LOCUS       XM_047416500           15919 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ubiquitin protein ligase E3 component
            n-recognin 4 (UBR4), transcript variant X24, mRNA.
ACCESSION   XM_047416500
VERSION     XM_047416500.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15919
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..15919
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /note="ubiquitin protein ligase E3 component n-recognin 4;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 12 mRNAs, 354 ESTs, 4657 long SRA reads, 8
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 9 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:23352"
                     /db_xref="HGNC:HGNC:30313"
                     /db_xref="MIM:609890"
     CDS             19..15597
                     /gene="UBR4"
                     /gene_synonym="p600; RBAF600; ZUBR1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UBR4 isoform X24"
                     /protein_id="XP_047272456.1"
                     /db_xref="GeneID:23352"
                     /db_xref="HGNC:HGNC:30313"
                     /db_xref="MIM:609890"
                     /translation="MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAF
                     EMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAA
                     ACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKL
                     PQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVE
                     GENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDA
                     VLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSL
                     SCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAI
                     SSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
                     TKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGWETDGPPAA
                     LSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDS
                     NTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVK
                     SPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHH
                     MATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPF
                     SEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWDRFLSTMKQNALQGV
                     VPSETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQELSVNMDAQMRFVPLILA
                     RLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRATTPLYHGFKEV
                     EENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDSVACDVLFSKLVKYDELYAALTA
                     LLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYINQLSMNSPEM
                     SECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTTKCSSVKYDVE
                     IVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAET
                     DPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAAVLAI
                     GSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSESYI
                     SAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLE
                     SSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILE
                     ECLQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQ
                     LTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQL
                     LTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAG
                     HLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNAL
                     SQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQ
                     KEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLA
                     LVKRTPSSGMSSTMKESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPK
                     KSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQAL
                     SELHTVEKAVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMC
                     VLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLT
                     GNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELA
                     IVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQL
                     MEEASSAQQGPFYVTNVLEINHEDLKQDSNSQVAGGGVSVYYSHVLQMLFFSYCQGKS
                     FAATISRTTLEVLQLFPINIKSFVVCSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTT
                     GVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIY
                     MANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTD
                     VEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGT
                     QAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLNLFIGASVDPAGVTM
                     IDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTGDSDSAAPTTTSGTV
                     LESSETESLTKLDRLVVSSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPASV
                     QQQSKSLLASLHTSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARS
                     IAIMRPNNLVHFTESKLPQMETDCFFPRCACWSLGIVGILIGAPLETPSPEGMDEGKE
                     PQKQLEGDCCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGY
                     CTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTP
                     MDKDDDDDDDADEKMQSSGIPNGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVNN
                     GNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQAPASDDEGSTAAT
                     DGSTLRTSPADHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSS
                     STGAISTTTGHQEGDGSEGEGEGETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGG
                     VRAIPYMQVILMLTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNERSALNEV
                     HLVVMRLLSVFMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYW
                     KSQQNDEEPVATSQLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRL
                     PYQIKKITDTNSRIPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYR
                     QLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIA
                     AQRTINWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASSG
                     SSSASSSSAPVAASSGQATTQSKSSTKKSKKEEKEKEKDGETSGSQEDQLCTALVNQL
                     NKFADKETLIQFLRCFLLESNSSSVRWQAHCLTLHIYRNSSKSQQELLLDLMWSIWPE
                     LPAYGRKAAQFVDLLGYFSLKTPQTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNT
                     LSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISK
                     VTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDL
                     PLPIVASNLMIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRS
                     INYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKAD
                     RVYHQLMGHRPQLENLLCKVNEAAPEKPQDDSGTAGGISSTSASVNRYILQLAQEYCG
                     DCKNSFDELSKIIQKVFASRKELLEYDLQQREAATKSSRTSVQPTFTASQYRALSVLG
                     CGHTSSTKCYGCASAVTEHCITLLRALATNPALRHILVSQGLIRELFDYNLRRGAAAM
                     REEVRQLMCLLTRDNPEATQQMNDLIIGKVSTALKGHWANPDLASSLQYEMLLLTDSI
                     SKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDV
                     PVEALTTVKPYCNEIHAQAQLWLKRDPKASYDAWKKCLPIRGIDGNGKAPSKSELRHL
                     YLTEKYVWRWKQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALA
                     TIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQKLITSAHWKVYLAARGVLPYVGN
                     LITKEIARLLALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNG
                     YLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRT
                     PVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRD
                     IKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYR
                     MRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQG
                     RHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVA
                     EQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLL
                     RIIPYLSFGEVEKMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNG
                     HQLKDLILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQH
                     PGTQVLIGTDSIPNLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAE
                     KKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQP
                     TKVLGIYTFTKRVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESA
                     ALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLF
                     LRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKE
                     KWVESAFEVDGPYYFTVLALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTD
                     KAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAAD
                     KALKTFQEEFMPVETFSEFLDVAGLLSEITDPESFLKDLLNSVP"
ORIGIN      
        1 gcagtagtac gacggaagat ggcgacgagc ggcggcgaag aggcggcggc agcggctccg
       61 gcgccgggga ccccggcaac gggggcggac acgaccccgg gctgggaggt ggctgtgcgg
      121 cccctgctgt ccgcgtccta ctccgccttc gagatgaagg agttgccgca gctggtggcc
      181 tcagtcatcg agagtgaatc agaaatcctg caccatgaga agcagtacga gccattctac
      241 tcatcttttg ttgcactttc cacacactat attacaacag tttgcagtct cattccccgg
      301 aaccaacttc agtcagtggc agcagcctgt aaagttctaa ttgagttttc tctcctgcgt
      361 ctggagaatc cagatgaggc ttgtgctgtg tcccagaaac acttgattct cctaatcaag
      421 ggcctgtgca ctggctgtag ccgactagat agaactgaaa ttatcacatt tacagcaatg
      481 atgaaatccg ccaagctgcc ccaaacagtg aagacacttt cagacgtgga agatcagaaa
      541 gagctggcct caccagtaag ccctgagttg aggcaaaagg aggtacagat gaattttttg
      601 aaccagctga cctcagtttt taaccctaga actgtagcat cacaacctat cagtacacag
      661 actctggtgg aaggagaaaa tgatgagcag tcatctacag atcaagcctc agctatcaaa
      721 accaagaatg tgttcatagc tcagaacgtg gctagtcttc aagagcttgg tggctcggag
      781 aagctactgc gtgtatgttt gaacctgcca tatttcctac gctatatcaa tcggttccaa
      841 gatgcagttt tagctaattc cttcttcata atgcctgcaa cagtagcaga tgccactgct
      901 gttcgtaatg gctttcattc attggtgatt gatgtaacta tggcattgga taccctttct
      961 ctacctgtgt tggaacctct caatccttct cgtctacaag atgtgacagt cctcagccta
     1021 agttgtctgt atgcaggtgt gagtgtggca acgtgcatgg ccatcctcca tgtgggtagt
     1081 gcccagcaag tgcggacagg gtccacgagc tccaaagaag atgactatga aagtgacgca
     1141 gctacaattg tccagaaatg tctcgaaatc tatgacatga ttggacaagc aatcagcagt
     1201 tctcgccggg ctggtggtga gcactatcag aatttccaat tgctgggtgc ttggtgcttg
     1261 ttaaacagcc ttttcctcat actgaacctc agtcctactg cgttggctga taaggggaaa
     1321 gagaaggacc cactggctgc cctccgagtc agagacatcc tttctcgtac taaagaggga
     1381 gtgggctccc ctaaactggg gcctggaaaa gggcatcagg gatttggggt actctcagta
     1441 atattggcaa accatgccat caaactgcta acgtctctct ttcaagacct acaagtggag
     1501 gcccttcaca agggttggga gacagatggc ccccctgcag ccttgagcat tatggcccag
     1561 agcacctcca tacagaggat tcaacggctg attgactctg tcccactgat gaacctgctc
