcc agcaggtgtc
     7261 accatgatag atgctgtaaa aatttatggc aagactaagg agcagtttgg ctggcctgat
     7321 gagcccccag aagaattccc ttctgcctct gtcagcaaca tctgcccttc aaatctgaac
     7381 cagagcaacg gcactggaga tagcgactca gctgccccca ctacgaccag tggaactgtc
     7441 ctggagaggc tggttgtgag ttctttagaa gccctggaaa gctgctttgc cgttggccca
     7501 atcatcgaga aggagagaaa caagaatgct gctcaggagc tggccacttt gctgttgtcc
     7561 ctgccagcac ctgccagtgt ccagcagcag tccaagagcc ttctggccag cctgcacacc
     7621 agccgctcgg cctaccacag ccacaaggat caggccttgc tgagcaaagc tgtgcagtgt
     7681 ctcaacacat ctagcaaaga gggcaaggat ttggaccctg aggtgttcca gaggctagtg
     7741 atcacagctc gctccattgc catcatgcgc cccaacaacc ttgtccactt tacggagtca
     7801 aagctgcccc agatggaaac agaaggaatg gatgaaggga aggaaccgca gaagcagttg
     7861 gaaggagatt gctgtagttt catcacccag cttgtgaacc acttctggaa actccatgca
     7921 tccaaaccca agaatgcctt cttggcacct gcctgccttc caggactaac tcatattgaa
     7981 gctactgtca atgctctggt ggacatcatc catggctact gtacctgtga gctggattgt
     8041 attaacacag catccaagat ctacatgcag atgctcttgt gtcctgatcc tgctgtgagc
     8101 ttctcttgta aacaagctct aattcgagtc ctaaggccca ggaacaaacg gagacatgtg
     8161 actttaccct cttcccctcg aagcaacact ccaatggaca aggatgatga tgacgatgat
     8221 gatgcagatg agaaaatgca gtcatcaggg atcccgaatg gtggtcacat ccgtcaggaa
     8281 agccaggaac agagtgaggt ggaccatgga gattttgaga tggtgtctga gtcgatggtc
     8341 ctggagacag ctgaaaatgt caacaatggc aacccctctc ccctggaggc cctgctggca
     8401 ggcgcagagg gcttcccccc catgctggac atcccacctg atgcagatga cgagaccatg
     8461 gttgaactag ccattgccct gagcctgcag caggaccaac aaggcagcag cagcagtgcc
     8521 ctgggcctgc agagcctggg actgtccggc caggcaccca gctcttcctc tctggacgca
     8581 ggaaccctct ctgacaccac agcatcagcc tcagacgacg agggcagtac agcagcgaca
     8641 gatggttcta cccttcggac ctctcctgct gaccacggtg gtagtgtggg ctcggagagc
     8701 gggggcagtg cagtggactc agtggctggc gagcacagtg tatctggccg gagcagtgct
     8761 tatggcgatg ctacagctga ggggcatccg gctggaccag gaagtgtcag ctcaagcact
     8821 ggagccatca gcaccaccac tgggcaccag gagggagatg gctccgaggg agaaggagaa
     8881 ggagaaactg aaggagatgt ccacactagc aacaggctgc acatggtccg tctaatgctg
     8941 ttggagagat tactgcagac cctgcctcaa ttacgaaacg ttggcggtgt ccgggccatc
     9001 ccatacatgc aggtcattct aatgctcact acagatctgg atggagaaga tgagaaagac
     9061 aagggggccc tagacaacct gctctcccag cttattgctg agttgggtat ggataaaaag
     9121 gatgtctcca agaagaatga gcgcagcgcc ctgaatgaag tccatctggt agtaatgaga
     9181 ctcctgagtg tcttcatgtc ccgcaccaaa tctggatcca agtcttccat atgtgagtca
     9241 tcttccctca tctccagtgc cacagcagca gctctactga gctctggggc tgtggactac
     9301 tgcctgcacg tgctcaaatc actgctggaa tattggaaga gccaacagaa tgacgaggag
     9361 cctgtggcta ccagccagtt gctgaaacca catactacct cctccccacc tgacatgagc
