LOCUS       XM_047416511           15889 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ubiquitin protein ligase E3 component
            n-recognin 4 (UBR4), transcript variant X35, mRNA.
ACCESSION   XM_047416511
VERSION     XM_047416511.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15889
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..15889
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /note="ubiquitin protein ligase E3 component n-recognin 4;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 13 mRNAs, 370 ESTs, 5019 long SRA reads, 8
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 76 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:23352"
                     /db_xref="HGNC:HGNC:30313"
                     /db_xref="MIM:609890"
     CDS             19..15567
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UBR4 isoform X35"
                     /protein_id="XP_047272467.1"
                     /db_xref="GeneID:23352"
                     /db_xref="HGNC:HGNC:30313"
                     /db_xref="MIM:609890"
                     /translation="MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAF
                     EMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAA
                     ACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKL
                     PQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVE
                     GENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDA
                     VLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSL
                     SCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAI
                     SSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
                     TKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGWETDGPPAA
                     LSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDS
                     NTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVK
                     SPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHH
                     MATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPF
                     SEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWDRFLSTMKQNALQGV
                     VPSETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQELSVNMDAQMRFVPLILA
                     RLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRATTPLYHGFKEV
                     EENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDSVACDVLFSKLVKYDELYAALTA
                     LLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYINQLSMNSPEM
                     SECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTTKCSSVKYDVE
                     IVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAET
                     DPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAAVLAI
                     GSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSESYI
                     SAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLE
                     SSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILE
                     ECLQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQ
                     LTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQL
                     LTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAG
                     HLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNAL
                     SQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQ
                     KEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLA
                     LVKRTPSSGMSSTMKESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPK
                     KSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQAL
                     SELHTVEKAVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMC
                     VLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLT
                     GNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELA
                     IVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQL
                     MEEASSAQQGPFYVTNVLEINHEDLKDSNSQVAGGGVSVYYSHVLQMLFFSYCQGKSF
                     AATISRTTLEVLQLFPINIKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVV
                     MVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVEN
                     TSYWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTDVEFGGN
                     DLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGTQAIERA
                     PSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLNLFIGASVDPAGVTMIDAVKI
                     YGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTGDSDSAAPTTTSGTVLERLVV
                     SSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPASVQQQSKSLLASLHTSRSA
                     YHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSIAIMRPNNLVHFTESKL
                     PQMETEGMDEGKEPQKQLEGDCCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIE
                     ATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRR
                     HVTLPSSPRSNTPMDKDDDDDDDADEKMQSSGIPNGGHIRQESQEQSEVDHGDFEMVS
                     ESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQ
                     GSSSSALGLQSLGLSGQAPSSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPA
                     DHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTTTG
                     HQEGDGSEGEGEGETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVI
                     LMLTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLSV
                     FMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPV
                     ATSQLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKITDT
                     NSRIPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDS
                     HVRGIKKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKF
                     CIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASSGSSSASSSSAP
                     VAASSGQATTQSKSSTKKSKKEEKEKEKDGETSGSQEDQLCTALVNQLNKFADKETLI
                     QFLRCFLLESNSSSVRWQAHCLTLHIYRNSSKSQQELLLDLMWSIWPELPAYGRKAAQ
                     FVDLLGYFSLKTPQTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDGY
                     YLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKR
                     TKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLM
                     IEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFL
                     CNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHR
                     PQLENLLCKVNEAAPEKPQDDSGTAGGISSTSASVNRYILQLAQEYCGDCKNSFDELS
                     KIIQKVFASRKELLEYDLQQREAATKSSRTSVQPTFTASQYRALSVLGCGHTSSTKCY
                     GCASAVTEHCITLLRALATNPALRHILVSQGLIRELFDYNLRRGAAAMREEVRQLMCL
                     LTRDNPEATQQMNDLIIGKVSTALKGHWANPDLASSLQYEMLLLTDSISKEDSCWELR
                     LRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKP
                     YCNEIHAQAQLWLKRDPKASYDAWKKCLPIRGIDGNGKAPSKSELRHLYLTEKYVWRW
                     KQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALATIPSRKQQVL
                     DLLTSYLDELSIAGECAAEYLALYQKLITSAHWKVYLAARGVLPYVGNLITKEIARLL