     1621 ttgacgttac tttcaacttc ctacagaaag gcatgtgtcc tgcagcggca gaggaagggc
     1681 tccatgagca gcgatgccag cgcctccacc gactccaata cttactatga ggacgatttc
     1741 agtagcacgg aggaggacag cagccaagac gatgacagtg agcctatttt ggggcaatgg
     1801 tttgaggaga ctatttctcc cagtaaagag aaagcagcac ctccgcctcc tcccccacct
     1861 cctccactgg aaagctctcc tcgggttaaa agccccagta agcaggcccc tggtgagaag
     1921 ggcaacattc tggcgagtcg caaagatcct gagttgttct taggtctggc ttccaacatt
     1981 ttgaacttca tcacctcttc catgctgaac tctcggaaca attttatccg aaactatctg
     2041 agtgtatctc tttcagaaca ccatatggcc accctagcca gtatcatcaa ggaggtggac
     2101 aaagatggac tcaagggttc atcagatgaa gagtttgctg cagctctcta tcacttcaac
     2161 cactcactgg taacctctga ccttcagtca cctaacctgc agaacacact gttgcagcag
     2221 ctaggagtgg ctcctttttc tgagggccct tggcccttgt acattcaccc tcaaagcctc
     2281 tctgtgcttt cacgcctcct gctcatctgg caacataaag ccagtgctca aggtgaccct
     2341 gacgtcccag aatgccttaa agtttgggac aggtttttgt ctacaatgaa gcagaatgcc
     2401 ctgcaaggtg tggtgcccag tgagacagag gatctgaatg tagaacacct gcagatgctc
     2461 ctcctcattt tccacaattt caccgagaca ggccggcggg ccatattgtc gctttttgtc
     2521 cagatcatcc aggagttgag cgtcaacatg gatgctcaga tgcgcttcgt gccgcttatc
     2581 ttggctcgcc tccttctcat ctttgattat ctgcttcatc agtactccaa agcccctgtg
     2641 tatctatttg agcaggtaca gcataacctg ctaagtcctc cctttgggtg ggcaagtgga
     2701 tcccaggaca gcaacagccg ccgggcaacc actcctctct atcatggatt caaagaagta
     2761 gaagaaaact ggtctaagca tttctcatca gatgctgtcc cacaccccag attctactgt
     2821 gtcctgtccc cagaagcctc agaggatgat ttgaaccgac ttgattctgt ggcatgtgac
     2881 gtccttttct ccaagcttgt caagtatgat gagctttatg ctgcactgac agccctgctt
     2941 gcagctgggt cccagcttga tacagttagg agaaaggaaa acaagaatgt aacagccttg
     3001 gaggcctgtg cccttcaata ttacttcttg atactgtgga ggatcctagg aattttacca
     3061 ccatcaaaga cttacattaa ccagctatcc atgaactcac ctgagatgag cgaatgtgac
     3121 atcttgcaca ctctgcgatg gtcttctcgg ctccggatca gctcctatgt caactggata
     3181 aaggatcacc ttatcaaaca gggaatgaag gctgagcatg ctagctcgct tctagaactg
     3241 gcatccacca ctaagtgtag ctcagtgaaa tatgatgttg aaatagtaga ggaatacttc
     3301 gctcgacaga tctcatcctt ctgtagtatc gactgtacca ccatcttgca gctgcatgaa
     3361 attcccagtc tgcagtccat ctacaccctt gatgccgcga tctcaaaggt ccaggtctct
     3421 ttggatgagc atttttctaa gatggctgct gagactgatc ctcataagtc gtctgagatt
     3481 accaagaacc tacttccagc cacgctgcaa ctcattgaca cctatgcatc gttcaccaga
     3541 gcctatttgc tgcaaaactt taatgaagag ggaacaactg agaaaccttc caaggagaaa
     3601 ctgcaaggct ttgctgctgt tttggctatt ggctctagca ggtgcaaggc aaatactctg
     3661 ggtccgacac tggttcagaa tttgccatcg tcagtgcaga ctgtgtgtga gtcctggaac
     3721 aacatcaata ccaatgaatt tcccaatatt ggatcctggc gcaatgcctt tgccaatgac
     3781 accatccctt cagagagtta tattagtgca gtgcaggctg cacacctggg gactctctgt
     3841 agccaaagtc tgcccctggc tgcttccctg aagcataccc tcctctcact ggtcaggttg
     3901 actggagatc ttattgtttg gtcagatgag atgaacccac cacaggtaat tcggacactg
     3961 ctacctcttc ttttggaatc aagcactgag agtgttgccg agatcagtag caactccctg
     4021 gaacgcatct tgggccctgc tgagtctgat gagttcttgg ctcgtgttta tgagaagctg
     4081 atcactggtt gttacaacat tctggccaat catgcagatc ctaacagtgg actggatgaa
     4141 tccatcctgg aggaatgtct ccagtacttg gaaaagcagc tggaaagtag ccaggctcgt
     4201 aaagctatgg aggagttttt ctctgacagt ggagaacttg tacagatcat gatggcaaca
     4261 gccaatgaga acctctctgc taaattctgt aaccgagttt tgaaattctt caccaaactc
     4321 ttccagctga ctgagaagag ccctaacccg agcctgttgc atctctgtgg ctccctggca
     4381 caactggcct gtgtggaacc tgtgcgcctg caggcctggc tcacccgcat gactacatcg
     4441 cccccaaaag attctgatca gctggatgta attcaggaga accggcagct gctgcagtta