     9421 ccattctttc tccgccagta tgtgaagggt catgctgctg atgtgtttga ggcctatact
     9481 cagcttctaa cagaaatggt actgaggctt ccttaccaaa tcaaaaagat tactgacacc
     9541 aattctcgaa tcccacctcc tgtctttgac cactcgtggt tttactttct ctccgagtac
     9601 ctcatgatcc agcagactcc atttgtgcgc cgtcaagtcc gcaaacttct gctcttcatc
     9661 tgtggatcca aagagaagta ccgccagctc cgggatttgc acaccctgga ctctcacgtg
     9721 cgtgggatca agaagctgct agaagagcag gggatattcc tccgggcaag tgtggttaca
     9781 gccagctcag gctccgcctt gcaatatgac acactcatca gcctgatgga gcacctgaaa
     9841 gcctgtgcag agattgccgc ccagcgaacc atcaactggc agaaattctg catcaaagat
     9901 gactccgtcc tgtacttcct cctccaagtc agtttccttg tggatgaggg cgtgtcccca
     9961 gtgctgctgc aactgctctc ctgtgctctg tgcggcagca aggtgctcgc tgcactggca
    10021 gcctcttcgg gatcctccag tgcttcttcc tcctcagccc ctgtggctgc cagttctgga
    10081 caagccacaa cacagtccaa gtcttccact aaaaagagca agaaagaaga aaaagaaaag
    10141 gagaaagatg gtgagacctc tggcagccag gaggaccagc tgtgcacagc tctggtgaac
    10201 cagctgaaca aatttgccga taaggaaacc ctgatccagt tcctgcgttg tttcctgtta
    10261 gagtccaatt cttcctcggt gcgctggcag gcccactgtc tgacactgca catctacaga
    10321 aattccagca aatctcaaca ggagctcctg ctagatctga tgtggtccat ctggccagaa
    10381 ctcccagcct atggtcgtaa ggctgcccag tttgtggacc tactaggata tttctccctg
    10441 aaaactccac aaacagagaa gaagttgaag gagtattcac agaaggctgt ggagattctg
    10501 cggactcaaa accatattct taccaaccac cccaactcga acatttataa cactttgtct
    10561 ggcttagtgg agtttgatgg ctattacctg gagagcgatc cctgcctggt gtgtaataac
    10621 ccggaagtac cgttctgtta tatcaagctg tcttccatta aagtggacac gcggtacacc
    10681 accacccagc aggttgtgaa gctcattggc agtcacacca tcagcaaagt gacagtgaaa
    10741 atcggggatc tgaaacggac caagatggtg cggaccatca acctgtatta taacaaccga
    10801 accgtgcagg ccatcgtgga gttgaaaaac aagccagctc gctggcacaa agccaagaag
    10861 gttcagctga cccctggaca gacagaggtg aagattgacc tgccgttgcc cattgtggcc
    10921 tccaatctga tgattgagtt tgcagacttc tatgaaaact accaggcctc cacagagacc
    10981 ctgcagtgcc ctcgctgtag tgcctcggtc cctgccaacc caggagtctg tggcaactgt
    11041 ggagagaatg tgtaccagtg tcacaaatgc agatccatca actacgatga aaaggatccc
    11101 ttcctctgca atgcctgtgg cttctgtaaa tatgcccgct tcgacttcat gctctatgcc
    11161 aagccttgct gtgcagtgga tcccattgag aatgaagaag accggaagaa ggctgtatcc
    11221 aacatcaata cacttttgga caaagctgat cgagtgtatc atcagctgat gggacaccgg
    11281 ccacagctgg agaacctgct ctgcaaagtg aatgaggcag ctccagaaaa gccacaggat
    11341 gactcaggaa cagcaggggg catcagctcc acttctgcca gtgtgaatcg ttacatcctg
    11401 cagttggctc aggagtattg tggagactgc aagaactctt ttgatgaact ctccaaaatc
    11461 atccagaaag tctttgcttc gcgcaaagag ttgttggaat atgacctaca gcagagggaa
    11521 gcagccacta aatcatcccg gacctccgtg cagcccacat tcactgccag ccagtaccgt