                     ALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQ
                     RTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCS
                     IIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCD
                     LVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATE
                     EFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQGRHLLTVLLKL
                     FSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEII
                     LDESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGE
                     VEKMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQK
                     GITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTD
                     SIPNLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMRQ
                     KALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFT
                     KRVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCN
                     GLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFS
                     ADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEVD
                     GPYYFTVLALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYR
                     SSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEF
                     MPVETFSEFLDVAGLLSEITDPESFLKDLLNSVP"
ORIGIN      
        1 gcagtagtac gacggaagat ggcgacgagc ggcggcgaag aggcggcggc agcggctccg
       61 gcgccgggga ccccggcaac gggggcggac acgaccccgg gctgggaggt ggctgtgcgg
      121 cccctgctgt ccgcgtccta ctccgccttc gagatgaagg agttgccgca gctggtggcc
      181 tcagtcatcg agagtgaatc agaaatcctg caccatgaga agcagtacga gccattctac
      241 tcatcttttg ttgcactttc cacacactat attacaacag tttgcagtct cattccccgg
      301 aaccaacttc agtcagtggc agcagcctgt aaagttctaa ttgagttttc tctcctgcgt
      361 ctggagaatc cagatgaggc ttgtgctgtg tcccagaaac acttgattct cctaatcaag
      421 ggcctgtgca ctggctgtag ccgactagat agaactgaaa ttatcacatt tacagcaatg
      481 atgaaatccg ccaagctgcc ccaaacagtg aagacacttt cagacgtgga agatcagaaa
      541 gagctggcct caccagtaag ccctgagttg aggcaaaagg aggtacagat gaattttttg
      601 aaccagctga cctcagtttt taaccctaga actgtagcat cacaacctat cagtacacag
      661 actctggtgg aaggagaaaa tgatgagcag tcatctacag atcaagcctc agctatcaaa
      721 accaagaatg tgttcatagc tcagaacgtg gctagtcttc aagagcttgg tggctcggag
      781 aagctactgc gtgtatgttt gaacctgcca tatttcctac gctatatcaa tcggttccaa
      841 gatgcagttt tagctaattc cttcttcata atgcctgcaa cagtagcaga tgccactgct
      901 gttcgtaatg gctttcattc attggtgatt gatgtaacta tggcattgga taccctttct
      961 ctacctgtgt tggaacctct caatccttct cgtctacaag atgtgacagt cctcagccta
     1021 agttgtctgt atgcaggtgt gagtgtggca acgtgcatgg ccatcctcca tgtgggtagt
     1081 gcccagcaag tgcggacagg gtccacgagc tccaaagaag atgactatga aagtgacgca
     1141 gctacaattg tccagaaatg tctcgaaatc tatgacatga ttggacaagc aatcagcagt
     1201 tctcgccggg ctggtggtga gcactatcag aatttccaat tgctgggtgc ttggtgcttg
     1261 ttaaacagcc ttttcctcat actgaacctc agtcctactg cgttggctga taaggggaaa
     1321 gagaaggacc cactggctgc cctccgagtc agagacatcc tttctcgtac taaagaggga
     1381 gtgggctccc ctaaactggg gcctggaaaa gggcatcagg gatttggggt actctcagta
     1441 atattggcaa accatgccat caaactgcta acgtctctct ttcaagacct acaagtggag
     1501 gcccttcaca agggttggga gacagatggc ccccctgcag ccttgagcat tatggcccag
     1561 agcacctcca tacagaggat tcaacggctg attgactctg tcccactgat gaacctgctc
     1621 ttgacgttac tttcaacttc ctacagaaag gcatgtgtcc tgcagcggca gaggaagggc
     1681 tccatgagca gcgatgccag cgcctccacc gactccaata cttactatga ggacgatttc