     4501 ctgaccacat acattgttcg ggaaaacagc caagttgggg aaggtgtgtg tgctgttctt
     4561 ctgggcaccc tgactcccat ggcaacagag atgctggcca acggtgatgg gactggcttc
     4621 cctgaactta tggttgtgat ggccactctg gccagtgcag gtcaaggtgc tggtcacctt
     4681 cagcttcata atgctgctgt ggattggctg agcagatgca agaaatacct gtcacagaag
     4741 aatgtagttg aaaaactgaa tgccaatgta atgcatggaa agcatgtgat gatcttggag
     4801 tgcacatgcc atatcatgtc ttacttggct gatgtcacga atgccctgag ccagagtaat
     4861 ggtcaaggcc caagtcatct ctcagtggat ggggaagagc gggccattga agtagactca
     4921 gactgggtgg aggagttggc ggtggaagag gaagattccc aggctgagga ttcagatgaa
     4981 gattctcttt gcaataaact ctgcactttt acgatcacac agaaagaatt catgaaccag
     5041 cattggtacc actgtcacac ctgtaaaatg gtggatggcg tgggtgtctg cacagtgtgt
     5101 gctaaggtgt gccacaagga tcatgagatt tcctatgcca agtatggatc cttcttctgt
     5161 gactgtggag ccaaggaaga tggcagctgt ttggctctgg tgaagagaac tcctagcagt
     5221 ggcatgagct ctaccatgaa ggagtcggca tttcagagtg aacccaggat ttcagagagt
     5281 ctagtgcgtc atgccagcac ctcctcgcca gctgacaaag ccaaggttac catcagtgat
     5341 ggaaaggttg ctgacgaaga gaagcccaag aagagcagcc tctgccgcac agtagagggc
     5401 tgccgggagg aattacagaa ccaggccaat ttctccttcg ctcctctcgt gttagacatg
     5461 cttaatttcc ttatggatgc cattcagacc aacttccagc aagcttcagc cgtcgggagc
     5521 agcagccgtg ctcagcaagc cctcagtgag ctacacactg tggagaaggc agtggagatg
     5581 acagaccagc tgatggttcc caccttaggg tcccaggaag gtgcctttga gaatgtgcgg
     5641 atgaattaca gtggagacca gggccagacc atccggcagc tgatcagtgc tcatgtgctc
     5701 aggcgggtgg ctatgtgtgt gctctcctct ccccatgggc gccgccaaca tttggctgtc
     5761 agccatgaga agggcaagat caccgttctg cagctctctg cactcctgaa gcaagcagat
     5821 tccagcaaaa ggaagttaac tctgacccgc ttggcttctg ccccagttcc ttttactgtg
     5881 ttgagcctca caggaaatcc ctgcaaggaa gactacttgg cggtttgtgg gctaaaggac
     5941 tgtcatgtgc tcacctttag tagctcaggc tctgtttcgg atcacttggt tttgcaccct
     6001 cagttggcaa cggggaactt catcatcaaa gccgtgtggt tacctggttc acagaccgag
     6061 ttagcaattg tcaccgcaga ctttgttaag atttatgacc tgtgtgttga tgccttgagt
     6121 ccaaccttct attttctcct gccaagctca aagataagag atgttacctt ccttttcaat
     6181 gaggagggaa agaacatcat tgttataatg tcttcggctg ggtacatcta tactcagctt
     6241 atggaagagg ccagcagtgc ccagcaggga cccttctatg tcactaatgt gttggaaatc
     6301 aatcatgagg acctgaagca ggacagtaac agccaggtgg cgggcggtgg tgtgtccgtg
     6361 tactactccc acgtgttgca gatgttgttc ttcagctatt gtcaaggcaa atcattcgca
     6421 gccaccatca gcaggacaac cctggaggtg ttgcaactct tccccatcaa catcaaaagt
     6481 tttgttgtct gcagttccaa tggtggcagt aagacttctc ctgctctttg ccagtggtct
     6541 gaggtgatga accaccctgg cttggtgtgc tgtgtccagc aaactacagg ggtgccgctg
     6601 gtagttatgg tgaaaccaga cacttttctt atccaggaga ttaagactct tcctgctaaa
     6661 gcgaagatcc aagacatggt tgctattagg cacacggcct gcaatgagca gcagcggaca
     6721 acaatgattc tgctgtgtga ggatggcagc ctgcgcattt acatggccaa cgtggagaac
     6781 acctcctact ggctgcagcc atccctgcag cccagcagtg tcatcagcat catgaagcct
     6841 gttcgaaagc gcaaaacagc tacaatcaca acccgcacgt ctagccaggt gactttcccc
     6901 attgactttt ttgaacacaa ccagcagctg acagatgtgg agtttggtgg taacgacctc
     6961 ctacaggtct ataatgcaca acagataaaa caccggctga attccactgg catgtatgtg
     7021 gccaacacca agcccggagg cttcaccatt gagattagta acaacaatag cactatggtg
     7081 atgacaggca tgcggatcca gattgggact caagcaatag aacgggcccc gtcatatatc
     7141 gagatcttcg gcagaactat gcagctcaac ctgagtcgct cacgctggtt tgacttcccc
     7201 ttcaccagag aagaagccct gcaggctgat aagaagctga acctcttcat tggggcctcg
     7261 gtggatccag caggtgtcac catgatagat gctgtaaaaa tttatggcaa gactaaggag
     7321 cagtttggct ggcctgatga gcccccagaa gaattccctt ctgcctctgt cagcaacatc