    11581 gccttatccg tcctgggctg tggccacaca tcctccacca agtgctatgg ctgcgcctcg
    11641 gctgtcacag aacattgtat cacactactt cgggccctgg ccaccaaccc agccttgagg
    11701 cacatccttg tctcccaggg ccttatccgg gagctctttg attataatct tcgccgaggg
    11761 gctgcggcca tgcgggagga ggtccgccag ctcatgtgcc tcctaactcg agacaaccca
    11821 gaagccaccc aacagatgaa tgacctgatt attggcaagg tctccacagc cctgaagggc
    11881 cactgggcca accccgatct ggcaagtagc ctgcagtatg aaatgctgct gctgacggat
    11941 tctatctcca aggaggacag ctgctgggag ctccggttac gctgtgctct cagccttttc
    12001 ctcatggctg tgaacattaa gactcctgtg gtggttgaaa acattaccct catgtgcctg
    12061 aggatcttgc agaagctgat aaaaccacct gctcccacta gcaagaagaa caaggatgtc
    12121 cccgttgagg ccctcaccac ggtgaagcca tactgcaatg agatccatgc ccaggctcaa
    12181 ctgtggctca agagagaccc caaggcatcc tatgatgcct ggaagaagtg tcttcctatc
    12241 agagggatag atggcaatgg gaaagccccc agcaaatcag agctccgcca tctctatttg
    12301 actgagaagt atgtgtggag gtggaaacag ttcctgagtc gtcgggggaa gaggacctcc
    12361 cccttggatc tcaaactggg gcataacaac tggctgcgac aagtgctttt cactccagca
    12421 acgcaggccg cacggcaggc agcctgtacc attgtggaag ctctagccac cattcccagc
    12481 cgcaagcagc aggtcctgga cctgcttacc agttacctgg atgagctgag catagctggg
    12541 gagtgtgcag ctgagtacct ggctctctac cagaagctca tcacttctgc gcactggaaa
    12601 gtctacttgg cagctcgggg agtcctaccc tatgtgggca acctcatcac caaggaaata
    12661 gctcgtctgc tggccctgga ggaggctacc ctgagtaccg atctgcagca gggttatgcc
    12721 cttaaaagtc tcacaggcct tctctcctcc tttgttgagg tggaatccat caaaagacat
    12781 tttaaaagtc gcttggtggg tactgtgctg aatggatacc tgtgcttgcg gaagctggtg
    12841 gtgcagagga ccaagctgat cgatgagacg caggacatgc tgctggagat gctggaggac
    12901 atgaccacag gtacagaatc agaaaccaag gccttcatgg ctgtgtgcat tgagacagcc
    12961 aagcgctaca atctggatga ctaccggacc ccggtgttca tcttcgagag gctctgcagc
    13021 atcatttatc ctgaggagaa tgaagtcact gagttctttg tgaccctgga gaaggatccc
    13081 caacaagaag acttcttaca gggcaggatg cctgggaacc cgtatagcag caatgagcca
    13141 ggcatcgggc cgctgatgag ggatataaag aacaagattt gccaggactg tgacttagtg
    13201 gccctcctgg aagatgacag tggcatggag cttctagtga acaataaaat cattagtttg
    13261 gaccttcctg tggctgaagt ttacaagaaa gtctggtgta ccacgaatga gggagagccc
    13321 atgaggattg tttatcgtat gcgggggctg ctgggcgatg ccacagagga gttcattgag
    13381 tccctggact ctactacaga tgaagaagaa gatgaagaag aagtgtataa aatggctggt
    13441 gtgatggccc agtgtggggg cctggaatgc atgcttaaca gactcgcagg gatcagagat
    13501 ttcaagcagg gacgccacct tctaacagtg ctactgaaat tgttcagtta ctgcgtgaag
    13561 gtgaaagtca accggcagca actggtcaaa ctggaaatga acaccttgaa cgtcatgctg
    13621 gggaccctaa acctggccct tgtagctgaa caagaaagca aggacagtgg gggtgcagct
    13681 gtggctgagc aggtgcttag catcatggag atcattctag atgagtccaa tgctgagccc