     1741 agtagcacgg aggaggacag cagccaagac gatgacagtg agcctatttt ggggcaatgg
     1801 tttgaggaga ctatttctcc cagtaaagag aaagcagcac ctccgcctcc tcccccacct
     1861 cctccactgg aaagctctcc tcgggttaaa agccccagta agcaggcccc tggtgagaag
     1921 ggcaacattc tggcgagtcg caaagatcct gagttgttct taggtctggc ttccaacatt
     1981 ttgaacttca tcacctcttc catgctgaac tctcggaaca attttatccg aaactatctg
     2041 agtgtatctc tttcagaaca ccatatggcc accctagcca gtatcatcaa ggaggtggac
     2101 aaagatggac tcaagggttc atcagatgaa gagtttgctg cagctctcta tcacttcaac
     2161 cactcactgg taacctctga ccttcagtca cctaacctgc agaacacact gttgcagcag
     2221 ctaggagtgg ctcctttttc tgagggccct tggcccttgt acattcaccc tcaaagcctc
     2281 tctgtgcttt cacgcctcct gctcatctgg caacataaag ccagtgctca aggtgaccct
     2341 gacgtcccag aatgccttaa agtttgggac aggtttttgt ctacaatgaa gcagaatgcc
     2401 ctgcaaggtg tggtgcccag tgagacagag gatctgaatg tagaacacct gcagatgctc
     2461 ctcctcattt tccacaattt caccgagaca ggccggcggg ccatattgtc gctttttgtc
     2521 cagatcatcc aggagttgag cgtcaacatg gatgctcaga tgcgcttcgt gccgcttatc
     2581 ttggctcgcc tccttctcat ctttgattat ctgcttcatc agtactccaa agcccctgtg
     2641 tatctatttg agcaggtaca gcataacctg ctaagtcctc cctttgggtg ggcaagtgga
     2701 tcccaggaca gcaacagccg ccgggcaacc actcctctct atcatggatt caaagaagta
     2761 gaagaaaact ggtctaagca tttctcatca gatgctgtcc cacaccccag attctactgt
     2821 gtcctgtccc cagaagcctc agaggatgat ttgaaccgac ttgattctgt ggcatgtgac
     2881 gtccttttct ccaagcttgt caagtatgat gagctttatg ctgcactgac agccctgctt
     2941 gcagctgggt cccagcttga tacagttagg agaaaggaaa acaagaatgt aacagccttg
     3001 gaggcctgtg cccttcaata ttacttcttg atactgtgga ggatcctagg aattttacca
     3061 ccatcaaaga cttacattaa ccagctatcc atgaactcac ctgagatgag cgaatgtgac
     3121 atcttgcaca ctctgcgatg gtcttctcgg ctccggatca gctcctatgt caactggata
     3181 aaggatcacc ttatcaaaca gggaatgaag gctgagcatg ctagctcgct tctagaactg
     3241 gcatccacca ctaagtgtag ctcagtgaaa tatgatgttg aaatagtaga ggaatacttc
     3301 gctcgacaga tctcatcctt ctgtagtatc gactgtacca ccatcttgca gctgcatgaa
     3361 attcccagtc tgcagtccat ctacaccctt gatgccgcga tctcaaaggt ccaggtctct
     3421 ttggatgagc atttttctaa gatggctgct gagactgatc ctcataagtc gtctgagatt
     3481 accaagaacc tacttccagc cacgctgcaa ctcattgaca cctatgcatc gttcaccaga
     3541 gcctatttgc tgcaaaactt taatgaagag ggaacaactg agaaaccttc caaggagaaa
     3601 ctgcaaggct ttgctgctgt tttggctatt ggctctagca ggtgcaaggc aaatactctg
     3661 ggtccgacac tggttcagaa tttgccatcg tcagtgcaga ctgtgtgtga gtcctggaac
     3721 aacatcaata ccaatgaatt tcccaatatt ggatcctggc gcaatgcctt tgccaatgac
     3781 accatccctt cagagagtta tattagtgca gtgcaggctg cacacctggg gactctctgt
     3841 agccaaagtc tgcccctggc tgcttccctg aagcataccc tcctctcact ggtcaggttg
     3901 actggagatc ttattgtttg gtcagatgag atgaacccac cacaggtaat tcggacactg
     3961 ctacctcttc ttttggaatc aagcactgag agtgttgccg agatcagtag caactccctg
     4021 gaacgcatct tgggccctgc tgagtctgat gagttcttgg ctcgtgttta tgagaagctg
     4081 atcactggtt gttacaacat tctggccaat catgcagatc ctaacagtgg actggatgaa
     4141 tccatcctgg aggaatgtct ccagtacttg gaaaagcagc tggaaagtag ccaggctcgt
     4201 aaagctatgg aggagttttt ctctgacagt ggagaacttg tacagatcat gatggcaaca
     4261 gccaatgaga acctctctgc taaattctgt aaccgagttt tgaaattctt caccaaactc
     4321 ttccagctga ctgagaagag ccctaacccg agcctgttgc atctctgtgg ctccctggca
     4381 caactggcct gtgtggaacc tgtgcgcctg caggcctggc tcacccgcat gactacatcg
     4441 cccccaaaag attctgatca gctggatgta attcaggaga accggcagct gctgcagtta
     4501 ctgaccacat acattgttcg ggaaaacagc caagttgggg aaggtgtgtg tgctgttctt