     7381 tgcccttcaa atctgaacca gagcaacggc actggagata gcgactcagc tgcccccact
     7441 acgaccagtg gaactgtcct ggagagttct gaaactgagt ccctaaccaa gctggaccgg
     7501 ctggttgtga gttctttaga agccctggaa agctgctttg ccgttggccc aatcatcgag
     7561 aaggagagaa acaagaatgc tgctcaggag ctggccactt tgctgttgtc cctgccagca
     7621 cctgccagtg tccagcagca gtccaagagc cttctggcca gcctgcacac cagccgctcg
     7681 gcctaccaca gccacaagga tcaggccttg ctgagcaaag ctgtgcagtg tctcaacaca
     7741 tctagcaaag agggcaagga tttggaccct gaggtgttcc agaggctagt gatcacagct
     7801 cgctccattg ccatcatgcg ccccaacaac cttgtccact ttacggagtc aaagctgccc
     7861 cagatggaaa cagactgttt ttttcctaga tgtgcctgct ggagtctagg gatagttggc
     7921 atattgattg gggccccact tgaaactccc tccccagaag gaatggatga agggaaggaa
     7981 ccgcagaagc agttggaagg agattgctgt agtttcatca cccagcttgt gaaccacttc
     8041 tggaaactcc atgcatccaa acccaagaat gccttcttgg cacctgcctg ccttccagga
     8101 ctaactcata ttgaagctac tgtcaatgct ctggtggaca tcatccatgg ctactgtacc
     8161 tgtgagctgg attgtattaa cacagcatcc aagatctaca tgcagatgct cttgtgtcct
     8221 gatcctgctg tgagcttctc ttgtaaacaa gctctaattc gagtcctaag gcccaggaac
     8281 aaacggagac atgtgacttt accctcttcc cctcgaagca acactccaat ggacaaggat
     8341 gatgatgacg atgatgatgc agatgagaaa atgcagtcat cagggatccc gaatggtggt
     8401 cacatccgtc aggaaagcca ggaacagagt gaggtggacc atggagattt tgagatggtg
     8461 tctgagtcga tggtcctgga gacagctgaa aatgtcaaca atggcaaccc ctctcccctg
     8521 gaggccctgc tggcaggcgc agagggcttc ccccccatgc tggacatccc acctgatgca
     8581 gatgacgaga ccatggttga actagccatt gccctgagcc tgcagcagga ccaacaagct
     8641 ccagcctcag acgacgaggg cagtacagca gcgacagatg gttctaccct tcggacctct
     8701 cctgctgacc acggtggtag tgtgggctcg gagagcgggg gcagtgcagt ggactcagtg
     8761 gctggcgagc acagtgtatc tggccggagc agtgcttatg gcgatgctac agctgagggg
     8821 catccggctg gaccaggaag tgtcagctca agcactggag ccatcagcac caccactggg
     8881 caccaggagg gagatggctc cgagggagaa ggagaaggag aaactgaagg agatgtccac
     8941 actagcaaca ggctgcacat ggtccgtcta atgctgttgg agagattact gcagaccctg
     9001 cctcaattac gaaacgttgg cggtgtccgg gccatcccat acatgcaggt cattctaatg
     9061 ctcactacag atctggatgg agaagatgag aaagacaagg gggccctaga caacctgctc
     9121 tcccagctta ttgctgagtt gggtatggat aaaaaggatg tctccaagaa gaatgagcgc
     9181 agcgccctga atgaagtcca tctggtagta atgagactcc tgagtgtctt catgtcccgc
     9241 accaaatctg gatccaagtc ttccatatgt gagtcatctt ccctcatctc cagtgccaca
     9301 gcagcagctc tactgagctc tggggctgtg gactactgcc tgcacgtgct caaatcactg
     9361 ctggaatatt ggaagagcca acagaatgac gaggagcctg tggctaccag ccagttgctg
     9421 aaaccacata ctacctcctc cccacctgac atgagcccat tctttctccg ccagtatgtg
     9481 aagggtcatg ctgctgatgt gtttgaggcc tatactcagc ttctaacaga aatggtactg
     9541 aggcttcctt accaaatcaa aaagattact gacaccaatt ctcgaatccc acctcctgtc
     9601 tttgaccact cgtggtttta ctttctctcc gagtacctca tgatccagca gactccattt
     9661 gtgcgccgtc aagtccgcaa acttctgctc ttcatctgtg gatccaaaga gaagtaccgc
     9721 cagctccggg atttgcacac cctggactct cacgtgcgtg ggatcaagaa gctgctagaa
     9781 gagcagggga tattcctccg ggcaagtgtg gttacagcca gctcaggctc cgccttgcaa
     9841 tatgacacac tcatcagcct gatggagcac ctgaaagcct gtgcagagat tgccgcccag
     9901 cgaaccatca actggcagaa attctgcatc aaagatgact ccgtcctgta cttcctcctc
     9961 caagtcagtt tccttgtgga tgagggcgtg tccccagtgc tgctgcaact gctctcctgt
    10021 gctctgtgcg gcagcaaggt gctcgctgca ctggcagcct cttcgggatc ctccagtgct
    10081 tcttcctcct cagcccctgt ggctgccagt tctggacaag ccacaacaca gtccaagtct
    10141 tccactaaaa agagcaagaa agaagaaaaa gaaaaggaga aagatggtga gacctctggc