    13741 ctgagtgagg acaagggcaa cctcctcctg acaggtgaca aggatcaact ggtgatgctc
    13801 ttggaccaga tcaacagcac ctttgttcgc tccaacccca gtgtgctcca gggcctgctt
    13861 cgcatcatcc cgtacctttc ctttggagag gtggagaaaa tgcagatctt ggtggagcga
    13921 ttcaaaccat actgcaactt tgataaatat gatgaagatc acagtggtga tgataaagtc
    13981 ttcctggact gcttctgtaa aatagctgct ggcatcaaga acaacagcaa tgggcaccag
    14041 ctgaaggatc tgattctcca gaaggggatc acccagaatg cacttgacta catgaaaaag
    14101 cacatcccta gcgccaagaa tttggatgcc gacatctgga aaaagttttt gtctcgccca
    14161 gccttgccat ttatcctaag gctgcttcgg ggcctggcca tccagcaccc tggcacccag
    14221 gttctgattg gaactgattc catcccgaac ctgcataagc tggagcaggt gtccagtgat
    14281 gagggcattg ggaccttggc agagaacctg ctggaagccc tgcgggaaca ccctgacgta
    14341 aacaagaaga ttgacgcagc ccgcagggag acccgggcag agaagaagcg catggccatg
    14401 gcaatgaggc agaaggccct gggcaccctg ggcatgacga caaatgaaaa gggccaggtc
    14461 gtgaccaaga cagcactcct gaagcagatg gaagagctga tcgaggagcc tggcctcacg
    14521 tgctgcatct gcagggaggg atacaagttc cagcccacaa aggtcctggg catttatacc
    14581 ttcacgaagc gggtagcctt ggaggagatg gagaataagc cccggaaaca gcagggctac
    14641 agcaccgtgt cccacttcaa cattgtgcac tacgactgcc atctggctgc cgtcaggttg
    14701 gctcgaggcc gggaagagtg ggagagtgcc gccctgcaga atgccaacac caagtgcaac
    14761 gggctccttc cggtctgggg acctcatgtc cctgaatcag cttttgccac ttgcttggca
    14821 agacacaaca cttacctcca ggaatgtaca ggccagcggg agcccacgta tcagctcaac
    14881 atccatgaca tcaaactgct cttcctgcgc ttcgccatgg agcagtcgtt cagcgcagac
    14941 actggcgggg gcggccggga gagcaacatc cacctgatcc cgtacatcat tcacactgtg
    15001 ctttacgtcc tgaacacaac ccgagcaact tcccgagaag agaagaacct ccaaggcttt
    15061 ctggaacagc ccaaggagaa gtgggtggag agtgcctttg aagtggacgg gccctactat
    15121 ttcacagtct tggcccttca catcctgccc cctgagcagt ggagagccac acgtgtggaa
    15181 atcttgcgga ggctgttggt gacctcgcag gctcgggcag tggctccagg tggagccacc
    15241 aggctgacag ataaggcagt gaaggactat tccgcttacc gttcttccct tctcttttgg
    15301 gccctcgtcg atctcattta caacatgttt aagaaggtgc ctaccagtaa cacagaggga
    15361 ggctggtcct gctctctcgc tgagtacatc cgccacaacg acatgcccat ctacgaagct
    15421 gccgacaaag ccctgaaaac cttccaggag gagttcatgc cagtggagac cttctcagag
    15481 ttcctcgatg tggccggtct tttatcagaa atcaccgatc cagagagctt cctgaaggac
    15541 ctgttgaact cagtcccctg accaccacac agcagctgcg gcggcgaaga cgaagctggc
    15601 ttgccttcca ccctctgttc tccctccttg tgcattaagt tccctccgcg ggatgctgca
    15661 ttgttacccc gccctcccct ctctcatttt tcttggtgtg gcttggggtt tttaggcttc
    15721 ctgttttatc tcgtgtgtgt ggtgcaccag ctatgaggtt gtctgtaacc caagccatca
    15781 aagggcctgt acatacctag gagccatgag ttgtcccggc cagcttcata cttgagtgtg
    15841 cacatcttga gaaataaaca agtgacttaa cacacattga aaa
//