     4561 ctgggcaccc tgactcccat ggcaacagag atgctggcca acggtgatgg gactggcttc
     4621 cctgaactta tggttgtgat ggccactctg gccagtgcag gtcaaggtgc tggtcacctt
     4681 cagcttcata atgctgctgt ggattggctg agcagatgca agaaatacct gtcacagaag
     4741 aatgtagttg aaaaactgaa tgccaatgta atgcatggaa agcatgtgat gatcttggag
     4801 tgcacatgcc atatcatgtc ttacttggct gatgtcacga atgccctgag ccagagtaat
     4861 ggtcaaggcc caagtcatct ctcagtggat ggggaagagc gggccattga agtagactca
     4921 gactgggtgg aggagttggc ggtggaagag gaagattccc aggctgagga ttcagatgaa
     4981 gattctcttt gcaataaact ctgcactttt acgatcacac agaaagaatt catgaaccag
     5041 cattggtacc actgtcacac ctgtaaaatg gtggatggcg tgggtgtctg cacagtgtgt
     5101 gctaaggtgt gccacaagga tcatgagatt tcctatgcca agtatggatc cttcttctgt
     5161 gactgtggag ccaaggaaga tggcagctgt ttggctctgg tgaagagaac tcctagcagt
     5221 ggcatgagct ctaccatgaa ggagtcggca tttcagagtg aacccaggat ttcagagagt
     5281 ctagtgcgtc atgccagcac ctcctcgcca gctgacaaag ccaaggttac catcagtgat
     5341 ggaaaggttg ctgacgaaga gaagcccaag aagagcagcc tctgccgcac agtagagggc
     5401 tgccgggagg aattacagaa ccaggccaat ttctccttcg ctcctctcgt gttagacatg
     5461 cttaatttcc ttatggatgc cattcagacc aacttccagc aagcttcagc cgtcgggagc
     5521 agcagccgtg ctcagcaagc cctcagtgag ctacacactg tggagaaggc agtggagatg
     5581 acagaccagc tgatggttcc caccttaggg tcccaggaag gtgcctttga gaatgtgcgg
     5641 atgaattaca gtggagacca gggccagacc atccggcagc tgatcagtgc tcatgtgctc
     5701 aggcgggtgg ctatgtgtgt gctctcctct ccccatgggc gccgccaaca tttggctgtc
     5761 agccatgaga agggcaagat caccgttctg cagctctctg cactcctgaa gcaagcagat
     5821 tccagcaaaa ggaagttaac tctgacccgc ttggcttctg ccccagttcc ttttactgtg
     5881 ttgagcctca caggaaatcc ctgcaaggaa gactacttgg cggtttgtgg gctaaaggac
     5941 tgtcatgtgc tcacctttag tagctcaggc tctgtttcgg atcacttggt tttgcaccct
     6001 cagttggcaa cggggaactt catcatcaaa gccgtgtggt tacctggttc acagaccgag
     6061 ttagcaattg tcaccgcaga ctttgttaag atttatgacc tgtgtgttga tgccttgagt
     6121 ccaaccttct attttctcct gccaagctca aagataagag atgttacctt ccttttcaat
     6181 gaggagggaa agaacatcat tgttataatg tcttcggctg ggtacatcta tactcagctt
     6241 atggaagagg ccagcagtgc ccagcaggga cccttctatg tcactaatgt gttggaaatc
     6301 aatcatgagg acctgaagga cagtaacagc caggtggcgg gcggtggtgt gtccgtgtac
     6361 tactcccacg tgttgcagat gttgttcttc agctattgtc aaggcaaatc attcgcagcc
     6421 accatcagca ggacaaccct ggaggtgttg caactcttcc ccatcaacat caaaagttcc
     6481 aatggtggca gtaagacttc tcctgctctt tgccagtggt ctgaggtgat gaaccaccct
     6541 ggcttggtgt gctgtgtcca gcaaactaca ggggtgccgc tggtagttat ggtgaaacca
     6601 gacacttttc ttatccagga gattaagact cttcctgcta aagcgaagat ccaagacatg
     6661 gttgctatta ggcacacggc ctgcaatgag cagcagcgga caacaatgat tctgctgtgt
     6721 gaggatggca gcctgcgcat ttacatggcc aacgtggaga acacctccta ctggctgcag
     6781 ccatccctgc agcccagcag tgtcatcagc atcatgaagc ctgttcgaaa gcgcaaaaca
     6841 gctacaatca caacccgcac gtctagccag gtgactttcc ccattgactt ttttgaacac
     6901 aaccagcagc tgacagatgt ggagtttggt ggtaacgacc tcctacaggt ctataatgca
     6961 caacagataa aacaccggct gaattccact ggcatgtatg tggccaacac caagcccgga
     7021 ggcttcacca ttgagattag taacaacaat agcactatgg tgatgacagg catgcggatc
     7081 cagattggga ctcaagcaat agaacgggcc ccgtcatata tcgagatctt cggcagaact
     7141 atgcagctca acctgagtcg ctcacgctgg tttgacttcc ccttcaccag agaagaagcc
     7201 ctgcaggctg ataagaagct gaacctcttc attggggcct cggtggatcc agcaggtgtc
     7261 accatgatag atgctgtaaa aatttatggc aagactaagg agcagtttgg ctggcctgat
     7321 gagcccccag aagaattccc ttctgcctct gtcagcaaca tctgcccttc aaatctgaac