    10201 agccaggagg accagctgtg cacagctctg gtgaaccagc tgaacaaatt tgccgataag
    10261 gaaaccctga tccagttcct gcgttgtttc ctgttagagt ccaattcttc ctcggtgcgc
    10321 tggcaggccc actgtctgac actgcacatc tacagaaatt ccagcaaatc tcaacaggag
    10381 ctcctgctag atctgatgtg gtccatctgg ccagaactcc cagcctatgg tcgtaaggct
    10441 gcccagtttg tggacctact aggatatttc tccctgaaaa ctccacaaac agagaagaag
    10501 ttgaaggagt attcacagaa ggctgtggag attctgcgga ctcaaaacca tattcttacc
    10561 aaccacccca actcgaacat ttataacact ttgtctggct tagtggagtt tgatggctat
    10621 tacctggaga gcgatccctg cctggtgtgt aataacccgg aagtaccgtt ctgttatatc
    10681 aagctgtctt ccattaaagt ggacacgcgg tacaccacca cccagcaggt tgtgaagctc
    10741 attggcagtc acaccatcag caaagtgaca gtgaaaatcg gggatctgaa acggaccaag
    10801 atggtgcgga ccatcaacct gtattataac aaccgaaccg tgcaggccat cgtggagttg
    10861 aaaaacaagc cagctcgctg gcacaaagcc aagaaggttc agctgacccc tggacagaca
    10921 gaggtgaaga ttgacctgcc gttgcccatt gtggcctcca atctgatgat tgagtttgca
    10981 gacttctatg aaaactacca ggcctccaca gagaccctgc agtgccctcg ctgtagtgcc
    11041 tcggtccctg ccaacccagg agtctgtggc aactgtggag agaatgtgta ccagtgtcac
    11101 aaatgcagat ccatcaacta cgatgaaaag gatcccttcc tctgcaatgc ctgtggcttc
    11161 tgtaaatatg cccgcttcga cttcatgctc tatgccaagc cttgctgtgc agtggatccc
    11221 attgagaatg aagaagaccg gaagaaggct gtatccaaca tcaatacact tttggacaaa
    11281 gctgatcgag tgtatcatca gctgatggga caccggccac agctggagaa cctgctctgc
    11341 aaagtgaatg aggcagctcc agaaaagcca caggatgact caggaacagc agggggcatc
    11401 agctccactt ctgccagtgt gaatcgttac atcctgcagt tggctcagga gtattgtgga
    11461 gactgcaaga actcttttga tgaactctcc aaaatcatcc agaaagtctt tgcttcgcgc
    11521 aaagagttgt tggaatatga cctacagcag agggaagcag ccactaaatc atcccggacc
    11581 tccgtgcagc ccacattcac tgccagccag taccgtgcct tatccgtcct gggctgtggc
    11641 cacacatcct ccaccaagtg ctatggctgc gcctcggctg tcacagaaca ttgtatcaca
    11701 ctacttcggg ccctggccac caacccagcc ttgaggcaca tccttgtctc ccagggcctt
    11761 atccgggagc tctttgatta taatcttcgc cgaggggctg cggccatgcg ggaggaggtc
    11821 cgccagctca tgtgcctcct aactcgagac aacccagaag ccacccaaca gatgaatgac
    11881 ctgattattg gcaaggtctc cacagccctg aagggccact gggccaaccc cgatctggca
    11941 agtagcctgc agtatgaaat gctgctgctg acggattcta tctccaagga ggacagctgc
    12001 tgggagctcc ggttacgctg tgctctcagc cttttcctca tggctgtgaa cattaagact
    12061 cctgtggtgg ttgaaaacat taccctcatg tgcctgagga tcttgcagaa gctgataaaa
    12121 ccacctgctc ccactagcaa gaagaacaag gatgtccccg ttgaggccct caccacggtg
    12181 aagccatact gcaatgagat ccatgcccag gctcaactgt ggctcaagag agaccccaag
    12241 gcatcctatg atgcctggaa gaagtgtctt cctatcagag ggatagatgg caatgggaaa
    12301 gcccccagca aatcagagct ccgccatctc tatttgactg agaagtatgt gtggaggtgg
    12361 aaacagttcc tgagtcgtcg ggggaagagg acctccccct tggatctcaa actggggcat
    12421 aacaactggc tgcgacaagt gcttttcact ccagcaacgc aggccgcacg gcaggcagcc
    12481 tgtaccattg tggaagctct agccaccatt cccagccgca agcagcaggt cctggacctg
    12541 cttaccagtt acctggatga gctgagcata gctggggagt gtgcagctga gtacctggct
    12601 ctctaccaga agctcatcac ttctgcgcac tggaaagtct acttggcagc tcggggagtc
    12661 ctaccctatg tgggcaacct catcaccaag gaaatagctc gtctgctggc cctggaggag
    12721 gctaccctga gtaccgatct gcagcagggt tatgccctta aaagtctcac aggccttctc
    12781 tcctcctttg ttgaggtgga atccatcaaa agacatttta aaagtcgctt ggtgggtact
    12841 gtgctgaatg gatacctgtg cttgcggaag ctggtggtgc agaggaccaa gctgatcgat
    12901 gagacgcagg acatgctgct ggagatgctg gaggacatga ccacaggtac agaatcagaa
    12961 accaaggcct tcatggctgt gtgcattgag acagccaagc gctacaatct ggatgactac
    13021 cggaccccgg tgttcatctt cgagaggctc tgcagcatca tttatcctga ggagaatgaa