     7381 cagagcaacg gcactggaga tagcgactca gctgccccca ctacgaccag tggaactgtc
     7441 ctggagaggc tggttgtgag ttctttagaa gccctggaaa gctgctttgc cgttggccca
     7501 atcatcgaga aggagagaaa caagaatgct gctcaggagc tggccacttt gctgttgtcc
     7561 ctgccagcac ctgccagtgt ccagcagcag tccaagagcc ttctggccag cctgcacacc
     7621 agccgctcgg cctaccacag ccacaaggat caggccttgc tgagcaaagc tgtgcagtgt
     7681 ctcaacacat ctagcaaaga gggcaaggat ttggaccctg aggtgttcca gaggctagtg
     7741 atcacagctc gctccattgc catcatgcgc cccaacaacc ttgtccactt tacggagtca
     7801 aagctgcccc agatggaaac agaaggaatg gatgaaggga aggaaccgca gaagcagttg
     7861 gaaggagatt gctgtagttt catcacccag cttgtgaacc acttctggaa actccatgca
     7921 tccaaaccca agaatgcctt cttggcacct gcctgccttc caggactaac tcatattgaa
     7981 gctactgtca atgctctggt ggacatcatc catggctact gtacctgtga gctggattgt
     8041 attaacacag catccaagat ctacatgcag atgctcttgt gtcctgatcc tgctgtgagc
     8101 ttctcttgta aacaagctct aattcgagtc ctaaggccca ggaacaaacg gagacatgtg
     8161 actttaccct cttcccctcg aagcaacact ccaatggaca aggatgatga tgacgatgat
     8221 gatgcagatg agaaaatgca gtcatcaggg atcccgaatg gtggtcacat ccgtcaggaa
     8281 agccaggaac agagtgaggt ggaccatgga gattttgaga tggtgtctga gtcgatggtc
     8341 ctggagacag ctgaaaatgt caacaatggc aacccctctc ccctggaggc cctgctggca
     8401 ggcgcagagg gcttcccccc catgctggac atcccacctg atgcagatga cgagaccatg
     8461 gttgaactag ccattgccct gagcctgcag caggaccaac aaggcagcag cagcagtgcc
     8521 ctgggcctgc agagcctggg actgtccggc caggcaccca gctcttcctc tctggacgca
     8581 ggaaccctct ctgacaccac agcatcagct ccagcctcag acgacgaggg cagtacagca
     8641 gcgacagatg gttctaccct tcggacctct cctgctgacc acggtggtag tgtgggctcg
     8701 gagagcgggg gcagtgcagt ggactcagtg gctggcgagc acagtgtatc tggccggagc
     8761 agtgcttatg gcgatgctac agctgagggg catccggctg gaccaggaag tgtcagctca
     8821 agcactggag ccatcagcac caccactggg caccaggagg gagatggctc cgagggagaa
     8881 ggagaaggag aaactgaagg agatgtccac actagcaaca ggctgcacat ggtccgtcta
     8941 atgctgttgg agagattact gcagaccctg cctcaattac gaaacgttgg cggtgtccgg
     9001 gccatcccat acatgcaggt cattctaatg ctcactacag atctggatgg agaagatgag
     9061 aaagacaagg gggccctaga caacctgctc tcccagctta ttgctgagtt gggtatggat
     9121 aaaaaggatg tctccaagaa gaatgagcgc agcgccctga atgaagtcca tctggtagta
     9181 atgagactcc tgagtgtctt catgtcccgc accaaatctg gatccaagtc ttccatatgt
     9241 gagtcatctt ccctcatctc cagtgccaca gcagcagctc tactgagctc tggggctgtg
     9301 gactactgcc tgcacgtgct caaatcactg ctggaatatt ggaagagcca acagaatgac
     9361 gaggagcctg tggctaccag ccagttgctg aaaccacata ctacctcctc cccacctgac
     9421 atgagcccat tctttctccg ccagtatgtg aagggtcatg ctgctgatgt gtttgaggcc
     9481 tatactcagc ttctaacaga aatggtactg aggcttcctt accaaatcaa aaagattact
     9541 gacaccaatt ctcgaatccc acctcctgtc tttgaccact cgtggtttta ctttctctcc
     9601 gagtacctca tgatccagca gactccattt gtgcgccgtc aagtccgcaa acttctgctc
     9661 ttcatctgtg gatccaaaga gaagtaccgc cagctccggg atttgcacac cctggactct
     9721 cacgtgcgtg ggatcaagaa gctgctagaa gagcagggga tattcctccg ggcaagtgtg
     9781 gttacagcca gctcaggctc cgccttgcaa tatgacacac tcatcagcct gatggagcac
     9841 ctgaaagcct gtgcagagat tgccgcccag cgaaccatca actggcagaa attctgcatc
     9901 aaagatgact ccgtcctgta cttcctcctc caagtcagtt tccttgtgga tgagggcgtg
     9961 tccccagtgc tgctgcaact gctctcctgt gctctgtgcg gcagcaaggt gctcgctgca
    10021 ctggcagcct cttcgggatc ctccagtgct tcttcctcct cagcccctgt ggctgccagt
    10081 tctggacaag ccacaacaca gtccaagtct tccactaaaa agagcaagaa agaagaaaaa
    10141 gaaaaggaga aagatggtga gacctctggc agccaggagg accagctgtg cacagctctg
    10201 gtgaaccagc tgaacaaatt tgccgataag gaaaccctga tccagttcct gcgttgtttc
    10261 ctgttagagt ccaattcttc ctcggtgcgc tggcaggccc actgtctgac actgcacatc
    10321 tacagaaatt ccagcaaatc tcaacaggag ctcctgctag atctgatgtg gtccatctgg
    10381 ccagaactcc cagcctatgg tcgtaaggct gcccagtttg tggacctact aggatatttc
    10441 tccctgaaaa ctccacaaac agagaagaag ttgaaggagt attcacagaa ggctgtggag
    10501 attctgcgga ctcaaaacca tattcttacc aaccacccca actcgaacat ttataacact
    10561 ttgtctggct tagtggagtt tgatggctat tacctggaga gcgatccctg cctggtgtgt
    10621 aataacccgg aagtaccgtt ctgttatatc aagctgtctt ccattaaagt ggacacgcgg
    10681 tacaccacca cccagcaggt tgtgaagctc attggcagtc acaccatcag caaagtgaca
    10741 gtgaaaatcg gggatctgaa acggaccaag atggtgcgga ccatcaacct gtattataac
    10801 aaccgaaccg tgcaggccat cgtggagttg aaaaacaagc cagctcgctg gcacaaagcc
    10861 aagaaggttc agctgacccc tggacagaca gaggtgaaga ttgacctgcc gttgcccatt
    10921 gtggcctcca atctgatgat tgagtttgca gacttctatg aaaactacca ggcctccaca
    10981 gagaccctgc agtgccctcg ctgtagtgcc tcggtccctg ccaacccagg agtctgtggc
    11041 aactgtggag agaatgtgta ccagtgtcac aaatgcagat ccatcaacta cgatgaaaag
    11101 gatcccttcc tctgcaatgc ctgtggcttc tgtaaatatg cccgcttcga cttcatgctc
    11161 tatgccaagc cttgctgtgc agtggatccc attgagaatg aagaagaccg gaagaaggct
    11221 gtatccaaca tcaatacact tttggacaaa gctgatcgag tgtatcatca gctgatggga
    11281 caccggccac agctggagaa cctgctctgc aaagtgaatg aggcagctcc agaaaagcca
    11341 caggatgact caggaacagc agggggcatc agctccactt ctgccagtgt gaatcgttac
    11401 atcctgcagt tggctcagga gtattgtgga gactgcaaga actcttttga tgaactctcc
    11461 aaaatcatcc agaaagtctt tgcttcgcgc aaagagttgt tggaatatga cctacagcag
    11521 agggaagcag ccactaaatc atcccggacc tccgtgcagc ccacattcac tgccagccag
    11581 taccgtgcct tatccgtcct gggctgtggc cacacatcct ccaccaagtg ctatggctgc
    11641 gcctcggctg tcacagaaca ttgtatcaca ctacttcggg ccctggccac caacccagcc
    11701 ttgaggcaca tccttgtctc ccagggcctt atccgggagc tctttgatta taatcttcgc
    11761 cgaggggctg cggccatgcg ggaggaggtc cgccagctca tgtgcctcct aactcgagac
    11821 aacccagaag ccacccaaca gatgaatgac ctgattattg gcaaggtctc cacagccctg
    11881 aagggccact gggccaaccc cgatctggca agtagcctgc agtatgaaat gctgctgctg
    11941 acggattcta tctccaagga ggacagctgc tgggagctcc ggttacgctg tgctctcagc
    12001 cttttcctca tggctgtgaa cattaagact cctgtggtgg ttgaaaacat taccctcatg
    12061 tgcctgagga tcttgcagaa gctgataaaa ccacctgctc ccactagcaa gaagaacaag
    12121 gatgtccccg ttgaggccct caccacggtg aagccatact gcaatgagat ccatgcccag
    12181 gctcaactgt ggctcaagag agaccccaag gcatcctatg atgcctggaa gaagtgtctt
    12241 cctatcagag ggatagatgg caatgggaaa gcccccagca aatcagagct ccgccatctc
    12301 tatttgactg agaagtatgt gtggaggtgg aaacagttcc tgagtcgtcg ggggaagagg
    12361 acctccccct tggatctcaa actggggcat aacaactggc tgcgacaagt gcttttcact
    12421 ccagcaacgc aggccgcacg gcaggcagcc tgtaccattg tggaagctct agccaccatt
    12481 cccagccgca agcagcaggt cctggacctg cttaccagtt acctggatga gctgagcata
    12541 gctggggagt gtgcagctga gtacctggct ctctaccaga agctcatcac ttctgcgcac
    12601 tggaaagtct acttggcagc tcggggagtc ctaccctatg tgggcaacct catcaccaag
    12661 gaaatagctc gtctgctggc cctggaggag gctaccctga gtaccgatct gcagcagggt
    12721 tatgccctta aaagtctcac aggccttctc tcctcctttg ttgaggtgga atccatcaaa
    12781 agacatttta aaagtcgctt ggtgggtact gtgctgaatg gatacctgtg cttgcggaag
    12841 ctggtggtgc agaggaccaa gctgatcgat gagacgcagg acatgctgct ggagatgctg
    12901 gaggacatga ccacaggtac agaatcagaa accaaggcct tcatggctgt gtgcattgag
    12961 acagccaagc gctacaatct ggatgactac cggaccccgg tgttcatctt cgagaggctc
    13021 tgcagcatca tttatcctga ggagaatgaa gtcactgagt tctttgtgac cctggagaag