    13081 gtcactgagt tctttgtgac cctggagaag gatccccaac aagaagactt cttacagggc
    13141 aggatgcctg ggaacccgta tagcagcaat gagccaggca tcgggccgct gatgagggat
    13201 ataaagaaca agatttgcca ggactgtgac ttagtggccc tcctggaaga tgacagtggc
    13261 atggagcttc tagtgaacaa taaaatcatt agtttggacc ttcctgtggc tgaagtttac
    13321 aagaaagtct ggtgtaccac gaatgaggga gagcccatga ggattgttta tcgtatgcgg
    13381 gggctgctgg gcgatgccac agaggagttc attgagtccc tggactctac tacagatgaa
    13441 gaagaagatg aagaagaagt gtataaaatg gctggtgtga tggcccagtg tgggggcctg
    13501 gaatgcatgc ttaacagact cgcagggatc agagatttca agcagggacg ccaccttcta
    13561 acagtgctac tgaaattgtt cagttactgc gtgaaggtga aagtcaaccg gcagcaactg
    13621 gtcaaactgg aaatgaacac cttgaacgtc atgctgggga ccctaaacct ggcccttgta
    13681 gctgaacaag aaagcaagga cagtgggggt gcagctgtgg ctgagcaggt gcttagcatc
    13741 atggagatca ttctagatga gtccaatgct gagcccctga gtgaggacaa gggcaacctc
    13801 ctcctgacag gtgacaagga tcaactggtg atgctcttgg accagatcaa cagcaccttt
    13861 gttcgctcca accccagtgt gctccagggc ctgcttcgca tcatcccgta cctttccttt
    13921 ggagaggtgg agaaaatgca gatcttggtg gagcgattca aaccatactg caactttgat
    13981 aaatatgatg aagatcacag tggtgatgat aaagtcttcc tggactgctt ctgtaaaata
    14041 gctgctggca tcaagaacaa cagcaatggg caccagctga aggatctgat tctccagaag
    14101 gggatcaccc agaatgcact tgactacatg aaaaagcaca tccctagcgc caagaatttg
    14161 gatgccgaca tctggaaaaa gtttttgtct cgcccagcct tgccatttat cctaaggctg
    14221 cttcggggcc tggccatcca gcaccctggc acccaggttc tgattggaac tgattccatc
    14281 ccgaacctgc ataagctgga gcaggtgtcc agtgatgagg gcattgggac cttggcagag
    14341 aacctgctgg aagccctgcg ggaacaccct gacgtaaaca agaagattga cgcagcccgc
    14401 agggagaccc gggcagagaa gaagcgcatg gccatggcaa tgaggcagaa ggccctgggc
    14461 accctgggca tgacgacaaa tgaaaagggc caggtcgtga ccaagacagc actcctgaag
    14521 cagatggaag agctgatcga ggagcctggc ctcacgtgct gcatctgcag ggagggatac
    14581 aagttccagc ccacaaaggt cctgggcatt tataccttca cgaagcgggt agccttggag
    14641 gagatggaga ataagccccg gaaacagcag ggctacagca ccgtgtccca cttcaacatt
    14701 gtgcactacg actgccatct ggctgccgtc aggttggctc gaggccggga agagtgggag
    14761 agtgccgccc tgcagaatgc caacaccaag tgcaacgggc tccttccggt ctggggacct
    14821 catgtccctg aatcagcttt tgccacttgc ttggcaagac acaacactta cctccaggaa
    14881 tgtacaggcc agcgggagcc cacgtatcag ctcaacatcc atgacatcaa actgctcttc
    14941 ctgcgcttcg ccatggagca gtcgttcagc gcagacactg gcgggggcgg ccgggagagc
    15001 aacatccacc tgatcccgta catcattcac actgtgcttt acgtcctgaa cacaacccga
    15061 gcaacttccc gagaagagaa gaacctccaa ggctttctgg aacagcccaa ggagaagtgg
    15121 gtggagagtg cctttgaagt ggacgggccc tactatttca cagtcttggc ccttcacatc
    15181 ctgccccctg agcagtggag agccacacgt gtggaaatct tgcggaggct gttggtgacc
    15241 tcgcaggctc gggcagtggc tccaggtgga gccaccaggc tgacagataa ggcagtgaag
    15301 gactattccg cttaccgttc ttcccttctc ttttgggccc tcgtcgatct catttacaac
    15361 atgtttaaga aggtgcctac cagtaacaca gagggaggct ggtcctgctc tctcgctgag
    15421 tacatccgcc acaacgacat gcccatctac gaagctgccg acaaagccct gaaaaccttc
    15481 caggaggagt tcatgccagt ggagaccttc tcagagttcc tcgatgtggc cggtctttta
    15541 tcagaaatca ccgatccaga gagcttcctg aaggacctgt tgaactcagt cccctgacca
    15601 ccacacagca gctgcggcgg cgaagacgaa gctggcttgc cttccaccct ctgttctccc
    15661 tccttgtgca ttaagttccc tccgcgggat gctgcattgt taccccgccc tcccctctct
    15721 catttttctt ggtgtggctt ggggttttta ggcttcctgt tttatctcgt gtgtgtggtg
    15781 caccagctat gaggttgtct gtaacccaag ccatcaaagg gcctgtacat acctaggagc
    15841 catgagttgt cccggccagc ttcatacttg agtgtgcaca tcttgagaaa taaacaagtg
    15901 acttaacaca cattgaaaa
//