    13081 gatccccaac aagaagactt cttacagggc aggatgcctg ggaacccgta tagcagcaat
    13141 gagccaggca tcgggccgct gatgagggat ataaagaaca agatttgcca ggactgtgac
    13201 ttagtggccc tcctggaaga tgacagtggc atggagcttc tagtgaacaa taaaatcatt
    13261 agtttggacc ttcctgtggc tgaagtttac aagaaagtct ggtgtaccac gaatgaggga
    13321 gagcccatga ggattgttta tcgtatgcgg gggctgctgg gcgatgccac agaggagttc
    13381 attgagtccc tggactctac tacagatgaa gaagaagatg aagaagaagt gtataaaatg
    13441 gctggtgtga tggcccagtg tgggggcctg gaatgcatgc ttaacagact cgcagggatc
    13501 agagatttca agcagggacg ccaccttcta acagtgctac tgaaattgtt cagttactgc
    13561 gtgaaggtga aagtcaaccg gcagcaactg gtcaaactgg aaatgaacac cttgaacgtc
    13621 atgctgggga ccctaaacct ggcccttgta gctgaacaag aaagcaagga cagtgggggt
    13681 gcagctgtgg ctgagcaggt gcttagcatc atggagatca ttctagatga gtccaatgct
    13741 gagcccctga gtgaggacaa gggcaacctc ctcctgacag gtgacaagga tcaactggtg
    13801 atgctcttgg accagatcaa cagcaccttt gttcgctcca accccagtgt gctccagggc
    13861 ctgcttcgca tcatcccgta cctttccttt ggagaggtgg agaaaatgca gatcttggtg
    13921 gagcgattca aaccatactg caactttgat aaatatgatg aagatcacag tggtgatgat
    13981 aaagtcttcc tggactgctt ctgtaaaata gctgctggca tcaagaacaa cagcaatggg
    14041 caccagctga aggatctgat tctccagaag gggatcaccc agaatgcact tgactacatg
    14101 aaaaagcaca tccctagcgc caagaatttg gatgccgaca tctggaaaaa gtttttgtct
    14161 cgcccagcct tgccatttat cctaaggctg cttcggggcc tggccatcca gcaccctggc
    14221 acccaggttc tgattggaac tgattccatc ccgaacctgc ataagctgga gcaggtgtcc
    14281 agtgatgagg gcattgggac cttggcagag aacctgctgg aagccctgcg ggaacaccct
    14341 gacgtaaaca agaagattga cgcagcccgc agggagaccc gggcagagaa gaagcgcatg
    14401 gccatggcaa tgaggcagaa ggccctgggc accctgggca tgacgacaaa tgaaaagggc
    14461 caggtcgtga ccaagacagc actcctgaag cagatggaag agctgatcga ggagcctggc
    14521 ctcacgtgct gcatctgcag ggagggatac aagttccagc ccacaaaggt cctgggcatt
    14581 tataccttca cgaagcgggt agccttggag gagatggaga ataagccccg gaaacagcag
    14641 ggctacagca ccgtgtccca cttcaacatt gtgcactacg actgccatct ggctgccgtc
    14701 aggttggctc gaggccggga agagtgggag agtgccgccc tgcagaatgc caacaccaag
    14761 tgcaacgggc tccttccggt ctggggacct catgtccctg aatcagcttt tgccacttgc
    14821 ttggcaagac acaacactta cctccaggaa tgtacaggcc agcgggagcc cacgtatcag
    14881 ctcaacatcc atgacatcaa actgctcttc ctgcgcttcg ccatggagca gtcgttcagc
    14941 gcagacactg gcgggggcgg ccgggagagc aacatccacc tgatcccgta catcattcac
    15001 actgtgcttt acgtcctgaa cacaacccga gcaacttccc gagaagagaa gaacctccaa
    15061 ggctttctgg aacagcccaa ggagaagtgg gtggagagtg cctttgaagt ggacgggccc
    15121 tactatttca cagtcttggc ccttcacatc ctgccccctg agcagtggag agccacacgt
    15181 gtggaaatct tgcggaggct gttggtgacc tcgcaggctc gggcagtggc tccaggtgga
    15241 gccaccaggc tgacagataa ggcagtgaag gactattccg cttaccgttc ttcccttctc
    15301 ttttgggccc tcgtcgatct catttacaac atgtttaaga aggtgcctac cagtaacaca
    15361 gagggaggct ggtcctgctc tctcgctgag tacatccgcc acaacgacat gcccatctac
    15421 gaagctgccg acaaagccct gaaaaccttc caggaggagt tcatgccagt ggagaccttc
    15481 tcagagttcc tcgatgtggc cggtctttta tcagaaatca ccgatccaga gagcttcctg
    15541 aaggacctgt tgaactcagt cccctgacca ccacacagca gctgcggcgg cgaagacgaa
    15601 gctggcttgc cttccaccct ctgttctccc tccttgtgca ttaagttccc tccgcgggat
    15661 gctgcattgt taccccgccc tcccctctct catttttctt ggtgtggctt ggggttttta
    15721 ggcttcctgt tttatctcgt gtgtgtggtg caccagctat gaggttgtct gtaacccaag
    15781 ccatcaaagg gcctgtacat acctaggagc catgagttgt cccggccagc ttcatacttg
    15841 agtgtgcaca tcttgagaaa taaacaagtg acttaacaca cattgaaaa
//
